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M. Lindorfer · SciRah

Researcher profile · Semantic Scholar

M. Lindorfer

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M. Lindorfer — researcher profile on SciRah

h-index: 48
Works: 158
Citations: 6,843

Most-cited papers

Complement Is Activated by IgG Hexamers Assembled at the Cell Surface
C. A. Diebolder, F. Beurskens, R. D. de Jong, R. Koning +15 more
2014Science761 citations Open access
Semantic Scholar
Binding of Submaximal C1q Promotes Complement-Dependent Cytotoxicity (CDC) of B Cells Opsonized with Anti-CD20 mAbs Ofatumumab (OFA) or Rituximab (RTX): Considerably Higher Levels of CDC Are Induced by OFA than by RTX1
Andrew W. Pawluczkowycz, F. Beurskens, P. V. Beum, M. Lindorfer +3 more
2009Journal of Immunology274 citations
Semantic Scholar
Immunotherapeutic Mechanisms of Anti-CD20 Monoclonal Antibodies
R. Taylor, M. Lindorfer
2008Current Opinion in Immunology166 citations Open access
Semantic Scholar
Drug Insight: the mechanism of action of rituximab in autoimmune disease—the immune complex decoy hypothesis
R. Taylor, M. Lindorfer
2007Nature Clinical Practice Rheumatology164 citations
Semantic Scholar
The complement receptor 2/factor H fusion protein TT30 protects paroxysmal nocturnal hemoglobinuria erythrocytes from complement-mediated hemolysis and C3 fragment.
A. Risitano, R. Notaro, Caterina Pascariello, M. Sica +8 more
2012Blood142 citations Open access
Semantic Scholar
Complement Activation on B Lymphocytes Opsonized with Rituximab or Ofatumumab Produces Substantial Changes in Membrane Structure Preceding Cell Lysis1
P. V. Beum, M. Lindorfer, F. Beurskens, P. Stukenberg +5 more
2008Journal of Immunology138 citations Open access
Semantic Scholar
Loss of CD20 and Bound CD20 Antibody from Opsonized B Cells Occurs More Rapidly Because of Trogocytosis Mediated by Fc Receptor-Expressing Effector Cells Than Direct Internalization by the B Cells
P. V. Beum, Elizabeth M. Peek, M. Lindorfer, F. Beurskens +4 more
2011Journal of Immunology135 citations Open access
Semantic Scholar
Fcγ-receptor-mediated trogocytosis impacts mAb-based therapies: historical precedence and recent developments.
R. Taylor, M. Lindorfer
2015Blood133 citations Open access
Semantic Scholar
IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions
Chang-Han Lee, Gabrielle Romain, Wu-Peng Yan, Makiko Watanabe +21 more
2017Nature Immunology130 citations Open access
Semantic Scholar
Exhaustion of cytotoxic effector systems may limit mAb-based immunotherapy in cancer patients
F. Beurskens, M. Lindorfer, M. Farooqui, P. V. Beum +5 more
2012Journal of Immunology124 citations Open access
Semantic Scholar
Binding of Rituximab, Trastuzumab, Cetuximab, or mAb T101 to Cancer Cells Promotes Trogocytosis Mediated by THP-1 Cells and Monocytes1
P. V. Beum, David A. Mack, Andrew W. Pawluczkowycz, M. Lindorfer +1 more
2008Journal of Immunology102 citations
Semantic Scholar
Within Peripheral Blood Mononuclear Cells, Antibody-Dependent Cellular Cytotoxicity of Rituximab-Opsonized Daudi cells Is Promoted by NK Cells and Inhibited by Monocytes due to Shaving1
P. V. Beum, M. Lindorfer, R. Taylor
2008Journal of Immunology98 citations Open access
Semantic Scholar
A novel approach to preventing the hemolysis of paroxysmal nocturnal hemoglobinuria: both complement-mediated cytolysis and C3 deposition are blocked by a monoclonal antibody specific for the alternative pathway of complement.
M. Lindorfer, Andrew W. Pawluczkowycz, Elizabeth M. Peek, Kimberly Hickman +2 more
2010Blood84 citations Open access
Semantic Scholar
Complement C5a-induced changes in neutrophil morphology during inflammation
Stephanie Denk, Ronald P. Taylor, Rebecca Wiegner, Erika M. Cook +13 more
2017Scandinavian Journal of Immunology83 citations Open access
Semantic Scholar
Cytotoxic mechanisms of immunotherapy: Harnessing complement in the action of anti-tumor monoclonal antibodies.
R. Taylor, M. Lindorfer
2016Seminars in Immunology76 citations
Semantic Scholar
Rituximab-CD20 Complexes Are Shaved from Z138 Mantle Cell Lymphoma Cells in Intravenous and Subcutaneous SCID Mouse Models1
