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P. Fish · SciRah

Researcher profile · Semantic Scholar

P. Fish

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P. Fish — researcher profile on SciRah

h-index: 25
Works: 109
Citations: 4,194

Most-cited papers

Epigenetic protein families: a new frontier for drug discovery
C. Arrowsmith, C. Bountra, P. Fish, Kevin Lee +1 more
2012Nature reviews. Drug discovery1,290 citations
Semantic Scholar
Bridging solubility between drug discovery and development.
L. Di, P. Fish, T. Mano
2012Drug Discovery Today464 citations
Semantic Scholar
PFI-1 – A highly Selective Protein Interaction Inhibitor Targeting BET Bromodomains
S. Picaud, D. da Costa, A. Thanasopoulou, P. Filippakopoulos +13 more
2013Cancer Research230 citations Open access
Semantic Scholar
Apc-mutant cells deploy Notum to bias clonal competition and drive cancer
D. Flanagan, Nalle Pentinmikko, Kalle Luopajärvi, Nicky J. Willis +32 more
2021Nature208 citations Open access
Semantic Scholar
Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit
P. Fish, P. Filippakopoulos, G. Bish, P. Brennan +15 more
2012Journal of Medicinal Chemistry191 citations Open access
Semantic Scholar
(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells
D. Barsyte-Lovejoy, Feng-Ling Li, M. Oudhoff, J. Tatlock +29 more
2014Proceedings of the National Academy of Sciences of the United States of America171 citations Open access
Semantic Scholar
Predicting Penetration Across the Blood-Brain Barrier from Simple Descriptors and Fragmentation Schemes
Yuan H. Zhao, M. Abraham, Adam Ibrahim, P. Fish +4 more
2007Journal of Chemical Information and Modeling134 citations
Semantic Scholar
New approaches for the treatment of Alzheimer's disease.
P. Fish, D. Steadman, Elliott D. Bayle, P. Whiting
2019Bioorganic & Medicinal Chemistry Letters123 citations Open access
Semantic Scholar
UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria
Christel Brunschwig, N. Lawrence, D. Taylor, E. Abay +44 more
2018Antimicrobial Agents and Chemotherapy97 citations Open access
Semantic Scholar
Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate Inhibitors
Kanchan Devkota, M. Schapira, S. Perveen, Aliakbar Khalili Yazdi +16 more
2021SLAS discovery : advancing life sciences R & D67 citations Open access
Semantic Scholar
Potent and selective nonpeptidic inhibitors of procollagen C-proteinase.
P. Fish, G. Allan, Simon Bailey, J. Blagg +10 more
2007Journal of Medicinal Chemistry61 citations Open access
Semantic Scholar
The First Examples of Nonenzymic, Biomimetic Polyene Pentacyclizations. Total Synthesis of the Pentacyclic Triterpenoid Sophoradiol
P. Fish, W. S. Johnson
199458 citations
Semantic Scholar
Changing the HTS Paradigm: AI-Driven Iterative Screening for Hit Finding
Gabriel H S Dreiman, M. Bictash, P. Fish, Lewis D. Griffin +1 more
2020SLAS discovery : advancing life sciences R & D57 citations Open access
Semantic Scholar
Novel strategies for enhancing tissue integration in cartilage repair
R. Butt, J. Huggins, D. Greiling, B. Hopkins +16 more
200354 citations Open access
Semantic Scholar
Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines.
P. Fish, C. Barber, D. Brown, R. Butt +11 more
2007Journal of Medicinal Chemistry53 citations Open access
Semantic Scholar
Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling
Elliott D. Bayle, Fredrik Svensson, Benjamin N. Atkinson, D. Steadman +5 more
2021Journal of Medicinal Chemistry48 citations Open access
Semantic Scholar
Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies.
N. Igoe, Elliott D. Bayle, O. Fedorov, C. Tallant +13 more
2017Journal of Medicinal Chemistry40 citations Open access
Semantic Scholar
7-Sulfonamido-3-benzazepines as potent and selective 5-HT2C receptor agonists: hit-to-lead optimization.
P. Fish, A. Brown, Edelweiss Evrard, Lee R. Roberts
2009Bioorganic & Medicinal Chemistry Letters39 citations Open access
Semantic Scholar
