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P. Engelberts · SciRah

Researcher profile · Semantic Scholar

P. Engelberts

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P. Engelberts — researcher profile on SciRah

h-index: 11
Works: 34
Citations: 2,991

Most-cited papers

Statins Impair Antitumor Effects of Rituximab by Inducing Conformational Changes of CD20
M. Winiarska, J. Bil, E. Wilczek, Grzegorz M. Wilczynski +22 more
2008PLoS Medicine1,834 citations Open access
Semantic Scholar
A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface
R. D. de Jong, F. Beurskens, S. Verploegen, K. Strumane +9 more
2016PLoS Biology204 citations Open access
Semantic Scholar
Ibrutinib interferes with the cell-mediated anti-tumor activities of therapeutic CD20 antibodies: implications for combination therapy
F. Da Roit, P. Engelberts, R. Taylor, E. Breij +6 more
2015Haematologica150 citations Open access
Semantic Scholar
Overcoming Challenges for CD3-Bispecific Antibody Therapy in Solid Tumors
J. Middelburg, K. Kemper, P. Engelberts, A. Labrijn +2 more
2021Cancers145 citations Open access
Semantic Scholar
DuoBody-CD3xCD20 induces potent T-cell-mediated killing of malignant B cells in preclinical models and provides opportunities for subcutaneous dosing
P. Engelberts, I. Hiemstra, B. de Jong, D. Schuurhuis +12 more
2020EBioMedicine144 citations Open access
Semantic Scholar
Loss of CD20 and Bound CD20 Antibody from Opsonized B Cells Occurs More Rapidly Because of Trogocytosis Mediated by Fc Receptor-Expressing Effector Cells Than Direct Internalization by the B Cells
P. V. Beum, Elizabeth M. Peek, M. Lindorfer, F. Beurskens +4 more
2011Journal of Immunology135 citations Open access
Semantic Scholar
Exhaustion of cytotoxic effector systems may limit mAb-based immunotherapy in cancer patients
F. Beurskens, M. Lindorfer, M. Farooqui, P. V. Beum +5 more
2012Journal of Immunology124 citations Open access
Semantic Scholar
Regulation of the pap epigenetic switch by CpxAR: phosphorylated CpxR inhibits transition to the phase ON state by competition with Lrp.
Aaron D. Hernday, B. Braaten, G. Broitman-Maduro, P. Engelberts +1 more
2004Molecules and Cells90 citations Open access
Semantic Scholar
Human IgG is produced in a pro-form that requires clipping of C-terminal lysines for maximal complement activation
Ewald T. J. van den Bremer, F. Beurskens, M. Voorhorst, P. Engelberts +7 more
2015mAbs67 citations Open access
Semantic Scholar
Type I CD20 Antibodies Recruit the B Cell Receptor for Complement-Dependent Lysis of Malignant B Cells
P. Engelberts, M. Voorhorst, J. Schuurman, T. van Meerten +9 more
2016Journal of Immunology38 citations Open access
Semantic Scholar
CD3-engaging bispecific antibodies trigger a paracrine regulated wave of T-cell recruitment for effective tumor killing
Chen-Yi Liao, P. Engelberts, A. Ioan-Facsinay, Janna E. Klip +3 more
2024Communications Biology12 citations Open access
Semantic Scholar
A quantitative flow cytometric assay for determining binding characteristics of chimeric, humanized and human antibodies in whole blood: proof of principle with rituximab and ofatumumab.
P. Engelberts, Carole Badoil, F. Beurskens, D. Boulay-Moine +3 more
2013JIM - Journal of Immunological Methods11 citations
Semantic Scholar
Sojourn time approximations in queueing networks with feedback
B. Gijsen, R. D. van der Mei, P. Engelberts, Hans van den Berg +1 more
2006Performance evaluation (Print)11 citations
Semantic Scholar
Duobody-CD3xCD30 Demonstrates Potent Anti-Tumor Activity in Preclinical Models of CD30+ Hematologic Malignancies
S. Oostindie, M. F. Alemdehy, M. Janmaat, J. Meerding +6 more
2022Blood7 citations Open access
Semantic Scholar
Mechanistic and pharmacodynamic studies of DuoBody-CD3x5T4 in preclinical tumor models
K. Kemper, E. Gielen, P. Boross, M. Houtkamp +12 more
2022Life Science Alliance5 citations Open access
Semantic Scholar
CD3xHER2 bsAb‐Mediated Activation of Resting T‐cells at HER2 Positive Tumor Clusters Is Sufficient to Trigger Bystander Eradication of Distant HER2 Negative Clusters Through IFNγ and TNFα
