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L. Cluse · SciRah

Researcher profile · Semantic Scholar

L. Cluse

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L. Cluse — researcher profile on SciRah

h-index: 25
Works: 48
Citations: 4,116

Most-cited papers

Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis
M. Nguyen, R. Marcellus, A. Roulston, M. Watson +13 more
2007Proceedings of the National Academy of Sciences of the United States of America663 citations Open access
Semantic Scholar
Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53
M. Bywater, G. Poortinga, E. Sanij, Nadine Hein +19 more
2012Cancer Cell552 citations Open access
Semantic Scholar
Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3
A. Roberts, L. Robb, S. Rakar, L. Hartley +5 more
2001Proceedings of the National Academy of Sciences of the United States of America325 citations Open access
Semantic Scholar
SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis.
B. Croker, D. Metcalf, L. Robb, Wei Wei +11 more
2004Immunity305 citations Open access
Semantic Scholar
BET-Bromodomain Inhibitors Engage the Host Immune System and Regulate Expression of the Immune Checkpoint Ligand PD-L1
S. Hogg, S. Vervoort, S. Deswal, C. Ott +14 more
2017Cell Reports296 citations Open access
Semantic Scholar
Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma
R. Lindemann, A. Newbold, K. Whitecross, L. Cluse +13 more
2007Proceedings of the National Academy of Sciences of the United States of America224 citations Open access
Semantic Scholar
HDAC inhibitors induce tumor-cell-selective pro-apoptotic transcriptional responses
Jessica E. Bolden, W. Shi, K. Jankowski, C.-Y. Kan +5 more
2013Cell Death and Disease183 citations Open access
Semantic Scholar
Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition
S. Hogg, Olga Motorna, L. Cluse, Timothy M. Johanson +38 more
2021Molecules and Cells156 citations Open access
Semantic Scholar
The Rac2 Guanosine Triphosphatase Regulates B Lymphocyte Antigen Receptor Responses and Chemotaxis and Is Required for Establishment of B-1a and Marginal Zone B Lymphocytes1
B. Croker, D. Tarlinton, L. Cluse, A. Tuxen +4 more
2002Journal of Immunology134 citations Open access
Semantic Scholar
CDK13 cooperates with CDK12 to control global RNA polymerase II processivity
Zheng Fan, J. Devlin, S. Hogg, M. Doyle +17 more
2020Science Advances132 citations Open access
Semantic Scholar
Asymmetric Cell Division of T Cells Upon Antigen Presentation Utilizes Multiple Conserved Mechanisms
J. Oliaro, V. V. van Ham, F. Sacirbegovic, Anupama Pasam +18 more
2010Journal of Immunology129 citations Open access
Semantic Scholar
A dual role for Hdac1: oncosuppressor in tumorigenesis, oncogene in tumor maintenance.
F. Santoro, O. Botrugno, R. dal Zuffo, I. Pallavicini +11 more
2013Blood124 citations Open access
Semantic Scholar
An intact immune system is required for the anticancer activities of histone deacetylase inhibitors.
A. West, S. Mattarollo, J. Shortt, L. Cluse +3 more
2013Cancer Research120 citations Open access
Semantic Scholar
The histone deacetylase inhibitors LAQ824 and LBH589 do not require death receptor signaling or a functional apoptosome to mediate tumor cell death or therapeutic efficacy.
L. Ellis, M. Bots, R. Lindemann, Jessica E. Bolden +7 more
2009Blood120 citations Open access
Semantic Scholar
Defining the target specificity of ABT-737 and synergistic antitumor activities in combination with histone deacetylase inhibitors.
K. Whitecross, A. E. Alsop, L. Cluse, A. Wiegmans +6 more
2009Blood88 citations Open access
Semantic Scholar
Deciphering the molecular events necessary for synergistic tumor cell apoptosis mediated by the histone deacetylase inhibitor vorinostat and the BH3 mimetic ABT-737.
