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R. Geary · SciRah

Researcher profile · Semantic Scholar

R. Geary

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R. Geary — researcher profile on SciRah

h-index: 54
Works: 146
Citations: 10K

Most-cited papers

Antisense oligonucleotides targeting apolipoprotein(a) in people with raised lipoprotein(a): two randomised, double-blind, placebo-controlled, dose-ranging trials.
N. Viney, J. V. van Capelleveen, R. Geary, Shu-Ting Xia +10 more
2016The Lancet699 citations
Semantic Scholar
Cardiovascular and Metabolic Effects of ANGPTL3 Antisense Oligonucleotides
M. Graham, Richard G. Lee, T. A. Brandt, Li Tai +14 more
2017New England Journal of Medicine502 citations Open access
Semantic Scholar
Targeting APOC3 in the familial chylomicronemia syndrome.
D. Gaudet, D. Brisson, K. Tremblay, V. Alexander +7 more
2014New England Journal of Medicine456 citations Open access
Semantic Scholar
Antisense therapy targeting apolipoprotein(a): a randomised, double-blind, placebo-controlled phase 1 study.
S. Tsimikas, N. Viney, S. Hughes, W. Singleton +8 more
2015The Lancet444 citations
Semantic Scholar
Antisense Oligonucleotide Inhibition of Apolipoprotein C-III Reduces Plasma Triglycerides in Rodents, Nonhuman Primates, and Humans
M. Graham, Richard G. Lee, T. Bell, Wu-Xia Fu +10 more
2013Circulation Research366 citations Open access
Semantic Scholar
Antisense Inhibition of Apolipoprotein C-III in Patients with Hypertriglyceridemia.
D. Gaudet, V. Alexander, B. Baker, D. Brisson +10 more
2015New England Journal of Medicine305 citations Open access
Semantic Scholar
Vupanorsen, an N-acetyl galactosamine-conjugated antisense drug to ANGPTL3 mRNA, lowers triglycerides and atherogenic lipoproteins in patients with diabetes, hepatic steatosis, and hypertriglyceridaemia
D. Gaudet, E. Karwatowska-Prokopczuk, S. Baum, E. Hurh +9 more
2020European Heart Journal248 citations Open access
Semantic Scholar
Cross-Species Pharmacokinetic Comparison from Mouse to Man of a Second-Generation Antisense Oligonucleotide, ISIS 301012, Targeting Human Apolipoprotein B-100
R. Yu, Tae-Won Kim, A. Hong, Tanya Watanabe +2 more
2007Drug Metabolism And Disposition226 citations
Semantic Scholar
N-acetyl galactosamine-conjugated antisense drug to APOC3 mRNA, triglycerides and atherogenic lipoprotein levels
V. Alexander, Shu-Ting Xia, E. Hurh, S. Hughes +4 more
2019European Heart Journal208 citations Open access
Semantic Scholar
Antisense oligonucleotide pharmacokinetics and metabolism
R. Geary
2009170 citations
Semantic Scholar
Clinical pharmacological properties of mipomersen (Kynamro), a second generation antisense inhibitor of apolipoprotein B
S. Crooke, R. Geary
2013British Journal of Clinical Pharmacology158 citations Open access
Semantic Scholar
Clinical and Preclinical Pharmacokinetics and Pharmacodynamics of Mipomersen (Kynamro®): A Second-Generation Antisense Oligonucleotide Inhibitor of Apolipoprotein B
R. Geary, B. Baker, S. Crooke
2015Clinical Pharmacokinetics151 citations Open access
Semantic Scholar
Clinical pharmacokinetics of second generation antisense oligonucleotides
R. Yu, J. Grundy, R. Geary
2013Expert Opinion on Drug Metabolism & Toxicology136 citations
Semantic Scholar
Antisense oligonucleotide pharmacokinetics and metabolism.
R. Geary
2009Expert Opinion on Drug Metabolism & Toxicology133 citations
Semantic Scholar
Efficacy of apolipoprotein B synthesis inhibition in subjects with mild-to-moderate hyperlipidaemia.
F. Akdim, D. Tribble, Joann D. Flaim, R. Yu +6 more
2011European Heart Journal131 citations Open access
Semantic Scholar
Oral delivery of antisense oligonucleotides in man.
L. Tillman, R. Geary, G. Hardee
2008Journal of Pharmacy and Science123 citations
Semantic Scholar
Plasma Protein Binding of an Antisense Oligonucleotide Targeting Human ICAM-1 (ISIS 2302)
Tanya Watanabe, R. Geary, A. Levin
2006Oligonucleotides118 citations
Semantic Scholar
Cross-species comparison of in vivo PK/PD relationships for second-generation antisense oligonucleotides targeting apolipoprotein B-100.
R. Yu, Kristina M. Lemonidis, M. Graham, John E. Matson +5 more
