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Christopher J. Westlake · SciRah

Researcher profile · Semantic Scholar

Christopher J. Westlake

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Christopher J. Westlake — researcher profile on SciRah

h-index: 31
Works: 59
Citations: 5,146

Most-cited papers

A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis.
M. Nachury, A. Loktev, Qihong Zhang, Christopher J. Westlake +7 more
2007Cell1,453 citations Open access
Semantic Scholar
Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins.
R. Deeley, Christopher J. Westlake, S. Cole
2006Physiological Reviews770 citations
Semantic Scholar
Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome
Christopher J. Westlake, L. M. Baye, M. Nachury, K. J. Wright +9 more
2011Proceedings of the National Academy of Sciences of the United States of America441 citations Open access
Semantic Scholar
Early steps in primary cilium assembly require EHD1- and EHD3-dependent ciliary vesicle formation
Quanlong Lu, Christine Insinna, Carolyn M. Ott, Jimmy K. Stauffer +12 more
2015Nature Cell Biology304 citations Open access
Semantic Scholar
Primary Cilium-Mediated Retinal Pigment Epithelium Maturation Is Disrupted in Ciliopathy Patient Cells
H. May-Simera, Qin Wan, B. S. Jha, J. Hartford +22 more
2018Cell Reports141 citations Open access
Semantic Scholar
Primary cilia signaling mediates intraocular pressure sensation
Na Luo, Michael Conwell, Xingjuan Chen, Christine Insinna Kettenhofen +10 more
2014Proceedings of the National Academy of Sciences of the United States of America138 citations Open access
Semantic Scholar
In vitro modeling using ciliopathy patient-derived cells reveals distinct cilia dysfunctions caused by CEP290 mutations
Hiroko Shimada, Quanlong Lu, Christine Insinna-Kettenhofen, K. Nagashima +11 more
2017Cell Reports135 citations Open access
Semantic Scholar
Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity.
Ken-ichi Ito, C. Oleschuk, Christopher J. Westlake, M. Vasa +2 more
2001Journal of Biological Chemistry128 citations Open access
Semantic Scholar
Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy.
J. O'Toole, Yang-Jian Liu, E. Davis, Christopher J. Westlake +51 more
2010Journal of Clinical Investigation127 citations Open access
Semantic Scholar
Multidrug Resistance Protein
Mian Gao, M. Yamazaki, D. W. Loe, Christopher J. Westlake +3 more
1998Journal of Biological Chemistry122 citations Open access
Semantic Scholar
Chibby promotes ciliary vesicle formation and basal body docking during airway cell differentiation
Michael C. Burke, Feng-Qian Li, Benjamin Cyge, Takeshi Arashiro +10 more
2014Journal of Cell Biology99 citations Open access
Semantic Scholar
Role of the NH2-terminal membrane spanning domain of multidrug resistance protein 1/ABCC1 in protein processing and trafficking.
Christopher J. Westlake, S. Cole, R. Deeley
2005Molecular Biology of the Cell87 citations Open access
Semantic Scholar
Role of Carboxylate Residues Adjacent to the Conserved Core Walker B Motifs in the Catalytic Cycle of Multidrug Resistance Protein 1 (ABCC1)*
L. Payen, Mian Gao, Christopher J. Westlake, S. Cole +1 more
2003Journal of Biological Chemistry81 citations Open access
Semantic Scholar
Identification of Rab11 as a small GTPase binding protein for the Evi5 oncogene
Christopher J. Westlake, J. Junutula, Glenn C. Simon, Manohar Pilli +4 more
2007Proceedings of the National Academy of Sciences of the United States of America70 citations Open access
Semantic Scholar
Ciliogenesis membrane dynamics and organization
Huijie Zhao, Ziam Khan, Christopher J. Westlake
2022Seminars in Cell and Developmental Biology69 citations Open access
Semantic Scholar
Akt regulates a Rab11-effector switch required for ciliogenesis
Vijay Walia, Adrian A. Cuenca, M. Vetter, Christine Insinna +9 more
2019Developmental Cell62 citations Open access
Semantic Scholar
Characterization of Binding of Leukotriene C4 by Human Multidrug Resistance Protein 1
Yue-Ming Qian, W. Qiu, Mian Gao, Christopher J. Westlake +2 more