Selective Targeting of Bromodomains of the Bromodomain-PHD Fingers Family Impairs Osteoclast Differentiation
J. Meier, C. Tallant, O. Fedorov, H. Witwicka +23 more
2017ACS Chemical Biology38 citations Open access
Semantic Scholar
Multiparameter optimization in CNS drug discovery: design of pyrimido[4,5-d]azepines as potent 5-hydroxytryptamine 2C (5-HT₂C) receptor agonists with exquisite functional selectivity over 5-HT₂A and 5-HT₂B receptors.
R. I. Storer, P. Brennan, A. Brown, P. Bungay +18 more
2014Journal of Medicinal Chemistry34 citations Open access
Semantic Scholar
Design and synthesis of morpholine derivatives. SAR for dual serotonin & noradrenaline reuptake inhibition.
P. Fish, C. Deur, Xin-Min Gan, K. Greene +9 more
2008Bioorganic & Medicinal Chemistry Letters32 citations Open access
Semantic Scholar
Design of a Chemical Probe for the Bromodomain and Plant Homeodomain Finger-Containing (BRPF) Family of Proteins.
N. Igoe, Elliott D. Bayle, C. Tallant, O. Fedorov +13 more
2017Journal of Medicinal Chemistry30 citations Open access
Semantic Scholar
Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 3: 1-isoquinolinylguanidines.
C. Barber, R. Dickinson, P. Fish
2004Bioorganic & Medicinal Chemistry Letters30 citations Open access
Semantic Scholar
Enantiospecific syntheses of pseudopterosin aglycones. Part 1. Synthesis of the putative aglycone of pseudopterosin G–J via an A→AB→ABC annulation strategy
Roberta C. L. Chow, P. Kocieňski, A. Kuhl, Jean-Yves LeBrazidec +2 more
200128 citations
Semantic Scholar
Small-molecule inhibitors of carboxylesterase Notum
Yu-Guang Zhao, Sarah Jolly, S. Benvegnù, E. Jones +1 more
2021Future Medicinal Chemistry25 citations Open access
Semantic Scholar
New small molecule inhibitors of histone methyl transferase DOT1L with a nitrile as a non-traditional replacement for heavy halogen atoms.
S. S. Spurr, Elliott D. Bayle, Wen-Yu Yu, Feng-Ling Li +4 more
2016Bioorganic & Medicinal Chemistry Letters25 citations Open access
Semantic Scholar
N-(1,2-diphenylethyl)piperazines: a new class of dual serotonin/noradrenaline reuptake inhibitor.
M. Fray, G. Bish, A. Brown, P. Fish +3 more
2006Bioorganic & Medicinal Chemistry Letters25 citations Open access
Semantic Scholar
Pyridyl-phenyl ether monoamine reuptake inhibitors: Impact of lipophilicity on dual SNRI pharmacology and off-target promiscuity.
G. Whitlock, P. Fish, M. Fray, A. Stobie +1 more
2008Bioorganic & Medicinal Chemistry Letters23 citations Open access
Semantic Scholar
Succinyl hydroxamates as potent and selective non-peptidic inhibitors of procollagen C-proteinase: design, synthesis, and evaluation as topically applied, dermal anti-scarring agents.
Simon Bailey, P. Fish, S. Billotte, J. Bordner +6 more
2008Bioorganic & Medicinal Chemistry Letters23 citations Open access
Semantic Scholar
1-(2-Phenoxyphenyl)methanamines: SAR for dual serotonin/noradrenaline reuptake inhibition, metabolic stability and hERG affinity.
G. Whitlock, J. Blagg, P. Fish
2008Bioorganic & Medicinal Chemistry Letters21 citations Open access
Semantic Scholar
Structure-activity relationships of N-substituted piperazine amine reuptake inhibitors.
M. Fray, G. Bish, P. Fish, A. Stobie +2 more
2006Bioorganic & Medicinal Chemistry Letters20 citations Open access
Semantic Scholar
Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen
Benjamin N. Atkinson, D. Steadman, Yu-Guang Zhao, James Sipthorp +10 more
2019MedChemComm18 citations Open access
Semantic Scholar
Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors
Benjamin N. Atkinson, D. Steadman, W. Mahy, Yu-Guang Zhao +10 more
2019Bioorganic & Medicinal Chemistry Letters17 citations Open access
Semantic Scholar
Design of selective thrombin inhibitors based on the (R)-Phe-Pro-Arg sequence.
J. Danilewicz, S. M. Abel, A. Brown, P. Fish +7 more
2002Journal of Medicinal Chemistry17 citations Open access
Semantic Scholar
