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E. Trybulski · SciRah

Researcher profile · Semantic Scholar

E. Trybulski

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E. Trybulski — researcher profile on SciRah

h-index: 17
Works: 66
Citations: 1,221

Most-cited papers

Identification of pathway-selective estrogen receptor ligands that inhibit NF-kappaB transcriptional activity.
C. Chadwick, S. Chippari, E. Matelan, L. Borges-Marcucci +12 more
2005Proceedings of the National Academy of Sciences of the United States of America156 citations Open access
Semantic Scholar
Total Synthesis of Erythromycins. 4. Total Synthesis of Erythronolide B1
E. J. Corey, Sunggak Kim, S. Yoo, K. Nicolaou +6 more
1978126 citations
Semantic Scholar
A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation.
P. Bodine, Barbara Stauffer, H. Ponce-de-Leon, R. Bhat +17 more
2009Bone125 citations
Semantic Scholar
Synthesis in the tropane class of alkaloids. Pseudotropine and dl-cocaine
J. Tufariello, G. Mullen, J. J. Tegeler, E. Trybulski +2 more
1979120 citations
Semantic Scholar
Synthesis and activity of substituted 4-(indazol-3-yl)phenols as pathway-selective estrogen receptor ligands useful in the treatment of rheumatoid arthritis.
R. Steffan, E. Matelan, M. Ashwell, William J. Moore +11 more
2004Journal of Medicinal Chemistry64 citations Open access
Semantic Scholar
Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides.
William J. Moore, J. Kern, R. Bhat, T. Commons +11 more
2009Journal of Medicinal Chemistry55 citations Open access
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Pyridobenzodiazepines: a novel class of orally active, vasopressin V2 receptor selective agonists.
A. Failli, J. Shumsky, R. Steffan, T. Caggiano +8 more
2006Bioorganic & Medicinal Chemistry Letters40 citations Open access
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Synthesis and activity of a new class of dual acting norepinephrine and serotonin reuptake inhibitors: 3-(1H-indol-1-yl)-3-arylpropan-1-amines.
P. Mahaney, A. Vu, C. McComas, Pu-Wen Zhang +7 more
2006Bioorganic & Medicinal Chemistry30 citations
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Synthesis and activity of a new class of pathway-selective estrogen receptor ligands: hydroxybenzoyl-3,4-dihydroquinoxalin-2(1H)-ones.
P. Mahaney, M. Webb, F. Ye, J. Sabatucci +4 more
2006Bioorganic & Medicinal Chemistry30 citations
Semantic Scholar
Dual acting norepinephrine reuptake inhibitors and 5-HT(2A) receptor antagonists: Identification, synthesis and activity of novel 4-aminoethyl-3-(phenylsulfonyl)-1H-indoles.
G. Heffernan, R. Coghlan, E. Manas, R. Mcdevitt +13 more
2009Bioorganic & Medicinal Chemistry28 citations Open access
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Synthesis and evaluation of azabicyclo[3.2.1]octane derivatives as potent mixed vasopressin antagonists.
Aimee L. Crombie, T. Antrilli, Brandon Campbell, D. Crandall +6 more
2010Bioorganic & Medicinal Chemistry Letters25 citations Open access
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1- or 3-(3-Amino-2-hydroxy-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones: potent, selective, and orally efficacious norepinephrine reuptake inhibitors.
Pu-Wen Zhang, Eugene A. Terefenko, Jenifer A. Bray, D. Deecher +11 more
2009Journal of Medicinal Chemistry23 citations Open access
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Selective Kv1.5 blockers: development of (R)-1-(methylsulfonylamino)-3-[2-(4-methoxyphenyl)ethyl]-4-(4-methoxyphenyl)-2-imidazolidinone (KVI-020/WYE-160020) as a potential treatment for atrial arrhythmia.
B. Blass, Andrew Fensome, E. Trybulski, R. Magolda +10 more
2009Journal of Medicinal Chemistry22 citations Open access
Semantic Scholar
Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides: part II.
William J. Moore, J. Kern, R. Bhat, P. Bodine +6 more
2010Bioorganic & Medicinal Chemistry21 citations Open access
Semantic Scholar
Discovery of novel selective norepinephrine reuptake inhibitors: 4-[3-aryl-2,2-dioxido-2,1,3-benzothiadiazol-1(3H)-yl]-1-(methylamino)butan-2-ols (WYE-103231).
D. O'Neill, A. Adedoyin, P. Alfinito, Jenifer A. Bray +13 more
