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L. Ellis · SciRah

Researcher profile · Semantic Scholar

L. Ellis

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L. Ellis — researcher profile on SciRah

h-index: 31
Works: 104
Citations: 6,728

Most-cited papers

SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer
P. Mu, Ze-Da Zhang, M. Benelli, W. Karthaus +20 more
2017Science994 citations Open access
Semantic Scholar
Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance
S. Ku, S. Rosario, Yanqing Wang, P. Mu +13 more
2017Science984 citations Open access
Semantic Scholar
Epigenetics in cancer: Targeting chromatin modifications
L. Ellis, P. Atadja, R. Johnstone
2009Molecular Cancer Therapeutics486 citations Open access
Semantic Scholar
Histone Deacetylase Inhibitor Panobinostat Induces Clinical Responses with Associated Alterations in Gene Expression Profiles in Cutaneous T-Cell Lymphoma
L. Ellis, Yan-yan Pan, G. Smyth, D. George +12 more
2008Clinical Cancer Research298 citations Open access
Semantic Scholar
Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer
G. Zadra, C. Ribeiro, P. Chetta, Yeung Ho +28 more
2018Proceedings of the National Academy of Sciences of the United States of America276 citations Open access
Semantic Scholar
Prostate cancer reactivates developmental epigenomic programs during metastatic progression
M. Pomerantz, X. Qiu, Yanyun Zhu, D. Takeda +39 more
2020Nature Genetics234 citations Open access
Semantic Scholar
EZH2 inhibition activates a dsRNA–STING–interferon stress axis that potentiates response to PD-1 checkpoint blockade in prostate cancer
K. Morel, Anjali V. Sheahan, Deborah L. Burkhart, Sylvan C. Baca +33 more
2021Nature Cancer229 citations Open access
Semantic Scholar
ONECUT2 is a driver of neuroendocrine prostate cancer
Haiyang Guo, Xinpei Ci, Musaddeque Ahmed, Junjie T Hua +36 more
2019Nature Communications228 citations Open access
Semantic Scholar
Class I Histone Deacetylase Inhibitor Entinostat Suppresses Regulatory T Cells and Enhances Immunotherapies in Renal and Prostate Cancer Models
Li Shen, M. Ciesielski, Swathi Ramakrishnan, K. M. Miles +5 more
2012PLoS ONE191 citations Open access
Semantic Scholar
Reversible epithelial to mesenchymal transition and acquired resistance to sunitinib in patients with renal cell carcinoma: evidence from a xenograft study
H. Hammers, H. Verheul, Brenda C. Salumbides, Rajni B. Sharma +11 more
2010Molecular Cancer Therapeutics170 citations Open access
Semantic Scholar
High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program
D. Labbé, G. Zadra, Meng Yang, Jaime M. Reyes +30 more
2019Nature Communications157 citations Open access
Semantic Scholar
Integrative molecular characterization of sarcomatoid and rhabdoid renal cell carcinoma
Z. Bakouny, D. Braun, S. Shukla, Wenting Pan +49 more
2021Nature Communications155 citations Open access
Semantic Scholar
MYC drives aggressive prostate cancer by disrupting transcriptional pause release at androgen receptor targets
X. Qiu, N. Boufaied, Tarek Hallal, Avery Feit +31 more
2021Nature Communications145 citations Open access
Semantic Scholar
Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer
Sylvan C. Baca, D. Takeda, Ji-Heui Seo, Justin H. Hwang +37 more
2020Nature Communications139 citations Open access
Semantic Scholar
Subtype heterogeneity and epigenetic convergence in neuroendocrine prostate cancer
P. Cejas, Ying-Tian Xie, Alba Font-Tello, Klothilda Lim +34 more
2020Nature Communications137 citations Open access
Semantic Scholar
The histone deacetylase inhibitors LAQ824 and LBH589 do not require death receptor signaling or a functional apoptosome to mediate tumor cell death or therapeutic efficacy.
L. Ellis, M. Bots, R. Lindemann, Jessica E. Bolden +7 more
2009Blood120 citations Open access