2009Biochemical Pharmacology115 citations
Semantic Scholar
Integrated Assessment of the Clinical Performance of GalNAc3-Conjugated 2′-O-Methoxyethyl Chimeric Antisense Oligonucleotides: I. Human Volunteer Experience
S. Crooke, B. Baker, Shu-Ting Xia, R. Yu +4 more
2019Nucleic Acid Therapeutics114 citations Open access
Semantic Scholar
An oral antisense oligonucleotide for PCSK9 inhibition
Peter Gennemark, Katrin Walter, N. Clemmensen, D. Rekić +24 more
2021Science Translational Medicine109 citations
Semantic Scholar
Integrated Safety Assessment of 2′-O-Methoxyethyl Chimeric Antisense Oligonucleotides in NonHuman Primates and Healthy Human Volunteers
S. Crooke, B. Baker, T. Kwoh, W. Cheng +10 more
2016Molecular Therapy105 citations Open access
Semantic Scholar
Lack of Pharmacokinetic Interaction of Mipomersen Sodium (ISIS 301012), a 2′-—O-Methoxyethyl Modified Antisense Oligonucleotide Targeting Apolipoprotein B-100 Messenger RNA, with Simvastatin and Ezetimibe
R. Yu, R. Geary, Joann D. Flaim, G. Riley +3 more
2009Clinical Pharmacokinetics105 citations
Semantic Scholar
Antisense Drug Discovery and Development Technology Considered in a Pharmacological Context.
S. Crooke, Xue-Hai Liang, R. Crooke, B. Baker +1 more
2020Biochemical Pharmacology92 citations
Semantic Scholar
Disposition and Pharmacology of a GalNAc3-conjugated ASO Targeting Human Lipoprotein (a) in Mice
R. Yu, M. Graham, Noah M. Post, Stan J. Riney +10 more
2016Molecular Therapy: Nucleic Acids92 citations Open access
Semantic Scholar
Pharmacokinetics and Clinical Pharmacology Considerations of GalNAc3-Conjugated Antisense Oligonucleotides
Yanfeng Wang, R. Yu, S. Henry, R. Geary
2019Expert Opinion on Drug Metabolism & Toxicology90 citations
Semantic Scholar
Novel antisense inhibition of diacylglycerol O-acyltransferase 2 for treatment of non-alcoholic fatty liver disease: a multicentre, double-blind, randomised, placebo-controlled phase 2 trial.
R. Loomba, Erin S. Morgan, L. Watts, Shu-Ting Xia +4 more
2020The Lancet Gastroenterology and Hepatology88 citations
Semantic Scholar
Basic Principles of the Pharmacokinetics of Antisense Oligonucleotide Drugs
A. Levin, R. Yu, R. Geary
200787 citations
Semantic Scholar
Effect of dose and plasma concentration on liver uptake and pharmacologic activity of a 2'-methoxyethyl modified chimeric antisense oligonucleotide targeting PTEN.
R. Geary, E. Wancewicz, John E. Matson, Megan Pearce +3 more
2009Biochemical Pharmacology85 citations
Semantic Scholar
Ligand conjugated antisense oligonucleotide for the treatment of transthyretin amyloidosis: preclinical and phase 1 data
N. Viney, Shuling Guo, Li-Jung Tai, B. Baker +14 more
2020ESC Heart Failure83 citations Open access
Semantic Scholar
Anti-Inflammatory Activity of Inhaled IL-4 Receptor-α Antisense Oligonucleotide in Mice
J. Karras, J. Crosby, M. Guha, David Tung +5 more
200783 citations
Semantic Scholar
Antisense Inhibition of Angiotensinogen With IONIS-AGT-LRx
E. Morgan, Y. Tami, Kuo-Lung Hu, M. Brambatti +4 more
2021JACC: Basic to Translational Science78 citations Open access
Semantic Scholar
Phase 2 Study of the Factor XI Antisense Inhibitor IONIS-FXIRx in Patients With ESRD
M. Walsh, C. Bethune, A. Smyth, J. Tyrwhitt +6 more
2021Kidney International Reports71 citations Open access
Semantic Scholar
Assessment of efficacy and safety of volanesorsen for treatment of metabolic complications in patients with familial partial lipodystrophy: Results of the BROADEN study: Volanesorsen in FPLD; The BROADEN Study.
E. Oral, A. Garg, J. Tami, E. A. Huang +10 more
2022Journal of Clinical Lipidology61 citations
Semantic Scholar
The approach study: a randomized, double-blind, placebo-controlled, phase 3 study of volanesorsen administered subcutaneously to patients with familial chylomicronemia syndrome (FCS).
D. Gaudet, A. Digenio, V. Alexander, M. Arca +12 more
2017Atherosclerosis55 citations
Semantic Scholar
Population Pharmacokinetics of Nusinersen in the Cerebral Spinal Fluid and Plasma of Pediatric Patients With Spinal Muscular Atrophy Following Intrathecal Administrations
K. Luu, D. Norris, R. Gunawan, S. Henry +2 more
