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D. Kirkpatrick · SciRah

Researcher profile · Semantic Scholar

D. Kirkpatrick

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D. Kirkpatrick — researcher profile on SciRah

h-index: 53
Works: 109
Citations: 12K

Most-cited papers

The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy
Baris Bingol, Joy S. Tea, L. Phu, M. Reichelt +5 more
2014Nature846 citations
Semantic Scholar
Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies.
K. Newton, M. Matsumoto, I. Wertz, D. Kirkpatrick +16 more
2008Cell594 citations Open access
Semantic Scholar
Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain.
Fangtian Huang, D. Kirkpatrick, Xue-Jun Jiang, S. Gygi +1 more
2006Molecules and Cells569 citations Open access
Semantic Scholar
Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases.
Jeanne M. M. Tan, Esther Wong, D. Kirkpatrick, O. Pletnikova +9 more
2008Human Molecular Genetics471 citations Open access
Semantic Scholar
Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology
D. Kirkpatrick, Nathaniel A. Hathaway, John Hanna, Suzanne Elsasser +4 more
2006Nature Cell Biology452 citations
Semantic Scholar
Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome
Christopher J. Westlake, L. M. Baye, M. Nachury, K. J. Wright +9 more
2011Proceedings of the National Academy of Sciences of the United States of America441 citations Open access
Semantic Scholar
Loss of the tumor suppressor BAP1 causes myeloid transformation
A. Dey, D. Seshasayee, R. Noubade, D. French +23 more
2012Science424 citations Open access
Semantic Scholar
K11-linked polyubiquitination in cell cycle control revealed by a K11 linkage-specific antibody.
M. Matsumoto, Katherine E. Wickliffe, Ken C. Dong, Christine Yu +8 more
2010Molecules and Cells414 citations Open access
Semantic Scholar
Deubiquitinating enzyme Ubp6 functions noncatalytically to delay proteasomal degradation.
John Hanna, Nathaniel A. Hathaway, Yoshiko Tone, Bernat Crosas +6 more
2006Cell375 citations Open access
Semantic Scholar
Ser1292 Autophosphorylation Is an Indicator of LRRK2 Kinase Activity and Contributes to the Cellular Effects of PD Mutations
Zejuan Sheng, Shuo Zhang, D. Bustos, Tracy Kleinheinz +21 more
2012Science Translational Medicine363 citations
Semantic Scholar
USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria
Christian N. Cunningham, Joshua M. Baughman, L. Phu, Joy S. Tea +5 more
2015Nature Cell Biology330 citations
Semantic Scholar
Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies.
Y. Zuchero, Xiaocheng Chen, N. Bien-ly, D. Bumbaca +16 more
2016Neuron254 citations Open access
Semantic Scholar
Ubiquitin Ligase RNF146 Regulates Tankyrase and Axin to Promote Wnt Signaling
M. Callow, Hoanh Tran, L. Phu, Ted Lau +11 more
2011PLoS ONE221 citations Open access
Semantic Scholar
Ubiquitin binding to A20 ZnF4 is required for modulation of NF-κB signaling.
I. Bosanac, I. Wertz, B. Pan, Christine Yu +9 more
2010Molecules and Cells197 citations Open access
Semantic Scholar
OTULIN limits cell death and inflammation by deubiquitinating LUBAC
Klaus Heger, Katherine E. Wickliffe, Ada Ndoja, Juan Zhang +18 more
2018Nature193 citations
Semantic Scholar
The Indian cobra reference genome and transcriptome enables comprehensive identification of venom toxins
Kushal Suryamohan, Sajesh P. Krishnankutty, Joseph Guillory, Matthew J. Jevit +38 more
2020Nature Genetics163 citations Open access
Semantic Scholar
Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry.
Xiaodong Huang, Matthew K. Summers, Victoria C. Pham, J. Lill +6 more
2011Molecules and Cells162 citations Open access
Semantic Scholar
Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPβ in Microglia.
Ada Ndoja, R. Reja, Seung-Hye Lee, J. Webster +10 more
2020Cell157 citations Open access
Semantic Scholar
JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis
S. Huntwork-Rodriguez, Bei Wang, Trent A. Watkins, A. Ghosh +5 more
2013Journal of Cell Biology155 citations Open access
Semantic Scholar
MONOUBIQUITINATION OF RPN10 REGULATES SUBSTRATE RECRUITMENT TO THE PROTEASOME
M. Isasa, Elijah J. Katz, Woong Kim, Verónica Yugo +6 more
2010Molecules and Cells148 citations Open access
Semantic Scholar
Overcoming EMT-associated resistance to anti-cancer drugs via Src/FAK pathway inhibition
Catherine H. Wilson, Katrina Nicholes, D. Bustos, Eva Lin +4 more
2014OncoTarget144 citations Open access
Semantic Scholar
APC/C-mediated multiple monoubiquitination provides an alternative degradation signal for cyclin B1
Nevena V. Dimova, Nathaniel A. Hathaway, Byung-Hoon Lee, D. Kirkpatrick +4 more
2012Nature Cell Biology143 citations Open access
Semantic Scholar
A Perturbed Ubiquitin Landscape Distinguishes Between Ubiquitin in Trafficking and in Proteolysis
Inbal Ziv, Yulia Matiuhin, D. Kirkpatrick, Z. Erpapazoglou +8 more
2011Molecular & Cellular Proteomics142 citations Open access
Semantic Scholar
Dynamic Regulation of Mitochondrial Import by the Ubiquitin System.
L. Phu, Christopher M. Rose, Joy S. Tea, Christopher E Wall +4 more
2020Molecules and Cells138 citations Open access
Semantic Scholar
Improved Quantitative Mass Spectrometry Methods for Characterizing Complex Ubiquitin Signals
L. Phu, A. Izrael-Tomasevic, M. Matsumoto, D. Bustos +9 more
2010Molecular & Cellular Proteomics126 citations Open access
Semantic Scholar
Engineering and structural characterization of a linear polyubiquitin-specific antibody.
M. Matsumoto, Ken C. Dong, Christine Yu, L. Phu +6 more
2012Journal of Molecular Biology125 citations Open access
Semantic Scholar
Selective autophagy of the adaptor TRIF regulates innate inflammatory signaling
M. Samie, Junghyun Lim, E. Verschueren, Joshua M. Baughman +10 more
2018Nature Immunology124 citations
Semantic Scholar
Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells
S. Rutz, N. Kayagaki, Q. Phung, Celine Eidenschenk +17 more
2014Nature124 citations
Semantic Scholar
Transcription factor Etv5 is essential for the maintenance of alveolar type II cells
Zhen Zhang, K. Newton, S. Kummerfeld, J. Webster +9 more
2017Proceedings of the National Academy of Sciences of the United States of America116 citations Open access
Semantic Scholar
Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling.
Tatiana Goncharov, Stefanie Hedayati, Melinda M. Mulvihill, A. Izrael-Tomasevic +11 more
2018Molecules and Cells112 citations Open access
Semantic Scholar
Ribosome binding of a single copy of the SecY complex: implications for protein translocation.
J. Ménétret, Julia Schaletzky, W. Clemons, Andrew R Osborne +8 more
2007Molecules and Cells111 citations Open access
Semantic Scholar
Extraproteasomal Rpn10 restricts access of the polyubiquitin-binding protein Dsk2 to proteasome
Yulia Matiuhin, D. Kirkpatrick, Inbal Ziv, Woong Kim +5 more
2008Molecules and Cells103 citations Open access
Semantic Scholar
Application of Mass Spectrometry Profiling to Establish Brusatol as an Inhibitor of Global Protein Synthesis
Steffan Vartanian, Taylur P. Ma, James Lee, P. Haverty +3 more
2015Molecular & Cellular Proteomics99 citations Open access
Semantic Scholar
RTK-Dependent Inducible Degradation of Mutant PI3Kα Drives GDC-0077 (Inavolisib) Efficacy
Kyung Song, K. Edgar, Emily J. Hanan, M. Hafner +23 more
2021bioRxiv98 citations Open access
Semantic Scholar
