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Noelyn M. Kljavin · SciRah

Researcher profile · Semantic Scholar

Noelyn M. Kljavin

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Noelyn M. Kljavin — researcher profile on SciRah

h-index: 33
Works: 60
Citations: 6,404

Most-cited papers

Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17–producing T cells
M. Batten, Ji Li, S. Yi, Noelyn M. Kljavin +5 more
2006Nature Immunology912 citations
Semantic Scholar
A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer
F. de Sousa e Melo, A. Kurtova, J. Harnoss, Noelyn M. Kljavin +9 more
2017Nature715 citations
Semantic Scholar
Lgr5+ stem cells are indispensable for radiation-induced intestinal regeneration.
C. Metcalfe, Noelyn M. Kljavin, R. Ybarra, F. D. de Sauvage
2014Cell Stem Cell553 citations
Semantic Scholar
Oncogenic ERBB3 mutations in human cancers.
B. Jaiswal, Noelyn M. Kljavin, Eric W. Stawiski, Emily Chan +27 more
2013Cancer Cell359 citations Open access
Semantic Scholar
Somatic mutations in p85α promote tumorigenesis through class IA PI3K activation
B. Jaiswal, V. Janakiraman, Noelyn M. Kljavin, Subhra Chaudhuri +20 more
2009Cancer Cell308 citations Open access
Semantic Scholar
Antibody-drug conjugates for the treatment of non-Hodgkin's lymphoma: target and linker-drug selection.
A. Polson, Jill Calemine-Fenaux, Pamela Chan, Wesley S. Chang +26 more
2009Cancer Research237 citations Open access
Semantic Scholar
Cutting Edge: IL-27 Is a Potent Inducer of IL-10 but Not FoxP3 in Murine T Cells
M. Batten, Noelyn M. Kljavin, Ji Li, M. Walter +2 more
2008Journal of Immunology236 citations
Semantic Scholar
Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function
E. Storm, S. Durinck, F. de Sousa e Melo, Jarrod R. Tremayne +14 more
2015Nature235 citations
Semantic Scholar
Compromised Humoral and Delayed-Type Hypersensitivity Responses in IL-23-Deficient Mice1
N. Ghilardi, Noelyn M. Kljavin, Qi Chen, S. Lucas +2 more
2004Journal of Immunology225 citations
Semantic Scholar
IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells
M. Batten, N. Ramamoorthi, Noelyn M. Kljavin, Cindy S. Ma +11 more
2010Journal of Experimental Medicine214 citations Open access
Semantic Scholar
Antibody targeting of E3 ubiquitin ligases for receptor degradation
Hadir Marei, Wen-Ting K. Tsai, Y. Kee, Karen Ruiz +34 more
2022Nature213 citations Open access
Semantic Scholar
Maternal embryonic leucine zipper kinase/murine protein serine-threonine kinase 38 is a promising therapeutic target for multiple cancers.
Daniel C. Gray, A. Jubb, D. Hogue, P. Dowd +8 more
2005Cancer Research176 citations Open access
Semantic Scholar
Glucagon Couples Hepatic Amino Acid Catabolism to mTOR-Dependent Regulation of α-Cell Mass.
Mark J. Solloway, Azadeh Madjidi, C. Gu, J. Eastham-Anderson +13 more
2015Cell Reports173 citations Open access
Semantic Scholar
Actionable activating oncogenic ERRB2/HER2 transmembrane and juxtamembrane domain mutations
Kanika Bajaj Pahuja, Thong T. Nguyen, B. Jaiswal, K. Prabhash +30 more
2018Cancer Cell159 citations Open access
Semantic Scholar
Comparative oncogenomics identifies PSMB4 and SHMT2 as potential cancer driver genes.
Genee Y. Lee, P. Haverty, Li Li, Noelyn M. Kljavin +11 more
2014Cancer Research158 citations Open access
Semantic Scholar
Disruption of PH–kinase domain interactions leads to oncogenic activation of AKT in human cancers
C. Parikh, V. Janakiraman, Wen-I Wu, Catherine K. Foo +23 more
2012Proceedings of the National Academy of Sciences of the United States of America151 citations Open access
Semantic Scholar
Fibroblast Activation Protein Cleaves and Inactivates Fibroblast Growth Factor 21*
D. Dunshee, Travis W. Bainbridge, Noelyn M. Kljavin, José Zavala-Solorio +10 more
2016Journal of Biological Chemistry138 citations Open access
