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M. Philpott · SciRah

Researcher profile · Semantic Scholar

M. Philpott

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M. Philpott — researcher profile on SciRah

h-index: 37
Works: 95
Citations: 8,851

Most-cited papers

Selective inhibition of BET bromodomains
P. Filippakopoulos, J. Qi, S. Picaud, Yao Shen +21 more
2010Nature4,051 citations Open access
Semantic Scholar
RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain
S. Picaud, C. Wells, I. Felletár, D. Brotherton +11 more
2013Proceedings of the National Academy of Sciences of the United States of America442 citations Open access
Semantic Scholar
Discovery and Optimization of Small-Molecule Ligands for the CBP/p300 Bromodomains
D. Hay, O. Fedorov, Sarah Martin, Dean C. Singleton +16 more
2014Journal of the American Chemical Society272 citations Open access
Semantic Scholar
Dietary cancer and prevention using antimutagens.
L. Ferguson, M. Philpott, N. Karunasinghe
2004Toxicology255 citations
Semantic Scholar
PFI-1 – A highly Selective Protein Interaction Inhibitor Targeting BET Bromodomains
S. Picaud, D. da Costa, A. Thanasopoulou, P. Filippakopoulos +13 more
2013Cancer Research230 citations Open access
Semantic Scholar
3,5-Dimethylisoxazoles Act As Acetyl-lysine-mimetic Bromodomain Ligands
D. Hewings, Ming-Hua Wang, M. Philpott, O. Fedorov +8 more
2011Journal of Medicinal Chemistry211 citations Open access
Semantic Scholar
Generation of a selective small molecule inhibitor of the CBP/p300 bromodomain for leukemia therapy
S. Picaud, O. Fedorov, A. Thanasopoulou, K. Leonards +33 more
2015Cancer Research202 citations Open access
Semantic Scholar
Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit
P. Fish, P. Filippakopoulos, G. Bish, P. Brennan +15 more
2012Journal of Medicinal Chemistry191 citations Open access
Semantic Scholar
Structural analysis of human KDM5B guides histone demethylase inhibitor development.
C. Johansson, S. Velupillai, A. Tumber, A. Szykowska +20 more
2016Nature Chemical Biology175 citations Open access
Semantic Scholar
Affinity Map of Bromodomain Protein 4 (BRD4) Interactions with the Histone H4 Tail and the Small Molecule Inhibitor JQ1
Marie Jung, M. Philpott, S. Mueller, J. Schulze +7 more
2014Journal of Biological Chemistry144 citations Open access
Semantic Scholar
Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B
Pei-Jiun Chen, A. Chaikuad, P. Bamborough, M. Bantscheff +17 more
2015Journal of Medicinal Chemistry138 citations Open access
Semantic Scholar
In situ and in vitro antioxidant activity of sweetpotato anthocyanins.
M. Philpott, K. Gould, C. Lim, L. Ferguson
2004Journal of Agricultural and Food Chemistry137 citations
Semantic Scholar
Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance
O. Fedorov, Josefina Castex, C. Tallant, D. Owen +19 more
2015Science Advances132 citations Open access
Semantic Scholar
Bromodomain-peptide displacement assays for interactome mapping and inhibitor discovery.
M. Philpott, Jing Yang, Tony Tumber, O. Fedorov +8 more
2011Molecular Biosystems131 citations
Semantic Scholar
Nutrition and mutagenesis.
L. Ferguson, M. Philpott
2008Annual review of nutrition118 citations
Semantic Scholar
A Series of Potent CREBBP Bromodomain Ligands Reveals an Induced-Fit Pocket Stabilized by a Cation–π Interaction
T. Rooney, P. Filippakopoulos, O. Fedorov, S. Picaud +16 more
2014Angewandte Chemie112 citations Open access
Semantic Scholar
Immunonutrition and cancer.
M. Philpott, L. Ferguson
2004Mutation research106 citations
Semantic Scholar
Structure Enabled Design of BAZ2-ICR, A Chemical Probe Targeting the Bromodomains of BAZ2A and BAZ2B