2001Journal of Biological Chemistry59 citations Open access
Semantic Scholar
Investigation of F-BAR domain PACSIN proteins uncovers membrane tubulation function in cilia assembly and transport
Christine Insinna, Quanlong Lu, Isabella Teixeira, Adam Harned +7 more
2019Nature Communications57 citations Open access
Semantic Scholar
Identification of Regions Required for Apical Membrane Localization of Human Multidrug Resistance Protein 2
Paul E Bandler, Christopher J. Westlake, C. Grant, S. Cole +1 more
2008Molecular Pharmacology55 citations
Semantic Scholar
CLPTM1L promotes growth and enhances aneuploidy in pancreatic cancer cells
Jin-Ping Jia, Allen D. Bosley, Abbey C. Thompson, J. Hoskins +20 more
2014Cancer Research54 citations Open access
Semantic Scholar
Identification of the structural and functional boundaries of the multidrug resistance protein 1 cytoplasmic loop 3.
Christopher J. Westlake, Yue-Ming Qian, Mian Gao, M. Vasa +2 more
2003Biochemistry53 citations
Semantic Scholar
A role for the Golgi matrix protein giantin in ciliogenesis through control of the localization of dynein-2
David Asante, L. MacCarthy-Morrogh, Anna K. Townley, Matthew A. Weiss +5 more
2013Journal of Cell Science51 citations Open access
Semantic Scholar
Casein kinase 1δ functions at the centrosome and Golgi to promote ciliogenesis
Y. Greer, Christopher J. Westlake, B. Gao, K. Bharti +5 more
2014Molecular Biology of the Cell50 citations Open access
Semantic Scholar
An alternative cell cycle coordinates multiciliated cell differentiation
Semil P. Choksi, Lauren E. Byrnes, Mia J. Konjikusic, Benedict W. H. Tsai +4 more
2024Nature48 citations Open access
Semantic Scholar
Photolabeling of Human and Murine Multidrug Resistance Protein 1 with the High Affinity Inhibitor [125I]LY475776 and Azidophenacyl-[35S]Glutathione*
Yue-Ming Qian, C. Grant, Christopher J. Westlake, Da-Wei Zhang +5 more
2002Journal of Biological Chemistry48 citations Open access
Semantic Scholar
A ciliopathy complex builds distal appendages to initiate ciliogenesis
Dhivya Kumar, Addison B. Rains, V. Herranz-Pérez, Quanlong Lu +9 more
2021bioRxiv41 citations Open access
Semantic Scholar
Dynamics of HIV-1 RNA Near the Plasma Membrane during Virus Assembly
L. Sardo, Steven Hatch, Jianbo Chen, Olga A. Nikolaitchik +6 more
2015Journal of Virology41 citations Open access
Semantic Scholar
Recent advances in understanding assembly of the primary cilium membrane
Saurabh Shakya, Christopher J. Westlake
2021Faculty Reviews36 citations Open access
Semantic Scholar
RAB19 directs cortical remodeling and membrane growth for primary ciliogenesis
Cayla E. Jewett, Adam W. J. Soh, Carrie H Lin, Quanlong Lu +4 more
2021Developmental Cell34 citations Open access
Semantic Scholar
M-Ras/Shoc2 signaling modulates E-cadherin turnover and cell–cell adhesion during collective cell migration
Pradeep Kota, Elizabeth M. Terrell, Daniel A. Ritt, Christine Insinna +2 more
2019Proceedings of the National Academy of Sciences of the United States of America32 citations Open access
Semantic Scholar
Disruption of Wnt Planar Cell Polarity Signaling by Aberrant Accumulation of the MetAP-2 Substrate Rab37
Thomas B. Sundberg, N. Darricarrère, P. Cirone, Xia Li +6 more
2011Chemistry and Biology32 citations Open access
Semantic Scholar
A 584 bp deletion in CTRB2 inhibits chymotrypsin B2 activity and secretion and confers risk of pancreatic cancer.
Ashley Jermusyk, Jun Zhong, K. Connelly, N. Gordon +21 more
2021American Journal of Human Genetics29 citations Open access
Semantic Scholar
The C7orf43/TRAPPC14 component links the TRAPPII complex to Rabin8 for preciliary vesicle tethering at the mother centriole during ciliogenesis
Adrian A. Cuenca, Christine Insinna, Huijie Zhao, P. John +8 more
2019Journal of Biological Chemistry28 citations Open access
Semantic Scholar
Functional Interactions Between Nucleotide Binding Domains and Leukotriene C4 Binding Sites of Multidrug Resistance Protein 1 (ABCC1)
L. Payen, Mian Gao, Christopher J. Westlake, Ashley Theis +2 more
