Derek S. Welsbie

Most-cited papers

1. Molecular determinants of resistance to antiandrogen therapy

   C. Chen, Derek S. Welsbie, C. Tran, Sung Hee Baek +4 more

   2004Nature Medicine2,395 citations

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2. Development of a Second-Generation Antiandrogen for Treatment of Advanced Prostate Cancer

   C. Tran, Samedy Ouk, N. J. Clegg, Yu Chen +15 more

   2009Science2,251 citations Open access

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3. Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer

   G. Thomas, C. Tran, I. Mellinghoff, Derek S. Welsbie +4 more

   2006Nature Medicine643 citations

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4. Thyroid hormone signaling specifies cone subtypes in human retinal organoids

   K. Eldred, Sarah E. Hadyniak, Katarzyna A. Hussey, Boris Brenerman +9 more

   2018Science231 citations Open access

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5. Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death

   Derek S. Welsbie, Zhi-Yong Yang, Yan Ge, Katherine L. Mitchell +28 more

   2013Proceedings of the National Academy of Sciences of the United States of America221 citations Open access

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6. Structural Identification of a Novel Pro-inflammatory Epoxyisoprostane Phospholipid in Mildly Oxidized Low Density Lipoprotein*

   Andrew D. Watson, G. Subbanagounder, Derek S. Welsbie, K. Faull +4 more

   1999Journal of Biological Chemistry208 citations Open access

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7. Histone Deacetylases Are Required for Androgen Receptor Function in Hormone-Sensitive and Castrate-Resistant Prostate Cancer

   Derek S. Welsbie, Jin Xu, Yu Chen, L. Borsu +3 more

   2009Cancer Research184 citations Open access

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8. Hypoxic retinal Müller cells promote vascular permeability by HIF-1–dependent up-regulation of angiopoietin-like 4

   Xiaoban Xin, Murilo Rodrigues, Mahaa Umapathi, Fabiana Kashiwabuchi +13 more

   2013Proceedings of the National Academy of Sciences of the United States of America169 citations Open access

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9. Enhanced functional genomic screening identifies novel mediators of dual leucine zipper kinase-dependent injury signaling in neurons

   Derek S. Welsbie, Katherine L. Mitchell, Vinod Jaskula-Ranga, Valentin M. Sluch +17 more

   2017Neuron140 citations Open access

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10. Enhanced Stem Cell Differentiation and Immunopurification of Genome Engineered Human Retinal Ganglion Cells

    Valentin M. Sluch, X. Chamling, Melissa M. Liu, C. Berlinicke +4 more

    2017Stem Cells Translational Medicine129 citations Open access

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11. AI is a viable alternative to high throughput screening: a 318-target study

    Izhar Wallach, Denzil Bernard, Kong Nguyen, Gregory Ho +496 more

    2024Scientific Reports112 citations Open access

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12. Nrf2 in ischemic neurons promotes retinal vascular regeneration through regulation of semaphorin 6A

    Yanhong Wei, Jun-Song Gong, Zhenhua Xu, R. Thimmulappa +4 more

    2015Proceedings of the National Academy of Sciences of the United States of America85 citations Open access

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13. Ligand-specific allosteric regulation of coactivator functions of androgen receptor in prostate cancer cells.

    Sung Hee Baek, K. Ohgi, Charles A. Nelson, Derek S. Welsbie +4 more

    2006Proceedings of the National Academy of Sciences of the United States of America84 citations

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14. Retinal ganglion cell repopulation for vision restoration in optic neuropathy: a roadmap from the RReSTORe Consortium

    Jonathan R. Soucy, Erika A. Aguzzi, Julie Y. Cho, M. Gilhooley +131 more

    2023Molecular Neurodegeneration73 citations Open access

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15. Role of SARM1 and DR6 in retinal ganglion cell axonal and somal degeneration following axonal injury

    Kimberly A. Fernandes, Katherine L. Mitchell, Amit K. Patel, Olivia J. Marola +4 more

    2018Experimental Eye Research73 citations Open access

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16. Neuroprotective role of Nrf2 for retinal ganglion cells in ischemia-reperfusion

    Zhenhua Xu, Hongkwan Cho, M. Hartsock, Katherine L. Mitchell +9 more

    2015Journal of Neurochemistry68 citations Open access

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17. Losartan Treatment Protects Retinal Ganglion Cells and Alters Scleral Remodeling in Experimental Glaucoma

    H. Quigley, I. Pitha, Derek S. Welsbie, Cathy Nguyen +9 more

    2015PLoS ONE65 citations Open access

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18. Genetically Encodable Contrast Agents for Optical Coherence Tomography

    George J. Lu, Lidek Chou, Dina Malounda, Amit K. Patel +4 more

    2020ACS Nano48 citations Open access

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19. Potential of Ocular Transmission of SARS-CoV-2: A Review

    B. Barnett, K. Wahlin, M. Krawczyk, D. Spencer +3 more

    2020Vision40 citations Open access

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20. Dual leucine zipper kinase as a therapeutic target for neurodegenerative conditions.