Yong-Li Li, Michael E. Williams, J. Cousar, Andrew W. Pawluczkowycz +2 more
2007Journal of Immunology72 citations Open access
Semantic Scholar
The Direction of Plasma Membrane Exchange between Lymphocytes and Accessory Cells by Trogocytosis Is Influenced by the Nature of the Accessory Cell
S. Daubeuf, M. Lindorfer, R. Taylor, Etienne Joly +1 more
2010Journal of Immunology70 citations Open access
Semantic Scholar
Human IgG is produced in a pro-form that requires clipping of C-terminal lysines for maximal complement activation
Ewald T. J. van den Bremer, F. Beurskens, M. Voorhorst, P. Engelberts +7 more
2015mAbs67 citations Open access
Semantic Scholar
DuoHexaBody-CD37®, a novel biparatopic CD37 antibody with enhanced Fc-mediated hexamerization as a potential therapy for B-cell malignancies
S. Oostindie, Hilma J. van der Horst, Laurens P. Kil, K. Strumane +14 more
2020Blood Cancer Journal62 citations Open access
Semantic Scholar
Antigenic Modulation and Rituximab Resistance
R. Taylor, M. Lindorfer
2010Seminars in hematology (Print)62 citations Open access
Semantic Scholar
Endothelial Microparticles and Systemic Complement Activation in Patients With Chronic Kidney Disease
D. Jalal, B. Renner, J. Laskowski, Erik Stites +12 more
2018Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease58 citations Open access
Semantic Scholar
Critical role of C5a in sickle cell disease
G. Vercellotti, A. Dalmasso, Terry R. Schaid, J. Nguyen +7 more
2019American journal of hematology/oncology57 citations Open access
Semantic Scholar
Fractionated subcutaneous rituximab is well-tolerated and preserves CD20 expression on tumor cells in patients with chronic lymphocytic leukemia
G. Aue, M. Lindorfer, P. V. Beum, Andrew W. Pawluczkowycz +4 more
2010Haematologica57 citations Open access
Semantic Scholar
CD20 and CD37 antibodies synergize to activate complement by Fc-mediated clustering
S. Oostindie, Hilma J. van der Horst, M. Lindorfer, Erika M. Cook +13 more
2019Haematologica56 citations Open access
Semantic Scholar
Antibodies That Efficiently Form Hexamers upon Antigen Binding Can Induce Complement-Dependent Cytotoxicity under Complement-Limiting Conditions
Erika M. Cook, M. Lindorfer, Hilma J. van der Horst, S. Oostindie +6 more
2016Journal of Immunology55 citations Open access
Semantic Scholar
Induced Resistance to Ofatumumab Mediated Cell Clearance Mechanisms, Including Complement Dependent Cytotoxicity, in Chronic Lymphocytic Leukemia
Nisar A Baig, R. Taylor, M. Lindorfer, Amy K. Church +5 more
2014Journal of Immunology55 citations Open access
Semantic Scholar
Analyses of CD20 Monoclonal Antibody–Mediated Tumor Cell Killing Mechanisms: Rational Design of Dosing Strategies
R. Taylor, M. Lindorfer
2014Molecular Pharmacology49 citations Open access
Semantic Scholar
The role of complement in mAb-based therapies of cancer.
R. Taylor, M. Lindorfer
2014Methods48 citations
Semantic Scholar
Complement dependent cytotoxicity (CDC) in chronic lymphocytic leukemia (CLL): Ofatumumab enhances alemtuzumab CDC and reveals cells resistant to activated complement
Nisar A Baig, R. Taylor, M. Lindorfer, Amy K. Church +4 more
2012Leukemia and Lymphoma45 citations Open access
Semantic Scholar
Chemoimmunotherapy for Relapsed/Refractory and Progressive 17p13 Deleted Chronic Lymphocytic Leukemia (CLL) Combining Pentostatin, Alemtuzumab, and Low Dose Rituximab is Effective and Tolerable and Limits Loss of CD20 Expression by Circulating CLL Cells
C. Zent, Ronald P. Taylor, M. Lindorfer, P. V. Beum +13 more
2014American journal of hematology/oncology42 citations Open access
Semantic Scholar
Penetration of antibody‐opsonized cells by the membrane attack complex of complement promotes Ca2+ influx and induces streamers
Paul V. Beum, M. Lindorfer, Elizabeth M. Peek, P. Stukenberg +5 more
2011European Journal of Immunology35 citations Open access
Semantic Scholar
Antibody drug conjugate adverse effects can be understood and addressed based on immune complex clearance mechanisms.
Ronald P. Taylor, M. Lindorfer
2024Blood31 citations
Semantic Scholar
