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R. Hannan · SciRah

Researcher profile · Semantic Scholar

R. Hannan

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R. Hannan — researcher profile on SciRah

h-index: 58
Works: 223
Citations: 11K

Most-cited papers

Targeting the RNA Polymerase I Transcription for Cancer Therapy Comes of Age
R. Ferreira, J. Schneekloth, K. Panov, K. Hannan +1 more
2020Cells167 citations Open access
Semantic Scholar
First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematological Cancers: Results of a Phase I Dose Escalation Study.
A. Khot, N. Brajanovski, Donald P. Cameron, Nadine Hein +14 more
2019Cancer Discovery160 citations Open access
Semantic Scholar
Selective Translation Complex Profiling Reveals Staged Initiation and Co-translational Assembly of Initiation Factor Complexes
S. Wagner, Anna Herrmannová, Vladislava Hronová, Stanislava Gunišová +6 more
2019bioRxiv125 citations Open access
Semantic Scholar
Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma.
J. Devlin, K. Hannan, Nadine Hein, C. Cullinane +14 more
2016Cancer Discovery121 citations Open access
Semantic Scholar
The nucleolus as a fundamental regulator of the p53 response and a new target for cancer therapy.
S. Woods, K. Hannan, R. Pearson, R. Hannan
2015Biochimica et Biophysica Acta121 citations
Semantic Scholar
Patient-derived Models of Abiraterone- and Enzalutamide-resistant Prostate Cancer Reveal Sensitivity to Ribosome-directed Therapy
M. Lawrence, D. Obinata, S. Sandhu, L. Selth +48 more
2018European Urology105 citations Open access
Semantic Scholar
Therapeutic Approaches Targeting MYC-Driven Prostate Cancer
R. Rebello, R. Pearson, R. Hannan, Luc Furic
2017Genes103 citations Open access
Semantic Scholar
Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling
Jaclyn E. Quin, K. Chan, J. Devlin, Donald P. Cameron +16 more
2016OncoTarget103 citations Open access
Semantic Scholar
Regulation of rDNA transcription in response to growth factors, nutrients and energy.
E. Kusnadi, K. Hannan, R. Hicks, R. Hannan +2 more
2015Gene90 citations
Semantic Scholar
Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population.
Nadine Hein, Donald P. Cameron, K. Hannan, N. Nguyen +26 more
2017Blood87 citations Open access
Semantic Scholar
The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35
Pei Y. Liu, Andrew E. Tee, G. Milazzo, K. Hannan +31 more
2019Nature Communications86 citations Open access
Semantic Scholar
Ribosomal DNA copy loss and repeat instability in ATRX-mutated cancers
M. Udugama, E. Sanij, Hsiao P. J. Voon, Jinbae Son +11 more
2018Proceedings of the National Academy of Sciences of the United States of America84 citations Open access
Semantic Scholar
The Dual Inhibition of RNA Pol I Transcription and PIM Kinase as a New Therapeutic Approach to Treat Advanced Prostate Cancer
R. Rebello, E. Kusnadi, Donald P. Cameron, Helen B Pearson +11 more
2016Clinical Cancer Research75 citations Open access
Semantic Scholar
Palbociclib synergizes with BRAF and MEK inhibitors in treatment naïve melanoma but not after the development of BRAF inhibitor resistance
Claire A. Martin, C. Cullinane, Laura Kirby, S. Abuhammad +13 more
2018International Journal of Cancer70 citations Open access
Semantic Scholar
A functional genetic screen defines the AKT-induced senescence signaling network
K. Chan, S. Blake, Hao-Ran Zhu, Jian Kang +11 more
2019Cell Death and Differentiation65 citations Open access
Semantic Scholar
A novel role for the Pol I transcription factor UBTF in maintaining genome stability through the regulation of highly transcribed Pol II genes
E. Sanij, J. Diesch, Analia Lesmana, G. Poortinga +13 more
2015Genome Research63 citations Open access
Semantic Scholar
Nuclear stabilization of p53 requires a functional nucleolar surveillance pathway
K. Hannan, Priscilla Soo, Mei S. Wong, J. K. Lee +28 more
2022Cell Reports50 citations Open access
Semantic Scholar
Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene
M. Lefebure, R. Tothill, E. Kruse, E. Hawkins +22 more
2017Nature Communications41 citations Open access
Semantic Scholar
The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-grade serous ovarian cancer
Shunfei Yan, Jiachen Xuan, N. Brajanovski, Madeleine R. C. Tancock +11 more
2020British Journal of Cancer40 citations Open access
Semantic Scholar
Selective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis
L. Kerry, Elaine Pegg, Donald P. Cameron, James Budzak +4 more
2017PLoS Neglected Tropical Diseases40 citations Open access
Semantic Scholar
PGRMC1 phosphorylation affects cell shape, motility, glycolysis, mitochondrial form and function, and tumor growth
Bashar M. Thejer, P. Adhikary, Amandeep Kaur, S. Teakel +27 more
2020BMC Molecular and Cell Biology39 citations Open access
Semantic Scholar
Changes in long-range rDNA-genomic interactions associate with altered RNA polymerase II gene programs during malignant transformation
J. Diesch, M. Bywater, E. Sanij, Donald P. Cameron +12 more
2019Communications Biology39 citations Open access
Semantic Scholar
Implications of Epithelial–Mesenchymal Plasticity for Heterogeneity in Colorectal Cancer
L. Pereira, J. Mariadason, R. Hannan, A. Dhillon
2015Frontiers in Oncology32 citations Open access
Semantic Scholar
Transcriptional profiles for distinct aggregation states of mutant Huntingtin exon 1 protein unmask new Huntington's disease pathways
Nagaraj S. Moily, Angelique R. Ormsby, Aleksandar Stojilovic, Yasmin M. Ramdzan +6 more
2017Molecular and cellular neurosciences29 citations
Semantic Scholar
Self-reverting mutations partially correct the blood phenotype in a Diamond Blackfan anemia patient
P. Venugopal, S. Moore, D. Lawrence, Amee J. George +14 more
2017Haematologica28 citations Open access
Semantic Scholar
Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis
E. Kusnadi, A. Trigos, C. Cullinane, D. Goode +13 more
2020EMBO Journal26 citations Open access
Semantic Scholar
Glucocorticoids improve erythroid progenitor maintenance and dampen Trp53 response in a mouse model of Diamond–Blackfan anaemia
Sara Sjögren, K. Siva, S. Soneji, Amee J. George +6 more
2015British Journal of Haematology25 citations Open access
Semantic Scholar
CX-5461 Sensitizes DNA Damage Repair–proficient Castrate-resistant Prostate Cancer to PARP Inhibition
M. Lawrence, L. Porter, Nicholas Choo, D. Pook +14 more
2021Molecular Cancer Therapeutics24 citations
Semantic Scholar
Cohesin mutations are synthetic lethal with stimulation of WNT signaling
C. Chin, Jisha Antony, Sarada Ketharnathan, Anastasia A. Labudina +10 more
2020bioRxiv23 citations Open access
Semantic Scholar
A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction
K. Somers, V. Wen, Shiloh Middlemiss, B. Osborne +33 more
2019Oncogene23 citations Open access
Semantic Scholar
rDNA Chromatin Activity Status as a Biomarker of Sensitivity to the RNA Polymerase I Transcription Inhibitor CX-5461
Jinbae Son, K. Hannan, G. Poortinga, Nadine Hein +6 more
2020Frontiers in Cell and Developmental Biology21 citations Open access
Semantic Scholar
Clustered somatic mutations are frequent in transcription factor binding motifs within proximal promoter regions in melanoma and other cutaneous malignancies
A. Colebatch, L. Di Stefano, Stephen Q. Wong, R. Hannan +4 more
2016OncoTarget20 citations Open access
Semantic Scholar
Suppression of ABCE1-Mediated mRNA Translation Limits N-MYC–Driven Cancer Progression
Ji-Xuan Gao, MoonSun Jung, C. Mayoh, Pooja Venkat +11 more
2020Cancer Research19 citations Open access
Semantic Scholar
A functional genetic screen defines the AKT-induced senescence signaling network
K. Chan, S. Blake, Hao-Ran Zhu, Jian Kang +11 more
2019Cell Death and Differentiation19 citations Open access
Semantic Scholar
Migration of Small Ribosomal Subunits on the 5′ Untranslated Regions of Capped Messenger RNA