Preparation of distinct ubiquitin chain reagents of high purity and yield.
Ken C. Dong, E. Helgason, Christine Yu, L. Phu +8 more
2011Structure93 citations Open access
Semantic Scholar
Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration
C. Pozniak, Arundhati Sengupta Ghosh, Alvin Gogineni, Jesse E. Hanson +14 more
2013Journal of Experimental Medicine91 citations Open access
Semantic Scholar
Global site-specific neddylation profiling reveals that NEDDylated cofilin regulates actin dynamics
A. Vogl, L. Phu, Raquel Becerra, S. Giusti +12 more
2020Nature Structural & Molecular Biology84 citations Open access
Semantic Scholar
PIASy-dependent SUMOylation regulates DNA topoisomerase IIα activity
Hyunju Ryu, Maiko Furuta, D. Kirkpatrick, S. Gygi +1 more
2010Journal of Cell Biology78 citations Open access
Semantic Scholar
NeuCode proteomics reveals Bap1 regulation of metabolism
Joshua M. Baughman, Christopher M. Rose, Ganesh A. Kolumam, J. Webster +21 more
2016Cell Reports74 citations Open access
Semantic Scholar
PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network.
K. Reichermeier, R. Straube, Justin M. Reitsma, M. Sweredoski +10 more
2020Molecules and Cells70 citations Open access
Semantic Scholar
HectD1 E3 Ligase Modifies Adenomatous Polyposis Coli (APC) with Polyubiquitin to Promote the APC-Axin Interaction
Hoanh Tran, D. Bustos, R. Yeh, B. Rubinfeld +10 more
2012Journal of Biological Chemistry67 citations Open access
Semantic Scholar
The Hominoid-specific Oncogene TBC1D3 Activates Ras and Modulates Epidermal Growth Factor Receptor Signaling and Trafficking*
Marisa J. Wainszelbaum, A. Charron, C. Kong, D. Kirkpatrick +4 more
2008Journal of Biological Chemistry64 citations Open access
Semantic Scholar
Characterizing Ubiquitination Sites by Peptide-based Immunoaffinity Enrichment*
D. Bustos, C. Bakalarski, Yanling Yang, Junmin Peng +1 more
2012Molecular & Cellular Proteomics63 citations Open access
Semantic Scholar
PIASy Mediates SUMO-2/3 Conjugation of Poly(ADP-ribose) Polymerase 1 (PARP1) on Mitotic Chromosomes*
Hyunju Ryu, Gada K. Al-Ani, K. Deckert, D. Kirkpatrick +3 more
2010Journal of Biological Chemistry63 citations Open access
Semantic Scholar
The Gag protein PEG10 binds to RNA and regulates trophoblast stem cell lineage specification
Mona Abed, E. Verschueren, Hanna G. Budayeva, Peter S. Liu +14 more
2019bioRxiv62 citations Open access
Semantic Scholar
Conformational dynamics control ubiquitin-deubiquitinase interactions and influence in vivo signaling
Aaron H. Phillips, Ying-Nan Zhang, Christian N. Cunningham, Li-Juan Zhou +10 more
2013Proceedings of the National Academy of Sciences of the United States of America55 citations Open access
Semantic Scholar
Phosphoproteomic characterization of DNA damage response in melanoma cells following MEK/PI3K dual inhibition
D. Kirkpatrick, D. Bustos, Taner Dogan, J. Chan +7 more
2013Proceedings of the National Academy of Sciences of the United States of America53 citations Open access
Semantic Scholar
A Novel Reaction Mediated by Human Aldehyde Oxidase: Amide Hydrolysis of GDC-0834
J. Sodhi, Susan D. Wong, D. Kirkpatrick, Li-Chuan Liu +5 more
2015Drug Metabolism And Disposition50 citations Open access
Semantic Scholar
A Biologist's Field Guide to Multiplexed Quantitative Proteomics
C. Bakalarski, D. Kirkpatrick
2016Molecular & Cellular Proteomics48 citations Open access
Semantic Scholar
Ubiquilin1 promotes antigen-receptor mediated proliferation by eliminating mislocalized mitochondrial proteins
A. M. Whiteley, Miguel A. Prado, I. Peng, Alexander R. Abbas +13 more
2017eLife45 citations Open access
Semantic Scholar

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