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J. Hennan · SciRah

Researcher profile · Semantic Scholar

J. Hennan

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J. Hennan — researcher profile on SciRah

h-index: 20
Works: 64
Citations: 1,597

Most-cited papers

Effects of Selective Cyclooxygenase-2 Inhibition on Vascular Responses and Thrombosis in Canine Coronary Arteries
J. Hennan, Jin-Bao Huang, Terrance D. Barrett, E. Driscoll +4 more
2001Circulation175 citations Open access
Semantic Scholar
Tiplaxtinin, a novel, orally efficacious inhibitor of plasminogen activator inhibitor-1: design, synthesis, and preclinical characterization.
H. Elokdah, M. Abou-Gharbia, J. Hennan, G. Mcfarlane +3 more
2004Journal of Medicinal Chemistry168 citations Open access
Semantic Scholar
Identification of ischemia-regulated phosphorylation sites in connexin43: A possible target for the antiarrhythmic peptide analogue rotigaptide (ZP123).
L. Axelsen, M. Stahlhut, S. Mohammed, B. Larsen +6 more
2006Journal of Molecular and Cellular Cardiology144 citations
Semantic Scholar
Model-Dependent Effects of the Gap Junction Conduction–Enhancing Antiarrhythmic Peptide Rotigaptide (ZP123) on Experimental Atrial Fibrillation in Dogs
A. Shiroshita-Takeshita, M. Sakabe, K. Haugan, J. Hennan +1 more
2007Circulation134 citations Open access
Semantic Scholar
Rotigaptide (ZP123) Prevents Spontaneous Ventricular Arrhythmias and Reduces Infarct Size During Myocardial Ischemia/Reperfusion Injury in Open-Chest Dogs
J. Hennan, R. Swillo, G. A. Morgan, J. Keith +10 more
2006Journal of Pharmacology and Experimental Therapeutics97 citations
Semantic Scholar
C-Reactive-Protein-Associated Increase in Myocardial Infarct Size After Ischemia/Reperfusion
Terrance D. Barrett, J. Hennan, R. Marks, B. Lucchesi
2002Journal of Pharmacology and Experimental Therapeutics92 citations
Semantic Scholar
Pharmacological modulation of gap junction function with the novel compound rotigaptide: a promising new principle for prevention of arrhythmias.
A. Kjølbye, K. Haugan, J. Hennan, J. Petersen
2007Basic & Clinical Pharmacology & Toxicology58 citations
Semantic Scholar
Effects of Chronic Gap Junction Conduction–Enhancing Antiarrhythmic Peptide GAP-134 Administration on Experimental Atrial Fibrillation in Dogs
G. Laurent, H. Leong-Poi, I. Mangat, G. Moe +7 more
2009Circulation: Arrhythmia and Electrophysiology56 citations Open access
Semantic Scholar
The Gap Junction Modifier, GAP-134 [(2S,4R)-1-(2-Aminoacetyl)-4-benzamido-pyrrolidine-2-carboxylic Acid], Improves Conduction and Reduces Atrial Fibrillation/Flutter in the Canine Sterile Pericarditis Model
E. Rossman, Kun Liu, G. A. Morgan, R. Swillo +9 more
2009Journal of Pharmacology and Experimental Therapeutics54 citations
Semantic Scholar
Characterization of the Novel P-Selectin Inhibitor PSI-697 [2-(4-Chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[h] Quinoline-4-carboxylic acid] in Vitro and in Rodent Models of Vascular Inflammation and Thrombosis
Patricia W. Bedard, V. Clerin, N. Sushkova, B. Tchernychev +12 more
2008Journal of Pharmacology and Experimental Therapeutics52 citations
Semantic Scholar
Evaluation of PAI-039 [{1-Benzyl-5-[4-(trifluoromethoxy)phenyl]-1H-indol-3-yl}(oxo)acetic Acid], a Novel Plasminogen Activator Inhibitor-1 Inhibitor, in a Canine Model of Coronary Artery Thrombosis
