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Andrew W. Pawluczkowycz · SciRah

Researcher profile · Semantic Scholar

Andrew W. Pawluczkowycz

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Andrew W. Pawluczkowycz — researcher profile on SciRah

h-index: 10
Works: 21
Citations: 1,074

Most-cited papers

Binding of Submaximal C1q Promotes Complement-Dependent Cytotoxicity (CDC) of B Cells Opsonized with Anti-CD20 mAbs Ofatumumab (OFA) or Rituximab (RTX): Considerably Higher Levels of CDC Are Induced by OFA than by RTX1
Andrew W. Pawluczkowycz, F. Beurskens, P. V. Beum, M. Lindorfer +3 more
2009Journal of Immunology274 citations
Semantic Scholar
Thrice-Weekly Low-Dose Rituximab Decreases CD20 Loss via Shaving and Promotes Enhanced Targeting in Chronic Lymphocytic Leukemia1
Michael E. Williams, J. Densmore, Andrew W. Pawluczkowycz, P. V. Beum +5 more
2006Journal of Immunology162 citations Open access
Semantic Scholar
Complement Activation on B Lymphocytes Opsonized with Rituximab or Ofatumumab Produces Substantial Changes in Membrane Structure Preceding Cell Lysis1
P. V. Beum, M. Lindorfer, F. Beurskens, P. Stukenberg +5 more
2008Journal of Immunology138 citations Open access
Semantic Scholar
Binding of Rituximab, Trastuzumab, Cetuximab, or mAb T101 to Cancer Cells Promotes Trogocytosis Mediated by THP-1 Cells and Monocytes1
P. V. Beum, David A. Mack, Andrew W. Pawluczkowycz, M. Lindorfer +1 more
2008Journal of Immunology102 citations
Semantic Scholar
Hematin Promotes Complement Alternative Pathway-Mediated Deposition of C3 Activation Fragments on Human Erythrocytes: Potential Implications for the Pathogenesis of Anemia in Malaria1
Andrew W. Pawluczkowycz, M. Lindorfer, J. Waitumbi, R. Taylor
2007Journal of Immunology101 citations
Semantic Scholar
A novel approach to preventing the hemolysis of paroxysmal nocturnal hemoglobinuria: both complement-mediated cytolysis and C3 deposition are blocked by a monoclonal antibody specific for the alternative pathway of complement.
M. Lindorfer, Andrew W. Pawluczkowycz, Elizabeth M. Peek, Kimberly Hickman +2 more
2010Blood84 citations Open access
Semantic Scholar
Rituximab-CD20 Complexes Are Shaved from Z138 Mantle Cell Lymphoma Cells in Intravenous and Subcutaneous SCID Mouse Models1
Yong-Li Li, Michael E. Williams, J. Cousar, Andrew W. Pawluczkowycz +2 more
2007Journal of Immunology72 citations Open access
Semantic Scholar
Fractionated subcutaneous rituximab is well-tolerated and preserves CD20 expression on tumor cells in patients with chronic lymphocytic leukemia
G. Aue, M. Lindorfer, P. V. Beum, Andrew W. Pawluczkowycz +4 more
2010Haematologica57 citations Open access
Semantic Scholar
Selective and efficient inhibition of the alternative pathway of complement by a mAb that recognizes C3b/iC3b.
D. DiLillo, Andrew W. Pawluczkowycz, W. Peng, A. Kennedy +3 more
2006Molecular Immunology45 citations
Semantic Scholar
Binding of Submaximal C1q to B Cells Opsonized with Anti-CD20 Mabs Ofatumumab (OFA) or Rituximab (RTX) Promotes Complement Dependent Cytotoxicity (CDC), and Considerably Higher Levels of CDC Are Induced by OFA Than by RTX.
R. Taylor, Andrew W. Pawluczkowycz, M. Lindorfer, J. G. J. van de Winkel +2 more
200816 citations
Semantic Scholar
