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L. Trouw · SciRah

Researcher profile · Semantic Scholar

L. Trouw

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L. Trouw — researcher profile on SciRah

h-index: 62
Works: 288
Citations: 12K

Most-cited papers

Production of complement components by cells of the immune system
R. Lubbers, M. V. van Essen, C. van Kooten, L. Trouw
2017Clinical and Experimental Immunology430 citations Open access
Semantic Scholar
Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population
M. Gaya da Costa, F. Poppelaars, C. van Kooten, T. Mollnes +7 more
2018Frontiers in Immunology240 citations Open access
Semantic Scholar
The complement system as a potential therapeutic target in rheumatic disease
L. Trouw, M. Pickering, A. Blom
2017Nature Reviews Rheumatology179 citations
Semantic Scholar
Beyond citrullination: other post-translational protein modifications in rheumatoid arthritis
L. Trouw, T. Rispens, R. Toes
2017Nature Reviews Rheumatology156 citations
Semantic Scholar
Triple Positivity for Anti–Citrullinated Protein Autoantibodies, Rheumatoid Factor, and Anti–Carbamylated Protein Antibodies Conferring High Specificity for Rheumatoid Arthritis
M. Verheul, S. Bohringer, M. Delft, Jonathan D. Jones +14 more
2018Arthritis & Rheumatology104 citations Open access
Semantic Scholar
Presence of anticitrullinated protein antibodies in a large population-based cohort from the Netherlands
A. van Zanten, S. Arends, C. Roozendaal, P. Limburg +6 more
2017Annals of the Rheumatic Diseases99 citations Open access
Semantic Scholar
Complement Activation in Patients With Diabetic Nephropathy
P. Bus, J. Chua, Celine Q. F. Klessens, M. Zandbergen +5 more
2017Kidney International Reports80 citations Open access
Semantic Scholar
The risk of individual autoantibodies, autoantibody combinations and levels for arthritis development in Clinically Suspect Arthralgia
R. T. ten Brinck, H. V. van Steenbergen, M. V. van Delft, M. Verheul +3 more
2017Rheumatology66 citations Open access
Semantic Scholar
Complement Component C1q as Serum Biomarker to Detect Active Tuberculosis
R. Lubbers, J. Sutherland, D. Goletti, R. D. de Paus +16 more
2018Frontiers in Immunology61 citations Open access
Semantic Scholar
In rheumatoid arthritis, changes in autoantibody levels reflect intensity of immunosuppression, not subsequent treatment response
E. D. de Moel, V. Derksen, L. Trouw, H. Bang +7 more
2019Arthritis Research & Therapy50 citations Open access
Semantic Scholar
Different classes of anti-modified protein antibodies are induced on exposure to antigens expressing only one type of modification
A. Kampstra, J. Dekkers, M. Volkov, A. Dorjée +12 more
2019Annals of the Rheumatic Diseases49 citations Open access
Semantic Scholar
Pitfalls in the detection of citrullination and carbamylation.
M. Verheul, P. V. van Veelen, M. V. van Delft, De A. H. Ru +4 more
2017Autoimmunity Reviews49 citations Open access
Semantic Scholar
Circulating C1q levels in health and disease, more than just a biomarker.
F. S. van de Bovenkamp, D. Dijkstra, C. van Kooten, K. Gelderman +1 more
2021Molecular Immunology47 citations Open access
Semantic Scholar
The prevalence of ACPA is lower in rheumatoid arthritis patients with an older age of onset but the composition of the ACPA response appears identical
D. Boeters, L. Mangnus, S. Ajeganova, E. Lindqvist +8 more
2017Arthritis Research & Therapy47 citations Open access
Semantic Scholar
Baseline autoantibody profile in rheumatoid arthritis is associated with early treatment response but not long-term outcomes
E. D. de Moel, V. Derksen, G. Stoeken, L. Trouw +7 more
2018Arthritis Research & Therapy46 citations Open access
Semantic Scholar
PTX3 structure determination using a hybrid cryoelectron microscopy and AlphaFold approach offers insights into ligand binding and complement activation
Dylan P. Noone, D. Dijkstra, Teun van der Klugt, P. V. van Veelen +4 more
2022Proceedings of the National Academy of Sciences of the United States of America42 citations Open access
Semantic Scholar
Breach of autoreactive B cell tolerance by post-translationally modified proteins
J. Dekkers, M. Verheul, J. Stoop, Bi-Sheng Liu +9 more
2017Annals of the Rheumatic Diseases40 citations Open access
Semantic Scholar
