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Xue-Qing Chen · SciRah

Researcher profile · Semantic Scholar

Xue-Qing Chen

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Xue-Qing Chen — researcher profile on SciRah

h-index: 16
Works: 31
Citations: 901

Most-cited papers

In silico ADME/Tox: why models fail
T. Stouch, J. R. Kenyon, Stephen R. Johnson, Xue-Qing Chen +2 more
2003J. Comput. Aided Mol. Des.163 citations
Semantic Scholar
Aqueous and cosolvent solubility data for drug-like organic compounds
E. Rytting, K. Lentz, Xue-Qing Chen, F. Qian +1 more
2005AAPS Journal110 citations Open access
Semantic Scholar
Prediction of aqueous solubility of organic compounds using a quantitative structure-property relationship.
Xue-Qing Chen, Jin-Cho Sung, Yi Li, S. Venkatesh
2002Journal of Pharmacy and Science85 citations
Semantic Scholar
Application of lipid-based formulations in drug discovery.
Xue-Qing Chen, O. Gudmundsson, M. Hageman
2012Journal of Medicinal Chemistry61 citations
Semantic Scholar
Lipophilic salts of poorly soluble compounds to enable high‐dose lipidic SEDDS formulations in drug discovery
M. Morgen, Ajay Saxena, Xue-Qing Chen, Warren K Miller +11 more
2017European journal of pharmaceutics and biopharmaceutics55 citations Open access
Semantic Scholar
Miniature Device for Aqueous and Non-aqueous Solubility Measurements During Drug Discovery
Xue-Qing Chen, S. Venkatesh
2004Pharmaceutical Research52 citations
Semantic Scholar
Discovery pharmaceutics—Challenges and opportunities
Xue-Qing Chen, M. Antman, C. Gesenberg, O. Gudmundsson
2006AAPS Journal47 citations Open access
Semantic Scholar
Discovery of 4-aryl-7-hydroxyindoline-based P2Y1 antagonists as novel antiplatelet agents.
Wu Yang, Yufeng Wang, A. Lai, Jennifer X. Qiao +13 more
2014Journal of Medicinal Chemistry43 citations Open access
Semantic Scholar
A Quantitative Structure-Property Relationship for Predicting Drug Solubility in PEG 400/Water Cosolvent Systems
E. Rytting, K. Lentz, Xue-Qing Chen, F. Qian +1 more
2004Pharmaceutical Research43 citations
Semantic Scholar
A computational model for the prediction of aqueous solubility that includes crystal packing, intrinsic solubility, and ionization effects.
Stephen R. Johnson, Xue-Qing Chen, D. Murphy, O. Gudmundsson
2007Molecular Pharmaceutics39 citations
Semantic Scholar
In Vitro and In Vivo Evaluation of a Small-Molecule APJ (Apelin Receptor) Agonist, BMS-986224, as a Potential Treatment for Heart Failure
Peter S. Gargalovic, P. Wong, J. Onorato, Heather J. Finlay +12 more
2021Circulation: Heart Failure35 citations Open access
Semantic Scholar
Diphenylpyridylethanamine (DPPE) derivatives as cholesteryl ester transfer protein (CETP) inhibitors.
L. Harikrishnan, Heather J. Finlay, Jennifer X. Qiao, Muthoni G. Kamau +22 more
2012Journal of Medicinal Chemistry26 citations Open access
Semantic Scholar
Discovery of a Hydroxypyridinone APJ Receptor Agonist as a Clinical Candidate.
James A. Johnson, Soong-Hoon Kim, Ji Jiang, Monique Phillips +14 more
2021Journal of Medicinal Chemistry18 citations Open access
Semantic Scholar
Oral Delivery of Highly Lipophilic, Poorly Water-Soluble Drugs: Self-Emulsifying Drug Delivery Systems to Improve Oral Absorption and Enable High-Dose Toxicology Studies of a Cholesteryl Ester Transfer Protein Inhibitor in Preclinical Species.
Xue-Qing Chen, T. Ziemba, Christine S. Huang, Ming Chang +8 more
2018Journal of Pharmacy and Science18 citations
Semantic Scholar
Identification of 1-{2-[4-chloro-1'-(2,2-dimethylpropyl)-7-hydroxy-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]phenyl}-3-{5-chloro-[1,3]thiazolo[5,4-b]pyridin-2-yl}urea, a potent, efficacious and orally bioavailable P2Y(1) antagonist as an antiplatelet agent.
Y. Jeon, Wu Yang, Jennifer X. Qiao, Ling Li +29 more
2014Bioorganic & Medicinal Chemistry Letters18 citations Open access
Semantic Scholar
Oral delivery of highly lipophilic poorly water-soluble drugs: spray-dried dispersions to improve oral absorption and enable high-dose toxicology studies of a P2Y1 antagonist.