2010Journal of Medicinal Chemistry18 citations Open access
Semantic Scholar
Structure-activity relationships of the cycloalkanol ethylamine scaffold: discovery of selective norepinephrine reuptake inhibitors.
P. Mahaney, L. K. Gavrin, E. Trybulski, G. Stack +20 more
2008Journal of Medicinal Chemistry17 citations Open access
Semantic Scholar
5-(3-Cyclopentyl-2-thioxo-2,3-dihydro-1H-benzimidazol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile: A novel, highly potent, selective, and orally active non-steroidal progesterone receptor agonist.
Pu-Wen Zhang, Eugene A. Terefenko, J. Kern, Andrew Fensome +9 more
2007Bioorganic & Medicinal Chemistry17 citations Open access
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1-(Indolin-1-yl)-1-phenyl-3-propan-2-olamines as potent and selective norepinephrine reuptake inhibitors.
A. Vu, S. T. Cohn, Pu-Wen Zhang, Callain Y Kim +12 more
2010Journal of Medicinal Chemistry16 citations Open access
Semantic Scholar
Quinidine preferentially blocks the slow delayed rectifier potassium channel in the rested state.
Jian-An Yao, E. Trybulski, Gea-Ny Tseng
1996Journal of Pharmacology and Experimental Therapeutics16 citations
Semantic Scholar
WAY‐318068: a novel, potent and selective noradrenaline re‐uptake inhibitor with activity in rodent models of pain and depression
G. Whiteside, J. Dwyer, J. Harrison, C. Beyer +18 more
2010British Journal of Pharmacology15 citations Open access
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Control of chronic inflammation with pathway selective estrogen receptor ligands.
R. Steffan, E. Matelan, M. Ashwell, William J. Moore +12 more
2006Current Topics in Medicinal Chemistry15 citations
Semantic Scholar
2-Benzazepines. 9. Synthesis and chemistry of 3H-2-benzazepine and pyrimido[4,5-d][2]benzazepine derivatives
E. Trybulski, R. Fryer, E. Reeder, S. Vitone +1 more
198615 citations
Semantic Scholar
2-benzazepines. 5. Synthesis of pyrimido[5,4-d][2]benzazepines and their evaluation as anxiolytic agents.
E. Trybulski, L. E. Benjamin, J. V. Earley, R. Fryer +6 more
1983Journal of Medicinal Chemistry15 citations
Semantic Scholar
2-Benzazepines. I. Synthesis of 2-benzazepin-4-ones and -5-ones via 2-acetylenic benzophenones
E. Trybulski, E. Reeder, J. Blount, A. Walser +1 more
198215 citations
Semantic Scholar
Estrogen receptor dependent inhibitors of NF-kappaB transcriptional activation-1 synthesis and biological evaluation of substituted 2-cyanopropanoic acid derivatives: pathway selective inhibitors of NF-kappaB, a potential treatment for rheumatoid arthritis.
T. Caggiano, A. Brazzale, D. Ho, C. Kraml +8 more
2007Journal of Medicinal Chemistry13 citations Open access
Semantic Scholar
3-(Arylamino)-3-phenylpropan-2-olamines as a new series of dual norepinephrine and serotonin reuptake inhibitors.
A. Vu, S. T. Cohn, Eugene A. Terefenko, William J. Moore +9 more
2009Bioorganic & Medicinal Chemistry Letters12 citations Open access
Semantic Scholar
Desvenlafaxine Succinate Identifies Novel Antagonist Binding Determinants in the Human Norepinephrine Transporter
John N. Mason, D. Deecher, Rhonda L. Richmond, G. Stack +4 more
2007Journal of Pharmacology and Experimental Therapeutics12 citations
Semantic Scholar
Chapter 16. Vasopressin receptor modulators: From non-peptide antagonists to agonists
E. Trybulski
200112 citations
Semantic Scholar
Discovery of a new series of monoamine reuptake inhibitors, the 1-amino-3-(1H-indol-1-yl)-3-phenylpropan-2-ols.
Callain Y Kim, P. Mahaney, O. Mcconnell, Yingru Zhang +4 more
2009Bioorganic & Medicinal Chemistry Letters11 citations Open access
Semantic Scholar
Discovery of novel selective norepinephrine inhibitors: 1-(2-morpholin-2-ylethyl)-3-aryl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxides (WYE-114152).
D. O'Neill, A. Adedoyin, Jenifer A. Bray, D. Deecher +15 more
2011Journal of Medicinal Chemistry10 citations Open access
Semantic Scholar
1-Methyl-1H-pyrrole-2-carbonitrile containing tetrahydronaphthalene derivatives as non-steroidal progesterone receptor antagonists.
J. Kern, Eugene A. Terefenko, E. Trybulski, T. Berrodin +6 more
2010Bioorganic & Medicinal Chemistry Letters10 citations Open access
