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A. Tumber · SciRah

Researcher profile · Semantic Scholar

A. Tumber

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A. Tumber — researcher profile on SciRah

h-index: 41
Works: 163
Citations: 6,652

Most-cited papers

Structural analysis of human KDM5B guides histone demethylase inhibitor development.
C. Johansson, S. Velupillai, A. Tumber, A. Szykowska +20 more
2016Nature Chemical Biology175 citations Open access
Semantic Scholar
Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors
Melissa L. Boby, D. Fearon, Matteo P. Ferla, Mihajlo Filep +208 more
2020bioRxiv167 citations Open access
Semantic Scholar
The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway
Mélissa Carbonneau, Laurence M. Gagné, Marie-Eve Lalonde, M. Germain +14 more
2016Nature Communications167 citations Open access
Semantic Scholar
Highly selective inhibition of histone demethylases by de novo macrocyclic peptides
A. Kawamura, M. Münzel, T. Kojima, C. Yapp +15 more
2017Nature Communications126 citations Open access
Semantic Scholar
Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells
A. Tumber, A. Nuzzi, E. Hookway, S. Hatch +24 more
2017Cell Chemical Biology114 citations Open access
Semantic Scholar
Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases
M. Chan, N. Ilott, J. Schödel, David Sims +7 more
2016Journal of Biological Chemistry93 citations Open access
Semantic Scholar
8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors
V. Bavetsias, R. Lanigan, G. F. Ruda, B. Atrash +39 more
2016Journal of Medicinal Chemistry87 citations Open access
Semantic Scholar
Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials
Tzu-Lan Yeh, T. Leissing, M. Abboud, C. Thinnes +17 more
2017Chemical Science78 citations Open access
Semantic Scholar
Accelerating drug target inhibitor discovery with a deep generative foundation model
Vijil Chenthamarakshan, Samuel C. Hoffman, C. Owen, P. Lukacik +16 more
2023Science Advances47 citations Open access
Semantic Scholar
In vitro selection of macrocyclic peptide inhibitors containing cyclic γ2,4-amino acids targeting the SARS-CoV-2 main protease
T. Miura, T. R. Malla, C. Owen, A. Tumber +12 more
2023Nature Chemistry46 citations Open access
Semantic Scholar
Inhibition of histone H3K27 demethylases inactivates brachyury (TBXT) and promotes chordoma cell death
Lucia Cottone, A. Cribbs, Garima Khandelwal, G. Wells +12 more
2020Cancer Research44 citations Open access
Semantic Scholar
Penicillin Derivatives Inhibit the SARS-CoV-2 Main Protease by Reaction with Its Nucleophilic Cysteine
T. R. Malla, L. Brewitz, Dorian-Gabriel Muntean, Hiba Aslam +8 more
2022Journal of Medicinal Chemistry42 citations Open access
Semantic Scholar
Assessing histone demethylase inhibitors in cells: lessons learned
S. Hatch, C. Yapp, R. Montenegro, P. Savitsky +23 more
2017Epigenetics & Chromatin42 citations Open access
Semantic Scholar
Studies on the Interaction of the Histone Demethylase KDM5B with Tricarboxylic Acid Cycle Intermediates
H. Tarhonskaya, R. Nowak, C. Johansson, A. Szykowska +7 more
2017Journal of Molecular Biology38 citations Open access
Semantic Scholar
Discovery of a Highly Selective Cell‐Active Inhibitor of the Histone Lysine Demethylases KDM2/7
P. Gerken, Jamie R. Wolstenhulme, A. Tumber, S. Hatch +16 more
2017Angewandte Chemie37 citations Open access
Semantic Scholar
The selective prolyl hydroxylase inhibitor IOX5 stabilizes HIF-1α and compromises development and progression of acute myeloid leukemia
Hannah Lawson, J. Holt-Martyn, Vilma Dembitz, Y. Kabayama +24 more
2024Nature Cancer36 citations Open access
Semantic Scholar
JMJD6 is a druggable oxygenase that regulates AR-V7 expression in prostate cancer
A. Paschalis, J. Welti, A. Neeb, W. Yuan +29 more
