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D. Simic · SciRah

Researcher profile · Semantic Scholar

D. Simic

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D. Simic — researcher profile on SciRah

h-index: 10
Works: 29
Citations: 841

Most-cited papers

Reproducing human and cross-species drug toxicities using a Liver-Chip
Kyung-Jin Jang, M. Otieno, J. Ronxhi, H. Lim +27 more
2019Science Translational Medicine461 citations
Semantic Scholar
Organ‐on‐Chip Recapitulates Thrombosis Induced by an anti‐CD154 Monoclonal Antibody: Translational Potential of Advanced Microengineered Systems
R. Barrile, A. D. van der Meer, Hyoungshin Park, Jacob P. Fraser +10 more
2018Clinical pharmacology and therapy117 citations Open access
Semantic Scholar
Fasiglifam (TAK-875): Mechanistic Investigation and Retrospective Identification of Hazards for Drug Induced Liver Injury
M. Otieno, J. Snoeys, Wing Lam, A. Ghosh +7 more
2018Toxicological Sciences78 citations
Semantic Scholar
The utility of HepaRG cells for bioenergetic investigation and detection of drug-induced mitochondrial toxicity.
L. Kamalian, O. Douglas, C. Jolly, J. Snoeys +5 more
2018Toxicology in Vitro37 citations Open access
Semantic Scholar
Generation and Characterization of a Breast Cancer Resistance Protein Humanized Mouse Model
S. Dallas, L. Salphati, David Gomez-Zepeda, T. Wanek +20 more
2016Molecular Pharmacology26 citations Open access
Semantic Scholar
Acute Metabolic Switch Assay Using Glucose/Galactose Medium in HepaRG Cells to Detect Mitochondrial Toxicity
L. Kamalian, O. Douglas, C. Jolly, J. Snoeys +5 more
2019Current Protocols in Toxicology16 citations
Semantic Scholar
In vitro and in vivo evaluation of dasatinib and imatinib on physiological parameters of pulmonary arterial hypertension
Bethany R. Baumgart, M. Guha, J. Hennan, Julia P. Li +6 more
2017Cancer Chemotherapy and Pharmacology15 citations
Semantic Scholar
Investigating Cytoskeletal Alterations as a Potential Marker of Retinal and Lens Drug-Related Toxicity
M. E. Verdugo–Gazdik, D. Simic, A. Opsahl, M. Tengowski
2006Assay and drug development technologies15 citations Open access
Semantic Scholar
Blocking α5β1 Integrin Attenuates sCD40L-Mediated Platelet Activation
D. Simic, N. Bogdan, Fang Teng, M. Otieno
2017Clinical and applied thrombosis/hemostasis13 citations Open access
Semantic Scholar
Effects of BMS-986094, a Guanosine Nucleotide Analogue, on Mitochondrial DNA Synthesis and Function.
Bethany R. Baumgart, Fa-Ye Wang, J. Kwagh, C. Storck +12 more
2016Toxicological Sciences13 citations
Semantic Scholar
Liver-Chip: Reproducing Human and Cross-Species Toxicities
Kyung-Jin Jang, M. Otieno, J. Ronxhi, H. Lim +27 more
2019bioRxiv10 citations Open access
Semantic Scholar
Gene therapy for cross-correction of somatic organs and the CNS in mucopolysaccharidosis II in rodents and non-human primates
Nancy Chen, D. Ehmann, R. Crooker, K. Derakhchan +15 more
2023Molecular Therapy: Methods & Clinical Development9 citations Open access
Semantic Scholar
The utility of a differentiated preclinical liver model, HepaRG cells, in investigating delayed toxicity via inhibition of mitochondrial-replication induced by fialuridine
C. Jolly, O. Douglas, L. Kamalian, R. Jenkins +8 more
2020Toxicology and Applied Pharmacology8 citations Open access
Semantic Scholar
Compounds targeting Class II histone deacetylases do not cause panHDACi associated impairment of megakaryocyte differentiation