Chen-Yi Liao, P. Engelberts, Michiel van Dijk, A. Timmermans +3 more
2025European Journal of Immunology4 citations Open access
Semantic Scholar
Duobody-CD3xCD20 Shows Unique and Potent Preclinical Anti-Tumor Activity in Vitro and In Vivo, and Is Being Evaluated Clinically in Patients with B-Cell Malignancies
I. Hiemstra, P. Engelberts, B. de Jong, D. Schuurhuis +12 more
2018Blood4 citations
Semantic Scholar
Studying the effect of different macrostructures on in vitro cell behaviour and in vivo bone formation using a tissue engineering approach.
R. Dekker, C. V. van Blitterswijk, I. Hofland, P. Engelberts +2 more
2003Novartis Foundation symposium4 citations
Semantic Scholar
704 Preclinical mechanism of action and pharmacodynamic biomarker studies of DuoBody®-CD3x5T4 in vitro and in vivo in solid cancer models
K. Kemper, E. Gielen, M. Houtkamp, P. Boross +7 more
2020Journal for ImmunoTherapy of Cancer2 citations Open access
Semantic Scholar
Preclinical Comparison of Two CD3xB7H4 Bispecific Antibodies for Solid Tumor Therapy Reveals CD3 Affinity-Dependent Potency and Tolerability Tradeoffs.
L. Koopman, Farshid Alemdehy, S. D. de Poot, M. Paauwe +20 more
2026Molecular Cancer Therapeutics0 citations Open access
Semantic Scholar
1382 In-situ subtyping of γδT cells in the tumor microenvironment with spatially resolved transcriptomics
Fan Li, Angelo Harris, Clifton Drew, Scott Milos +8 more
2024Regular and Young Investigator Award Abstracts0 citations Open access
Semantic Scholar
PS1301 POTENT ANTI-TUMOR ACTIVITY OF DUOBODY®-CD3XCD20 IN PRECLINICAL MODELS IN VITRO AND IN VIVO
I. Hiemstra, P. Engelberts, B. de Jong, D. Schuurhuis +10 more
2019HemaSphere0 citations Open access
Semantic Scholar
CD20 as target for immunotherapy
P. Engelberts
20190 citations
Semantic Scholar
Abstract 5669: Establishment of a human CD3ϵ transgenic mouse model to assess anti-tumor efficacy of human T-cell-redirecting bispecific antibodies
Meng-Meng Yang, Ming-Kun Zhang, S. Verploegen, P. Engelberts +9 more
2018Immunology0 citations
Semantic Scholar
Immunotherapy in Cancer Patients May Limit Monoclonal Antibody-Based Exhaustion of Cytotoxic Effector Systems
May Limit, Monoclonal Antibody-Based, P. T. Mackus, P. Parren +8 more
20120 citations
Semantic Scholar
252Type I CD20 antibodies take over the B-cell receptor for complement-dependent cytotoxicity (CDC) of malignant B cells
P. Engelberts, M. Voorhorst, J. Schuurman, T. van Meerten +6 more
20120 citations
Semantic Scholar
Direct Internalization by the B Cells Fc Receptor-Expressing Effector Cells Than Rapidly Because of Trogocytosis Mediated by from Opsonized B Cells Occurs More Loss of CD20 and Bound CD20 Antibody
Parren, J. G. J. van de Winkel, R. Taylor, F. Beurskens +5 more
20110 citations
Semantic Scholar
222 Ofatumumab binds to a membrane-proximal epitope which comprises amino acids in the small and large loops of CD20
P. Engelberts, Frank J. Beurskens, Wendy J. M. Mackus, J. Bakker +5 more
20100 citations
Semantic Scholar
II CD 20 monoclonal antibodies Complement activation impacts B-cell depletion by both type I and type
P. Parren, F. Beurskens, S. Ruuls, P. Engelberts +2 more
20080 citations
Semantic Scholar
Complement activation impacts B-cell depletion by both type I and type II CD20 monoclonal antibodies. Authors' reply
F. Beurskens, S. Ruuls, P. Engelberts, Tom Vink +6 more
20080 citations
Semantic Scholar
Statins Impair Antitumor Effects of CD20 mAb by Inducing Conformational Changes of CD20.
J. Gołąb, M. Winiarska, J. Bil, E. Wilczek +19 more
20070 citations
Semantic Scholar
[Alcoholism in geriatrics].
P. Engelberts
1986Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis0 citations
Semantic Scholar
[Psychopharmacology in geriatrics].
I. Simeone, P. Engelberts
1983Revue medicale de la Suisse romande0 citations
Semantic Scholar
[Sign of the hand guided toward the face (note on neuro-geriatric semeiology)].
J. Richard, R. Tissot, P. Engelberts
1978Revue medicale de la Suisse romande0 citations
Semantic Scholar

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