Semantic Scholar
IL-27 promotes T cell–dependent colitis through multiple mechanisms
J. Cox, Noelyn M. Kljavin, N. Ramamoorthi, L. Diehl +2 more
2011Journal of Experimental Medicine132 citations Open access
Semantic Scholar
Combined Targeting of BRAF and CRAF or BRAF and PI3K Effector Pathways Is Required for Efficacy in NRAS Mutant Tumors
B. Jaiswal, V. Janakiraman, Noelyn M. Kljavin, J. Eastham-Anderson +5 more
2009PLoS ONE120 citations Open access
Semantic Scholar
Opposing consequences of IL-23 signaling mediated by innate and adaptive cells in chemically induced colitis in mice
J. Cox, Noelyn M. Kljavin, Naruhisa Ota, J. Leonard +4 more
2011Mucosal Immunology113 citations Open access
Semantic Scholar
Homeostatic IL-23 receptor signaling limits Th17 response through IL-22–mediated containment of commensal microbiota
V. Shih, J. Cox, Noelyn M. Kljavin, Hart S. Dengler +7 more
2014Proceedings of the National Academy of Sciences of the United States of America107 citations Open access
Semantic Scholar
The Hippo pathway effector TAZ induces TEAD-dependent liver inflammation and tumors
Thijs J. Hagenbeek, J. Webster, Noelyn M. Kljavin, Matthew T. Chang +21 more
2018Science Signaling85 citations Open access
Semantic Scholar
Conditional activation of Pik3caH1047R in a knock-in mouse model promotes mammary tumorigenesis and emergence of mutations
Wenlin Yuan, Eric W. Stawiski, V. Janakiraman, Emily Chan +17 more
2012Oncogene80 citations Open access
Semantic Scholar
Stem cell plasticity enables hair regeneration following Lgr5+ cell loss
J. Hoeck, B. Biehs, A. Kurtova, Noelyn M. Kljavin +6 more
2017Nature Cell Biology71 citations
Semantic Scholar
Multiplexed, image-based pooled screens in primary cells and tissues with PerturbView
Takamasa Kudo, Ana M. Meireles, Reuben Moncada, Yushu Chen +35 more
2024Nature Biotechnology63 citations Open access
Semantic Scholar
Negative regulation of autoimmune demyelination by the inhibitory receptor CLM-1
Hong-Kang Xi, K. Katschke, K. Helmy, P. Wark +7 more
2010Journal of Experimental Medicine57 citations Open access
Semantic Scholar
IL-1R1–dependent signaling coordinates epithelial regeneration in response to intestinal damage
Christian B. Cox, E. Storm, V. Kapoor, Joseph Chavarria-Smith +13 more
2021Science immunology53 citations
Semantic Scholar
A Clinically Applicable Gene-Expression Classifier Reveals Intrinsic and Extrinsic Contributions to Consensus Molecular Subtypes in Primary and Metastatic Colon Cancer
R. Piskol, L. Huw, Ismail Sergin, Christiaan Kljin +14 more
2019Clinical Cancer Research48 citations Open access
Semantic Scholar
Requirement for BUB1B/BUBR1 in tumor progression of lung adenocarcinoma
Hong-Lin Chen, James Lee, Noelyn M. Kljavin, Benjamin Haley +3 more
2015Genes & cancer47 citations Open access
Semantic Scholar
Adrenergic nerves regulate intestinal regeneration through IL-22 signaling from type 3 innate lymphoid cells.
Putianqi Wang, Noelyn M. Kljavin, Thi Thu Thao Nguyen, E. Storm +6 more
2023Cell Stem Cell44 citations Open access
Semantic Scholar
A requirement for wild-type Ras isoforms in mutant KRas-driven signalling and transformation.
Carolyn Bentley, Stefanie S Jurinka, Noelyn M. Kljavin, Steffan Vartanian +8 more
2013Biochemical Journal43 citations
Semantic Scholar
Tumor-intrinsic expression of the autophagy gene Atg16l1 suppresses anti-tumor immunity in colorectal cancer
L. Taraborrelli, Y. Şenbabaoğlu, Lifen Wang, Junghyun Lim +21 more
2023Nature Communications42 citations Open access
Semantic Scholar
Selective Homogeneous Assay for Circulating Endopeptidase Fibroblast Activation Protein (FAP)
Travis W. Bainbridge, D. Dunshee, Noelyn M. Kljavin, N. Skelton +2 more
2017Scientific Reports33 citations Open access
Semantic Scholar
Cooperation between the Hippo and MAPK pathway activation drives acquired resistance to TEAD inhibition