J. Hennan, H. Elokdah, M. Leal, A. Ji +6 more
2005Journal of Pharmacology and Experimental Therapeutics44 citations
Semantic Scholar
The Antiarrhythmic Peptide Rotigaptide (ZP123) Increases Connexin 43 Protein Expression in Neonatal Rat Ventricular Cardiomyocytes
M. Stahlhut, J. Petersen, J. Hennan, M. T. Ramirez
2006Cell Communication & Adhesion42 citations Open access
Semantic Scholar
Pharmacologic inhibition of platelet vWF-GPIbα interaction prevents coronary artery thrombosis
J. Hennan, R. Swillo, G. A. Morgan, C. E. Leik +5 more
2006Thrombosis and Haemostasis42 citations
Semantic Scholar
Discovery of (2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid hydrochloride (GAP-134)13, an orally active small molecule gap-junction modifier for the treatment of atrial fibrillation.
J. Butera, B. Larsen, J. Hennan, E. Kerns +11 more
2009Journal of Medicinal Chemistry41 citations
Semantic Scholar
Treatment With the Gap Junction Modifier Rotigaptide (ZP123) Reduces Infarct Size in Rats With Chronic Myocardial Infarction
K. Haugan, N. Marcussen, A. Kjølbye, M. Nielsen +2 more
2006Journal of Cardiovascular Pharmacology38 citations Open access
Semantic Scholar
Enhancement of ventricular gap-junction coupling by rotigaptide.
Xianming Lin, Christian W. Zemlin, J. Hennan, J. Petersen +1 more
2008Cardiovascular Research37 citations Open access
Semantic Scholar
Identification and Preclinical Pharmacology of BMS-986104: A Differentiated S1P1 Receptor Modulator in Clinical Trials.
T. G. Murali Dhar, Hai-Yun Xiao, Jenny H. Xie, L. Lehman-Mckeeman +25 more
2016ACS Medicinal Chemistry Letters30 citations Open access
Semantic Scholar
Identification of a Potent, Selective, and Efficacious Phosphatidylinositol 3-Kinase δ (PI3Kδ) Inhibitor for the Treatment of Immunological Disorders.
Qingjie Liu, Qing Shi, D. Marcoux, D. Batt +54 more
2017Journal of Medicinal Chemistry27 citations Open access
Semantic Scholar
GAP-134 ([2S,4R]-1-[2-Aminoacetyl]4-Benzamidopyrrolidine-2-Carboxylic Acid) Prevents Spontaneous Ventricular Arrhythmias and Reduces Infarct Size During Myocardial Ischemia/Reperfusion Injury in Open-Chest Dogs
J. Hennan, R. Swillo, G. A. Morgan, E. Rossman +5 more
2009Journal of Cardiovascular Pharmacology and Therapeutics24 citations
Semantic Scholar
Selective Kv1.5 blockers: development of (R)-1-(methylsulfonylamino)-3-[2-(4-methoxyphenyl)ethyl]-4-(4-methoxyphenyl)-2-imidazolidinone (KVI-020/WYE-160020) as a potential treatment for atrial arrhythmia.
B. Blass, Andrew Fensome, E. Trybulski, R. Magolda +10 more
2009Journal of Medicinal Chemistry22 citations Open access
Semantic Scholar
Selective IKur Inhibitors for the Potential Treatment of Atrial Fibrillation: Optimization of the Phenyl Quinazoline Series Leading to Clinical Candidate 5-[5-Phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl]pyridine-3-sulfonamide.
P. Gunaga, J. Lloyd, S. Mummadi, A. Banerjee +27 more
2017Journal of Medicinal Chemistry19 citations Open access
Semantic Scholar
Increasing Gap Junctional Coupling: A Tool for Dissecting the Role of Gap Junctions
L. Axelsen, K. Haugan, M. Stahlhut, A. Kjølbye +4 more
2007Journal of Membrane Biology19 citations
Semantic Scholar
Pharmacologic inhibition of platelet vWF-GPIb alpha interaction prevents coronary artery thrombosis.