Xue-Qing Chen, K. Stefanski, Hong Shen, Christine S. Huang +6 more
2014Journal of Pharmacy and Science16 citations
Semantic Scholar
Metabolomic Profiling and Drug Interaction Characterization Reveal Riboflavin As a Breast Cancer Resistance Protein–Specific Endogenous Biomarker That Demonstrates Prediction of Transporter Activity In Vivo
Yue-Ping Zhang, P. Shipkova, B. Warrack, D. Nelson +11 more
2023Drug Metabolism And Disposition14 citations
Semantic Scholar
Linking (Pyr)1apelin-13 pharmacokinetics to efficacy: Stabilization and measurement of a high clearance peptide in rodents.
J. Onorato, Carrie Xu, Xue-Qing Chen, Anne V. Rose +18 more
2019Analytical Biochemistry14 citations
Semantic Scholar
Triphenylethanamine Derivatives as Cholesteryl Ester Transfer Protein Inhibitors: Discovery of N-[(1R)-1-(3-Cyclopropoxy-4-fluorophenyl)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)benzamide (BMS-795311).
Jennifer X. Qiao, Tammy C. Wang, L. Adam, A. Y. Chen +29 more
2015Journal of Medicinal Chemistry10 citations
Semantic Scholar
Discovery of a Phenylpyrazole Amide ROCK Inhibitor as a Tool Molecule for in vivo Studies.
Zi-Lun Hu, Cai-Lan Wang, P. Glunz, Julia P. Li +17 more
2020Bioorganic & Medicinal Chemistry Letters9 citations Open access
Semantic Scholar
Sulfonylated Benzothiazoles as Inhibitors of Endothelial Lipase.
James A. Johnson, George O. Tora, Z. Pi, Monique Phillips +19 more
2018ACS Medicinal Chemistry Letters7 citations Open access
Semantic Scholar
Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)-1H-pyrazol-1-yl)methyl)phosphonate (BMS-820132).
Yan Shi, Ying Wang, Wei Meng, R. Brigance +59 more
2022Journal of Medicinal Chemistry6 citations Open access
Semantic Scholar
Evaluation of Encequidar as An Intestinal P-gp and BCRP Specific Inhibitor to Assess the Role of Intestinal P-gp and BCRP in Drug-Drug Interactions
J. Chu, Erika Panfen, Linna Wang, A. Marino +9 more
2023Pharmaceutical Research5 citations
Semantic Scholar
Identification of substituted benzothiazole sulfones as potent and selective inhibitors of endothelial lipase.
Soong-Hoon Kim, James A. Johnson, Ji Jiang, Brandon L. Parkhurst +22 more
2019Bioorganic & Medicinal Chemistry Letters3 citations Open access
Semantic Scholar
Repression of Organic Anion Transporting Polypeptide (OATP) 1B Expression and Increase of Plasma Coproporphyrin Level as Evidence for OATP1B Downregulation in Cynomolgus Monkeys Treated with Chenodeoxycholic Acid
Yue-Ping Zhang, Shenjue Chen, Cliff Chen, Xue-Qing Chen +7 more
2022Drug Metabolism And Disposition2 citations Open access
Semantic Scholar
Discovery of a Lead Triphenylethanamine Cholesterol Ester Transfer Protein (CETP) Inhibitor.
Heather J. Finlay, Ji Jiang, R. Rampulla, M. Salvati +17 more
2019ACS Medicinal Chemistry Letters1 citations Open access
Semantic Scholar
Utilizing Flux to Inform Formulation Strategy Decisions in Preclinical Studies.
Laura I. Mosquera-Giraldo, Zina Patel, Dong-Yue Yu, T. Ziemba +7 more
2026Molecular Pharmaceutics0 citations
Semantic Scholar
From Lead to Clinical Candidate: Discovery of BMS-986331 as a Potent and Selective N-Formyl Peptide Receptor 2 Agonist.
Pravin S. Shirude, D. Cheney, A. K. Chattopadhyay, Balaji Seshadri +30 more
2026Journal of Medicinal Chemistry0 citations
Semantic Scholar
Mechanistic Insights into Drug Release from PLGA- and PLA-Based Implants
Dong-Yue Yu, Ryan V. Schroder, Arnold Teo, S. Traeger +10 more
2026Molecular Pharmaceutics0 citations
Semantic Scholar
Corrigendum to "Identification of substituted benzothiazole sulfones as potent and selective inhibitors of endothelial lipase" [Bioorg. Med. Chem. Lett. 29 (2019) 1918-1921].
Soong-Hoon Kim, James A. Johnson, Ji Jiang, Brandon L. Parkhurst +22 more
2019Bioorganic & Medicinal Chemistry Letters0 citations
Semantic Scholar
Differential Cardiac Effects of an AT1R Biased Ligand, AT1R Antagonist and ACE Inhibitor in Mouse Models of Post-Myocardial Infarction Heart Failure
Xiu-Ying Ma, Shahid Tannu, John Allocco, Dike Qiu +8 more
20160 citations
Semantic Scholar

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