    D. Ferraris, Zhiyong Yang, Derek S. Welsbie

    2013Future Medicinal Chemistry40 citations

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21. Targeted disruption of dual leucine zipper kinase and leucine zipper kinase promotes neuronal survival in a model of diffuse traumatic brain injury

    Derek S. Welsbie, Nikolaos Ziogas, Le-Yan Xu, Byung-Jin Kim +8 more

    2019Molecular Neurodegeneration36 citations Open access

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22. A Randomized Controlled Trial Comparing Subconjunctival Injection to Direct Scleral Application of Mitomycin C in Trabeculectomy.

    Jiun L. Do, Benjamin Y. Xu, Brandon J. Wong, A. Camp +7 more

    2020American journal of ophthalmology-glaucoma33 citations Open access

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23. Aqueous shunts with mitomycin C versus aqueous shunts alone for glaucoma.

    V. Foo, H. M. Htoon, Derek S. Welsbie, S. Perera

    2015Cochrane Database of Systematic Reviews32 citations Open access

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24. Inhibition of GCK-IV kinases dissociates cell death and axon regeneration in CNS neurons

    Amit K. Patel, Risa M. Broyer, Cassidy D. Lee, Tianlun Lu +16 more

    2020Proceedings of the National Academy of Sciences of the United States of America27 citations Open access

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25. Osteopontin drives retinal ganglion cell resiliency in glaucomatous optic neuropathy

    Mengya Zhao, Ken-ichi Toma, B. Kinde, Liang Li +12 more

    2023Cell Reports26 citations Open access

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26. Human retinal ganglion cell neurons generated by synchronous BMP inhibition and transcription factor mediated reprogramming

    Devansh Agarwal, Nicholas Dash, Kevin W Mazo, Manan Chopra +18 more

    2023npj Regenerative Medicine20 citations Open access

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27. Qualitative Evaluation of the 10-2 and 24-2 Visual Field Tests for Detecting Central Visual Field Abnormalities in Glaucoma

    Adi Orbach, G. Ang, A. Camp, Derek S. Welsbie +7 more

    2021American journal of ophthalmology-glaucoma20 citations Open access

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28. Lateral Hypothalamic Signaling Mechanisms Underlying Feeding Stimulation: Differential Contributions of Src Family Tyrosine Kinases to Feeding Triggered Either by NMDA Injection or by Food Deprivation

    Arshad M. Khan, Herman H. Cheung, Elizabeth R. Gillard, Jennifer A. Palarca +3 more

    2004Journal of Neuroscience17 citations Open access

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29. Traumatic Axonal Injury in the Optic Nerve: The Selective Role of SARM1 in the Evolution of Distal Axonopathy

    Athanasios S. Alexandris, Youngrim Lee, M. Lehar, Zahra Alam +6 more

    2023Journal of Neurotrauma15 citations Open access

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30. Usability and Clinician Acceptance of a Deep Learning-based Clinical Decision Support Tool for Predicting Glaucomatous Visual Field Progression

    Jimmy S. Chen, Sally L. Baxter, A. van den Brandt, Alexander C. Lieu +7 more

    2022Journal of glaucoma13 citations Open access

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31. A deep learning approach to improve retinal structural predictions and aid glaucoma neuroprotective clinical trial design.

    M. Christopher, P. Hoseini, E. Walker, J. Proudfoot +9 more

    2022Ophthalmology Glaucoma13 citations Open access

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32. Optineurin-facilitated axonal mitochondria delivery promotes neuroprotection and axon regeneration

    Dong Liu, Hannah C. Webber, Fuyun Bian, Yangfan Xu +20 more

    2024bioRxiv10 citations Open access

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33. Mechanical Disruption of the Inner Limiting Membrane In Vivo Enhances Targeting to the Inner Retina

    Jiun L. Do, Nicole Pedroarena-Leal, Mikaela J. Louie, Paula Avila Garcia +6 more

    2023Investigative Ophthalmology and Visual Science9 citations Open access

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34. Superior segmental optic nerve hypoplasia: A review.