A. Wiegmans, A. E. Alsop, M. Bots, L. Cluse +7 more
2011Cancer Research69 citations Open access
Semantic Scholar
Characterisation of the novel apoptotic and therapeutic activities of the histone deacetylase inhibitor romidepsin
A. Newbold, R. Lindemann, L. Cluse, K. Whitecross +2 more
2008Molecular Cancer Therapeutics66 citations Open access
Semantic Scholar
Rac2‐deficient mice display perturbed T‐cell distribution and chemotaxis, but only minor abnormalities in TH1 responses
B. Croker, E. Handman, J. Hayball, T. Baldwin +5 more
2002Immunology and Cell Biology66 citations
Semantic Scholar
BET Inhibition Induces Apoptosis in Aggressive B-Cell Lymphoma via Epigenetic Regulation of BCL-2 Family Members
S. Hogg, A. Newbold, S. Vervoort, L. Cluse +8 more
2016Molecular Cancer Therapeutics61 citations
Semantic Scholar
Functional-genetic dissection of HDAC dependencies in mouse lymphoid and myeloid malignancies.
G. Matthews, P. Mehdipour, L. Cluse, K. Falkenberg +11 more
2015Blood61 citations Open access
Semantic Scholar
Translation inhibitors induce cell death by multiple mechanisms and Mcl-1 reduction is only a minor contributor
L. Lindqvist, I. Vikström, J. Chambers, K. McArthur +12 more
2012Cell Death and Disease56 citations Open access
Semantic Scholar
Molecular and Biologic Analysis of Histone Deacetylase Inhibitors with Diverse Specificities
A. Newbold, G. Matthews, M. Bots, L. Cluse +16 more
2013Molecular Cancer Therapeutics43 citations Open access
Semantic Scholar
Stem-like memory and precursors of exhausted T cells share a common progenitor defined by ID3 expression
Catarina Gago da Graça, Amania A. Sheikh, Dane M. Newman, Li-Fen Wen +25 more
2025Science immunology40 citations Open access
Semantic Scholar
Epigenetic Activation of Plasmacytoid DCs Drives IFNAR-Dependent Therapeutic Differentiation of AML
J. Salmon, Izabela Todorovski, K. Stanley, Claudia Bruedigam +31 more
2022Cancer Discovery25 citations Open access
Semantic Scholar
CDK13 cooperates with CDK12 to control global RNA polymerase II processivity
Zheng Fan, J. Devlin, S. Hogg, M. Doyle +17 more
2020Science Advances25 citations Open access
Semantic Scholar
BET Inhibition Enhances TNF-Mediated Antitumor Immunity
Lisa C. Wellinger, S. Hogg, Dane M. Newman, T. Friess +18 more
2021Cancer immunology research22 citations Open access
Semantic Scholar
Lipid-metabolism-focused CRISPR screens identify enzymes of the mevalonate pathway as essential for prostate cancer growth.
Gio Fidelito, Izabela Todorovski, L. Cluse, S. Vervoort +2 more
2025Cell Reports15 citations Open access
Semantic Scholar
The Rac 2 Guanosine Triphosphatase Regulates B Lymphocyte Antigen Receptor Responses and Chemotaxis and Is Required for Establishment of B-1 a and Marginal Zone B Lymphocytes 1
B. Croker, D. Tarlinton, L. Cluse, A. Tuxen +4 more
20028 citations
Semantic Scholar
A Comprehensive Protocol Resource for Performing Pooled shRNA and CRISPR Screens.
L. Cluse, I. Nikolić, D. Knight, P. Madhamshettiwar +7 more
2018Methods in molecular biology4 citations
Semantic Scholar
Dual Bcl-2/Bcl-xl inhibition via AZD0466 combines with immune checkpoint blockade to enhance anti-tumour activity
Dane M. Newman, Courtney L. Andersen, L. Cluse, A. Newbold +5 more
2026Cell Death and Disease2 citations Open access
Semantic Scholar
Epigenetic reprogramming of plasmacytoid dendritic cells drives type I interferon-dependent differentiation of acute myeloid leukemias for therapeutic benefit
J. Salmon, Izabela Todorovski, S. Vervoort, K. Stanley +24 more
2020bioRxiv2 citations Open access
Semantic Scholar
Discovery and characterisation of VPRBP/DCAF1 kinase inhibitor analogues as microtubular destabilising agents with potent anti-myeloma activity.
Olivia Susanto, Emily Gruber, C. Wun, Rheana L Franich +18 more
