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Carl Ng · SciRah

Researcher profile · Semantic Scholar

Carl Ng

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Carl Ng — researcher profile on SciRah

h-index: 16
Works: 26
Citations: 2,105

Most-cited papers

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index
J. Junutula, H. Raab, Suzanna Clark, Sunil Bhakta +27 more
2008Nature Biotechnology1,271 citations
Semantic Scholar
Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates.
Leanna R. Staben, Stefan G. Koenig, Sophie M. Lehar, R. Vandlen +19 more
2016Nature Chemistry114 citations
Semantic Scholar
Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα).
P. Dragovich, Pragya Adhikari, R. Blake, N. Blaquiere +39 more
2019Bioorganic & Medicinal Chemistry Letters103 citations
Semantic Scholar
High-Throughput Cysteine Scanning To Identify Stable Antibody Conjugation Sites for Maleimide- and Disulfide-Based Linkers.
R. Ohri, Sunil Bhakta, Aimee Fourie-O'Donohue, Josefa Dela Cruz-Chuh +16 more
2018Bioconjugate chemistry99 citations
Semantic Scholar
Modulating Antibody-Drug Conjugate Payload Metabolism by Conjugation Site and Linker Modification.
Dian Su, K. Kozak, J. Sadowsky, Shang-Fan Yu +23 more
2018Bioconjugate chemistry69 citations
Semantic Scholar
Characterization of in vitro antibody-dependent cell-mediated cytotoxicity activity of therapeutic antibodies - impact of effector cells.
Shan Chung, Y. Lin, Chae Reed, Carl Ng +5 more
2014JIM - Journal of Immunological Methods58 citations
Semantic Scholar
High-Resolution Accurate-Mass Mass Spectrometry Enabling In-Depth Characterization of in Vivo Biotransformations for Intact Antibody-Drug Conjugates.
Jintang He, Dian Su, Carl Ng, Luna Liu +11 more
2017Analytical Chemistry51 citations Open access
Semantic Scholar
Custom-Designed Affinity Capture LC-MS F(ab')2 Assay for Biotransformation Assessment of Site-Specific Antibody Drug Conjugates.
Dian Su, Carl Ng, M. Khosraviani, Shang-Fan Yu +3 more
2016Analytical Chemistry51 citations
Semantic Scholar
Modulating Therapeutic Activity and Toxicity of Pyrrolobenzodiazepine Antibody–Drug Conjugates with Self-Immolative Disulfide Linkers
Thomas H. Pillow, M. Schutten, Shang-Fan Yu, R. Ohri +27 more
2017Molecular Cancer Therapeutics47 citations Open access
Semantic Scholar
Development of Efficient Chemistry to Generate Site-Specific Disulfide-Linked Protein- and Peptide-Payload Conjugates: Application to THIOMAB Antibody-Drug Conjugates.
J. Sadowsky, Thomas H. Pillow, Jinhua Chen, Fang Fan +22 more
2017Bioconjugate chemistry41 citations
Semantic Scholar
A homogeneous high-DAR antibody-drug conjugate platform combining THIOMABTM antibodies and XTEN polypeptides
Neelie T Zacharias, V. Podust, Kimberly K. Kajihara, D. Leipold +37 more
202132 citations Open access
Semantic Scholar
Quantitative determination of humanized monoclonal antibody rhuMAb2H7 in cynomolgus monkey serum using a Generic Immunoglobulin Pharmacokinetic (GRIP) assay.
Ji-Hong Yang, Carl Ng, H. Lowman, Regina E Chestnut +5 more
2008JIM - Journal of Immunological Methods28 citations
Semantic Scholar
Calicheamicin Antibody–Drug Conjugates with Improved Properties
Breanna S. Vollmar, C. Frantz, M. Schutten, Fiona Zhong +17 more
2021Molecular Cancer Therapeutics25 citations Open access
Semantic Scholar
Improved translation of stability for conjugated antibodies using an in vitro whole blood assay
