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Gemma L. Kelly · SciRah

Researcher profile · Semantic Scholar

Gemma L. Kelly

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Gemma L. Kelly — researcher profile on SciRah

h-index: 32
Works: 70
Citations: 7,011

Most-cited papers

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models
A. Kotschy, Z. Szlávik, J. Murray, J. Davidson +49 more
2016Nature995 citations
Semantic Scholar
How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?
B. Aubrey, Gemma L. Kelly, A. Janic, M. Herold +1 more
2017Cell Death and Differentiation991 citations Open access
Semantic Scholar
BCL-2 protein family: attractive targets for cancer therapy
Deeksha Kaloni, Sarah T. Diepstraten, A. Strasser, Gemma L. Kelly
2022Apoptosis446 citations Open access
Semantic Scholar
An inducible lentiviral guide RNA platform enables the identification of tumor-essential genes and tumor-promoting mutations in vivo.
B. Aubrey, Gemma L. Kelly, A. Kueh, Margs S. Brennan +6 more
2015Cell Reports385 citations Open access
Semantic Scholar
How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?
B. Aubrey, Gemma L. Kelly, A. Janic, M. Herold +1 more
2018346 citations Open access
Semantic Scholar
Tumor-Suppressor Functions of the TP53 Pathway.
B. Aubrey, A. Strasser, Gemma L. Kelly
2016Cold Spring Harbor Perspectives in Medicine294 citations Open access
Semantic Scholar
The manipulation of apoptosis for cancer therapy using BH3-mimetic drugs
Sarah T. Diepstraten, M. Anderson, P. Czabotar, G. Lessene +2 more
2021Nature Reviews. Cancer288 citations
Semantic Scholar
Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth
J. Baell, D. Leaver, S. Hermans, Gemma L. Kelly +48 more
2018Nature279 citations Open access
Semantic Scholar
BH3-Mimetic Drugs: Blazing the Trail for New Cancer Medicines.
D. Merino, Gemma L. Kelly, G. Lessene, A. Wei +2 more
2018Cancer Cell256 citations Open access
Semantic Scholar
Epstein–Barr virus–associated Burkitt lymphomagenesis selects for downregulation of the nuclear antigen EBNA2
Gemma L. Kelly, A. Bell, A. Rickinson
2002Nature Medicine248 citations
Semantic Scholar
An Epstein-Barr Virus Anti-Apoptotic Protein Constitutively Expressed in Transformed Cells and Implicated in Burkitt Lymphomagenesis: The Wp/BHRF1 Link
Gemma L. Kelly, Heather M. Long, Julianna Stylianou, W. Thomas +6 more
2009PLoS Pathogens183 citations Open access
Semantic Scholar
Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53
Gemma L. Kelly, S. Grabow, Stefan P. Glaser, Leah Fitzsimmons +15 more
2014Genes & Development172 citations Open access
Semantic Scholar
VDAC2 enables BAX to mediate apoptosis and limit tumor development
Hui-San Chin, Mark Li, I. Tan, R. Ninnis +23 more
2018Nature Communications171 citations Open access
Semantic Scholar
Three restricted forms of Epstein–Barr virus latency counteracting apoptosis in c-myc-expressing Burkitt lymphoma cells
Gemma L. Kelly, A. E. Milner, G. Baldwin, A. Bell +1 more
2006Proceedings of the National Academy of Sciences of the United States of America167 citations Open access
Semantic Scholar
Should mutant TP53 be targeted for cancer therapy?
Zilu Wang, A. Strasser, Gemma L. Kelly
2022Cell Death and Differentiation143 citations Open access
Semantic Scholar
Analysis of Epstein-Barr virus latent gene expression in endemic Burkitt's lymphoma and nasopharyngeal carcinoma tumour cells by using quantitative real-time PCR assays.
A. Bell, Katherine C Groves, Gemma L. Kelly, D. Croom-carter +3 more
2006Journal of General Virology139 citations Open access
Semantic Scholar
Down-regulation of the TGF-beta target gene, PTPRK, by the Epstein-Barr virus encoded EBNA1 contributes to the growth and survival of Hodgkin lymphoma cells.
J. Flavell, K. Baumforth, V. Wood, G. Davies +7 more
2008Blood128 citations
Semantic Scholar