Complement activation and C3b deposition on rituximab-opsonized cells substantially blocks binding of phycoerythrin-labeled anti-mouse IgG probes to rituximab.
P. V. Beum, A. Kennedy, Yong-Li Li, Andrew W. Pawluczkowycz +2 more
2004JIM - Journal of Immunological Methods7 citations
Semantic Scholar
Complement Activation and Complement-Mediated Killing of B Cells Promoted by Anti-CD20 Monoclonal Antibodies (mAb) Rituximab and Ofatumumab Are Rapid, and Ofatumumab Kills Cells More Rapidly and with Greater Efficacy.
R. Taylor, Andrew W. Pawluczkowycz, P. V. Beum, M. Lindorfer +3 more
20076 citations
Semantic Scholar
Complement (C) Activation Followed by Penetration of the Membrane Attack Complex (MAC) on B Cells Opsonized with CD20 Mabs Allows for Calcium Influx Which Induces Streamers. Generalization of Streaming to Include other Mabs and Target Cells.
R. Taylor, P. V. Beum, P. Stukenberg, Andrew W. Pawluczkowycz +4 more
20083 citations
Semantic Scholar
Spinning disk confocal fluorescent microscopy (SDCFM) analyses of complement activation promoted by anti-CD20 mAbs rituximab and ofatumumab (HuMax-CD20)
R. Taylor, P. V. Beum, Andrew W. Pawluczkowycz, F. Beurskens +2 more
20072 citations
Semantic Scholar
The Shaving Reaction Is Facilitated through Trogocytosis: Concerted Transfer of Both Rituximab (RTX) and the Membrane Dye PKH26 from B Lymphocytes to Macrophages Is Demonstrable by Flow Cytometry, Fluorescence Microscopy, and High Resolution Digital Imaging in a Flow Cytometric Environment.
David A. Mack, P. V. Beum, M. Lindorfer, Andrew W. Pawluczkowycz +1 more
20062 citations
Semantic Scholar
A Pilot Study of Thrice-Weekly Low Dose Rituximab (RTX) in the Treatment of Chronic Lymphocytic Leukemia (CLL) Suggests Enhanced Therapeutic Targeting Compared to Standard Dose Regimens.
R. Taylor, Andrew W. Pawluczkowycz, P. V. Beum, A. Kennedy +5 more
20041 citations
Semantic Scholar
A Novel Approach to Treatment of Paroxysmal Nocturnal Hemoglobinuria (PNH): Both Hemolysis and C3 Deposition Are Blocked by a Monoclonal Antibody (mAb) Specific for the Alternative Pathway of Complement (APC) C3/C5 Convertase.
R. Taylor, M. Lindorfer, Andrew W. Pawluczkowycz, C. Parker
20090 citations
Semantic Scholar
Induced by OFA than by RTX Considerably Higher Levels of CDC Are Ofatumumab (OFA) or Rituximab (RTX): of B Cells Opsonized with Anti-CD20 mAbs Complement-Dependent Cytotoxicity (CDC) Binding of Submaximal C1q Promotes
W. H. I. Parren, R. Taylor, Beum, M. Lindorfer +4 more
20090 citations
Semantic Scholar
Spinning Disk Confocal Fluorescent Microscopy (SDCFM) Analyses of Complement Activation Promoted by Anti-CD20 Monoclonal Antibodies (mAbs) Rituximab and Ofatumumab.
R. Taylor, P. V. Beum, Andrew W. Pawluczkowycz, M. Lindorfer +3 more
20070 citations
Semantic Scholar
Lymphocytic Leukemia Promotes Enhanced Targeting in Chronic Decreases CD20 Loss via Shaving and Thrice-Weekly Low-Dose Rituximab
Michael E. Williams, J. Densmore, Andrew W. Pawluczkowycz, P. V. Beum +5 more
20060 citations
Semantic Scholar
Pilot Study of Thrice-Weekly Low-Dose Rituximab (RTX) in Chronic Lymphocytic Leukemia (CLL): Decreased CD20 Loss Via “Shaving” and a Novel Strategy for Enhanced Therapeutic Targeting.
Michael E. Williams, J. Densmore, Andrew W. Pawluczkowycz, P. V. Beum +6 more
20050 citations
Semantic Scholar

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