Semantic Scholar
5-Aryl indanones and derivatives as non-steroidal progesterone receptor modulators.
J. Kern, Eugene A. Terefenko, E. Trybulski, T. Berrodin +6 more
2009Bioorganic & Medicinal Chemistry Letters10 citations Open access
Semantic Scholar
Structure-activity relationships of the 1-amino-3-(1H-indol-1-yl)-3-phenylpropan-2-ol series of monoamine reuptake inhibitors.
P. Mahaney, Callain Y Kim, R. Coghlan, S. T. Cohn +11 more
2009Bioorganic & Medicinal Chemistry Letters10 citations Open access
Semantic Scholar
Synthesis and activity of novel 1- or 3-(3-amino-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones as selective norepinephrine reuptake inhibitors.
Pu-Wen Zhang, Eugene A. Terefenko, C. McComas, P. Mahaney +6 more
2008Bioorganic & Medicinal Chemistry Letters10 citations Open access
Semantic Scholar
Identification and synthesis of major metabolites of Vasopressin V2-receptor agonist WAY-151932, and antagonist, Lixivaptan.
A. Molinari, E. Trybulski, J. Bagli, Susan Croce +6 more
2007Bioorganic & Medicinal Chemistry Letters10 citations Open access
Semantic Scholar
Synthesis and activity of 1-(3-amino-1-phenylpropyl)indolin-2-ones: a new class of selective norepinephrine reuptake inhibitors.
C. McComas, A. Vu, P. Mahaney, S. T. Cohn +11 more
2008Bioorganic & Medicinal Chemistry Letters9 citations Open access
Semantic Scholar
A SYNTHETIC APPROACH TO THE SKELETON OF HISTRIONICOTOXIN
J. Tufariello, E. Trybulski
19759 citations
Semantic Scholar
Heterocyclic cycloalkanol ethylamines as norepinephrine reuptake inhibitors.
J. Sabatucci, P. Mahaney, J. Leiter, G. Johnston +6 more
2010Bioorganic & Medicinal Chemistry Letters7 citations Open access
Semantic Scholar
Structure-activity relationships of norepinephrine reuptake inhibitors with benzothiadiazine dioxide or dihydrosulfostyril cores.
Andrew Fensome, Joel A. Goldberg, C. McComas, E. Trybulski +4 more
2010Bioorganic & Medicinal Chemistry Letters7 citations Open access
Semantic Scholar
Substituted 4-hydroxyphenyl sulfonamides as pathway-selective estrogen receptor ligands.
J. Sabatucci, M. Ashwell, E. Trybulski, M. O’Donnell +3 more
2006Bioorganic & Medicinal Chemistry Letters7 citations Open access
Semantic Scholar
The synthesis of 4H‐imidazo[5,1‐c][1,4]benzothiazine derivatives
R. Fryer, R. Lauer, E. Trybulski, S. Vitone +2 more
19837 citations
Semantic Scholar
Quinazolines and 1,4-benzodiazepines. 88. Synthesis and rearrangement of 3,4,5,6-tetrahydro-3H-imidazo[1,5-a][1,4]benzodiazepines
R. Fryer, J. Blount, E. Reeder, E. Trybulski +1 more
19787 citations
Semantic Scholar
The synthesis and structure activity relationships of enantiomerically pure hydroxylated oxotremorine derivatives
E. Trybulski, R. Kramss, R. Mangano, H. Brabander +1 more
19926 citations
Semantic Scholar
A new protecting group for the carbonyl function
E. J. Corey, E. Trybulski, J. Suggs
19776 citations
Semantic Scholar
TOTAL SYNTHESIS OF ERYTHROMYCINS. 4. TOTAL SYNTHESIS OF ERYTHRONOLIDE B
E. J. Corey, Sunggak Kim, S. Yoo, K. Nicolaou +6 more
19784 citations
Semantic Scholar
Discovery of WAY-260022, a Potent and Selective Inhibitor of the Norepinephrine Transporter.
L. K. Gavrin, P. Mahaney, D. Jenkins, L. Nogle +11 more
2010ACS Medicinal Chemistry Letters3 citations Open access
Semantic Scholar
QUINAZOLINES AND 1,4‐BENZODIAZEPINES. 91. STRUCTURE‐ACTIVITY RELATIONSHIP BETWEEN SUBSTITUTED 2‐AMINO‐N‐(2‐BENZOYL‐4‐CHLOROPHENYL)ACETAMIDES AND 1,4‐BENZODIAZEPINONES
R. Fryer, W. Leimgruber, E. Trybulski
20023 citations
Semantic Scholar
Anti-arrhythmic agents
E. Trybulski
19971 citations
Semantic Scholar
2-BENZAZEPINES. (1,2,3)TRIAZOLO(4,5-D)(2)BENZAZEPINES AND DIBENZO(C,F)(1,2,3)TRIAZOLO(3,4-A)AZEPINES. SYNTHESIS AND EVALUATION AS CENTRAL NERVOUS SYSTEM AGENTS
E. Trybulski, L. E. Benjamin, S. Vitone, A. Walser +1 more
19831 citations
Semantic Scholar
JPET # 125716 1 DESVENLAFAXINE SUCCINATE ( DVS ) IDENTIFIES NOVEL ANTAGONIST BINDING DETERMINANTS IN THE HUMAN NOREPINEPHRINE TRANSPORTER
John N. Mason, D. Deecher, Rhonda L. Richmond, G. Stack +4 more
20070 citations
Semantic Scholar

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