Epstein-Barr Virus Nuclear Antigen 2 (EBNA2) Gene Deletion Is Consistently Linked with EBNA3A, -3B, and -3C Expression in Burkitt's Lymphoma Cells and with Increased Resistance to Apoptosis
Gemma L. Kelly, A. E. Milner, R. Tierney, D. Croom-carter +4 more
2005Journal of Virology125 citations Open access
Semantic Scholar
Intact TP53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias.
R. Thijssen, Sarah T. Diepstraten, D. Moujalled, E. Chew +32 more
2021Blood119 citations Open access
Semantic Scholar
Burkitt's lymphoma: The Rosetta Stone deciphering Epstein-Barr virus biology
M. Rowe, Gemma L. Kelly, A. Bell, A. Rickinson
2009Seminars in Cancer Biology116 citations Open access
Semantic Scholar
Quantitative Studies of Epstein-Barr Virus-Encoded MicroRNAs Provide Novel Insights into Their Regulation
R. Amoroso, Leah Fitzsimmons, W. Thomas, Gemma L. Kelly +2 more
2010Journal of Virology111 citations Open access
Semantic Scholar
The essential role of evasion from cell death in cancer
Gemma L. Kelly, A. Strasser
2011Advances in Cancer Research101 citations Open access
Semantic Scholar
Of the many cellular responses activated by TP53, which ones are critical for tumour suppression?
Annabella F Thomas, Gemma L. Kelly, A. Strasser
2022Cell Death and Differentiation91 citations Open access
Semantic Scholar
Humanized Mcl-1 mice enable accurate pre-clinical evaluation of MCL-1 inhibitors destined for clinical use
Margs S. Brennan, Catherine Chang, L. Tai, G. Lessene +4 more
2018bioRxiv84 citations Open access
Semantic Scholar
EBV and Apoptosis: The Viral Master Regulator of Cell Fate?
Leah Fitzsimmons, Gemma L. Kelly
2017Viruses70 citations Open access
Semantic Scholar
EBV BCL-2 homologue BHRF1 drives chemoresistance and lymphomagenesis by inhibiting multiple cellular pro-apoptotic proteins
Leah Fitzsimmons, Rachel Cartlidge, Catherine Chang, N. Sejic +15 more
2019Cell Death and Differentiation60 citations Open access
Semantic Scholar
Different Patterns of Epstein-Barr Virus Latency in Endemic Burkitt Lymphoma (BL) Lead to Distinct Variants within the BL-Associated Gene Expression Signature
Gemma L. Kelly, Julianna Stylianou, J. Rasaiyaah, Wenbin Wei +8 more
2012Journal of Virology58 citations Open access
Semantic Scholar
Genetic analysis of the Epstein-Barr virus-coded leader protein EBNA-LP as a co-activator of EBNA2 function.
E. McCann, Gemma L. Kelly, A. Rickinson, A. Bell
2001Journal of General Virology52 citations Open access
Semantic Scholar
Toward Targeting Antiapoptotic MCL-1 for Cancer Therapy
Gemma L. Kelly, A. Strasser
2020Annual Review of Cancer Biology43 citations Open access
Semantic Scholar
Mutant TRP53 exerts a target gene-selective dominant-negative effect to drive tumor development
B. Aubrey, A. Janic, Yun-Shun Chen, Catherine Chang +11 more
2018Genes & Development43 citations Open access
Semantic Scholar
Truncated Form of the Epstein-Barr Virus Protein EBNA-LP Protects against Caspase-Dependent Apoptosis by Inhibiting Protein Phosphatase 2A
J. Garibal, E. Hollville, A. Bell, Gemma L. Kelly +4 more
2007Journal of Virology42 citations Open access
Semantic Scholar
Therapeutic Response to Non-genotoxic Activation of p53 by Nutlin3a Is Driven by PUMA-Mediated Apoptosis in Lymphoma Cells.
L. J. Valente, B. Aubrey, M. Herold, Gemma L. Kelly +7 more
2016Cell Reports37 citations Open access
Semantic Scholar
The Transcription Factor ASCIZ and Its Target DYNLL1 Are Essential for the Development and Expansion of MYC-Driven B Cell Lymphoma.
D. M. Wong, Lingli Li, S. Jurado, Ashleigh King +8 more
2016Cell Reports31 citations Open access
Semantic Scholar
Coordinated repression of BIM and PUMA by Epstein–Barr virus latent genes maintains the survival of Burkitt lymphoma cells
Leah Fitzsimmons, Andrew Boyce, Wenbin Wei, Catherine Chang +7 more
2017Cell Death and Differentiation24 citations Open access
Semantic Scholar