Sayantanee Paul, Thijs J. Hagenbeek, Julien Tremblay, Vasumathi Kameswaran +19 more
2025Nature Communications25 citations Open access
Semantic Scholar
Elevated Serum Amino Acids Induce a Subpopulation of Alpha Cells to Initiate Pancreatic Neuroendocrine Tumor Formation
Derek K. Smith, L. Kates, S. Durinck, N. Patel +7 more
2020Cell Reports Medicine19 citations Open access
Semantic Scholar
TEAD-targeting small molecules induce a cofactor switch to regulate the Hippo pathway
Alissa D. Guarnaccia, Thijs J. Hagenbeek, Wendy Lee, Noelyn M. Kljavin +13 more
2025Proceedings of the National Academy of Sciences of the United States of America14 citations Open access
Semantic Scholar
TEAD Proteins Associate With DNA Repair Proteins to Facilitate Cellular Recovery From DNA Damage
Philamer C. Calses, Victoria C. Pham, Alissa D. Guarnaccia, Meena Choi +17 more
2023Molecular & Cellular Proteomics14 citations Open access
Semantic Scholar
Highly multiplexed, image-based pooled screens in primary cells and tissues with PerturbView
Takamasa Kudo, Ana M. Meireles, Reuben Moncada, Yushu Chen +28 more
2023bioRxiv11 citations Open access
Semantic Scholar
Modeling Colorectal Cancer Progression Through Orthotopic Implantation of Organoids.
F. de Sousa e Melo, J. Harnoss, Noelyn M. Kljavin, Ryan Scott +3 more
2020Methods in molecular biology7 citations
Semantic Scholar
S100a4 upregulation in Pik3caH1047R;Trp53R270H;MMTV-Cre-driven mammary tumors promotes metastasis
Wenlin Yuan, Leonard D. Goldstein, S. Durinck, Y. Chen +8 more
2019Breast Cancer Research7 citations Open access
Semantic Scholar
A high-MAPK, low-WNT cell state drives metastatic dissemination in colorectal cancer
Melanie Heinlein, G. Li, Noelyn M. Kljavin, Amanda R. Moore +10 more
2026Nature Cancer5 citations
Semantic Scholar
TEAD-targeting small molecules induce a cofactor switch to regulate the Hippo pathway
Alissa D. Guarnaccia, Thijs J. Hagenbeek, Wendy Lee, Noelyn M. Kljavin +11 more
2024bioRxiv5 citations Open access
Semantic Scholar
Disruption of stem cell niche–confined R-spondin 3 expression leads to impaired hematopoiesis
A. Kurtova, Melanie Heinlein, S. Haas, Lars Velten +17 more
2022Blood Advances5 citations Open access
Semantic Scholar
Dynamic transitioning between MAPK-driven and WNT-driven cell states drives intestinal cancer and shapes therapy response
Amanda R. Moore, B. Biehs, Noelyn M. Kljavin, Thi Thu Thao Nguyen +19 more
2026Nature Genetics2 citations
Semantic Scholar
Single-Cell RNA-seq Reveals a Subpopulation of Cells Underlying β Cell Expansion in the Postnatal Islets
Jing-Li Zhang, C. Gu, Derek K. Smith, Monica Beltran +6 more
2018bioRxiv1 citations Open access
Semantic Scholar
Abstract 2259: Requirement for BUB1B in tumor progression of lung adenocarcinoma
Hong-Lin Chen, James Lee, Noelyn M. Kljavin, Benjamin Haley +3 more
20151 citations
Semantic Scholar
Abstract 6377: TEAD-targeting small molecules induce a cofactor switch to regulate the Hippo pathway
Alissa D. Guarnaccia, Thijs J. Hagenbeek, Wendy Lee, Noelyn M. Kljavin +11 more
2025Cancer Research0 citations
Semantic Scholar
Author Correction: Multiplexed, image-based pooled screens in primary cells and tissues with PerturbView
Takamasa Kudo, Ana M. Meireles, Reuben Moncada, Yushu Chen +35 more
2025Nature Biotechnology0 citations Open access
Semantic Scholar
Abstract A18: Location, location, location: Avenues to regulating Hippo
Philamer C. Calses, Victoria C. Pham, E. Verschueren, Noelyn M. Kljavin +9 more
20200 citations
Semantic Scholar
GCGR Loss-of-Function Mutations Promote Amino Acid-Dependent Pancreatic Neuroendocrine Tumor Initiation from a Subpopulation of Alpha Cells
Derek K. Smith, L. Kates, S. Durinck, Nisha Patel +7 more
20200 citations
Semantic Scholar

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