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M. Albertella · SciRah

Researcher profile · Semantic Scholar

M. Albertella

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M. Albertella — researcher profile on SciRah

h-index: 17
Works: 52
Citations: 2,674

Most-cited papers

Small molecule inhibition of METTL3 as a strategy against myeloid leukaemia
E. Yankova, W. Blackaby, M. Albertella, Justyna Rak +21 more
2021Nature1,197 citations Open access
Semantic Scholar
The overexpression of specialized DNA polymerases in cancer.
M. Albertella, A. Lau, M. O'Connor
2005DNA Repair251 citations
Semantic Scholar
A role for polymerase eta in the cellular tolerance to cisplatin-induced damage.
M. Albertella, C. Green, A. Lehmann, M. O'Connor
2005Cancer Research228 citations Open access
Semantic Scholar
Aneuploid colon cancer cells have a robust spindle checkpoint
A. Tighe, V. L. Johnson, M. Albertella, Stephen S. Taylor
2001EMBO Reports182 citations Open access
Semantic Scholar
Targeting the m6A RNA modification pathway blocks SARS-CoV-2 and HCoV-OC43 replication
Hannah M. Burgess, D. Depledge, Letitia Thompson, K. P. Srinivas +10 more
2021Genes & Development123 citations Open access
Semantic Scholar
Hypoxia-Selective Targeting by the Bioreductive Prodrug AQ4N in Patients with Solid Tumors: Results of a Phase I Study
M. Albertella, P. Loadman, Philip H. Jones, R. Phillips +10 more
2008Clinical Cancer Research122 citations Open access
Semantic Scholar
Inhibition of METTL3 results in a cell-intrinsic interferon response that enhances anti-tumour immunity.
A. Guirguis, Y. Ofir-Rosenfeld, K. Knezevic, W. Blackaby +23 more
2023Cancer Discovery102 citations Open access
Semantic Scholar
Characterization of a novel gene in the human major histocompatibility complex that encodes a potential new member of the I kappa B family of proteins.
M. Albertella, R. Campbell
1994Human Molecular Genetics64 citations
Semantic Scholar
Design and Preclinical Evaluation of a Novel B7-H4-Directed Antibody-Drug Conjugate, AZD8205, Alone and in Combination with the PARP1-Selective Inhibitor AZD5305.
Krista Kinneer, Philipp Wortmann, Z. Cooper, Niall J Dickinson +28 more
2022Clinical Cancer Research57 citations Open access
Semantic Scholar
The RON Receptor Tyrosine Kinase Promotes Metastasis by Triggering MBD4-Dependent DNA Methylation Reprogramming
S. Cunha, Yi-Chun Lin, Elizabeth A. Goossen, Christa I. DeVette +4 more
2014Cell Reports51 citations Open access
Semantic Scholar
Selective Tumor Targeting by the Hypoxia-Activated Prodrug AQ4N Blocks Tumor Growth and Metastasis in Preclinical Models of Pancreatic Cancer
A. Lalani, S. Alters, A. Wong, M. Albertella +2 more
2007Clinical Cancer Research51 citations Open access
Semantic Scholar
In vivo activation of the hypoxia-targeted cytotoxin AQ4N in human tumor xenografts
K. Williams, M. Albertella, B. Fitzpatrick, P. Loadman +6 more
2006Molecular Cancer Therapeutics45 citations Open access
Semantic Scholar
STC-15, an oral small molecule inhibitor of the RNA methyltransferase METTL3, inhibits tumour growth through activation of anti-cancer immune responses associated with increased interferon signalling, and synergises with T cell checkpoint blockade
Y. Ofir-Rosenfeld, L. Vasiliauskaitė, C. Saunders, A. Sapetschnig +6 more
2022European Journal of Cancer30 citations Open access
Semantic Scholar
Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: optimization of kinase selectivity and pharmacokinetics.
K. Hornberger, Xin Chen, A. Crew, Andrew Kleinberg +15 more
2013Bioorganic & Medicinal Chemistry Letters28 citations Open access
Semantic Scholar
The thymidine dideoxynucleoside analog, alovudine, inhibits the mitochondrial DNA polymerase γ, impairs oxidative phosphorylation and promotes monocytic differentiation in acute myeloid leukemia
D. Yehudai, Sanduni U. Liyanage, R. Hurren, B. Rizoska +10 more
2018Haematologica27 citations Open access
Semantic Scholar
Pharmacological Inhibition of the RNA m6a Writer METTL3 As a Novel Therapeutic Strategy for Acute Myeloid Leukemia
K. Tzelepis, E. De Braekeleer, E. Yankova, Justyna Rak +13 more
