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Emily J. Hanan · SciRah

Researcher profile · Semantic Scholar

Emily J. Hanan

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Emily J. Hanan — researcher profile on SciRah

h-index: 19
Works: 37
Citations: 1,199

Most-cited papers

Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα.
Emily J. Hanan, Marie-Gabrielle Braun, R. Heald, Calum Macleod +31 more
2022Journal of Medicinal Chemistry129 citations Open access
Semantic Scholar
Discovery of a potent and selective aurora kinase inhibitor.
J. Oslob, M. Romanowski, D. Allen, S. Baskaran +24 more
2008Bioorganic & Medicinal Chemistry Letters102 citations Open access
Semantic Scholar
RTK-Dependent Inducible Degradation of Mutant PI3Kα Drives GDC-0077 (Inavolisib) Efficacy
Kyung Song, K. Edgar, Emily J. Hanan, M. Hafner +23 more
2021bioRxiv98 citations Open access
Semantic Scholar
Discovery and Development of Potent LFA-1/ICAM-1 Antagonist SAR 1118 as an Ophthalmic Solution for Treating Dry Eye.
M. Zhong, Thomas R. Gadek, M. Bui, W. Shen +14 more
2012ACS Medicinal Chemistry Letters97 citations Open access
Semantic Scholar
Structure of the essential inner membrane lipopolysaccharide–PbgA complex
T. Clairfeuille, Kerry R. Buchholz, Qingling Li, E. Verschueren +25 more
2020Nature88 citations
Semantic Scholar
Discovery of potent and selective pyrazolopyrimidine janus kinase 2 inhibitors.
Emily J. Hanan, A. V. van Abbema, K. Barrett, W. Blair +19 more
2012Journal of Medicinal Chemistry78 citations Open access
Semantic Scholar
Discovery and optimization of C-2 methyl imidazopyrrolopyridines as potent and orally bioavailable JAK1 inhibitors with selectivity over JAK2.
M. Zak, Rohan V. Mendonca, M. Balazs, K. Barrett +40 more
2012Journal of Medicinal Chemistry63 citations Open access
Semantic Scholar
Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation
Emily J. Hanan, C. Eigenbrot, M. Bryan, D. Burdick +21 more
2014Journal of Medicinal Chemistry54 citations Open access
Semantic Scholar
Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study.
R. Heald, K. Bowman, M. Bryan, D. Burdick +27 more
2015Journal of Medicinal Chemistry52 citations Open access
Semantic Scholar
Monomeric targeted protein degraders.
Emily J. Hanan, Jun Liang, Xiaojing Wang, R. Blake +2 more
2020Journal of Medicinal Chemistry50 citations Open access
Semantic Scholar
Mild and General One-Pot Reductionand Cyclization of Aromatic and Heteroaromatic 2-Nitroaminesto Bicyclic 2H-Imidazoles
Emily J. Hanan, Bryan K. Chan, Anthony A. Estrada, D. Shore +1 more
201045 citations
Semantic Scholar
Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling.
M. Zak, Emily J. Hanan, P. Lupardus, D. Brown +25 more
2019Bioorganic & Medicinal Chemistry Letters43 citations Open access
Semantic Scholar
4-Aminoindazolyl-dihydrofuro[3,4-d]pyrimidines as non-covalent inhibitors of mutant epidermal growth factor receptor tyrosine kinase.
Emily J. Hanan, M. Baumgardner, M. Bryan, Yuan Chen +12 more
2016Bioorganic & Medicinal Chemistry Letters41 citations Open access
Semantic Scholar
2-Aminobenzimidazoles as potent Aurora kinase inhibitors.
M. Zhong, M. Bui, W. Shen, S. Baskaran +25 more
2009Bioorganic & Medicinal Chemistry Letters36 citations Open access
Semantic Scholar
Pyridones as Highly Selective, Noncovalent Inhibitors of T790M Double Mutants of EGFR.
M. Bryan, D. Burdick, Bryan K. Chan, Yuan Chen +20 more
2016ACS Medicinal Chemistry Letters31 citations Open access
Semantic Scholar
Unstable Mechanisms of Resistance to Inhibitors of Escherichia coli Lipoprotein Signal Peptidase
Homer Pantua, Elizabeth Skippington, Marie-Gabrielle Braun, C. Noland +18 more
2020mBio25 citations Open access
Semantic Scholar
Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors.
R. Fucini, Emily J. Hanan, M. Romanowski, R. Elling +15 more
2008Bioorganic & Medicinal Chemistry Letters25 citations Open access
Semantic Scholar
Discovery of a Noncovalent, Mutant-Selective Epidermal Growth Factor Receptor Inhibitor.
Bryan K. Chan, Emily J. Hanan, K. Bowman, M. Bryan +25 more
2016Journal of Medicinal Chemistry24 citations Open access
Semantic Scholar
Optimization of globomycin analogs as novel gram-negative antibiotics.
Keira Garland, Homer Pantua, Marie-Gabrielle Braun, D. Burdick +19 more
2020Bioorganic & Medicinal Chemistry Letters21 citations
Semantic Scholar