2021Cancer Research32 citations Open access
Semantic Scholar
Mass spectrometry reveals potential of β-lactams as SARS-CoV-2 Mpro inhibitors
T. R. Malla, A. Tumber, T. John, L. Brewitz +11 more
2021Chemical Communications29 citations Open access
Semantic Scholar
Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19
M. Redhead, C. Owen, L. Brewitz, A. Collette +24 more
2021Scientific Reports29 citations Open access
Semantic Scholar
Targeting the Mycobacterium tuberculosis transpeptidase LdtMt2 with cysteine-reactive inhibitors including ebselen
Mariska de Munnik, C. Lohans, P. Lang, G. Langley +4 more
2019Chemical Communications29 citations Open access
Semantic Scholar
Advances and challenges in understanding histone demethylase biology.
R. Nowak, A. Tumber, C. Johansson, K. Che +3 more
2016Current Opinion in Chemical Biology28 citations
Semantic Scholar
Widespread hydroxylation of unstructured lysine-rich protein domains by JMJD6
M. Cockman, Y. Sugimoto, Hamish B Pegg, N. Masson +6 more
2022Proceedings of the National Academy of Sciences of the United States of America27 citations Open access
Semantic Scholar
Development and Characterization of Type I, Type II, and Type III LIM-Kinase Chemical Probes
T. Hanke, S. Mathea, J. Woortman, E. Salah +7 more
2022Journal of Medicinal Chemistry27 citations Open access
Semantic Scholar
2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases
Y. Nakashima, L. Brewitz, A. Tumber, E. Salah +1 more
2021Nature Communications26 citations Open access
Semantic Scholar
Structure‐Activity Relationship and Crystallographic Studies on 4‐Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors
J. Holt-Martyn, R. Chowdhury, A. Tumber, T. Yeh +9 more
2019ChemMedChem26 citations Open access
Semantic Scholar
Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors
L. Brewitz, A. Tumber, I. Pfeffer, M. McDonough +1 more
2020Scientific Reports25 citations Open access
Semantic Scholar
Cyclic β2,3-amino acids improve the serum stability of macrocyclic peptide inhibitors targeting the SARS-CoV-2 main protease
Takashi Miura, T. R. Malla, L. Brewitz, A. Tumber +11 more
2024Bulletin of the Chemical Society of Japan24 citations Open access
Semantic Scholar
Investigating D-Lysine Stereochemistry for Epigenetic Methylation, Demethylation and Recognition
R. Belle, Abbas H. K. Al Temimi, Kiran Kumar, Bas J. Pieters +10 more
2017Chemical Communications24 citations Open access
Semantic Scholar
Mass Spectrometric Assays Reveal Discrepancies in Inhibition Profiles for the SARS‐CoV‐2 Papain‐Like Protease
L. Brewitz, J. Kamps, P. Lukacik, C. Strain-Damerell +6 more
2022ChemMedChem21 citations Open access
Semantic Scholar
Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors
Shifali Shishodia, M. Demetriades, Dong Zhang, Nok-Yin Tam +12 more
2021Journal of Medicinal Chemistry21 citations Open access
Semantic Scholar
Structure‐Activity Studies Reveal Scope for Optimisation of Ebselen‐Type Inhibition of SARS‐CoV‐2 Main Protease
Siegfried T. D. Thun‐Hohenstein, Timothy F. Suits, T. R. Malla, A. Tumber +4 more
2021ChemMedChem20 citations Open access
Semantic Scholar
Kinetic parameters of human aspartate/asparagine–β-hydroxylase suggest that it has a possible function in oxygen sensing
L. Brewitz, A. Tumber, C. Schofield
2020Journal of Biological Chemistry20 citations Open access
Semantic Scholar
Lessons from LIMK1 enzymology and their impact on inhibitor design
E. Salah, D. Chatterjee, A. Beltrami, A. Tumber +7 more
2019Biochemical Journal19 citations Open access
Semantic Scholar
Inhibitors of both the N-methyl lysyl- and arginyl-demethylase activities of the JmjC oxygenases
Joanna Bonnici, A. Tumber, A. Kawamura, C. Schofield
2018Philosophical Transactions of the Royal Society B: Biological Sciences17 citations Open access