2017Journal of clinical pharmacology55 citations
Semantic Scholar
Apolipoprotein C-III reduction in subjects with moderate hypertriglyceridaemia and at high cardiovascular risk
J. Tardif, E. Karwatowska-Prokopczuk, Eric St Amour, C. Ballantyne +14 more
2022European Heart Journal52 citations Open access
Semantic Scholar
Design and Rationale of the Global Phase 3 NEURO-TTRansform Study of Antisense Oligonucleotide AKCEA-TTR-LRx (ION-682884-CS3) in Hereditary Transthyretin-Mediated Amyloid Polyneuropathy
T. Coelho, Y. Ando, M. Benson, J. Berk +18 more
2021Neurological Therapeutics51 citations Open access
Semantic Scholar
Anti-inflammatory activity of inhaled IL-4 receptor-alpha antisense oligonucleotide in mice.
J. Karras, J. Crosby, M. Guha, David Tung +5 more
2007American Journal of Respiratory Cell and Molecular Biology51 citations
Semantic Scholar
Antisense Inhibition of Glucagon Receptor by IONIS-GCGRRx Improves Type 2 Diabetes Without Increase in Hepatic Glycogen Content in Patients With Type 2 Diabetes on Stable Metformin Therapy
Erin S. Morgan, Li-Jung Tai, N. Pham, J. K. Overman +9 more
2019Diabetes Care46 citations Open access
Semantic Scholar
Lack of Pharmacokinetic Interaction for ISIS 113715, a 2′-0-Methoxyethyl Modified Antisense Oligonucleotide Targeting Protein Tyrosine Phosphatase 1B Messenger RNA, with Oral Antidiabetic Compounds Metformin, Glipizide or Rosiglitazone
R. Geary, J. Bradley, Tanya Watanabe, Younggil Kwon +3 more
2006Clinical Pharmacokinetics44 citations
Semantic Scholar
Inhaled CD86 Antisense Oligonucleotide Suppresses Pulmonary Inflammation and Airway Hyper-Responsiveness in Allergic Mice
J. Crosby, M. Guha, David Tung, Doreen A. Miller +7 more
2007Journal of Pharmacology and Experimental Therapeutics43 citations
Semantic Scholar
Predictive Dose-Based Estimation of Systemic Exposure Multiples in Mouse and Monkey Relative to Human for Antisense Oligonucleotides With 2′-O-(2-Methoxyethyl) Modifications
R. Yu, J. Grundy, S. Henry, Tae-Won Kim +5 more
2015Molecular Therapy: Nucleic Acids42 citations Open access
Semantic Scholar
Pharmacokinetic and Pharmacodynamic Investigations of ION-353382, a Model Antisense Oligonucleotide: Using Alpha-2-Macroglobulin and Murinoglobulin Double-Knockout Mice
C. Shemesh, R. Yu, H. Gaus, P. Seth +5 more
2016Nucleic Acid Therapeutics40 citations
Semantic Scholar
In Vitro Metabolic Stabilities and Metabolism of 2′-O-(Methoxyethyl) Partially Modified Phosphorothioate Antisense Oligonucleotides in Preincubated Rat or Human Whole Liver Homogenates
M. Baek, R. Yu, H. Gaus, J. Grundy +1 more
2010Oligonucleotides40 citations
Semantic Scholar
Pharmacokinetic/Pharmacodynamic Properties ofPhosphorothioate 2'-O-(2-Methoxyethyl)-ModifiedAntisense Oligonucleotides in Animals and Man
R. Yu, R. Geary, A. Siwkowski, A. Levin
200739 citations
Semantic Scholar
Antisense Inhibition of Protein Tyrosine Phosphatase 1B With IONIS-PTP-1BRx Improves Insulin Sensitivity and Reduces Weight in Overweight Patients With Type 2 Diabetes
A. Digenio, N. Pham, L. Watts, Erin S. Morgan +4 more
2018Diabetes Care38 citations Open access
Semantic Scholar
A phase I trial of aprinocarsen (ISIS 3521/LY900003), an antisense inhibitor of protein kinase C-α administered as a 24-hour weekly infusion schedule in patients with advanced cancer
R. Advani, B. Lum, G. Fisher, J. Halsey +5 more
2005Investigational new drugs38 citations
Semantic Scholar
PK/PD modeling of FXI antisense oligonucleotides to bridge the dose‐FXI activity relation from healthy volunteers to end‐stage renal disease patients
S. Willmann, Eleonora Marostica, N. Snelder, A. Solms +10 more
2021CPT: Pharmacometrics & Systems Pharmacology35 citations Open access
Semantic Scholar
Development of IONIS-FB-LRx to Treat Geographic Atrophy Associated with AMD
G. Jaffe, J. Sahni, S. Fauser, R. Geary +2 more
202031 citations
Semantic Scholar
Antisense Inhibition of Prekallikrein to Control Hereditary Angioedema.
D. Cohn, N. Viney, Lauré M. Fijen, E. Schneider +9 more
2020New England Journal of Medicine31 citations Open access
Semantic Scholar

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