2019Blood25 citations Open access
Semantic Scholar
The PARP1 Inhibitor AZD5305 Impairs Ovarian Adenocarcinoma Progression and Visceral Metastases in Patient-derived Xenografts Alone and in Combination with Carboplatin
Giulia Dellavedova, A. Decio, Laura Formenti, M. Albertella +6 more
2023Cancer Research Communications20 citations Open access
Semantic Scholar
Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
K. Hornberger, D. Berger, A. Crew, Han-Qing Dong +20 more
2013Bioorganic & Medicinal Chemistry Letters17 citations Open access
Semantic Scholar
Novel 6-aminofuro[3,2-c]pyridines as potent, orally efficacious inhibitors of cMET and RON kinases.
A. Steinig, An-Hu Li, Jing Wang, Xin Chen +26 more
2013Bioorganic & Medicinal Chemistry Letters15 citations Open access
Semantic Scholar
Determination of the recommended phase II dose of birinapant in combination with pembrolizumab: Results from the dose-escalation phase of BPT-201.
R. Schilder, M. Albertella, J. Strauss, M. Sydvander +7 more
2019Journal of Clinical Oncology6 citations
Semantic Scholar
Novel L-nucleoside analog, 5-fluorotroxacitabine, displays potent efficacy against acute myeloid leukemia
Aniket Bankar, Thirushi P. Siriwardena, B. Rizoska, C. Rydergård +17 more
2019Haematologica5 citations Open access
Semantic Scholar
Abstract LB025: First disclosure of AZD5335, a TOP1i-ADC targeting low and high FRα-expressing ovarian cancer with superior preclinical activity vs FRα-MTI ADC
Marco Gymnopoulos, Tima Thomas, Diana Gasper, J. Anderton +17 more
2023Cancer Research4 citations
Semantic Scholar
1373 STC-15, an oral small molecule inhibitor of the RNA methyltransferase METTL3, inhibits tumour growth through activation of anti-cancer immune responses and synergises with immune checkpoint blockade
Yaara Ofir -Rosenfeld, Oliver Rausch, Jerry McMahon, L. Vasiliauskaitė +7 more
2022Regular and Young Investigator Award Abstracts4 citations Open access
Semantic Scholar
A phase 1/2 study with birinapant in combination with pembrolizumab.
R. Schilder, M. Albertella, J. Strauss, M. Sydvander +4 more
20184 citations
Semantic Scholar
Identification of potent water-soluble DNA-dependent protein kinase (DNA-PK) inhibitors using a small-molecule library approach [abstract]
Kappusamy Saravanan, M. Albertella, C. Cano, N. Curtin +13 more
20084 citations
Semantic Scholar
Abstract A18: STC-15, a novel METTL3 inhibitor, and its combination with Venetoclax confer anti-tumour activity in AML models
L. Vasiliauskaitė, Y. Ofir-Rosenfeld, M. Albertella, C. Hoareau-Aveilla +2 more
2023Blood Cancer Discovery3 citations
Semantic Scholar
Abstract B126: A small molecule inhibitor of the RNA m6A writer METTL3 inhibits the development of acute myeloid leukemia (AML) in vivo
M. Albertella, W. Blackaby, R. Fosbeary, A. Hendrick +7 more
2019New Molecular Targets3 citations
Semantic Scholar
Abstract 3011: Development of selective small-molecule inhibitors of cellular MALT1 protease activity
F. Öberg, S. Karlstrom, Ian R. Henderson, E. Hewitt +6 more
20162 citations
Semantic Scholar
Abstract B058: Combination of the PARP1-selective inhibitor AZD5305 with the ATR inhibitor ceralasertib for the treatment of PARPi-resistant cancer
M. Albertella, P. Wijnhoven, A. Demin, G. Illuzzi +5 more
2023Molecular Cancer Therapeutics1 citations
Semantic Scholar
Abstract 2794: A Quantitative Systems Pharmacology (QSP) model to characterize dose-dependent antitumor activity of AZD5305, PARP1 selective inhibitor, across multiple xenograft models
Ganesha Moorthy, Veronika M. Voronova, Cesar Pichardo, K. Peskov +4 more
2023Cancer Research1 citations
Semantic Scholar
5-Fluorotroxacitabine Displays Potent Anti-Leukemic Effects and Circumvents Resistance to Ara-C
Aniket Bankar, Thirushi P. Siriwardena, B. Rizoska, C. Rydergård +15 more
2018Blood1 citations Open access
Semantic Scholar
Liver-targeting with the novel nucleotide prodrug MIV-818 designed for the treatment of liver cancers
R. Bethell, K. Tunblad, B. Rizoska, A. Linqvist +6 more
20171 citations
Semantic Scholar
