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Emily Chan · SciRah

Researcher profile · Semantic Scholar

Emily Chan

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Emily Chan — researcher profile on SciRah

h-index: 22
Works: 39
Citations: 6,836

Most-cited papers

In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship.
D. Mendel, A. Laird, Xiaohua Xin, S. Louie +19 more
2003Clinical Cancer Research2,038 citations
Semantic Scholar
Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors
T. Wilson, J. Fridlyand, Yi-Bing Yan, E. Penuel +14 more
2012Nature1,159 citations Open access
Semantic Scholar
Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer
G. Thomas, C. Tran, I. Mellinghoff, Derek S. Welsbie +4 more
2006Nature Medicine643 citations
Semantic Scholar
A selective small molecule inhibitor of c-Met kinase inhibits c-Met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo.
J. Christensen, R. Schreck, J. Burrows, Poonam A. Kuruganti +12 more
2003Cancer Research543 citations
Semantic Scholar
Oncogenic ERBB3 mutations in human cancers.
B. Jaiswal, Noelyn M. Kljavin, Eric W. Stawiski, Emily Chan +27 more
2013Cancer Cell359 citations Open access
Semantic Scholar
Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation.
Ryan M. Raisner, S. Kharbanda, Ling-Yan Jin, E. Jeng +10 more
2018Cell Reports311 citations Open access
Semantic Scholar
A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth.
Ted Lau, Emily Chan, M. Callow, J. Waaler +15 more
2013Cancer Research302 citations
Semantic Scholar
Activation of p38 mitogen-activated protein kinase is required for osteoblast differentiation.
Yuan-Yu Hu, Emily Chan, Sherry X. Wang, Bao-Jie Li
2003Endocrinology208 citations Open access
Semantic Scholar
Multiple roles for the receptor tyrosine kinase axl in tumor formation.
S. Holland, M. Powell, C. Franci, Emily Chan +16 more
2005Cancer Research205 citations Open access
Semantic Scholar
An allosteric pan-TEAD inhibitor blocks oncogenic YAP/TAZ signaling and overcomes KRAS G12C inhibitor resistance
Thijs J. Hagenbeek, J. Zbieg, M. Hafner, R. Mroue +38 more
2023Nature Cancer189 citations Open access
Semantic Scholar
Therapeutic Targeting of the CBP/p300 Bromodomain Blocks the Growth of Castration-Resistant Prostate Cancer.
Ling-Yan Jin, Jesse Garcia, Emily Chan, C. C. de la Cruz +13 more
2017Cancer Research118 citations
Semantic Scholar
FGFR3 stimulates stearoyl CoA desaturase 1 activity to promote bladder tumor growth.
Xiangnan Du, Qian-Rena Wang, Emily Chan, M. Merchant +4 more
2012Cancer Research94 citations Open access
Semantic Scholar
Non-Covalent Wild-Type-Sparing Inhibitors of EGFR T790M
Ho-June Lee, G. Schaefer, T. Heffron, Lily Shao +11 more
2012Cancer Discovery87 citations Open access
Semantic Scholar
Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300.
Terry D. Crawford, F. A. Romero, K. Lai, V. Tsui +41 more
2016Journal of Medicinal Chemistry81 citations Open access
Semantic Scholar
Conditional activation of Pik3caH1047R in a knock-in mouse model promotes mammary tumorigenesis and emergence of mutations
Wenlin Yuan, Eric W. Stawiski, V. Janakiraman, Emily Chan +17 more
2012Oncogene80 citations Open access
Semantic Scholar
CD44 regulates cell migration in human colon cancer cells via Lyn kinase and AKT phosphorylation.
V. Subramaniam, Isabella R Vincent, H. Gardner, Emily Chan +2 more
2007Experimental and molecular pathology (Print)72 citations
Semantic Scholar
Regulation of Tumor-Associated Myeloid Cell Activity by CBP/EP300 Bromodomain Modulation of H3K27 Acetylation.
D. E. de Almeida Nagata, E. Chiang, S. Jhunjhunwala, P. Caplazi +10 more
2019Cell Reports70 citations Open access
Semantic Scholar
Modeling Targeted Inhibition of MEK and PI3 Kinase in Human Pancreatic Cancer
M. Junttila, V. Devasthali, Jason H. Cheng, J. Castillo +13 more
2014Molecular Cancer Therapeutics60 citations Open access
Semantic Scholar
Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study.
R. Heald, K. Bowman, M. Bryan, D. Burdick +27 more
2015Journal of Medicinal Chemistry52 citations Open access
Semantic Scholar
Discovery of novel allosteric mitogen-activated protein kinase kinase (MEK) 1,2 inhibitors possessing bidentate Ser212 interactions.
R. Heald, P. Jackson, P. Savy, M. Jones +14 more