Semantic Scholar
TOP2A and EZH2 provide early detection of an aggressive prostate cancer subgroup
D. Labbé, C. Sweeney, Myles A. Brown, Phillip Galbo +20 more
2017Clinical Cancer Research102 citations Open access
Semantic Scholar
Tasquinimod modulates suppressive myeloid cells and enhances cancer immunotherapies in murine models
Li Shen, A. Sundstedt, M. Ciesielski, K. M. Miles +12 more
2014Cancer immunology research89 citations Open access
Semantic Scholar
Nanosponge-encapsulated camptothecin exerts anti-tumor activity in human prostate cancer cells.
R. Minelli, R. Cavalli, L. Ellis, P. Pettazzoni +6 more
2012European Journal of Pharmaceutical Sciences77 citations Open access
Semantic Scholar
Combinatorial antitumor effect of HDACs and the PI3K-Akt-mTOR pathway inhibition in a Pten deficient model of prostate cancer
L. Ellis, S. Ku, Swathi Ramakrishnan, E. Lasorsa +3 more
2013OncoTarget72 citations Open access
Semantic Scholar
Connexin 43 expression is associated with increased malignancy in prostate cancer cell lines and functions to promote migration
Ao Zhang, M. Hitomi, Noah Bar-Shain, Zafardjan Dalimov +5 more
2015OncoTarget71 citations Open access
Semantic Scholar
Histone Deacetylase Inhibitors: Advancing Therapeutic Strategies in Hematological and Solid Malignancies
L. Ellis, R. Pili
2010Pharmaceuticals67 citations Open access
Semantic Scholar
CREB5 Promotes Resistance to Androgen-Receptor Antagonists and Androgen Deprivation in Prostate Cancer
Justin H. Hwang, Ji-Heui Seo, Michael L. Beshiri, S. Wankowicz +28 more
2019Cell Reports65 citations Open access
Semantic Scholar
Top2a identifies and provides epigenetic rationale for novel combination therapeutic strategies for aggressive prostate cancer
J. Kirk, Kevin Schaarschuch, Zafardjan Dalimov, E. Lasorsa +7 more
2014OncoTarget58 citations Open access
Semantic Scholar
Induction of cell cycle arrest and DNA damage by the HDAC inhibitor panobinostat (LBH589) and the lipid peroxidation end product 4-hydroxynonenal in prostate cancer cells.
P. Pettazzoni, S. Pizzimenti, C. Toaldo, P. Sotomayor +10 more
2011Free Radical Biology & Medicine56 citations
Semantic Scholar
HDAC 1 and 6 modulate cell invasion and migration in clear cell renal cell carcinoma
Swathi Ramakrishnan, S. Ku, E. Ciamporcero, K. M. Miles +11 more
2016BMC Cancer46 citations Open access
Semantic Scholar
Targeting RET Kinase in Neuroendocrine Prostate Cancer
Halena R. VanDeusen, Johnny R. Ramroop, K. Morel, S. Y. Bae +18 more
2020Molecular Cancer Research44 citations Open access
Semantic Scholar
Receptor-interacting protein kinase 2 (RIPK2) stabilizes c-Myc and is a therapeutic target in prostate cancer metastasis
Yiwu Yan, Bo Zhou, Chen Qian, A. Vasquez +15 more
2022Nature Communications39 citations Open access
Semantic Scholar
Targeting RING domains of Mdm2–MdmX E3 complex activates apoptotic arm of the p53 pathway in leukemia/lymphoma cells
W. Wu, Chao Xu, X. Ling, Chuandong Fan +6 more
2015Cell Death and Disease38 citations Open access
Semantic Scholar
Polycomb Directed Cell Fate Decisions in Development and Cancer
Beatriz Germán, L. Ellis
2022Epigenomes29 citations Open access
Semantic Scholar
Prostate cancer cells express more androgen receptor (AR) following androgen deprivation, improving recognition by AR-specific T cells
B. Olson, M. Gamat, Joseph Seliski, Thomas Sawicki +5 more
2017Cancer immunology research29 citations Open access
Semantic Scholar
Targeting Glutamine Metabolism in Prostate Cancer
N. Bhowmick, E. Posadas, L. Ellis, S. Freedland +5 more
2023Frontiers in Bioscience28 citations Open access
Semantic Scholar
Generation of a C57BL/6 MYC-Driven Mouse Model and Cell Line of Prostate Cancer
L. Ellis, S. Ku, Qiuhui Li, G. Azabdaftari +7 more
2016The Prostate27 citations Open access