Ludovic Drouin, Sally McGrath, L. Vidler, A. Chaikuad +12 more
2015Journal of Medicinal Chemistry98 citations Open access
Semantic Scholar
Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming
A. Ebrahimi, Kenan Sevinç, Gülben Gürhan Sevinç, A. Cribbs +8 more
2019Nature Chemical Biology91 citations Open access
Semantic Scholar
Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism
A. Cribbs, Stefan Terlecki-Zaniewicz, M. Philpott, J. Baardman +13 more
2019Proceedings of the National Academy of Sciences of the United States of America90 citations Open access
Semantic Scholar
Targeting Low-Druggability Bromodomains: Fragment Based Screening and Inhibitor Design against the BAZ2B Bromodomain
F. Ferguson, O. Fedorov, A. Chaikuad, M. Philpott +7 more
2013Journal of Medicinal Chemistry89 citations Open access
Semantic Scholar
Nanopore sequencing of single-cell transcriptomes with scCOLOR-seq
M. Philpott, J. Watson, A. Thakurta, T. Brown +3 more
2021Nature Biotechnology87 citations Open access
Semantic Scholar
Inhibition of histone H3K27 demethylases selectively modulates inflammatory phenotypes of natural killer cells
A. Cribbs, E. Hookway, G. Wells, M. Lindow +10 more
2018Journal of Biological Chemistry85 citations Open access
Semantic Scholar
[1,2,4]Triazolo[4,3-a]phthalazines: Inhibitors of Diverse Bromodomains
O. Fedorov, Hannah Lingard, C. Wells, Octovia P. Monteiro +11 more
2013Journal of Medicinal Chemistry85 citations Open access
Semantic Scholar
Induction of tumour necrosis factor-α by single and repeated doses of the antitumour agent 5,6-dimethylxanthenone-4-acetic acid
M. Philpott, B. Baguley, Lai-Ming Ching
2004Cancer Chemotherapy and Pharmacology80 citations
Semantic Scholar
Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching
M. Philpott, Catherine Rogers, C. Yapp, C. Wells +6 more
2014Epigenetics & Chromatin72 citations Open access
Semantic Scholar
Cancer prevention by dietary bioactive components that target the immune response.
L. Ferguson, M. Philpott
2007Current Cancer Drug Targets71 citations
Semantic Scholar
Interleukin-17A Causes Osteoarthritis-Like Transcriptional Changes in Human Osteoarthritis-Derived Chondrocytes and Synovial Fibroblasts In Vitro
J. Mimpen, M. Baldwin, A. Cribbs, M. Philpott +3 more
2021bioRxiv61 citations Open access
Semantic Scholar
Enhanced coloration reveals high antioxidant potential in new sweetpotato cultivars
M. Philpott, K. Gould, K. Markham, S. Lewthwaite +1 more
200358 citations
Semantic Scholar
KDM5 inhibition offers a novel therapeutic strategy for the treatment of KMT2D mutant lymphomas
J. Heward, L. Koniali, A. D'Avola, K. Close +23 more
2020bioRxiv52 citations Open access
Semantic Scholar
Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy
M. Lechner, V. Schartinger, C. Steele, W. Nei +68 more
2021Nature Communications49 citations Open access
Semantic Scholar
The design and synthesis of 5- and 6-isoxazolylbenzimidazoles as selective inhibitors of the BET bromodomains
D. Hay, O. Fedorov, P. Filippakopoulos, Sarah Martin +8 more
2013MedChemComm46 citations Open access
Semantic Scholar
Inhibition of histone H3K27 demethylases inactivates brachyury (TBXT) and promotes chordoma cell death
Lucia Cottone, A. Cribbs, Garima Khandelwal, G. Wells +12 more
2020Cancer Research44 citations Open access
Semantic Scholar
The antitumour agent 5,6-dimethylxanthenone-4-acetic acid acts in vitro on human mononuclear cells as a co-stimulator with other inducers of tumour necrosis factor.
M. Philpott, Lai-Ming Ching, B. Baguley
2001European Journal of Cancer43 citations
Semantic Scholar
Cell culture models in developing nutrigenomics foods for inflammatory bowel disease.
