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F. Beurskens · SciRah

Researcher profile · Semantic Scholar

F. Beurskens

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F. Beurskens — researcher profile on SciRah

h-index: 34
Works: 103
Citations: 5,658

Most-cited papers

Fc receptor but not complement binding is important in antibody protection against HIV
A. Hessell, Lars Hangartner, Meredith Hunter, C. Havenith +8 more
2007Nature942 citations
Semantic Scholar
Complement Is Activated by IgG Hexamers Assembled at the Cell Surface
C. A. Diebolder, F. Beurskens, R. D. de Jong, R. Koning +15 more
2014Science761 citations Open access
Semantic Scholar
Targeting interleukin-15 in patients with rheumatoid arthritis: a proof-of-concept study.
B. Baslund, N. Tvede, B. Danneskiold-Samsøe, P. Larsson +11 more
2005Arthritis & Rheumatism292 citations
Semantic Scholar
Binding of Submaximal C1q Promotes Complement-Dependent Cytotoxicity (CDC) of B Cells Opsonized with Anti-CD20 mAbs Ofatumumab (OFA) or Rituximab (RTX): Considerably Higher Levels of CDC Are Induced by OFA than by RTX1
Andrew W. Pawluczkowycz, F. Beurskens, P. V. Beum, M. Lindorfer +3 more
2009Journal of Immunology274 citations
Semantic Scholar
A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface
R. D. de Jong, F. Beurskens, S. Verploegen, K. Strumane +9 more
2016PLoS Biology204 citations Open access
Semantic Scholar
Resolution of psoriasis upon blockade of IL-15 biological activity in a xenograft mouse model.
L. Villadsen, J. Schuurman, F. Beurskens, T. N. Dam +9 more
2003Journal of Clinical Investigation198 citations Open access
Semantic Scholar
Complement activation by (auto-) antibodies.
N. Daha, N. Banda, A. Roos, F. Beurskens +3 more
2011Molecular Immunology169 citations
Semantic Scholar
IL-8 as Antibody Therapeutic Target in Inflammatory Diseases: Reduction of Clinical Activity in Palmoplantar Pustulosis1
L. Skov, F. Beurskens, C. Zachariae, S. Reitamo +8 more
2008Journal of Immunology168 citations Open access
Semantic Scholar
Structures of C1-IgG1 provide insights into how danger pattern recognition activates complement
D. Ugurlar, S. Howes, B. de Kreuk, R. Koning +7 more
2018Science164 citations Open access
Semantic Scholar
Molecular Basis of Assembly and Activation of Complement Component C1 in Complex with Immunoglobulin G1 and Antigen.
Guan-Bo Wang, R. D. de Jong, Ewald T. J. van den Bremer, F. Beurskens +6 more
2016Molecules and Cells153 citations Open access
Semantic Scholar
Ibrutinib interferes with the cell-mediated anti-tumor activities of therapeutic CD20 antibodies: implications for combination therapy
F. Da Roit, P. Engelberts, R. Taylor, E. Breij +6 more
2015Haematologica150 citations Open access
Semantic Scholar
Complement Activation on B Lymphocytes Opsonized with Rituximab or Ofatumumab Produces Substantial Changes in Membrane Structure Preceding Cell Lysis1
P. V. Beum, M. Lindorfer, F. Beurskens, P. Stukenberg +5 more
2008Journal of Immunology138 citations Open access
Semantic Scholar
In vivo cytotoxicity of type I CD20 antibodies critically depends on Fc receptor ITAM signaling.
S. de Haij, J. H. Marco Jansen, P. Boross, F. Beurskens +7 more
2010Cancer Research137 citations Open access
Semantic Scholar
Loss of CD20 and Bound CD20 Antibody from Opsonized B Cells Occurs More Rapidly Because of Trogocytosis Mediated by Fc Receptor-Expressing Effector Cells Than Direct Internalization by the B Cells
P. V. Beum, Elizabeth M. Peek, M. Lindorfer, F. Beurskens +4 more
2011Journal of Immunology135 citations Open access
Semantic Scholar
Complement in therapy and disease: Regulating the complement system with antibody-based therapeutics.
Joost P. M. Melis, K. Strumane, S. Ruuls, F. Beurskens +2 more
2015Molecular Immunology127 citations Open access
Semantic Scholar
Exhaustion of cytotoxic effector systems may limit mAb-based immunotherapy in cancer patients
F. Beurskens, M. Lindorfer, M. Farooqui, P. V. Beum +5 more
2012Journal of Immunology124 citations Open access
Semantic Scholar
Staphylococcal protein A inhibits complement activation by interfering with IgG hexamer formation
A. R. Cruz, M. A. den Boer, Jürgen Strasser, S. Zwarthoff +12 more
2020Proceedings of the National Academy of Sciences of the United States of America101 citations Open access
Semantic Scholar