    Jo-Hsuan Wu, Chao-Wen Lin, Chun-Hsiu Liu, R. Weinreb +1 more

    2022Survey of ophthalmology9 citations

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35. Optic Nerve Engraftment of Neural Stem Cells

    Jiun L. Do, Salam Allahwerdy, R. C. David, R. Weinreb +2 more

    2021Investigative Ophthalmology and Visual Science9 citations Open access

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36. Biomolecular Contrast Agents for Optical Coherence Tomography

    George J. Lu, Lidek Chou, Dina Malounda, Amit K. Patel +4 more

    2019bioRxiv9 citations Open access

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37. Defining functional requirements for a patient-centric computerized glaucoma treatment and care ecosystem

    N. Goldmann, S. Skalicky, R. Weinreb, R. A. Paletta Guedes +10 more

    2023Journal of Medical Artificial Intelligence8 citations Open access

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38. Progressive Thinning of Retinal Nerve Fiber Layer and Ganglion Cell-Inner Plexiform Layer in Glaucoma Eyes with Disc Hemorrhage

    Xiongfei Liu, Alicia Lau, Huiyuan Hou, S. Moghimi +9 more

    2021Ophthalmology Glaucoma6 citations Open access

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39. GLANCE: Visual Analytics for Monitoring Glaucoma Progression

    A. van den Brandt, M. Christopher, L. Zangwill, Jasmin Rezapour +9 more

    2020Eurographics Workshop on Visual Computing for Biomedicine6 citations

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40. More than just optic disc swelling.

    R. Channa, Derek S. Welsbie, V. Patel

    2013JAMA ophthalmology4 citations

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41. Sheath-Preserving Optic Nerve Transection in Rats to Assess Axon Regeneration and Interventions Targeting the Retinal Ganglion Cell Axon

    Jiun L. Do, Salam Allahwerdy, R. C. David, R. Weinreb +1 more

    2020Journal of Visualized Experiments3 citations Open access

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42. Identification of a retinal neuroprotective kinase inhibitor with preferential activity against DLK compared to LZK

    Derek S. Welsbie, H. Schirok, Katherine L. Mitchell, M. Koch +12 more

    20183 citations

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43. Author Correction: AI is a viable alternative to high throughput screening: a 318-target study

    Izhar Denzil Kong Gregory Adrian Adrian Andreana Ann Mar Wallach Bernard Nguyen Ho Morrison Stecula Rosnik , Izhar Wallach, Denzil Bernard, Kong Nguyen +496 more

    2024Scientific Reports2 citations Open access

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44. Live, Die, or Regenerate? New insights from multi-omic analyses

    Nicole Y. Tsai, Derek S. Welsbie, Xin Duan

    2022Neuron2 citations Open access

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45. Epoxyisoprostane E2-containing phospholipids in oxidized low density lipoprotein and atherosclerotic lesions

    Andrew D. Watson, G. Subbanagounder, K. Faull, N. Leitinger +5 more

    19992 citations

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46. Polymorphous low-grade adenocarcinoma with cavernous sinus involvement presenting as third nerve palsy

    Alison X. Chan, Aimee C. Chang, Jiun L. Do, Sonya J. Koo +2 more

    2022American Journal of Ophthalmology Case Reports1 citations Open access

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47. Glance: A Visual Analytics Approach for Opening the Black Box to Explain Deep Learning Predictions of Glaucomatous Visual Field Damage from Optical Coherence Tomography Scans

    A. van den Brandt, Mark A. Christopher, Jasmin Rezapour, Derek S. Welsbie +11 more

    20201 citations

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48. Functional genomic screening identifies dual leucine zipper- bearing kinase as a therapeutic target in glaucoma

    Derek S. Welsbie, Zhi-Yong Yang, Yan Ge, Katherine L. Mitchell +24 more

    20131 citations

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49. Serial analysis of macular and circumpapillary structures in glaucomatous eyes with peripapillary retinoschisis.

    Jooyoung Yoon, Ji Hong Kim, Yu Jeong Kim, Han-Woong Lim +3 more

    2026Canadian Journal of Ophthalmology-journal Canadien D Ophtalmologie0 citations

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50. Pentosan polysulfate

    J. Arnett, Fritz Gerald, Paguiligan Kalaw, Nehal Ines Nagel +156 more

    2026Reactions weekly0 citations

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