Aimee Fourie-O'Donohue, Phillip Y. Chu, Josefa Dela Cruz-Chuh, Robert Tchelepi +12 more
2020mAbs19 citations Open access
Semantic Scholar
Exploration of Pyrrolobenzodiazepine (PBD)-Dimers Containing Disulfide-Based Prodrugs as Payloads for Antibody-Drug Conjugates.
Z. Pei, Chun-Jiao Chen, Jinhua Chen, Josefa Dela Cruz-Chuh +33 more
2018Molecular Pharmaceutics19 citations
Semantic Scholar
Antibody-Drug Conjugates Derived from Cytotoxic seco-CBI-Dimer Payloads Are Highly Efficacious in Xenograft Models and Form Protein Adducts In Vivo.
Dian Su, Jinhua Chen, Ely Cosino, Josefa Dela Cruz-Chuh +39 more
2019Bioconjugate chemistry17 citations
Semantic Scholar
On Demand Bioorthogonal Switching of an Antibody-Conjugated SPECT Probe to a Cytotoxic Payload: from Imaging to Therapy.
Pragya Adhikari, Guangmin Li, M. Go, Danielle Mandikian +17 more
2024Journal of the American Chemical Society14 citations
Semantic Scholar
Systematic Variation of Pyrrolobenzodiazepine (PBD)-dimer Payload Physicochemical Properties Impacts Efficacy and Tolerability of the Corresponding Antibody-Drug Conjugates.
Leanna R. Staben, Jinhua Chen, Josefa Dela Cruz-Chuh, Geoffrey Del Rosario +16 more
2020Journal of Medicinal Chemistry14 citations
Semantic Scholar
Assessment of KRAS G12C Target Engagement by a Covalent Inhibitor in Tumor Biopsies Using an Ultra-Sensitive Immunoaffinity 2D-LC-MS/MS Approach.
Lingyao Meng, Emily Chan, Carl Ng, J. Aimi +9 more
2022Analytical Chemistry12 citations
Semantic Scholar
Generation and characterization of a unique reagent that recognizes a panel of recombinant human monoclonal antibody therapeutics in the presence of endogenous human IgG
Xiang-dang Wang, V. Quarmby, Carl Ng, A. Chuntharapai +14 more
2013mAbs10 citations Open access
Semantic Scholar
A homogeneous high-DAR antibody–drug conjugate platform combining THIOMAB antibodies and XTEN polypeptides
Neelie T Zacharias, V. Podust, K. Kajihara, Doug Leipold +38 more
2022Chemical Science7 citations Open access
Semantic Scholar
Primate cerebrospinal fluid CHI3L1 reflects brain TREM2 agonism
Stephen P. Schauer, Hoon-Cho Chang, Gloriia Novikova, Gillie Roth +43 more
2024Alzheimer's & Dementia5 citations Open access
Semantic Scholar
Anti–Lymphocyte Antigen 6 Complex, Locus E-Seco-Cyclopropabenzindol-4-One-Dimer Antibody-Drug Conjugate That Forms Adduct with α1-Microglobulin Demonstrates Slower Systemic Antibody Clearance and Reduced Tumor Distribution in Animals
Victor Yip, I. Figueroa, B. Latifi, Shabkhaiz Masih +4 more
2020Drug Metabolism And Disposition3 citations Open access
Semantic Scholar
Anti-Ly6E-seco-CBI-Dimer Antibody-Drug Conjugate (ADC) That Forms Adduct with Alpha-1-microglobulin (A1M) Demonstrates Slower Systemic Antibody Clearance and Reduced Tumor Distribution in Animals
Victor Yip, I. Figueroa, B. Latifi, Shabkhaiz Masih +4 more
20201 citations
Semantic Scholar
A homogeneous high-DAR antibody-drug conjugate 1 platform combining THIOMAB TM antibodies and XTEN 2 polypeptides 3
Neelie T Zacharias, V. Podust, K. Kajihara, Doug Leipold +37 more
20210 citations
Semantic Scholar
Quantifying biomolecular interactions via a novel biophysical method: Composition-Gradient Static Light Scattering (CG-SLS) as a complimentary and orthogonal technique to Surface Plasmon Resonance (SPR)
D. Some, Jihong Yang, Aym Berges, Carl Ng
20110 citations
Semantic Scholar

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