Complement is activated by elevated IgG3 hexameric platforms and deposits C4b onto distinct antibody domains
Leoni Abendstein, D. Dijkstra, R. Tjokrodirijo, P. V. van Veelen +3 more
2023Nature Communications39 citations Open access
Semantic Scholar
Complement activation and regulation in rheumatic disease.
D. Dijkstra, Jivan V. Joeloemsingh, I. Bajema, L. Trouw
2019Seminars in Immunology35 citations Open access
Semantic Scholar
The role of complement activation in autoimmune liver disease.
M. Biewenga, A. F. Sarasqueta, M. Tushuizen, E. D. de Jonge-Muller +2 more
2020Autoimmunity Reviews33 citations Open access
Semantic Scholar
Expression and production of the SERPING1-encoded endogenous complement regulator C1-inhibitor in multiple cohorts of tuberculosis patients.
R. Lubbers, J. Sutherland, D. Goletti, R. D. de Paus +14 more
2020Molecular Immunology31 citations Open access
Semantic Scholar
Structural basis for surface activation of the classical complement cascade by the short pentraxin C-reactive protein
Dylan P. Noone, Marjolein M. E. Isendoorn, Sebastiaan M W R Hamers, Mariska E. Keizer +6 more
2024bioRxiv29 citations Open access
Semantic Scholar
Auto-Antibodies to Post-Translationally Modified Proteins in Osteoarthritis.
Xuan-Xiao Xie, M. V. van Delft, Farag Shuweihdi, S. Kingsbury +4 more
2021Osteoarthritis and Cartilage29 citations Open access
Semantic Scholar
Glomerular C4d deposition can precede the development of focal segmental glomerulosclerosis.
N. A. van de Lest, M. Zandbergen, R. Wolterbeek, R. Kreutz +6 more
2019Kidney International29 citations Open access
Semantic Scholar
Secretory form of rheumatoid arthritis–associated autoantibodies in serum are mainly of the IgM isotype, suggesting a continuous reactivation of autoantibody responses at mucosal surfaces
M. V. van Delft, D. van der Woude, R. Toes, L. Trouw
2018Annals of the Rheumatic Diseases29 citations Open access
Semantic Scholar
Complement component C1q is produced by isolated articular chondrocytes.
R. Lubbers, Rosanne A. van Schaarenburg, J. Kwekkeboom, Nivine Levarht +8 more
2020Osteoarthritis and Cartilage26 citations Open access
Semantic Scholar
Cross-reactivity of IgM anti-modified protein antibodies in rheumatoid arthritis despite limited mutational load
S. Reijm, T. Kissel, G. Stoeken-Rijsbergen, L. Slot +13 more
2021Arthritis Research & Therapy23 citations Open access
Semantic Scholar
Enhancing complement activation by therapeutic anti-tumor antibodies: Mechanisms, strategies, and engineering approaches.
Vitalijs Ovcinnikovs, Karin Dijkman, Gijs G. Zom, F. Beurskens +1 more
2024Seminars in Immunology21 citations Open access
Semantic Scholar
Circulating Levels of Anti-C1q and Anti-Factor H Autoantibodies and Their Targets in Normal Pregnancy and Preeclampsia
D. Dijkstra, A. Lokki, L. Gierman, N. V. Borggreven +7 more
2022Frontiers in Immunology21 citations Open access
Semantic Scholar
HLA–B*08 Identified as the Most Prominently Associated Major Histocompatibility Complex Locus for Anti–Carbamylated Protein Antibody–Positive/Anti–Cyclic Citrullinated Peptide–Negative Rheumatoid Arthritis
C. Regueiro, Desiré Casares-Marfil, K. Lundberg, R. Knevel +24 more
2020Arthritis & Rheumatology20 citations
Semantic Scholar
In RA, becoming seronegative over the first year of treatment does not translate to better chances of drug-free remission
E. D. de Moel, V. Derksen, L. Trouw, H. Bang +6 more
2018Annals of the Rheumatic Diseases20 citations
Semantic Scholar
Placental Complement Activation in Fetal and Neonatal Alloimmune Thrombocytopenia: An Observational Study
T. D. de Vos, D. Winkelhorst, H. Baelde, K. Dijkstra +15 more
2021International Journal of Molecular Sciences18 citations Open access
Semantic Scholar
Systemic and pulmonary C1q as biomarker of progressive disease in experimental non-human primate tuberculosis
K. Dijkman, R. Lubbers, N. V. Borggreven, T. Ottenhoff +3 more
2020Scientific Reports18 citations Open access
Semantic Scholar
Mass-spectrometric identification of carbamylated proteins present in the joints of rheumatoid arthritis patients and controls.
M. Verheul, G. Janssen, Arnoud H. de Ru, G. Stoeken-Rijsbergen +10 more
2020Clinical and Experimental Rheumatology17 citations
Semantic Scholar
Human anti-C1q autoantibodies bind specifically to solid-phase C1q and enhance phagocytosis but not complement activation