M. Philpott, L. Mackay, L. Ferguson, D. Forbes +1 more
2007Mutation research42 citations
Semantic Scholar
Genetic analysis of MDR1 and inflammatory bowel disease reveals protective effect of heterozygous variants for ulcerative colitis
Claudia Huebner, B. Browning, I. Petermann, D. Han +6 more
2009Inflammatory Bowel Diseases41 citations
Semantic Scholar
Dietary Protection Against Free Radicals: A Case for Multiple Testing to Establish Structure-activity Relationships for Antioxidant Potential of Anthocyanic Plant Species
M. Philpott, C. Lim, L. Ferguson
2009International Journal of Molecular Sciences39 citations Open access
Semantic Scholar
A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function.
V. Fagan, C. Johansson, C. Gileadi, Octovia P. Monteiro +30 more
2019Journal of Medicinal Chemistry37 citations Open access
Semantic Scholar
Production of tumour necrosis factor-alpha by cultured human peripheral blood leucocytes in response to the anti-tumour agent 5,6-dimethylxanthenone-4-acetic acid (NSC 640488).
M. Philpott, W. Joseph, K. Crosier, B. Baguley +1 more
1997British Journal of Cancer33 citations Open access
Semantic Scholar
Nucleotide-binding oligomerization domain containing 1 (NOD1) haplotypes and single nucleotide polymorphisms modify susceptibility to inflammatory bowel diseases in a New Zealand caucasian population: a case-control study
Claudia Huebner, L. Ferguson, D. Han, M. Philpott +5 more
2009BMC Research Notes30 citations Open access
Semantic Scholar
Oxidative DNA damage and repair: significance and biomarkers.
L. Ferguson, M. Philpott, N. Karunasinghe
2006Journal of NutriLife29 citations Open access
Semantic Scholar
Epigenetic events and protection from colon cancer in New Zealand
L. Ferguson, N. Karunasinghe, M. Philpott
2004Environmental and Molecular Mutagenesis29 citations
Semantic Scholar
Food-derived bioactives as potential regulators of the IL-12/IL-23 pathway implicated in inflammatory bowel diseases.
F. Danesi, M. Philpott, Claudia Huebner, A. Bordoni +1 more
2010Mutation research28 citations
Semantic Scholar
Interactions among genes influencing bacterial recognition increase IBD risk in a population-based New Zealand cohort.
I. Petermann, Claudia Huebner, B. Browning, R. Gearry +7 more
2009Human Immunology28 citations
Semantic Scholar
BRD9-SMAD2/3 Orchestrates Stemness and Tumorigenesis in Pancreatic Ductal Adenocarcinoma
Yu-Liang Feng, Liu-Yang Cai, Martin Pook, Feng Liu +21 more
2023Gastroenterology26 citations Open access
Semantic Scholar
Cancer-preventive Properties of an Anthocyanin-enriched Sweet Potato in the APCMIN Mouse Model
Khalid Asadi, L. Ferguson, M. Philpott, N. Karunasinghe
2017Journal of Cancer Prevention26 citations Open access
Semantic Scholar
Dissecting the Role of BET Bromodomain Proteins BRD2 and BRD4 in Human NK Cell Function
A. Cribbs, P. Filippakopoulos, M. Philpott, G. Wells +5 more
2021Frontiers in Immunology22 citations Open access
Semantic Scholar
Electrospun Scaffold Micro-Architecture Induces an Activated Transcriptional Phenotype within Tendon Fibroblasts
M. Baldwin, J. Mimpen, A. Cribbs, E. Stace +4 more
2022Frontiers in Bioengineering and Biotechnology20 citations Open access
Semantic Scholar
The Prolyl-tRNA Synthetase Inhibitor Halofuginone Inhibits SARS-CoV-2 Infection
Daniel R. Sandoval, T. M. Clausen, Chelsea L. Nora, A. Cribbs +42 more
2021bioRxiv20 citations Open access
Semantic Scholar
Prolyl-tRNA synthetase as a novel therapeutic target in multiple myeloma
K. Kurata, Anna James-Bott, M. Tye, Leona Yamamoto +25 more
2023Blood Cancer Journal19 citations Open access
Semantic Scholar

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