J. Hennan, R. Swillo, G. A. Morgan, C. E. Leik +5 more
2006Thrombosis and Haemostasis19 citations
Semantic Scholar
Intimatan prevents arterial and venous thrombosis in a canine model of deep vessel wall injury.
J. Hennan, Ting-Ting Hong, A. Shergill, E. Driscoll +2 more
2002Journal of Pharmacology and Experimental Therapeutics18 citations
Semantic Scholar
In vitro and in vivo evaluation of dasatinib and imatinib on physiological parameters of pulmonary arterial hypertension
Bethany R. Baumgart, M. Guha, J. Hennan, Julia P. Li +6 more
2017Cancer Chemotherapy and Pharmacology15 citations
Semantic Scholar
Effects of Rotigaptide, a Gap Junction Modifier, on Defibrillation Energy and Resuscitation From Cardiac Arrest in Rabbits
Jing-Quan Zhong, G. Laurent, P. So, Xudong Hu +2 more
2007Journal of Cardiovascular Pharmacology and Therapeutics15 citations Open access
Semantic Scholar
Rotigaptide (ZP123) Reverts Established Atrial Conduction Velocity Slowing
K. Haugan, A. Kjølbye, J. Hennan, J. Petersen
2005Cell Communication & Adhesion15 citations Open access
Semantic Scholar
Linking (Pyr)1apelin-13 pharmacokinetics to efficacy: Stabilization and measurement of a high clearance peptide in rodents.
J. Onorato, Carrie Xu, Xue-Qing Chen, Anne V. Rose +18 more
2019Analytical Biochemistry14 citations
Semantic Scholar
WAY-140312 reduces plasma PAI-1 while maintaining normal platelet aggregation.
D. Crandall, J. Hennan, H. Elokdah, G. Krishnamurthy +4 more
2003Biochemical and Biophysical Research Communications - BBRC13 citations
Semantic Scholar
Activation of guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase in rat vas deferens and distal colon is not accompanied by inhibition of contraction.
Ashwinkumar I. Patel, J. Hennan, Jack Diamond
1997Journal of Pharmacology and Experimental Therapeutics13 citations
Semantic Scholar
High-Throughput Screening for Kv1.3 Channel Blockers Using an Improved FLIPR-Based Membrane-Potential Assay
Kun Liu, M. Samuel, Jeff Tillett, J. Hennan +5 more
2010Journal of biomolecular screening11 citations Open access
Semantic Scholar
Discovery of a Phenylpyrazole Amide ROCK Inhibitor as a Tool Molecule for in vivo Studies.
Zi-Lun Hu, Cai-Lan Wang, P. Glunz, Julia P. Li +17 more
2020Bioorganic & Medicinal Chemistry Letters9 citations Open access
Semantic Scholar
Quantitative regression of qFibrosis with resmetirom: Exploratory histologic endpoints from the MAESTRO-NASH phase III clinical trial.
J. Schattenberg, P. Bedossa, Cynthia D. Guy, R. Taub +8 more
2026Journal of Hepatology5 citations Open access
Semantic Scholar
From the Cover: Investigative Nonclinical Cardiovascular Safety and Toxicology Studies with BMS-986094, an NS5b RNA-Dependent RNA Polymerase Inhibitor
M. Gill, K. Horn, J. Hennan, Randy White +7 more
2017Toxicological Sciences5 citations
Semantic Scholar
Discovery of a class of potent gap-junction modifiers as novel antiarrhythmic agents.
Eugene L. Piatnitski Chekler, J. Butera, L. Di, R. Swillo +5 more
2009Bioorganic & Medicinal Chemistry Letters5 citations
Semantic Scholar
Effect of Sodium/Hydrogen Exchange Inhibition on Myocardial Infarct Size after Coronary Artery Thrombosis and Thrombolysis
J. Hennan, E. Driscoll, Terrance D. Barrett, P. Fischbach +1 more
2006Pharmacology5 citations
Semantic Scholar