Deletion of a previously uncharacterized lipoprotein lirL confers resistance to an inhibitor of type II signal peptidase in Acinetobacter baumannii
Ke‐Jung Huang, Homer Pantua, J. Diao, Elizabeth Skippington +15 more
2022Proceedings of the National Academy of Sciences of the United States of America17 citations Open access
Semantic Scholar
Structure-activity relationship (SAR) of the α-amino acid residue of potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonists.
M. Zhong, Emily J. Hanan, W. Shen, M. Bui +14 more
2011Bioorganic & Medicinal Chemistry Letters17 citations Open access
Semantic Scholar
Discovery of tetrahydroisoquinoline (THIQ) derivatives as potent and orally bioavailable LFA-1/ICAM-1 antagonists.
M. Zhong, W. Shen, K. Barr, Jennifer P. Arbitrario +21 more
2010Bioorganic & Medicinal Chemistry Letters15 citations Open access
Semantic Scholar
Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors.
Emily J. Hanan, R. Fucini, M. Romanowski, R. Elling +4 more
2008Bioorganic & Medicinal Chemistry Letters15 citations
Semantic Scholar
Abstract 156: Preclinical characterization of GDC-0077, a specific PI3K alpha inhibitor in early clinical development
K. Edgar, Emily J. Hanan, S. Staben, S. Schmidt +10 more
20179 citations
Semantic Scholar
Mild and General One-Pot Reduction and Cyclization of Aromatic and Heteroaromatic 2-Nitroamines to Bicyclic 2H-Imidazoles.
Emily J. Hanan, Bryan K. Chan, Anthony A. Estrada, D. Shore +1 more
20118 citations
Semantic Scholar
Structure of the Brachydanio rerio Polo-like kinase 1 (Plk1) catalytic domain in complex with an extended inhibitor targeting the adaptive pocket of the enzyme.
R. Elling, R. Fucini, Emily J. Hanan, K. Barr +4 more
2008Acta Crystallographica. Section F : Structural Biology and Crystallization Communications8 citations Open access
Semantic Scholar
Discovery of potent dihydro-oxazinoquinolinone inhibitors of GuaB for the treatment of tuberculosis.
Yue-Biao Zhou, Ignacio Aliagas, Shu-Mei Wang, Chun-Sing Li +31 more
2024Bioorganic & Medicinal Chemistry Letters5 citations Open access
Semantic Scholar
Lipid Tales: Optimizing Arylomycin Membrane Anchors.
Michael F. T. Koehler, Yi-Chen Chen, Yong-Sheng Chen, Yuan Chen +13 more
2023ACS Medicinal Chemistry Letters4 citations
Semantic Scholar
Correction to Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study.
R. Heald, K. Bowman, M. Bryan, D. Burdick +27 more
2016Journal of Medicinal Chemistry1 citations Open access
Semantic Scholar
Abstract A20: Development and validation of a novel acute myeloid leukemia xenograft model that is dependent on the JAK2V617F mutation for growth in vivo
L. Lee, Emily J. Hanan, Aihe Zhou, T. Rawson +11 more
20091 citations
Semantic Scholar
Development of GuaB Inhibitors to Treat Mycobacterium tuberculosis Infection
Eric M. Kofoed, Terry D. Crawford, Christine M. Bowman, Jessica Sims +26 more
2026ACS Infectious Diseases0 citations Open access
Semantic Scholar
Abstract PR03: Selective degradation of mutant PIK3CA promotes increased mutant specificity in a subset of PI3K ATP-competitive inhibitors
Lanh Nguyen, K. Edgar, Kyung Song, S. Schmidt +15 more
2020Oral Presentations - Proffered Abstracts0 citations
Semantic Scholar
Preclinical development of the PI3K Alpha selective and PIK3CA Mutant selective inhibitor GDC-0077 and prediction of its human pharmacokinetics
Jodie Pang, M. Baumgardner, Marie-Gabrielle Braun, J. Cheong +11 more
2019Drug Metabolism and Pharmacokinetics0 citations
Semantic Scholar
Abstract 1735: Discovery of novel and selective reversible inhibitors of EGFR containing the T790M drug resistance mutation with activity in vitro and in vivo
G. Schaefer, Emily J. Hanan, Emily Chan, Lily Shao +7 more
20140 citations
Semantic Scholar
Composés d'azaindazole en tant qu'inhibiteurs de la t790m contenant des mutants de l'egfr
Marian C. Bryan, Bryan K. Chan, François Diederich, Jennafer Dotson +5 more
20140 citations
Semantic Scholar
Trizyklische heterozyklische verbindungen und zusammensetzungen sowie anwendungsverfahren dafür
S. Babu, Phillippe Bergeron, P. Dragovich, Hazel Joan Dyke +14 more
20110 citations
Semantic Scholar
A Facile Reduction of 2‐Aminopyrimidines with Triethylsilane and Trifluoroacetic Acid.
S. Baskaran, Emily J. Hanan, Daniel Byun, W. Shen
20040 citations
Semantic Scholar

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