D. Simic, N. Sang
2019Experimental Hematology4 citations Open access
Semantic Scholar
MicroRNA changes associated with atypical CYP1A1 inducer BMS-764459.
D. Simic, Catherine Euler, Emily Haines, A. He +4 more
2013Toxicology4 citations
Semantic Scholar
Assessing Cell Fusion and Cytokinesis Failure as Mechanisms of Clone 9 Hepatocyte Multinucleation In Vitro
D. Simic, Catherine Euler, Christina Thurby, Michael Peden +4 more
2012Current Protocols in Toxicology4 citations
Semantic Scholar
Determination of relative Notch1 and gamma-secretase-related gene expression in puromycin-treated microdissected rat kidneys.
D. Simic, Frank J Simutis, Catherine Euler, Christina Thurby +5 more
2013Gene Expression3 citations Open access
Semantic Scholar
An alternative method for high throughput RNA isolation from whole blood
D. Simic, T. V. Van Vleet, Catherine Euler, P F Marx +4 more
20112 citations
Semantic Scholar
Drug-Induced Lens Toxicity and Differential Expression of miRNA
D. Simic, S. Deng, C. Somps
20082 citations
Semantic Scholar
Early MNU–induced retinal toxicity detected by electroretinography and visual acuity in funduscopically normal rats
Chang-Ning Liu, D. Simic, D. Baltrukonis, Colleen M Doshna +5 more
20042 citations
Semantic Scholar
Liver-chip identifies mitochondrial dysfunction, oxidative stress, and innate immune response as potential pathways of toxicity for the GPR40 agonist TAK-875
Kyung-Jin Jang, M. Otieno, J. Ronxhi, Konstantia R. Kodella +11 more
2018Toxicology Letters1 citations
Semantic Scholar
d‐α‐tocopheryl polyethylene glycol 1000 succinate‐containing vehicles provide no detectable chemoprotection from oxidative damage
Bethany R. Baumgart, T. V. Van Vleet, D. Simic, T. Salcedo +6 more
2015Journal of Applied Toxicology1 citations
Semantic Scholar
Clinical cases in which coronary CT angiography confers superior diagnostic information compared with invasive coronary angiography
K. Ćorić, M. Jukić, L. Pavić, J. Bulum +3 more
20141 citations Open access
Semantic Scholar
Outward Current in SRA 01/04 Human Lens Epithelial Cells is Reduced Following BK Channel Knockdown With RNAi
D. Simic, Chang-Ning Liu, D. Baltrukonis, C. Somps
20051 citations
Semantic Scholar
Organs-on-chips for toxicity testing: lung-thrombosis chip as a practical example
M. Otieno, R. Barrile, A. D. van der Meer, Hyoungshin Park +12 more
2018Toxicology Letters0 citations
Semantic Scholar
Evaluation of Ribonucleic Acid (RNA) amplification efficiency to determine optimal RNA concentration ranges from formalin-fixed paraffin-embedded rodent tissues for gene expression analysis
Catherine Euler, Michael Isaacs, D. Simic, T. V. Van Vleet +2 more
20150 citations
Semantic Scholar
Abstract 2426:In vitroandin vivoevaluation of dasatinib and imatinib on physiological parameters of pulmonary arterial hypertension .
M. Guha, J. Hennan, Julia P. Li, D. Simic +5 more
20130 citations
Semantic Scholar
Effect of Reduced Cathepsin D on Phagocytosis of Rat RPE Cells
D. Simic, D. Baltrukonis, S. Sokolowski, C. Somps
20060 citations
Semantic Scholar
Disclosure of novel mechanisms in which nicotine triggers structural and functional alterations of arterial smooth muscle cells, implications to pathogenesis of the occlusive arterial diseases
D. Simic
20010 citations
Semantic Scholar

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