Researcher profile · Semantic Scholar

M. Guha

h-index: 19
Works: 34
Citations: 6,393

Most-cited papers

LPS induction of gene expression in human monocytes.
M. Guha, N. Mackman
2001Cellular Signalling2,431 citations
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The Phosphatidylinositol 3-Kinase-Akt Pathway Limits Lipopolysaccharide Activation of Signaling Pathways and Expression of Inflammatory Mediators in Human Monocytic Cells*
M. Guha, N. Mackman
2002Journal of Biological Chemistry868 citations Open access
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Toll-like receptor 2–mediated NF-κB activation requires a Rac1-dependent pathway
L. Arbibe, J. Mira, N. Teusch, L. Kline +5 more
2000Nature Immunology681 citations
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High glucose-induced expression of proinflammatory cytokine and chemokine genes in monocytic cells.
N. Shanmugam, Marpadga A. Reddy, M. Guha, R. Natarajan
2003Diabetes552 citations
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Lipopolysaccharide activation of the MEK-ERK1/2 pathway in human monocytic cells mediates tissue factor and tumor necrosis factor alpha expression by inducing Elk-1 phosphorylation and Egr-1 expression.
M. Guha, Maria A. O'Connell, R. Pawlinski, A. Hollis +4 more
2001Blood407 citations Open access
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Molecular Mechanisms of Tumor Necrosis Factor α Gene Expression in Monocytic Cells via Hyperglycemia-induced Oxidant Stress-dependent and -independent Pathways*
M. Guha, Wei Bai, J. Nadler, R. Natarajan
2000Journal of Biological Chemistry326 citations Open access
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Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway.
L. Arbibe, J. Mira, N. Teusch, L. Kline +5 more
2000Nature Immunology290 citations
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Clinical features of pulmonary arterial hypertension in patients receiving dasatinib
Neil P. Shah, N. Wallis, H. Farber, Michael J. Mauro +5 more
2015American journal of hematology/oncology123 citations Open access
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The impact of dasatinib on pregnancy outcomes
Jorge E. Cortes, E. Abruzzese, E. Chelysheva, M. Guha +2 more
2015American journal of hematology/oncology120 citations Open access
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Regulation of tissue factor and inflammatory mediators by Egr-1 in a mouse endotoxemia model.
R. Pawlinski, B. Pedersen, B. Kehrle, W. Aird +3 more
2003Blood100 citations Open access
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Anti-Inflammatory Activity of Inhaled IL-4 Receptor-α Antisense Oligonucleotide in Mice
J. Karras, J. Crosby, M. Guha, David Tung +5 more
200783 citations
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Synthesis and SAR of 2-aryl-3-aminomethylquinolines as agonists of the bile acid receptor TGR5.
M. Herbert, Dana L. Siegel, L. Staszewski, Charmagne S. Cayanan +14 more
2010Bioorganic & Medicinal Chemistry Letters59 citations Open access
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Anti-inflammatory activity of inhaled IL-4 receptor-alpha antisense oligonucleotide in mice.
J. Karras, J. Crosby, M. Guha, David Tung +5 more
2007American Journal of Respiratory Cell and Molecular Biology51 citations
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Enzalutamide and Apalutamide: In vitro Chemical Reactivity Studies and Activity in a Mouse Drug Allergy Model.
Chang-Hua Ji, M. Guha, X. Zhu, Jessica Whritenour +8 more
2019Chemical Research in Toxicology48 citations
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Assessment of biomarkers of drug-induced kidney injury in cynomolgus monkeys treated with a triple reuptake inhibitor.
M. Guha, Annabelle Heier, Sally A. Price, M. Bielenstein +5 more
2011Toxicological Sciences43 citations Open access
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Inhaled CD86 Antisense Oligonucleotide Suppresses Pulmonary Inflammation and Airway Hyper-Responsiveness in Allergic Mice
J. Crosby, M. Guha, David Tung, Doreen A. Miller +7 more
2007Journal of Pharmacology and Experimental Therapeutics43 citations
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Dexamethasone enhances LPS induction of tissue factor expression in human monocytic cells by increasing tissue factor mRNA stability
K. Reddy, G. Bhattacharjee, G. Schabbauer, A. Hollis +5 more
2004Journal of Leukocyte Biology41 citations
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Tissue drug accumulation and ultrastructural changes during amiodarone administration in rats.
R. Kannan, J. Sarma, M. Guha, K. Venkataraman
