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A. Schimmer · SciRah

Researcher profile · Semantic Scholar

A. Schimmer

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A. Schimmer — researcher profile on SciRah

h-index: 72
Works: 493
Citations: 18K

Most-cited papers

Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia
Qi Zhang, B. Riley-Gillis, Li-Na Han, Yan-Nan Jia +37 more
2022Signal Transduction and Targeted Therapy187 citations Open access
Semantic Scholar
Venetoclax enhances T cell–mediated antileukemic activity by increasing ROS production
Jongbok Lee, Dilshad H. Khan, R. Hurren, Ming-Jing Xu +14 more
2021Blood148 citations Open access
Semantic Scholar
Mitochondrial ClpP serine protease-biological function and emerging target for cancer therapy
K. Nouri, Yue Feng, A. Schimmer
2020Cell Death and Disease125 citations Open access
Semantic Scholar
Very long chain fatty acid metabolism is required in acute myeloid leukemia.
Matthew Tcheng, Alessia Roma, Nawaz Ahmed, Richard W. Smith +12 more
2021Blood102 citations Open access
Semantic Scholar
E1 Enzymes as Therapeutic Targets in Cancer
Samir H. Barghout, A. Schimmer
2021Pharmacological Reviews97 citations Open access
Semantic Scholar
Targeting nuclear import and export in hematological malignancies
B. Nachmias, A. Schimmer
2020Leukemia75 citations Open access
Semantic Scholar
Disrupting Mitochondrial Copper Distribution Inhibits Leukemic Stem Cell Self-Renewal.
R. Singh, D. Jeyaraju, V. Voisin, R. Hurren +22 more
2020Cell Stem Cell60 citations Open access
Semantic Scholar
Cardiovascular Disease Among Patients With AML and CHIP-Related Mutations
O. Calvillo-Arguelles, Alice Schoffel, Jose-Mario Capo-Chichi, H. Abdel-Qadir +9 more
2022JACC CardioOncology56 citations Open access
Semantic Scholar
Biological and therapeutic implications of a unique subtype of NPM1 mutated AML
A. Mer, E. Heath, S. A. Madani Tonekaboni, Nergiz Dogan-Artun +17 more
2021Nature Communications47 citations Open access
Semantic Scholar
Measurable residual disease monitoring provides insufficient lead-time to prevent morphological relapse in the majority of patients with core-binding factor acute myeloid leukemia
Robert Puckrin, E. Atenafu, J. Claudio, Steven M. Chan +12 more
2020Haematologica44 citations Open access
Semantic Scholar
Mammary epithelial cells have lineage-rooted metabolic identities
Mathepan Mahendralingam, Hyeyeon Kim, Curtis W. McCloskey, Kazeera Aliar +19 more
2021Nature Metabolism42 citations Open access
Semantic Scholar
Mitochondrial and metabolic pathways regulate nuclear gene expression to control differentiation, stem cell function, and immune response in leukemia.
Grace Egan, Dilshad H. Khan, Jongbok Lee, S. Mirali +2 more
2021Cancer Discovery42 citations Open access
Semantic Scholar
Targeting the Ubiquitin–Proteasome System Using the UBA1 Inhibitor TAK-243 is a Potential Therapeutic Strategy for Small-Cell Lung Cancer
S. Majeed, M. Aparnathi, K. Nixon, V. Venkatasubramanian +12 more
2022Clinical Cancer Research40 citations Open access
Semantic Scholar
The mitochondrial peptidase, neurolysin, regulates respiratory chain supercomplex formation and is necessary for AML viability
S. Mirali, Aaron Botham, V. Voisin, Changjiang Xu +18 more
2020Science Translational Medicine40 citations Open access
Semantic Scholar
Contribution of metabolic abnormalities to acute myeloid leukemia pathogenesis.
Grace Egan, A. Schimmer
2022Trends in Cell Biology29 citations
Semantic Scholar
A genome-wide CRISPR/Cas9 screen in acute myeloid leukemia cells identifies regulators of TAK-243 sensitivity
Samir H. Barghout, Ahmed M. Aman, K. Nouri, Zachary Blatman +10 more
2021JCI Insight29 citations Open access
Semantic Scholar
Mitochondrial ATP-Dependent Proteases—Biological Function and Potential Anti-Cancer Targets
Yue Feng, K. Nouri, A. Schimmer
2021Cancers29 citations Open access
Semantic Scholar
Allogeneic double‐negative T cell therapy for relapsed acute myeloid leukemia patients post allogeneic hematopoietic stem cell transplantation: A first‐in‐human phase I study