D. Dijkstra, F. S. van de Bovenkamp, Leoni Abendstein, Rob Zuijderduijn +12 more
2023Proceedings of the National Academy of Sciences of the United States of America16 citations Open access
Semantic Scholar
Host biomarker-based quantitative rapid tests for detection and treatment monitoring of tuberculosis and COVID-19
Louise Pierneef, A. van Hooij, D. de Jong, Elisa M. Tjon Kon Fat +50 more
2022iScience16 citations Open access
Semantic Scholar
B-cell activating factor and IL-21 levels predict treatment response in autoimmune hepatitis
M. Biewenga, S. Heidt, M. Vergunst, C. J. Marijnissen +5 more
2022JHEP Reports15 citations Open access
Semantic Scholar
Autoantibodies against specific post-translationally modified proteins are present in patients with lupus and associate with major neuropsychiatric manifestations
R. Monahan, M. D. van den Beukel, N. V. Borggreven, R. Fronczek +4 more
2022RMD Open15 citations Open access
Semantic Scholar
Carbamylation reduces the capacity of IgG for hexamerization and complement activation
R. Lubbers, S. Oostindie, D. Dijkstra, P. Parren +11 more
2019Clinical and Experimental Immunology15 citations Open access
Semantic Scholar
Does information on novel identified autoantibodies contribute to predicting the progression from undifferentiated arthritis to rheumatoid arthritis: a study on anti-CarP antibodies as an example
D. Boeters, L. Trouw, A. H. M. van der Helm-van Mil, H. V. van Steenbergen
2018Arthritis Research & Therapy15 citations Open access
Semantic Scholar
DNA Nanostructure-Templated Antibody Complexes Provide Insights into the Geometric Requirements of Human Complement Cascade Activation
Leoni Abendstein, W. Noteborn, Luc S. Veenman, D. Dijkstra +3 more
2023bioRxiv14 citations Open access
Semantic Scholar
Presence of Autoantibodies in Erosive Hand Osteoarthritis and Association with Clinical Presentation
M. V. van Delft, S. van Beest, M. Kloppenburg, L. Trouw +1 more
2018Journal of Rheumatology14 citations Open access
Semantic Scholar
The anti-carbamylated protein antibody response is of overall low avidity despite extensive isotype switching
M. V. van Delft, M. Verheul, L. Burgers, S. Rantapää-Dahlqvist +4 more
2018Rheumatology13 citations Open access
Semantic Scholar
Targeted complement inhibition using bispecific antibodies that bind local antigens and endogenous complement regulators
Hai-Yu Wang, F. S. van de Bovenkamp, D. Dijkstra, Leoni Abendstein +12 more
2024Frontiers in Immunology12 citations Open access
Semantic Scholar
Antibodies against advanced glycation end-products and malondialdehyde-acetaldehyde adducts identify a new specific subgroup of hitherto patients with seronegative arthritis with a distinct clinical phenotype and an HLA class II association
M. D. van den Beukel, T. V. van Wesemael, Anna Titia W Hoogslag, N. V. Borggreven +5 more
2023RMD Open12 citations Open access
Semantic Scholar
Arthritis autoantibodies in individuals without rheumatoid arthritis: follow-up data from a Dutch population-based cohort (Lifelines)
J. Westra, E. Brouwer, Elisabeth Raveling-Eelsing, S. Arends +7 more
2020Rheumatology12 citations Open access
Semantic Scholar
Geo-epidemiology of autoantibodies in rheumatoid arthritis: comparison between four ethnically diverse populations
E. D. de Moel, L. Trouw, Chikashi Terao, N. Govind +7 more
2023Arthritis Research & Therapy11 citations Open access
Semantic Scholar
Development of bispecific antibodies that drive selective targeted local complement inhibition on rheumatoid arthritis-related antigens.
Hai-Yu Wang, S. Nugteren, R. Groenland, S. van der Meulen +8 more
2025Annals of the Rheumatic Diseases10 citations Open access
Semantic Scholar
Identification of circulating monocytes as producers of tuberculosis disease biomarker C1q
P. Niewold, D. Dijkstra, Yi Cai, D. Goletti +13 more
2023Scientific Reports10 citations Open access
Semantic Scholar
Inverse correlation between serum complement component C1q levels and whole blood type‐1 interferon signature in active tuberculosis and QuantiFERON‐positive uveitis: implications for diagnosis
B. Schrijver, D. Dijkstra, N. V. Borggreven, R. La Distia Nora +6 more
2020Clinical & Translational Immunology10 citations Open access
Semantic Scholar

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