Unraveling the Macromolecular Pathways of IgG Oligomerization and Complement Activation on Antigenic Surfaces.
Jürgen Strasser, R. D. de Jong, F. Beurskens, Guan-Bo Wang +5 more
2019Nano letters (Print)92 citations Open access
Semantic Scholar
Manifestations of Inflammatory Arthritis Are Critically Dependent on LFA-11
Gerald F. M. Watts, F. Beurskens, I. Martìn-padura, C. Ballantyne +3 more
2005Journal of Immunology92 citations Open access
Semantic Scholar
Complement alone drives efficacy of a chimeric antigonococcal monoclonal antibody
S. Gulati, F. Beurskens, B. de Kreuk, Marcel Roza +13 more
2019PLoS Biology82 citations Open access
Semantic Scholar
The in vivo mechanism of action of CD20 monoclonal antibodies depends on local tumor burden
P. Boross, J. H. Marco Jansen, S. de Haij, F. Beurskens +7 more
2011Haematologica73 citations Open access
Semantic Scholar
Human IgG is produced in a pro-form that requires clipping of C-terminal lysines for maximal complement activation
Ewald T. J. van den Bremer, F. Beurskens, M. Voorhorst, P. Engelberts +7 more
2015mAbs67 citations Open access
Semantic Scholar
DuoHexaBody-CD37®, a novel biparatopic CD37 antibody with enhanced Fc-mediated hexamerization as a potential therapy for B-cell malignancies
S. Oostindie, Hilma J. van der Horst, Laurens P. Kil, K. Strumane +14 more
2020Blood Cancer Journal62 citations Open access
Semantic Scholar
C1q, antibodies and anti-C1q autoantibodies.
F. Beurskens, Rosanne A. van Schaarenburg, L. Trouw
2015Molecular Immunology62 citations
Semantic Scholar
CD20 and CD37 antibodies synergize to activate complement by Fc-mediated clustering
S. Oostindie, Hilma J. van der Horst, M. Lindorfer, Erika M. Cook +13 more
2019Haematologica56 citations Open access
Semantic Scholar
Antibodies That Efficiently Form Hexamers upon Antigen Binding Can Induce Complement-Dependent Cytotoxicity under Complement-Limiting Conditions
Erika M. Cook, M. Lindorfer, Hilma J. van der Horst, S. Oostindie +6 more
2016Journal of Immunology55 citations Open access
Semantic Scholar
The novel tribody [(CD20)2xCD16] efficiently triggers effector cell-mediated lysis of malignant B cells
P. Glorius, A. Baerenwaldt, C. Kellner, M. Staudinger +11 more
2013Leukemia53 citations Open access
Semantic Scholar
C1q binding to surface-bound IgG is stabilized by C1r2s2 proteases
S. Zwarthoff, Kevin Widmer, A. Kuipers, Jürgen Strasser +15 more
2021Proceedings of the National Academy of Sciences of the United States of America48 citations Open access
Semantic Scholar
Complement activation by IgG subclasses is governed by their ability to oligomerize upon antigen binding
Nikolaus Frischauf, Jürgen Strasser, Ellen G. F. Borg, A. Labrijn +2 more
2024bioRxiv39 citations Open access
Semantic Scholar
Logic-gated antibody pairs that selectively act on cells co-expressing two antigens
S. Oostindie, D. Rinaldi, Gijs G. Zom, M. Wester +16 more
2022Nature Biotechnology39 citations Open access
Semantic Scholar
Weak Fragment Crystallizable (Fc) Domain Interactions Drive the Dynamic Assembly of IgG Oligomers upon Antigen Recognition.
Jürgen Strasser, R. D. de Jong, F. Beurskens, J. Schuurman +3 more
2019ACS Nano39 citations Open access
Semantic Scholar
Dual Epitope Targeting and Enhanced Hexamerization by DR5 Antibodies as a Novel Approach to Induce Potent Antitumor Activity Through DR5 Agonism
M. Overdijk, K. Strumane, F. Beurskens, Antonio Ortiz Buijsse +12 more
2020Molecular Cancer Therapeutics38 citations Open access
Semantic Scholar
Type I CD20 Antibodies Recruit the B Cell Receptor for Complement-Dependent Lysis of Malignant B Cells
P. Engelberts, M. Voorhorst, J. Schuurman, T. van Meerten +9 more
2016Journal of Immunology38 citations Open access
Semantic Scholar
Penetration of antibody‐opsonized cells by the membrane attack complex of complement promotes Ca2+ influx and induces streamers
Paul V. Beum, M. Lindorfer, Elizabeth M. Peek, P. Stukenberg +5 more
2011European Journal of Immunology35 citations Open access
Semantic Scholar
Complement in antibody-based tumor therapy.
S. Derer, F. Beurskens, Thies Rosner, M. Peipp +1 more
2014Critical Reviews in Immunology34 citations
Semantic Scholar
Antibody Responses and Opsonic Activity in Sera of Preterm Neonates with Coagulase-Negative Staphylococcal Septicemia and the Effect of the Administration of Fresh Frozen Plasma
T. Krediet, F. Beurskens, H. van Dijk, L. Gerards +1 more
1998Pediatric Research33 citations