Abstract 1837: Effects of the Gap Junction Modifier, GAP-134, on Conduction and Atrial Fibrillation/Flutter Inducibility in Dogs
E. Rossman, Kun Liu, G. A. Morgan, R. Swillo +6 more
20074 citations
Semantic Scholar
Prevention of Carotid Artery Thrombosis After Oral Administration of the Glycoprotein IIb/IIIa Antagonist CRL42796
J. Hennan, David Willens, E. Driscoll, Ting-Ting Hong +2 more
2003Journal of Cardiovascular Pharmacology4 citations Open access
Semantic Scholar
An updated two-dimensional gel electrophoresis technique for the detection of drug-induced changes in protein phosphorylation in intact smooth muscle.
J. Hennan, J. Diamond
1999Journal of pharmacological and toxicological methods3 citations
Semantic Scholar
Pharmacokinetics, mass balance and metabolic profiling of resmetirom in healthy subjects and nonclinical metabolism and disposition
J. Hennan, Raul C. Camacho, E. Solon, Brian J. Schmidt +3 more
2026Xenobiotica; the fate of foreign compounds in biological systems2 citations Open access
Semantic Scholar
Abstract 21061: Mild IKr inhibition Significantly Enhances IKur-induced Selective Prolongation of Atrial Refractoriness
Hua-Bin Sun, D. Xing, J. Lloyd, J. Hennan +1 more
20102 citations
Semantic Scholar
Postischemic reperfusion is the prerequisite for tunel positivity
M. Rodriguez, J. Hennan, B. Lucchesi, J. Schaper
20022 citations
Semantic Scholar
ID: 190 Efficacy of PAI-749, an orally active PAI-1 inhibitor, in dog and rat models of arterial and venous thrombosis
J. Hennan, G. A. Morgan, R. E. Swillo, A. Ji +2 more
20061 citations
Semantic Scholar
Rotigaptide Reverts Atrial Conduction Slowing Cell Communication and Adhesion ( Special Gap Junction Issue ) Rotigaptide ( ZP 123 ) Reverts Established Atrial Conduction Velocity Slowing
K. Haugan, A. Kjølbye, J. Hennan, J. Petersen
20051 citations
Semantic Scholar
Mo1676: VELACUR’S VDFF OUTPERFORMS FIBROSCAN CAP IN ASSESSMENT OF LIVER STEATOSIS IN A LARGE COHORT OF MASLD AND MASH PATIENTS
C. Schneider, J. Hennan, M. Dauphin, Brandon Hill +1 more
2025Gastroenterology0 citations
Semantic Scholar
Abstract #1184634: Effect of Resmetirom, a Selective Thyroid Hormone Receptor Beta Agonist, On Hepatic Hypothyroidism in a 52-Week Non-Cirrhotic NASH Phase 3 Clinical Trial
Jean Lucas, M. Abdelmalek, S. Baum, S. Harrison +2 more
2022Endocrine Practice0 citations
Semantic Scholar
Characterization of a renal hypertensive model in telemetrized cynomolgus monkeys.
S. R. Arthur, Arlene Love, D. Bounous, J. Ehrmann +6 more
2019Journal of pharmacological and toxicological methods0 citations
Semantic Scholar
Use of Cardiovascular Telemetry to Elucidate the Pathogenesis of Drug-Induced Exacerbation of Atrial Thrombosis in Mice with Isoproterenol-Induced Cardiomyopathy
Julia P. Li, M. Basso, P. Sleph, Lei Zhao +6 more
20170 citations
Semantic Scholar
Acute anesthetized measurements of right ventricular and pulmonary artery pressure in a rat model of pulmonary artery hypertension
D. Xing, Rodney Smith, J. Hennan, P. Levesque
20130 citations
Semantic Scholar
Abstract 2426:In vitroandin vivoevaluation of dasatinib and imatinib on physiological parameters of pulmonary arterial hypertension .
M. Guha, J. Hennan, Julia P. Li, D. Simic +5 more
20130 citations
Semantic Scholar

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