N. Shirokikh, Yulia S Dutikova, Maria A Staroverova, R. Hannan +1 more
2019International Journal of Molecular Sciences19 citations Open access
Semantic Scholar
The Ribosomal Gene Loci—The Power behind the Throne
K. Panov, K. Hannan, R. Hannan, Nadine Hein
2021Genes18 citations Open access
Semantic Scholar
CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer
E. Sanij, K. Hannan, Jiachen Xuan, Shunfei Yan +24 more
2020Nature Communications18 citations Open access
Semantic Scholar
A new method for determining ribosomal DNA copy number shows differences between Saccharomyces cerevisiae populations
D. Sharma, S. H. Denmat, N. Matzke, K. Hannan +3 more
2021bioRxiv16 citations Open access
Semantic Scholar
Defining the essential function of FBP/KSRP proteins: Drosophila Psi interacts with the mediator complex to modulate MYC transcription and tissue growth
Lin-Na Guo, Olga Zaysteva, Z. Nie, Naomi C. Mitchell +8 more
2016Nucleic Acids Research16 citations Open access
Semantic Scholar
S6 Kinase is essential for MYC-dependent rDNA transcription in Drosophila.
Naomi C. Mitchell, E. B. Tchoubrieva, Arjun S. Chahal, S. Woods +9 more
2015Cellular Signalling16 citations
Semantic Scholar
Cell cycle and growth stimuli regulate different steps of RNA polymerase I transcription.
Sandy S. C. Hung, Analia Lesmana, Abigail Peck, Rachel S. Lee +10 more
2017Gene15 citations Open access
Semantic Scholar
Harnessing the self-assembly of peptides for the targeted delivery of anti-cancer agents
Stephanie J Franks, Kate Firipis, R. Ferreira, K. Hannan +3 more
2020Materials Horizons13 citations Open access
Semantic Scholar
Defective Hfp-dependent transcriptional repression of dMYC is fundamental to tissue overgrowth in Drosophila XPB models
J. Lee, Naomi C. Mitchell, O. Zaytseva, Arjun S. Chahal +7 more
2015Nature Communications12 citations Open access
Semantic Scholar
A phase 1, open-label, dose escalation, safety, PK and PD study of a first in class Pol1 inhibitor (CX-5461) in patients with advanced hematologic malignancies (HM).
S. Harrison, A. Khot, N. Brajanovski, Donald P. Cameron +11 more
201512 citations
Semantic Scholar
Genome wide mapping of UBF binding-sites in mouse and human cell lines
J. Diesch, R. Hannan, E. Sanij
2015Genomics Data12 citations Open access
Semantic Scholar
Cell death and barrier disruption by clinically used iodine concentrations
Anne Steins, Christina Carroll, F. J. Choong, Amee J. George +13 more
2023Life Science Alliance11 citations Open access
Semantic Scholar
High-Content Imaging Approaches to Quantitate Stress-Induced Changes in Nucleolar Morphology
Jin-Shu He, Priscilla Soo, M. Evers, Kate M. Parsons +4 more
2018Assay and drug development technologies10 citations Open access
Semantic Scholar
Amino acid-dependent signaling via S6K1 and MYC is essential for regulation of rDNA transcription
Jian Kang, E. Kusnadi, A. J. Ogden, R. Hicks +7 more
2016OncoTarget10 citations Open access
Semantic Scholar
Changes in long-range rDNA-genomic interactions associate with altered RNA polymerase II gene programs during malignant transformation
J. Diesch, M. Bywater, E. Sanij, Donald P. Cameron +12 more
2019Communications Biology9 citations Open access
Semantic Scholar
Combining High-Content Imaging and Phenotypic Classification Analysis of Senescence-Associated Beta-Galactosidase Staining to Identify Regulators of Oncogene-Induced Senescence
K. Chan, L. Paavolainen, K. Hannan, Amee J. George +4 more
2016Assay and drug development technologies9 citations
Semantic Scholar

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E. Sanij×19
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G. Poortinga×16
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Donald P. Cameron

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G. McArthur×11

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J. Diesch — researcher profile on SciRah

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