2025Molecular Cancer Therapeutics1 citations
Semantic Scholar
An orally active dual CBP/p300 degrader targets core dependencies of multiple myeloma
Praveen K. Tiwari, Bomin Ku, Drew A Harrison, S. Rizvi +29 more
2026Cell Reports0 citations Open access
Semantic Scholar
Abstract B047: dCBP-30: A rationally designed, orally bioavailable, near-linkerless PROTAC for potent CBP/p300 degradation
Praveen K. Tiwari, Bomin Ku, Sai Reddy Doda, Drew A Harrison +29 more
2026Clinical Cancer Research0 citations
Semantic Scholar
Enhanced efficacy of a specific HDAC3 inhibitor in combination with 5-azacitidine against diffuse large B-cell lymphoma
Calixte Calaud, Emilio Serrano-Lopez, L. Cluse, Izabela Todorovski +17 more
2025bioRxiv0 citations Open access
Semantic Scholar
P300/CBP acetyltransferase inhibition and degradation disrupt oncogenic transcriptional programs and reveal epigenetic vulnerabilities in multiple myeloma
Olga Motorna, S. Hogg, Izabela Todorovski, L. Cluse +2 more
2025Blood0 citations
Semantic Scholar
3224 – CHARACTERIZATION OF A NOVEL THERAPEUTIC AGENT EXHIBITING POTENT ANTI-MYELOMA ACTIVITY BY DESTABILISING MICROTUBULES.
C. Wun, Rheana L Franich, O. Susanto, Zahra Sabouri-Thompson +10 more
2023Experimental Hematology0 citations
Semantic Scholar
Abstract A29: A selective HDAC3 inhibitor synergizes with 5-azacytidine in diffuse large B-cell lymphoma
Pilar M. Dominguez, L. Cluse, Noura Tawfic, Peter J Fraser +7 more
2022Blood Cancer Discovery0 citations
Semantic Scholar
Abstract A149: EµTel-Jak2 T-ALL mouse model is dependent upon Myb function and susceptible to immune checkpoint therapy
S. Roth, S. Sampurno, M. Waibel, L. Cluse +3 more
2019Maintenance of Immune Balance: Effects of Targeted and Immune Therapies0 citations
Semantic Scholar
Abstract 5533: RNAi-mediated depletion of histone deacetylases highlights the potential for isoform-specific inhibitors in B-cell lymphoma and acute myeloid leukemia
G. Matthews, L. Cluse, Eric Wang, Mareike Roth +5 more
20140 citations
Semantic Scholar
Therapeutics , Targets , and Chemical Biology An Intact Immune System Is Required for the Anticancer Activities of Histone Deacetylase Inhibitors
A. West, S. Mattarollo, J. Shortt, L. Cluse +3 more
20130 citations
Semantic Scholar
Genetically engineered mouse models of the MLL-AF9 translocation +/- NRAS to study leukemogenesis and identify key molecular targets
Adele J. Baker, I. Verbrugge, Margherita Ghissi, J. Salmon +4 more
20120 citations
Semantic Scholar
Abstract PR15: Inhibition of RNA Polymerase I as a therapeutic strategy for cancer-specific activation of p53
M. Bywater, K. Anderes, N. Huser, C. Proffitt +18 more
20110 citations
Semantic Scholar
124 Mechanisms of action of histone deacetylase inhibitors (HDACi)
A. Newbold, M. Bots, L. Cluse, R. Lindemann +6 more
20100 citations
Semantic Scholar
cell death or therapeutic efficacy death receptor signaling or a functional apoptosome to mediate tumor The histone deacetylase inhibitors LAQ824 and LBH589 do not require
C. Scott, A. Strasser, P. Atadja, S. Lowe +7 more
20100 citations
Semantic Scholar
Defining the apoptotic pathways underlying HDAC inhibitor-mediated tumor therapy in vivo
R. Lindemann, A. Newbold, K. Whitecross, L. Cluse +13 more
20080 citations
Semantic Scholar
Mechanisms of tumour-selective apoptosis induced by the histone deacetylase inhibitor vorinostat
Jessica E. Bolden, Wei Shi, G. Smyth, L. Cluse +1 more
20080 citations
Semantic Scholar
Characterization of the apoptotic and therapeutic activities of the histone deacetylase inhibitors LAQ824 and LBH589 using a mouse model of B cell lymphoma.
L. Ellis, R. Lindemann, A. Newbold, K. Whitecross +7 more
20070 citations
Semantic Scholar

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