B. Tang, Jongbok Lee, Siqi Cheng, Tianzhong Pan +16 more
2022American journal of hematology/oncology24 citations
Semantic Scholar
Anticoagulation prophylaxis reduces venous thromboembolism rate in adult acute lymphoblastic leukaemia treated with asparaginase‐based therapy
H. Sibai, Rui-Qi Chen, Xing Liu, Umberto Falcone +14 more
2020British Journal of Haematology24 citations Open access
Semantic Scholar
Mitochondrial carrier homolog 2 (MTCH2) is necessary for AML survival.
Dilshad H. Khan, M. Mullokandov, Yan Wu, V. Voisin +17 more
2020Blood22 citations Open access
Semantic Scholar
Macrophage Jak2 deficiency accelerates atherosclerosis through defects in cholesterol efflux
I. Dotan, Jiaqi Yang, Jiro Ikeda, Ziv Roth +25 more
2022Communications Biology21 citations Open access
Semantic Scholar
Enasidenib in Combination with Venetoclax in IDH2-Mutated Myeloid Malignancies: Preliminary Results of the Phase Ib/II Enaven-AML Trial
Steven M. Chan, Charina Cameron, S. Cathelin, V. Gupta +9 more
2021Blood20 citations
Semantic Scholar
Abstract 3099: The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal hematopoietic stem/progenitor cells to maintain stemness
G. Thomas, Grace Egan, Laura Garcia Prat, Aaron Botham +16 more
2021Tumor Biology19 citations
Semantic Scholar
Preclinical characterization and clinical trial of CFI-400945, a polo-like kinase 4 inhibitor, in patients with relapsed/refractory acute myeloid leukemia and higher-risk myelodysplastic neoplasms
T. Murphy, J. Mason, Brian Leber, M. R. Bray +16 more
2023Leukemia17 citations Open access
Semantic Scholar
Randomized Phase II Study to Assess the Role of Nivolumab As Single Agent to Eliminate Minimal Residual Disease and Maintain Remission in Acute Myelogenous Leukemia (AML) Patients after Chemotherapy (NCI9706 protocol; REMAIN Trial)
Hong-Tao Liu, E. Sharon, T. Karrison, Y. Zha +25 more
2022Blood16 citations Open access
Semantic Scholar
Prognostic impact of the adverse molecular-genetic profile on long-term outcomes following allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia
Georgina S. Daher-Reyes, TaeHyung Kim, I. Novitzky-Basso, Kyuoung Ha Kim +25 more
2021Bone Marrow Transplantation16 citations
Semantic Scholar
The proteomic landscape of genotoxic stress-induced micronuclei.
Kate M. MacDonald, Shahbaz Khan, Brian Lin, R. Hurren +3 more
2024Molecules and Cells15 citations Open access
Semantic Scholar
Combined Targeting of the Glutathione and Thioredoxin Antioxidant Systems in Pancreatic Cancer.
Francesco Fazzari, S. Chow, M. Cheung, Samir H. Barghout +3 more
2022ACS Pharmacology & Translational Science15 citations Open access
Semantic Scholar
Outcomes of intensive and nonintensive blast-reduction strategies in accelerated and blast-phase MPN
M. Davidson, James A. Kennedy, Jose-Mario Capo-Chichi, Yuliang Shi +15 more
2024Blood Advances14 citations Open access
Semantic Scholar
Final Results of the Phase Ib/II Study Evaluating Enasidenib in Combination with Venetoclax in Patients with IDH2-Mutated Relapsed/Refractory Myeloid Malignancies
Guillaume Richard-Carpentier, Gopila Gupta, Charina Cameron, S. Cathelin +14 more
2023Blood14 citations
Semantic Scholar
Serine phosphorylation facilitates protein degradation by the human mitochondrial ClpXP protease
Yue Feng, Monica M. Goncalves, Y. Jitkova, Alexander F. A. Keszei +24 more
2025Proceedings of the National Academy of Sciences of the United States of America13 citations Open access
Semantic Scholar
The role of mitochondrial proteases in leukemic cells and leukemic stem cells
S. Mirali, A. Schimmer
2020Stem Cells Translational Medicine13 citations Open access
Semantic Scholar
Combinatorial Anticancer Drug Screen Identifies Off-Target Effects of Epigenetic Chemical Probes.
Samir H. Barghout, M. Mann, Ahmed M. Aman, Yifan Yu +5 more
2022ACS Chemical Biology12 citations Open access
Semantic Scholar
IPO11 regulates the nuclear import of BZW1/2 and is necessary for AML cells and stem cells
Boaz Nachmias, Dilshad H. Khan, V. Voisin, A. Mer +20 more