Semantic Scholar
Immune Effector Functions of Human IgG2 Antibodies against EGFR
T. Rösner, Steffen Kahle, Francesca Montenegro, H. Matlung +6 more
2018Molecular Cancer Therapeutics29 citations Open access
Semantic Scholar
Real-time analysis of the detailed sequence of cellular events in mAb-mediated complement-dependent cytotoxicity of B-cell lines and of chronic lymphocytic leukemia B-cells.
M. Lindorfer, Erika M. Cook, J. Tupitza, C. Zent +6 more
2016Molecular Immunology28 citations
Semantic Scholar
Functional reconstruction of structurally complex epitopes using CLIPS™ technology
P. Timmerman, W. Puijk, R. Boshuizen, P. van Dijken +6 more
200926 citations Open access
Semantic Scholar
Synthetic DNA Delivery of an Optimized and Engineered Monoclonal Antibody Provides Rapid and Prolonged Protection against Experimental Gonococcal Infection
Elizabeth M. Parzych, S. Gulati, Bo Zheng, M. Bah +9 more
2021mBio24 citations Open access
Semantic Scholar
Monoclonal Antibodies against Epidermal Growth Factor Receptor Acquire an Ability To Kill Tumor Cells through Complement Activation by Mutations That Selectively Facilitate the Hexamerization of IgG on Opsonized Cells
Annalina Tammen, S. Derer, R. Schwanbeck, T. Rösner +5 more
2017Journal of Immunology23 citations Open access
Semantic Scholar
Generating Informative Sequence Tags from Antigen-Binding Regions of Heavily Glycosylated IgA1 Antibodies by Native Top-Down Electron Capture Dissociation
Jean-François Greisch, M. A. den Boer, F. Beurskens, J. Schuurman +3 more
2021Journal of the American Society for Mass Spectrometry22 citations Open access
Semantic Scholar
Enhancing complement activation by therapeutic anti-tumor antibodies: Mechanisms, strategies, and engineering approaches.
Vitalijs Ovcinnikovs, Karin Dijkman, Gijs G. Zom, F. Beurskens +1 more
2024Seminars in Immunology21 citations Open access
Semantic Scholar
A role for lipid rafts in C1q-triggered O2- generation by human neutrophils.
Iyore A. Otabor, S. Tyagi, F. Beurskens, I. Ghiran +3 more
2004Molecular Immunology20 citations
Semantic Scholar
A Complement-Optimized EGFR Antibody Improves Cytotoxic Functions of Polymorphonuclear Cells against Tumor Cells
S. Derer, M. Cossham, T. Rösner, C. Kellner +6 more
2015Journal of Immunology16 citations Open access
Semantic Scholar
Binding of Submaximal C1q to B Cells Opsonized with Anti-CD20 Mabs Ofatumumab (OFA) or Rituximab (RTX) Promotes Complement Dependent Cytotoxicity (CDC), and Considerably Higher Levels of CDC Are Induced by OFA Than by RTX.
R. Taylor, Andrew W. Pawluczkowycz, M. Lindorfer, J. G. J. van de Winkel +2 more
200816 citations
Semantic Scholar
Carbamylation reduces the capacity of IgG for hexamerization and complement activation
R. Lubbers, S. Oostindie, D. Dijkstra, P. Parren +11 more
2019Clinical and Experimental Immunology15 citations Open access
Semantic Scholar
Agnostic B cell selection approach identifies antibodies against K. pneumoniae that synergistically drive complement activation
Sjors P. A. van der Lans, B. Bardoel, M. Ruyken, C. D. de Haas +11 more
2024Nature Communications14 citations Open access
Semantic Scholar
Hinge-deleted IgG4 blocker therapy for acetylcholine receptor myasthenia gravis in rhesus monkeys
M. Losen, A. Labrijn, V. V. van Kranen-Mastenbroek, M. Janmaat +12 more
2017Scientific Reports13 citations Open access
Semantic Scholar
Hexamerization-enhanced CD20 antibody mediates complement-dependent cytotoxicity in serum genetically deficient in C9.
R. Taylor, M. Lindorfer, Erika M. Cook, F. Beurskens +7 more
2017Clinical Immunology12 citations Open access
Semantic Scholar

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P. Parren×34
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P. Parren — researcher profile on SciRah
J. Schuurman×24
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J. Schuurman — researcher profile on SciRah
R. Taylor×14
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R. Taylor — researcher profile on SciRah
M. Lindorfer×13
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M. Lindorfer — researcher profile on SciRah

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R. D. de Jong — researcher profile on SciRah

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K. Strumane — researcher profile on SciRah

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