Semantic Scholar
Synthesis of Novel Pyridine‐Carboxylates as Small‐Molecule Inhibitors of Human Aspartate/Asparagine‐β‐Hydroxylase
L. Brewitz, A. Tumber, Armin Thalhammer, E. Salah +2 more
2020ChemMedChem16 citations Open access
Semantic Scholar
Structure-activity studies of a macrocyclic peptide inhibitor of histone lysine demethylase 4A.
T. Passioura, B. Bhushan, A. Tumber, A. Kawamura +1 more
2018Bioorganic & Medicinal Chemistry16 citations Open access
Semantic Scholar
Human Oxygenase Variants Employing a Single Protein FeII Ligand Are Catalytically Active
A. Brasnett, I. Pfeffer, L. Brewitz, R. Chowdhury +4 more
2021Angewandte Chemie15 citations Open access
Semantic Scholar
Studies on enmetazobactam clarify mechanisms of widely used β-lactamase inhibitors
P. Lang, R. Raj, A. Tumber, C. Lohans +4 more
2022Proceedings of the National Academy of Sciences of the United States of America14 citations Open access
Semantic Scholar
Plant Cysteine Oxidase Oxygen-Sensing Function Is Conserved in Early Land Plants and Algae
Leah J. Taylor-Kearney, S. Madden, Jack Wilson, W. Myers +6 more
2022ACS Bio & Med Chem Au14 citations Open access
Semantic Scholar
C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays
Y. Le Bihan, Rachel M. Lanigan, B. Atrash, Mark G. McLaughlin +25 more
2019European journal of medicinal chemistry14 citations Open access
Semantic Scholar
Fluorinated derivatives of pyridine-2,4-dicarboxylate are potent inhibitors of human 2-oxoglutarate dependent oxygenases
L. Brewitz, Y. Nakashima, A. Tumber, E. Salah +1 more
2021Journal of fluorine chemistry13 citations Open access
Semantic Scholar
Biochemical and biophysical analyses of hypoxia sensing prolyl hydroxylases from Dictyostelium discoideum and Toxoplasma gondii
Tongri Liu, M. Abboud, R. Chowdhury, A. Tumber +8 more
2020Journal of Biological Chemistry13 citations Open access
Semantic Scholar
Focused Screening Identifies Different Sensitivities of Human TET Oxygenases to the Oncometabolite 2-Hydroxyglutarate
R. Belle, Hilal Saraç, E. Salah, B. Bhushan +8 more
2024Journal of Medicinal Chemistry12 citations Open access
Semantic Scholar
5-Substituted Pyridine-2,4-dicarboxylate Derivatives Have Potential for Selective Inhibition of Human Jumonji-C Domain-Containing Protein 5
L. Brewitz, Y. Nakashima, Sonia Piasecka, E. Salah +9 more
2023Journal of Medicinal Chemistry11 citations Open access
Semantic Scholar
First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53
R. Nowak, A. Tumber, E. Hendrix, Mohammad Salik Zeya Ansari +20 more
2021Journal of Medicinal Chemistry11 citations Open access
Semantic Scholar
Small-molecule active pharmaceutical ingredients of approved cancer therapeutics inhibit human aspartate/asparagine-β-hydroxylase
L. Brewitz, A. Tumber, Xiaojin Zhang, C. Schofield
2020Bioorganic & Medicinal Chemistry11 citations Open access
Semantic Scholar
Structural basis for binding of the renal carcinoma target hypoxia‐inducible factor 2α to prolyl hydroxylase domain 2
W. Figg, G. Fiorini, R. Chowdhury, Y. Nakashima +3 more
2023Proteins: Structure, Function, and Bioinformatics10 citations Open access
Semantic Scholar
Mass spectrometry reveals potential of b -lactams as SARS-CoV-2 M pro inhibitors
T. R. Malla, A. Tumber, T. John, L. Brewitz +11 more
202110 citations
Semantic Scholar
Selective Inhibitors of a Human Prolyl Hydroxylase (OGFOD1) Involved in Ribosomal Decoding
C. Thinnes, C. Lohans, M. Abboud, T. Yeh +7 more
2019Chemistry10 citations Open access
Semantic Scholar
Kinetic and inhibition studies on human Jumonji-C (JmjC) domain-containing protein 5
A. Tumber, E. Salah, L. Brewitz, Thomas P. Corner +1 more
2023RSC Chemical Biology9 citations Open access
Semantic Scholar

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