1989Fundamental and Applied Toxicology34 citations
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Amiodarone toxicity. II. Desethylamiodarone-induced phospholipidosis and ultrastructural changes during repeated administration in rats.
R. Kannan, J. Sarma, M. Guha, K. Venkataraman
1991Fundamental and Applied Toxicology28 citations
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In vitro and in vivo evaluation of dasatinib and imatinib on physiological parameters of pulmonary arterial hypertension
Bethany R. Baumgart, M. Guha, J. Hennan, Julia P. Li +6 more
2017Cancer Chemotherapy and Pharmacology15 citations
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Improved ruggedness of an ion-pairing liquid chromatography/tandem mass spectrometry assay for the quantitative analysis of the triphosphate metabolite of a nucleoside reverse transcriptase inhibitor in peripheral blood mononuclear cells.
Yue Zhao, Guo-Wen Liu, Yifei Liu, Long Yuan +4 more
2013Rapid Communications in Mass Spectrometry15 citations
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Corrigendum to “LPS induction of gene expression in human monocytes” [Cell. Signall. 13 (2001) 85–94]
M. Guha, N. Mackman
20069 citations
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Expression in insect cells and immune reactivity of a 28K tegument protein of human cytomegalovirus.
T. D. Giugni, M. A. Churchill, H. Pande, K. Campo +2 more
1992Journal of General Virology7 citations Open access
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Discovery of MDV6058 (PF-06952229), a Selective and Potent TGFβR1 Inhibitor: Design, Synthesis and Optimization.
Brahmam Pujala, Sreekanth A. Ramachandran, Mukesh Sonawane, Maruti M. Kamble +17 more
2022Bioorganic & Medicinal Chemistry Letters6 citations Open access
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Rat Self-Administration
D. Gauvin, M. Guha, T. Baird
20154 citations
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Presented in abstract form at the 42nd annual meeting of the American Society expression by inducing Elk-1 phosphorylation and Egr-1 expression : α monocytic cells mediates tissue factor and tumor necrosis factor Lipopolysaccharide activation of the MEK-ERK1/2 pathway in human
D. Stern, N. Mackman, M. Guha, M. O'Connell +4 more
20134 citations
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Desethylamiodarone-induced phospholipidosis in lung, liver, and pulmonary macrophages and its relationship to tissue drug accumulation in rats
R. Kannan, J. Sarma, M. Guha, K. Venkataraman
19904 citations
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Comparative Analyses of Poly(ADP-Ribose) Polymerase Inhibitors
M. Guha, Z. Sobol, Mathew P. Martin, M. Hemkens +6 more
2022International journal of toxicology3 citations
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Salt Selection Matters: Differential Renal Toxicity With MDV1634.Maleate Versus MDV1634.2HCl
M. Guha, L. Nguyen, F. Poitout-Belissent, A. Bédard +1 more
2017International journal of toxicology2 citations
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Enzalutamide (ENZA) and apalutamide (APA) In vitro chemical reactivity studies and activity in a mouse drug allergy model (MDAM)
M. Guha, Chang-Hua Ji, X. Zhu, Jessica Whritenour +8 more
2019Annals of Oncology1 citations Open access
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Nonclinical Profile of PF-06952229 (MDV6058), a Novel TGFβRI/Activin Like Kinase 5 Inhibitor Supports Clinical Evaluation in Cancer
M. Guha, S. Thibault, Son M. Pham, S. Bernales +6 more
2024Journal of Pharmacology and Experimental Therapeutics0 citations Open access
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Abstract 2426:In vitroandin vivoevaluation of dasatinib and imatinib on physiological parameters of pulmonary arterial hypertension .
M. Guha, J. Hennan, Julia P. Li, D. Simic +5 more
20130 citations
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Abstract 3921: KD3010, a PPAR{beta}/{delta} Selective Small Molecule Agonist, Improves Hyperglycemia And Insulin Resistance while alleviating Rosiglitazone-Induced Side Effects in Murine Models
M. Guha, M. Deng, J. Malecha, A. Kabakibi +2 more
20060 citations
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Dexamethasone enhances LPS induction of tissue factor expression in monocytic cells via a post-transcriptional mechanism
V. Reddy, G. Bhattacharjee, A. Hollis, K. Kempf +3 more
20030 citations
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J. Karras

×3

J. Crosby×3

David Tung×3

Doreen A. Miller×3

R. Geary×3

B. Monia×3

Susan A. Gregory×3

N. Khan×3