Screening of a custom-designed acid fragment library identifies 1-phenylpyrroles and 1-phenylpyrrolidines as inhibitors of Notum carboxylesterase activity.
W. Mahy, Mikesh Patel, D. Steadman, H. Woodward +16 more
2020Journal of Medicinal Chemistry16 citations Open access
Semantic Scholar
5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit.
W. Mahy, Nicky J. Willis, Yu-Guang Zhao, H. Woodward +14 more
2020Journal of Medicinal Chemistry16 citations Open access
Semantic Scholar
Antimalarial Lead-Optimization Studies on a 2,6-Imidazopyridine Series within a Constrained Chemical Space To Circumvent Atypical Dose-Response Curves against Multidrug Resistant Parasite Strains.
Claire Le Manach, Tanya Paquet, K. Wicht, Aloysius T. Nchinda +12 more
2018Journal of Medicinal Chemistry16 citations Open access
Semantic Scholar
Small molecule modulation of stem cells in regenerative medicine: recent applications and future direction
T. Allsopp, Mark E. Bunnage, P. Fish
201015 citations
Semantic Scholar
N-Benzyl-N-(tetrahydro-2H-pyran-4-yl)pyrrolidin-3-amines as selective dual serotonin/noradrenaline reuptake inhibitors.
P. Fish, M. Fray, A. Stobie, Florian Wakenhut +1 more
2007Bioorganic & Medicinal Chemistry Letters15 citations Open access
Semantic Scholar
Structural Insights into Notum Covalent Inhibition
Yu-Guang Zhao, Fredrik Svensson, D. Steadman, S. Frew +7 more
2021Journal of Medicinal Chemistry14 citations Open access
Semantic Scholar
4-Piperidines and 3-pyrrolidines as dual serotonin and noradrenaline reuptake inhibitors: design, synthesis and structure-activity relationships.
P. Fish, M. Andrews, M. Fray, A. Stobie +2 more
2009Bioorganic & Medicinal Chemistry Letters14 citations Open access
Semantic Scholar
Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit
Nicky J. Willis, W. Mahy, James Sipthorp, Yu-Guang Zhao +20 more
2022Journal of Medicinal Chemistry13 citations Open access
Semantic Scholar
Pyrimido[4,5-d]azepines as potent and selective 5-HT2C receptor agonists: design, synthesis, and evaluation of PF-3246799 as a treatment for urinary incontinence.
M. Andrews, P. Fish, J. Blagg, T. Brabham +21 more
2011Bioorganic & Medicinal Chemistry Letters13 citations Open access
Semantic Scholar
6,7-Dihydro-5H-pyrrolo[1,2-a] imidazoles as potent and selective alpha1A adrenoceptor partial agonists.
Lee R. Roberts, P. Fish, R. I. Storer, G. Whitlock
2009Bioorganic & Medicinal Chemistry Letters13 citations Open access
Semantic Scholar
The tetramethylallyl cation as a surrogate for the epoxide function as an initiator of biomimetic polyene pentacyclizations. Total synthesis of sophoradiol
P. Fish, W. S. Johnson
199413 citations Open access
Semantic Scholar
Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity.
D. Steadman, Benjamin N. Atkinson, Yu-Guang Zhao, Nicky J. Willis +10 more
2021Journal of Medicinal Chemistry12 citations Open access
Semantic Scholar
Selective termination of a polyene cyclization by an internally situated allylsilane group
P. Fish
199412 citations Open access
Semantic Scholar
Identification of 2,4-disubstituted imidazopyridines as hemozoin formation inhibitors with fast killing kinetics and in vivo efficacy in the Plasmodium falciparum NSG mouse model
A. Horatscheck, A. Andrijević, Aloysius T. Nchinda, Claire Le Manach +23 more
2020Journal of Medicinal Chemistry11 citations Open access
Semantic Scholar
An improved, scalable synthesis of Notum inhibitor LP-922056 using 1-chloro-1,2-benziodoxol-3-one as a superior electrophilic chlorinating agent
Nicky J. Willis, Elliott D. Bayle, G. Papageorgiou, D. Steadman +3 more
2019Beilstein Journal of Organic Chemistry11 citations Open access
Semantic Scholar
Design, Synthesis, and Evaluation of Tetrasubstituted Pyridines as Potent 5-HT2C Receptor Agonists.
G. Rouquet, Dianna E. Moore, M. Spain, Daniel M. Allwood +8 more
2015ACS Medicinal Chemistry Letters11 citations Open access
Semantic Scholar

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