2012Journal of Medicinal Chemistry36 citations Open access
Semantic Scholar
Cotargeting of MEK and PDGFR/STAT3 Pathways to Treat Pancreatic Ductal Adenocarcinoma
Nisebita Sahu, Emily Chan, Felix Chu, Thinh Pham +4 more
2017Molecular Cancer Therapeutics29 citations Open access
Semantic Scholar
Discovery of a Noncovalent, Mutant-Selective Epidermal Growth Factor Receptor Inhibitor.
Bryan K. Chan, Emily J. Hanan, K. Bowman, M. Bryan +25 more
2016Journal of Medicinal Chemistry24 citations Open access
Semantic Scholar
CUB domain containing protein 1 (CDCP1) is a target for radioligand therapy in castration resistant prostate cancer including PSMA null disease
Ning Zhao, S. Chopra, K. Trepka, Yung-hua Wang +19 more
2022Clinical Cancer Research20 citations Open access
Semantic Scholar
Mutations in the BRCT Domain Confer Temperature Sensitivity to BRCA1 in Transcription Activation
M. A. Carvalho, B. Billack, Emily Chan, Terri L. Worley +2 more
2002Cancer Biology & Therapy19 citations Open access
Semantic Scholar
Conformation-locking antibodies for the discovery and characterization of KRAS inhibitors
C. Davies, A. Oh, R. Mroue, M. Steffek +23 more
2022Nature Biotechnology16 citations Open access
Semantic Scholar
Assessment of KRAS G12C Target Engagement by a Covalent Inhibitor in Tumor Biopsies Using an Ultra-Sensitive Immunoaffinity 2D-LC-MS/MS Approach.
Lingyao Meng, Emily Chan, Carl Ng, J. Aimi +9 more
2022Analytical Chemistry12 citations
Semantic Scholar
Quantifying KRAS G12C Covalent Drug Inhibitor Activity in Mouse Tumors Using Mass Spectrometry.
J. C. Tran, Thomas L. Hunsaker, Christina Bell, Taylur P. Ma +21 more
2023Analytical Chemistry10 citations
Semantic Scholar
CLAMPs allow single cell tracking of KRASG12C inhibition and endow druggability to KRAS mutants
M. Evangelista, C. Davies, A. Oh, R. Mroue +16 more
20211 citations Open access
Semantic Scholar
Correction to Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study.
R. Heald, K. Bowman, M. Bryan, D. Burdick +27 more
2016Journal of Medicinal Chemistry1 citations Open access
Semantic Scholar
502 Preclinical Pharmacokinetics and Efficacy Assessment of a Potent and Selective MEK Inhibitor, GDC-0623
Edna F. Choo, M. Belvin, M. Merchant, Emily Chan +6 more
20121 citations
Semantic Scholar
Abstract A250: Preclinical combination efficacy and identification of biomarkers of MEK and PI3K inhibitors in phase I
K. Hoeflich, M. Merchant, Doug Den Otter, J. Chan +8 more
20091 citations
Semantic Scholar
Abstract 5687: Selective, chemically-induced degradation of BRM (SMARCA2) enablesin vivoefficacy in BRG1 (SMARCA4)-deficient xenograft tumor models
Michael Berlin, Jennifer L. Cantley, Jing Wang, M. Bookbinder +27 more
2020Cancer Chemistry0 citations
Semantic Scholar
Abstract 1483: Targeting oncogenic enhancer activity with a small-molecule CBP/P300 bromodomain inhibitor
Ryan M. Raisner, Russell Bainer, Emily Chan, Jesse Garcia +2 more
2018Molecular and Cellular Biology / Genetics0 citations
Semantic Scholar
Abstract 4905: Effects of MAPK pathway inhibitors in the tumor immune microenvironment
M. Belvin, E. Williams, Shiuh-Ming Luoh, J. Cheung +6 more
20160 citations
Semantic Scholar
Abstract 1735: Discovery of novel and selective reversible inhibitors of EGFR containing the T790M drug resistance mutation with activity in vitro and in vivo
G. Schaefer, Emily J. Hanan, Emily Chan, Lily Shao +7 more
20140 citations
Semantic Scholar
Abstract PR6: Widespread potential for growth factor-driven resistance to anti-cancer kinase inhibitors
T. Wilson, J. Fridlyand, A. Ribas, Jiang Li +12 more
2012Clinical Cancer Research0 citations Open access
Semantic Scholar
Molecular and Cellular Pathobiology FGFR 3 Stimulates Stearoyl CoA Desaturase 1 Activity to Promote Bladder Tumor Growth
Xiangnan Du, Qian-Rena Wang, Emily Chan, M. Merchant +4 more
20120 citations
Semantic Scholar
Discovery of Novel Allosteric MEK Inhibitors Possessing Classical and Non-classical Bidentate Ser212 Interactions.
R. Heald, P. Jackson, P. Savy, M. Jones +12 more
20120 citations
Semantic Scholar
CD44 modulates cofilin expression in human colon cancer cells
V. Subramaniam, Isabella R Vincent, Emily Chan, S. Jothy
20060 citations
Semantic Scholar

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