2020Leukemia11 citations Open access
Semantic Scholar
Applying CRISPR-Cas9 screens to dissect hematological malignancies
D. Iyer, A. Schimmer, Hong Chang
2022Blood Advances9 citations Open access
Semantic Scholar
Traumatic stress symptoms in family caregivers of patients with acute leukaemia: protocol for a multisite mixed methods, longitudinal, observational study
L. Jibb, Stephanie M. Nanos, S. Alexander, C. Malfitano +10 more
2022BMJ Open9 citations Open access
Semantic Scholar
Correction: Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia
Qi Zhang, B. Riley-Gillis, Li-Na Han, Yan-Nan Jia +37 more
2022Signal Transduction and Targeted Therapy8 citations Open access
Semantic Scholar
Venous thromboembolism incidence associated with pegylated asparaginase (ASP) compared to the native L‐ASP: A retrospective analysis with an ASP‐based protocol in adult patients with acute lymphoblastic leukaemia
Rui-Qi Chen, E. Atenafu, J. Seki, Xing Liu +8 more
2023British Journal of Haematology5 citations Open access
Semantic Scholar
Exclusion of persistent mutations in splicing factor genes and isocitrate dehydrogenase 2 improves the prognostic power of molecular measurable residual disease assessment in acute myeloid leukemia
T. Murphy, Jinfeng Zou, A. Arruda, Ting-Ting Wang +14 more
2023Haematologica5 citations Open access
Semantic Scholar
Safety of re‐challenging adults with acute lymphoblastic leukemia with PEG‐asparaginase‐induced severe hypertriglyceridemia when treated with a pediatric‐inspired regimen
Ibrahim Al Nabhani, C. Andrews, J. Sibai, E. Atenafu +8 more
2022eJHaem4 citations Open access
Semantic Scholar
Preliminary Results from a Phase 1 Study of Cfi-400495, a PLK4 Inhibitor, in Patients with Acute Myeloid Leukemia and High Risk MDS
T. Murphy, B. Leber, M. Bray, Steven M. Chan +12 more
2020Blood4 citations Open access
Semantic Scholar
COVID‐19: a pandemic experience that illuminates potential reforms to health research
Hannah N. Kozlowski, M. Farkouh, M. Irwin, L. Radvanyi +3 more
2020EMBO Molecular Medicine3 citations Open access
Semantic Scholar
Total Synthesis of the 2,5-Disubstituted γ-Pyrone E1 UAE Inhibitor Himeic Acid A.
Heyuan Lu, Kishor L. Handore, Tabitha E. Wood, Grace K. Shimokura +2 more
2023Organic Letters2 citations
Semantic Scholar
AML Drug Tolerant Persister (DTP) Cells Survive Chemotherapy By Transiently Altering Cellular Lipidomics to Increase Plasma Membrane Rigidity, but Also Increases Sensitivity to Immune Cell Killing
Yael Morgenstern, Jongbok Lee, Yoosu Na, W. Gwynne +14 more
2023Blood2 citations Open access
Semantic Scholar
Translational Control by 4E-BP1/2 Suppressor Proteins Regulates Mitochondrial Biosynthesis and Function during CD8+ T Cell Proliferation
I. Dimitriou, D. Meiri, Y. Jitkova, Alisha R. Elford +5 more
2022Journal of Immunology2 citations
Semantic Scholar
A First-in-Human Phase I/IIa Study of Allogeneic Double Negative T Cell for the Treatment of Relapsed AML Post Allo-HSCT
B. Tang, Jongbok Lee, Siqi Cheng, Tianzhong Pan +17 more
20212 citations Open access
Semantic Scholar
Mitochondria regulate AML differentiation independent of oxidative phosphorylation and metabolism
R. Singh, A. Schimmer
2020Molecular & Cellular Oncology2 citations Open access
Semantic Scholar
Transduction of Primary AML Cells with Lentiviral Vector for In Vitro Study or In Vivo Engraftment
A. Schimmer, R. Singh, Ayesh K. Seneviratne, G. Thomas +2 more
2020STAR Protocols2 citations Open access
Semantic Scholar
Targeting neurolysin in acute myeloid leukemia
S. Mirali, A. Schimmer
2020Molecular & Cellular Oncology2 citations Open access
Semantic Scholar
Abstract 3033: Increased mitochondrial protein import necessitates greater reliance on the mitochondrial unfolded protein response (UPRmt) and the protease LONP1 to maintain mitochondrial protein solubility and cell viability in acute myeloid leukemia (AML)
Matthew Tcheng, V. Voisin, M. Gronda, R. Hurren +9 more
2025Cancer Research1 citations
Semantic Scholar

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