Methylation Status of theEpstein-Barr Virus (EBV) BamHI W Latent Cycle Promoter and Promoter Activity: Analysis with Novel EBV-Positive Burkitt and LymphoblastoidCell Lines
Isabel A. Hutchings, R. Tierney, Gemma L. Kelly, Julianna Stylianou +2 more
2006Journal of Virology24 citations Open access
Semantic Scholar
Potent efficacy of MCL-1 inhibitor-based therapies in preclinical models of mantle cell lymphoma
M. Dengler, Charis E. Teh, R. Thijssen, L. Gangoda +6 more
2019Oncogene22 citations Open access
Semantic Scholar
Discussion of some ‘knowns’ and some ‘unknowns’ about the tumour suppressor p53
Elizabeth Lieschke, Zilu Wang, Gemma L. Kelly, A. Strasser
2018Journal of Molecular Cell Biology22 citations Open access
Semantic Scholar
BCL-XL inhibition by BH3-mimetic drugs induces apoptosis in models of Epstein-Barr virus-associated T/NK-cell lymphoma.
N. Sejic, Lindsay George, R. Tierney, Catherine Chang +9 more
2020Blood Advances20 citations
Semantic Scholar
Methylation Status of the Epstein-Barr Virus (EBV) BamHI W Latent Cycle Promoter and Promoter Activity: Analysis with Novel EBV-Positive Burkitt and Lymphoblastoid Cell Lines (cid:1)
Isabel A. Hutchings, R. Tierney, Gemma L. Kelly, Julianna Stylianou +2 more
200620 citations
Semantic Scholar
Flow cytometric single cell-based assay to simultaneously detect cell death, cell cycling, DNA content and cell senescence
Elizabeth Lieschke, Zilu Wang, Catherine Chang, C. Weeden +2 more
2022Cell Death and Differentiation16 citations Open access
Semantic Scholar
BCL-W is dispensable for the sustained survival of select Burkitt lymphoma and diffuse large B-cell lymphoma cell lines.
Sarah T. Diepstraten, Catherine Chang, L. Tai, J. Gong +5 more
2020Blood Advances16 citations Open access
Semantic Scholar
Generation of a CRISPR activation mouse that enables modelling of aggressive lymphoma and interrogation of venetoclax resistance
Yexuan Deng, Sarah T. Diepstraten, Margaret A. Potts, Göknur Giner +19 more
2022Nature Communications15 citations Open access
Semantic Scholar
MCL-1 is essential for survival but dispensable for metabolic fitness of FOXP3+ regulatory T cells
Charis E. Teh, A. Robbins, D. Henstridge, G. Dewson +7 more
2020Cell Death and Differentiation10 citations Open access
Semantic Scholar
ASCIZ/ATMIN is dispensable for ATM signaling in response to replication stress
Rui Liu, Ashleigh King, N. Hoch, Catherine Chang +3 more
2017DNA Repair10 citations Open access
Semantic Scholar
BCL‐XL exerts a protective role against anemia caused by radiation‐induced kidney damage
Kerstin Brinkmann, P. Waring, Stefan P. Glaser, Verena C. Wimmer +11 more
2020EMBO Journal8 citations Open access
Semantic Scholar
Three Restricted Forms of Epstein-Barr Virus Latency Counteracting Apoptosis in c-Myc Expressing Burkitt Lymphoma Cells.
Gemma L. Kelly, Julianna Stylianou, A. Bell, Wenbin Wei +2 more
20074 citations Open access
Semantic Scholar
Loss of TRP53 reduces but does not overcome dependency of lymphoma cells on MCL-1
B. Aubrey, Margs S. Brennan, Sarah T. Diepstraten, Zilu Wang +4 more
2022Cell Death and Differentiation3 citations Open access
Semantic Scholar
DOWNREGULATION OF THE TGF-BETA TARGET GENE , PTPRK , BY THE EPSTEIN-BARR VIRUS ENCODED EBNA 1 CONTRIBUTES TO THE GROWTH AND SURVIVAL OF HODGKIN ’ S LYMPHOMA CELLS
J. Flavell, K. Baumforth, V. Wood, G. Davies +7 more
20072 citations
Semantic Scholar
Author Correction: Generation of a CRISPR activation mouse that enables modelling of aggressive lymphoma and interrogation of venetoclax resistance
Yexuan Deng, Sarah T. Diepstraten, Margaret A. Potts, Göknur Giner +19 more
2022Nature Communications1 citations Open access
Semantic Scholar
Genome-wide in vivo CRISPR screens identify GATOR1 as a TP53 induced tumour suppressor
S. Mizutani, Margaret A. Potts, Yexuan Deng, Göknur Giner +14 more
20211 citations
Semantic Scholar

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