Researcher profile · Semantic Scholar

Dean C. Singleton

h-index: 14
Works: 28
Citations: 1,914

Most-cited papers

Therapeutic targeting of the hypoxic tumour microenvironment
Dean C. Singleton, A. Macann, W. Wilson
2021Nature Reviews Clinical Oncology425 citations
Semantic Scholar
Discovery and Optimization of Small-Molecule Ligands for the CBP/p300 Bromodomains
D. Hay, O. Fedorov, Sarah Martin, Dean C. Singleton +16 more
2014Journal of the American Chemical Society272 citations Open access
Semantic Scholar
Role of ATF4 in regulation of autophagy and resistance to drugs and hypoxia
T. Rzymski, M. Milani, Dean C. Singleton, A. Harris
2009Cell Cycle204 citations Open access
Semantic Scholar
LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor
P. G. Clark, L. C. C. Vieira, C. Tallant, O. Fedorov +11 more
2015Angewandte Chemie171 citations Open access
Semantic Scholar
Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival.
Luke R. G. Pike, Dean C. Singleton, F. Buffa, O. Abramczyk +5 more
2013Biochemical Journal147 citations Open access
Semantic Scholar
Targeting the ATF4 pathway in cancer therapy
Dean C. Singleton, A. Harris
2012Expert opinion on therapeutic targets125 citations Open access
Semantic Scholar
Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium
E. O. Pettersen, P. Ebbesen, R. Gieling, K. Williams +43 more
2015Journal of Enzyme Inhibition and Medicinal Chemistry113 citations Open access
Semantic Scholar
Bystander or No Bystander for Gene Directed Enzyme Prodrug Therapy
G. Dachs, Michelle A. Hunt, S. Syddall, Dean C. Singleton +1 more
2009Molecules113 citations Open access
Semantic Scholar
Disrupting Hypoxia-Induced Bicarbonate Transport Acidifies Tumor Cells and Suppresses Tumor Growth.
A. McIntyre, A. Hulikova, I. Ledaki, C. Snell +10 more
2016Cancer Research86 citations Open access
Semantic Scholar
Dichloroacetate Reverses the Hypoxic Adaptation to Bevacizumab and Enhances its Antitumor Effects in Mouse Xenografts
Krishna Kumar, S. Wigfield, H. Gee, C. Devlin +10 more
2013Journal of molecular medicine79 citations Open access
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Hypoxic regulation of RIOK3 is a major mechanism for cancer cell invasion and metastasis
Dean C. Singleton, P. Rouhi, C. Zois, S. Haider +4 more
2014Oncogene48 citations Open access
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Pyruvate anaplerosis is a mechanism of resistance to pharmacological glutaminase inhibition in triple-receptor negative breast cancer
Dean C. Singleton, A. Dechaume, P. Murray, William P. Katt +2 more
2020BMC Cancer37 citations Open access
Semantic Scholar
Patient-Derived Xenograft and Organoid Models for Precision Medicine Targeting of the Tumour Microenvironment in Head and Neck Cancer
T. Lee, A. Lai, J. Harms, Dean C. Singleton +4 more
2020Cancers36 citations Open access
Semantic Scholar
N -Methyl-D-Aspartate Receptor Hypofunction in Meg-01 Cells Reveals a Role for Intracellular Calcium Homeostasis in Balancing Megakaryocytic-Erythroid Differentiation
J. Hearn, Taryn N. Green, Martin Chopra, Y. Nursalim +7 more
2020Thrombosis and Haemostasis15 citations Open access
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Derivation of Breast Cancer Cell Lines Under Physiological (5%) Oxygen Concentrations
E. Leung, Marjan E. Askarian-Amiri, Dean C. Singleton, C. Ferraro-Peyret +7 more
2018Frontiers in Oncology12 citations Open access
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Hypoxia-Activated Prodrugs of PERK Inhibitors.
L. Liew, Dean C. Singleton, W. Wong, G. Cheng +2 more
2019Chemistry - An Asian Journal11 citations
Semantic Scholar
Bioreductive prodrug PR-104 improves the tumour distribution and titre of the nitroreductase-armed oncolytic adenovirus ONYX-411NTR leading to therapeutic benefit
Dean C. Singleton, A. Mowday, C. Guise, S. Syddall +6 more
2021Cancer Gene Therapy8 citations
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ATF4, Hypoxia and Treatment Resistance in Cancer
Dean C. Singleton, A. Harris
2019Cancer Drug Discovery and Development6 citations
Semantic Scholar
In vitro and computational analysis of the putative furin cleavage site (RRARS) in the divergent spike protein of the rodent coronavirus AcCoV-JC34 (sub-genus luchacovirus)
Annette Choi, Dean C. Singleton, Alison E. Stout, J. Millet +1 more
2021bioRxiv5 citations Open access
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Microenvironmental induced essentiality of autophagy
Dean C. Singleton, A. Harris
2013Clinical Cancer Research3 citations Open access
Semantic Scholar
Antitumour efficacy of the nitroreductase-armed oncolytic adenovirus ONYX-411NTR in combination with dinitrobenzamide mustard prodrugs in preclinical models.
Dean C. Singleton
20091 citations
Semantic Scholar
Functional genomics screens to identify genes involved in tolerance of tumour microenvironment stress
T. W. Lee, H. Yong, S. Bhatta, Dean C. Singleton +7 more
20200 citations
Semantic Scholar
Abstract 3561: HIF-1α stabilisation in triple receptor negative breast cancer is sensitive to glutaminase inhibition
Laura Cussonneau, A. Dechaume, P. Murray, H. Liyanage +4 more
2020Molecular and Cellular Biology / Genetics0 citations
Semantic Scholar
The Development of Hypoxia-selective PERK Inhibitor Prodrugs
L. Liew, W. Wong, Dean C. Singleton, S. Jamieson +3 more
20170 citations
Semantic Scholar
Abstract BS02-1: Hypoxia metabolism in breast cancer – How to overcome resistance to anti-angiogenic therapy
A. Harris, F. Buffa, S. Haider, K. Bensaad +7 more
20130 citations
Semantic Scholar
Hypoxia metabolism in breast cancer - How to overcome resistance to anti-angiogenic therapy
A. Harris, F. Buffa, S. Haider, K. Bensaad +7 more
20130 citations
Semantic Scholar
Abstract 3947: Hypoxic regulation of RIO kinase 3 promotes cell migration and invasion
Dean C. Singleton, P. Rouhi, Yi-Hai Cao, A. Harris
20120 citations
Semantic Scholar
300 POSTER Oncolytic adenovirus ONYX-411NTR enhances the antitumour efficacy of the bioreductive alkylator prodrug PR-104
Dean C. Singleton, S. Syddall, S.-Y. Bai, Dan Li +3 more
20080 citations
Semantic Scholar

S. Jamieson

×4

Yi-Hai Cao×3

S. Syddall×3

A. Patterson×3

A. McIntyre×3

I. Ledaki×3

E. Leung×3

M. Hay×3