Abstract A116: Radio‐ and chemosensitization through inhibition of DNA‐PK by KU‐0060648
J. Bardos, K. Shea, Nahida Parveen, M. Peacock +6 more
20091 citations
Semantic Scholar
Potent in vitro and in vivo radiosensitisation by the selective DNA-dependent protein kinase inhibitor KU-0060648
M. Albertella, A. Slade, K. Shea, J. Bardos +11 more
20081 citations
Semantic Scholar
[Lymphatic system of the lower extremities in post-thrombophlebitic syndromes before and after treatment with combination of vasoactive drugs].
B. Rizzi, E. Terni, M. Albertella, A. Ripamonti +1 more
1972Minerva Cardioangiologica : a Journal on Cardiovascular Pathophysiology, Clinical Medicine and Therapy1 citations
Semantic Scholar
Abstract 2947: Preclinical evaluation of a novel B7-H4 targeted antibody-drug conjugate AZD8205 as a single agent and in combination with novel PARP inhibitor and checkpoint blockade
A. Cazes, Krista Kinneer, Bilal Omar, Jon Chesebrough +16 more
2023Cancer Research0 citations
Semantic Scholar
Abstract C056: MIV-818 stimulates an antitumor immune response in vitro and enhances the effects of pembrolizumab
F. Oberg, K. Tunblad, A. Slipicevic, R. Bethell +1 more
2019Therapeutic Agents: Other0 citations
Semantic Scholar
Protides of 5-Fluorotroxacitabine Display Potent Anti-Proliferative Properties and Circumvent Deoxycytidine Kinase-Mediated Resistance Associated with Cytotoxic Cytidine Analogues; A Novel Approach for Acute Myeloid Leukemia
P. Pinho, H. Kylefjord, Vilma Rraklli, C. Rydergård +12 more
2018Blood0 citations Open access
Semantic Scholar
The biomarker potential of Ki67 and pH2AX immunohistochemistry in guiding use of the liver-targeting nucleotide MIV-818 in patients with hepatocellular carcinoma
M. Albertella, B. Rizoska, M. McCain, C. Kirk +3 more
20180 citations
Semantic Scholar
Abstract 2930: Synergistic and additive anti-tumor effects of MIV-818 in combination with sorafenib in nonclinical hepatocellular carcinoma models
B. Rizoska, J. Bylund, S. Briem, A. Kyle +4 more
2018Experimental and Molecular Therapeutics0 citations
Semantic Scholar
The Thymidine Dideoxynucleoside Analogue, Alovudine, Inhibits the Mitochondrial DNA Polyermase, POLG, Impairs Oxidative Phosphorylation and Promotes Monocytic Differentiation in AML
Dana Yehudai-Ofir, Sanduni U. Liyanage, R. Hurren, M. Gronda +8 more
20170 citations
Semantic Scholar
Abstract 5101: Defining exposure-PD and efficacy relationships with the novel liver-targeting nucleotide prodrug MIV-818 for the treatment of liver cancers
M. Albertella, B. Rizoska, A. Kyle, A. Minchinton +9 more
20170 citations
Semantic Scholar
Abstract 5137: Parallel approaches to the discovery of novel BRD4 inhibitors
David H. Jones, M. D. de Groot, R. Heald, E. Arhin +14 more
20140 citations
Semantic Scholar
C-Met in complex with OSI ligand
Jing Wang, A. Steinig, An-Hu Li, Xin Chen +12 more
20140 citations
Semantic Scholar
The RON Receptor Tyrosine Kinase Promotes Metastasis by Triggering Epigenetic Reprogramming through the Thymine Glycosylase MBD 4
S. Cunha, Yi-Chun Lin, Elizabeth A. Goossen, Christa I. DeVette +4 more
20130 citations
Semantic Scholar
Abstract A143: A preclinical in vivo model to assess pharmacodynamic inhibition of ACK1.
M. Albertella, Shilina Roman, M. Briggs, A. Cranston +10 more
20130 citations
Semantic Scholar
Abstract 2915: Discovery and characterization of OSI-296, a dual inhibitor of cMET and RON kinases
A. Steinig, An-Hu Li, Jing Wang, Andrew Kleinberg +21 more
20120 citations
Semantic Scholar
Abstract 3928: KU-0060019, a novel small molecule inhibitor of ATM
K. Shea, M. Albertella, J. Bardos, M. Batey +13 more
20100 citations
Semantic Scholar
346 Activated RON tyrosine kinase drives cellular proliferation, migration and invasion with corresponding tumor growth and metastasis in mice
M. Albertella, Yue Peng, Siobhan McCormack, Jennifer Kahler +6 more
20100 citations
Semantic Scholar
Chemosensitisation of cancer cells by KU-0060648, a potent and selective inhibitor of DNA-PK
M. Batey, Yan Zhao, K. Shea, J. Bardos +9 more
20080 citations
Semantic Scholar

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