2005Molecular Pharmacology28 citations
Semantic Scholar
Male infertility‐associated Ccdc108 regulates multiciliogenesis via the intraflagellar transport machinery
Hui-Jie Zhao, Jian Sun, Christine Insinna, Quanlong Lu +8 more
2022EMBO Reports22 citations Open access
Semantic Scholar
Genomic knockout of alms1 in zebrafish recapitulates Alström syndrome and provides insight into metabolic phenotypes
Jessica E. Nesmith, Timothy L. Hostelley, C. Leitch, Maggie S. Matern +7 more
2018bioRxiv18 citations Open access
Semantic Scholar
Variants in the WDR44 WD40-repeat domain cause a spectrum of ciliopathy by impairing ciliogenesis initiation
A. Accogli, Saurabh Shakya, Taewoo Yang, Christine Insinna +54 more
2024Nature Communications17 citations Open access
Semantic Scholar
Oncogenic RAS-Induced Perinuclear Signaling Complexes Requiring KSR1 Regulate Signal Transmission to Downstream Targets
S. Basu, Sook Lee, Jacqueline Salotti, Srikanta Basu +6 more
2017Cancer Research17 citations Open access
Semantic Scholar
Identification and Characterization of Functionally Important Elements in the Multidrug Resistance Protein 1 COOH-terminal Region*
Christopher J. Westlake, L. Payen, Mian Gao, S. Cole +1 more
2004Journal of Biological Chemistry15 citations Open access
Semantic Scholar
Intracellular connections between basal bodies promote the coordinated behavior of motile cilia
Adam W. J. Soh, Louis G. Woodhams, Anthony D Junker, Cassidy M. Enloe +7 more
2022bioRxiv13 citations Open access
Semantic Scholar
The deubiquitinating enzyme USP37 enhances CHK1 activity to promote the cellular response to replication stress
Benjamin R. Stromberg, Mayank Singh, Adrian E. Torres, A. Burrows +6 more
2021Journal of Biological Chemistry13 citations Open access
Semantic Scholar
CEP97 phosphorylation by Dyrk1a is critical for centriole separation during multiciliogenesis
Moonsup Lee, K. Nagashima, Jaeho Yoon, Jian Sun +6 more
2021Journal of Cell Biology9 citations Open access
Semantic Scholar
Live-cell fluorescence imaging of ciliary dynamics
Quan-Long Lu, Chuanmao Zhang, Christopher J. Westlake
2021Biophysics Reports5 citations Open access
Semantic Scholar
Publisher Correction: Investigation of F-BAR domain PACSIN proteins uncovers membrane tubulation function in cilia assembly and transport
Christine Insinna, Quanlong Lu, Isabella Teixeira, Adam Harned +7 more
2019Nature Communications5 citations Open access
Semantic Scholar
CLEM Characterization of Rab8 and Associated Membrane Trafficking Regulators at Primary Cilium Structures
Quanlong Lu, Christopher J. Westlake
2021Methods in molecular biology4 citations
Semantic Scholar
The Deubiquitinating Enzyme USP37 Stabilizes CHK1 to Promote the Cellular Response to Replication Stress
Mayank Singh, A. Burrows, Adrian E. Torres, Debjani Pal +5 more
2019bioRxiv2 citations Open access
Semantic Scholar
Characterization of membrane structures regulating primary ciliogenesis by quantitative isotropic ultrastructure imaging
Quan-Long Lu, Huijie Zhao, Ziam Khan, Adam Harned +6 more
2025bioRxiv1 citations
Semantic Scholar
Multi-color live-cell fluorescence imaging of primary ciliary membrane assembly dynamics
Quanlong Lu, Christopher J. Westlake
2023Methods in Cell Biology1 citations Open access
Semantic Scholar
Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy (Journal of Clinical Investigation (2010) 120, 3 (791-802) DOI: 10.1172/JCI40076)
J. O'Toole, Yang-Jian Liu, E. Davis, Christopher J. Westlake +50 more
20101 citations Open access
Semantic Scholar
Characterization of membrane structures regulating primary ciliogenesis by quantitative isotropic ultrastructure imaging
Quan-Long Lu, Hui-Jie Zhao, Ziam Khan, Adam Harned +8 more
2026Nature Communications0 citations Open access
Semantic Scholar

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Christine Insinna×10
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Jimmy K. Stauffer

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Mian Gao — researcher profile on SciRah

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