Semantic Scholar
Vascular Disruption in Combination with mTOR Inhibition in Renal Cell Carcinoma
L. Ellis, P. Shah, H. Hammers, Kristin Lehet +4 more
2011Molecular Cancer Therapeutics25 citations Open access
Semantic Scholar
Epigenetic reprogramming: A key mechanism driving therapeutic resistance.
Anjali V. Sheahan, L. Ellis
2018Urologic oncology23 citations
Semantic Scholar
LSD1: A single target to combat lineage plasticity in lethal prostate cancer
L. Ellis, M. Loda
2018Proceedings of the National Academy of Sciences of the United States of America23 citations Open access
Semantic Scholar
Development of a Castrate Resistant Transplant Tumor Model of Prostate Cancer
L. Ellis, Kristin Lehet, Swathi Ramakrishnan, Remi Adelaiye +1 more
2011The Prostate22 citations Open access
Semantic Scholar
NF-κB blockade with oral administration of dimethylaminoparthenolide (DMAPT), delays prostate cancer resistance to androgen receptor (AR) inhibition and inhibits AR variants
K. Morel, A. Hamid, J. Clohessy, Nicole Pandell +2 more
2021Molecular Cancer Research20 citations Open access
Semantic Scholar
Live cell molecular analysis of primary prostate cancer organoids identifies persistent androgen receptor signaling
E. Heninger, D. Kosoff, Tamara S. Rodems, N. Sethakorn +11 more
2021Medical Oncology19 citations Open access
Semantic Scholar
Advanced neuroendocrine prostate tumors regress to stemness
L. Ellis, M. Loda
2015Proceedings of the National Academy of Sciences of the United States of America19 citations Open access
Semantic Scholar
Concurrent HDAC and mTORC1 Inhibition Attenuate Androgen Receptor and Hypoxia Signaling Associated with Alterations in MicroRNA Expression
L. Ellis, Kristin Lehet, Swathi Ramakrishnan, Remi Adelaiye +6 more
2011PLoS ONE19 citations Open access
Semantic Scholar
The Role of RB in Prostate Cancer Progression.
Deborah L. Burkhart, K. Morel, Anjali V. Sheahan, Zachary A. Richards +1 more
2019Advances in Experimental Medicine and Biology18 citations
Semantic Scholar
Histone modifications: implications in renal cell carcinoma
Swathi Ramakrishnan, L. Ellis, R. Pili
2013Epigenomics18 citations Open access
Semantic Scholar
Mitochondrial protection impairs BET bromodomain inhibitor-mediated cell death and provides rationale for combination therapeutic strategies
E. Lasorsa, M. Smonksey, J. Kirk, S. Rosario +2 more
2015Cell Death and Disease16 citations Open access
Semantic Scholar
Clinical Utility of Olaparib in the Treatment of Metastatic Castration-Resistant Prostate Cancer: A Review of Current Evidence and Patient Selection
A. LeVee, Ching-Ying Lin, E. Posadas, R. Figlin +8 more
2021OncoTargets and Therapy15 citations Open access
Semantic Scholar
EZH2 inhibition re-sensitizes multidrug resistant B-cell lymphomas to etoposide mediated apoptosis
Matthew T. Smonskey, E. Lasorsa, S. Rosario, J. Kirk +2 more
2016Oncoscience15 citations Open access
Semantic Scholar
Inhibition of Hsp90 Augments Docetaxel Therapy in Castrate Resistant Prostate Cancer
S. Ku, E. Lasorsa, Remi Adelaiye, Swathi Ramakrishnan +2 more
2014PLoS ONE15 citations Open access
Semantic Scholar
Phenotypic Plasticity – Alternate Transcriptional Programs Driving Treatment Resistant Prostate Cancer
J. Nanda, Praveen Koganti, G. Perri, L. Ellis
2022Critical reviews in oncogenesis14 citations Open access
Semantic Scholar
Understanding cancer lineage plasticity: reversing therapeutic resistance in metastatic prostate cancer.
L. Ellis
2017Pharmacogenomics (London)13 citations Open access
Semantic Scholar
miR-30e* is overexpressed in prostate cancer and promotes NF-κB-mediated proliferation and tumor growth
Shawn M. Egan, E. Karasik, L. Ellis, S. Gollnick
2017OncoTarget13 citations Open access
Semantic Scholar

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