Real-time analysis of the detailed sequence of cellular events in mAb-mediated complement-dependent cytotoxicity of B-cell lines and of chronic lymphocytic leukemia B-cells.
M. Lindorfer, Erika M. Cook, J. Tupitza, C. Zent +6 more
2016Molecular Immunology28 citations
Semantic Scholar
A humanised antibody that regulates the alternative pathway convertase: potential for therapy of renal disease associated with nephritic factors
D. Paixão-Cavalcante, Eva Torreira, M. Lindorfer, S. de Córdoba +4 more
2014Journal of Immunology28 citations Open access
Semantic Scholar
Compstatin Cp40 blocks hematin-mediated deposition of C3b fragments on erythrocytes: Implications for treatment of malarial anemia
M. Lindorfer, Erika M. Cook, E. Reis, D. Ricklin +3 more
2016Clinical Immunology27 citations Open access
Semantic Scholar
Monoclonal antibody (mAb)-based cancer therapy
M. Lindorfer, A. Wiestner, C. Zent, R. Taylor
2012Oncoimmunology25 citations Open access
Semantic Scholar
Interactions Between the Complement System and Fcγ Receptors
M. Lindorfer, J. Köhl, R. Taylor
201423 citations
Semantic Scholar
C3(H2O) prevents rescue of complement-mediated C3 glomerulopathy in Cfh-/- Cfd-/- mice.
Yu-Zhou Zhang, Adam Keenan, Dao-Fu Dai, K. May +6 more
2020JCI Insight22 citations Open access
Semantic Scholar
Low doses of antigen coupled to anti-CR2 mAbs induce rapid and enduring IgG immune responses in mice and in cynomolgus monkeys.
Emily C. Whipple, Andrew H. Ditto, Ryan S. Shanahan, Jeremy J. Gatesman +3 more
2007Molecular Immunology22 citations
Semantic Scholar
Activation of complement by monoclonal antibodies that target cell-associated β₂-microglobulin: implications for cancer immunotherapy.
Michael Pokrass, Mo Liu, M. Lindorfer, R. Taylor
2013Molecular Immunology17 citations
Semantic Scholar
Binding of Submaximal C1q to B Cells Opsonized with Anti-CD20 Mabs Ofatumumab (OFA) or Rituximab (RTX) Promotes Complement Dependent Cytotoxicity (CDC), and Considerably Higher Levels of CDC Are Induced by OFA Than by RTX.
R. Taylor, Andrew W. Pawluczkowycz, M. Lindorfer, J. G. J. van de Winkel +2 more
200816 citations
Semantic Scholar
Mechanisms of enhanced neutralization of botulinum neurotoxin by monoclonal antibodies conjugated to antibodies specific for the erythrocyte complement receptor
Rashmi R Sharma, Huiwu Zhao, Fetweh H. Al-Saleem, Ahmed Syed Ubaid +9 more
2013Molecular Immunology15 citations Open access
Semantic Scholar
FcγR-Mediated Trogocytosis 2.0: Revisiting History Gives Rise to a Unifying Hypothesis
M. Lindorfer, R. Taylor
2022Antibodies14 citations Open access
Semantic Scholar
Mechanisms of Complement-Mediated Damage in Hematological Disorders.
R. Taylor, M. Lindorfer
2018Seminars in hematology (Print)13 citations
Semantic Scholar
CD20 mAb-Mediated Complement Dependent Cytotoxicity of Tumor Cells is Enhanced by Blocking the Action of Factor I
M. Lindorfer, P. V. Beum, R. Taylor
201313 citations Open access
Semantic Scholar
Monoclonal antibodies: new therapeutic agents for autoimmune hemolytic anemia?
G. D'Arena, R. Taylor, N. Cascavilla, M. Lindorfer
2008Endocrine, Metabolic & Immune Disorders - Drug Targets13 citations
Semantic Scholar
Hexamerization-enhanced CD20 antibody mediates complement-dependent cytotoxicity in serum genetically deficient in C9.
R. Taylor, M. Lindorfer, Erika M. Cook, F. Beurskens +7 more
2017Clinical Immunology12 citations Open access
Semantic Scholar
Complement Activation in a Murine Model of Sickle Cell Disease: Inhibition of Vaso-Occlusion By Blocking C5 Activation
Terry R. Schaid, J. Nguyen, Chun-Sheng Chen, F. Abdulla +8 more
20169 citations
Semantic Scholar
Ofatumumab (Arzerra®): a Next‐Generation Human Therapeutic CD20 Antibody with Potent Complement‐Dependent Cytotoxicity
M. Lindorfer, J. Bakker, P. Parren, R. Taylor
20148 citations
Semantic Scholar
Rapid clearance of rituximab may contribute to the continued high incidence of autoimmune hematologic complications of chemoimmunotherapy for chronic lymphocytic leukemia
C. Mo, N. Njuguna, P. V. Beum, M. Lindorfer +6 more
2013Haematologica8 citations Open access
Semantic Scholar

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