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M. Varasi · SciRah

Researcher profile · Semantic Scholar

M. Varasi

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M. Varasi — researcher profile on SciRah

h-index: 35
Works: 169
Citations: 3,715

Most-cited papers

1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: identification of a potent Aurora kinase inhibitor with a favorable antitumor kinase inhibition profile.
D. Fancelli, J. Moll, M. Varasi, R. Bravo +21 more
2006Journal of Medicinal Chemistry183 citations Open access
Semantic Scholar
PHA-680632, a Novel Aurora Kinase Inhibitor with Potent Antitumoral Activity
C. Soncini, P. Carpinelli, L. Gianellini, D. Fancelli +14 more
2006Clinical Cancer Research170 citations Open access
Semantic Scholar
3-Aminopyrazole inhibitors of CDK2/cyclin A as antitumor agents. 1. Lead finding.
P. Pevarello, M. Brasca, R. Amici, P. Orsini +26 more
2004Journal of Medicinal Chemistry161 citations Open access
Semantic Scholar
Potent and selective Aurora inhibitors identified by the expansion of a novel scaffold for protein kinase inhibition.
D. Fancelli, D. Berta, S. Bindi, A. Cameron +19 more
2005Journal of Medicinal Chemistry136 citations Open access
Semantic Scholar
High-throughput NMR-based screening with competition binding experiments.
C. Dalvit, M. Flocco, S. Knapp, M. Mostardini +4 more
2002Journal of the American Chemical Society130 citations
Semantic Scholar
3-Aminopyrazole inhibitors of CDK2/cyclin A as antitumor agents. 2. Lead optimization.
P. Pevarello, M. Brasca, P. Orsini, G. Traquandi +18 more
2005Journal of Medicinal Chemistry103 citations Open access
Semantic Scholar
Toward Highly Potent Cancer Agents by Modulating the C-2 Group of the Arylthioindole Class of Tubulin Polymerization Inhibitors
G. La Regina, Ruo-Li Bai, Whilelmina Maria Rensen, Erica Di Cesare +28 more
2012Journal of Medicinal Chemistry100 citations Open access
Semantic Scholar
Biochemical and electrophysiological studies on the mechanism of action of PNU-151774E, a novel antiepileptic compound.
Patricia Salvati, Roberto Maj, C. Caccia, M. A. Cervini +11 more
1999Journal of Pharmacology and Experimental Therapeutics87 citations
Semantic Scholar
Cdc7 kinase inhibitors: pyrrolopyridinones as potential antitumor agents. 1. Synthesis and structure-activity relationships.
E. Vanotti, R. Amici, A. Bargiotti, J. Berthelsen +20 more
2008Journal of Medicinal Chemistry86 citations Open access
Semantic Scholar
Kynurenergic manipulations influence excitatory synaptic function and excitotoxic vulnerability in the rat hippocampus in vivo.
Hui Wu, P. Guidetti, J. Goodman, M. Varasi +4 more
2000Neuroscience79 citations
Semantic Scholar
New Pyrrole Derivatives with Potent Tubulin Polymerization Inhibiting Activity As Anticancer Agents Including Hedgehog-Dependent Cancer
G. La Regina, Ruo-Li Bai, Antonio Coluccia, Valeria Famiglini +21 more
2014Journal of Medicinal Chemistry76 citations Open access
Semantic Scholar
Design and Synthesis of 2-Heterocyclyl-3-arylthio-1H-indoles as Potent Tubulin Polymerization and Cell Growth Inhibitors with Improved Metabolic Stability
G. La Regina, Ruo-Li Bai, W. Rensen, Antonio Coluccia +20 more
2011Journal of Medicinal Chemistry73 citations Open access
Semantic Scholar
Cinnamic anilides as new mitochondrial permeability transition pore inhibitors endowed with ischemia-reperfusion injury protective effect in vivo.
D. Fancelli, Agnese Abate, R. Amici, P. Bernardi +18 more
2014Journal of Medicinal Chemistry72 citations
Semantic Scholar
Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent.
P. Vianello, O. Botrugno, Anna Cappa, R. dal Zuffo +13 more
2016Journal of Medicinal Chemistry71 citations Open access
Semantic Scholar
Targeting the scaffolding role of LSD1 (KDM1A) poises acute myeloid leukemia cells for retinoic acid–induced differentiation
R. Ravasio, E. Ceccacci, L. Nicosia, A. Hosseini +13 more
2020Science Advances68 citations Open access
Semantic Scholar
First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery.
M. Menichincheri, A. Bargiotti, J. Berthelsen, J. Bertrand +28 more
2009Journal of Medicinal Chemistry67 citations Open access
Semantic Scholar
Optimization of 6,6-dimethyl pyrrolo[3,4-c]pyrazoles: Identification of PHA-793887, a potent CDK inhibitor suitable for intravenous dosing.
M. Brasca, C. Albanese, R. Alzani, R. Amici +19 more
2010Bioorganic & Medicinal Chemistry66 citations Open access
Semantic Scholar
Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 1: High-Throughput Screening and Preliminary Exploration.
Luca Sartori, C. Mercurio, Federica Amigoni, Anna Cappa +22 more
2017Journal of Medicinal Chemistry65 citations Open access
Semantic Scholar
Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship.
P. Vianello, Luca Sartori, Federica Amigoni, Anna Cappa +20 more
2017Journal of Medicinal Chemistry64 citations Open access
Semantic Scholar
Cdc7 kinase inhibitors: 5-heteroaryl-3-carboxamido-2-aryl pyrroles as potential antitumor agents. 1. Lead finding.
M. Menichincheri, C. Albanese, C. Alli, D. Ballinari +33 more
2010Journal of Medicinal Chemistry64 citations Open access
Semantic Scholar
Synthesis, biological activity and mechanistic insights of 1-substituted cyclopropylamine derivatives: a novel class of irreversible inhibitors of histone demethylase KDM1A.
P. Vianello, O. Botrugno, Anna Cappa, G. Ciossani +12 more
2014European journal of medicinal chemistry55 citations Open access
Semantic Scholar
PP2A Controls Genome Integrity by Integrating Nutrient-Sensing and Metabolic Pathways with the DNA Damage Response
Elisa Ferrari, Christopher Bruhn, M. Peretti, Corinne Cassani +9 more
2017Molecules and Cells54 citations Open access
Semantic Scholar
Discovery of a Novel Hsp90 Inhibitor by Fragment Linking
J. Barker, Oliver Barker, S. M. Courtney, Mihaly Gardiner +8 more
2010ChemMedChem54 citations
Semantic Scholar
Discovery, synthesis, and pharmacological evaluation of spiropiperidine hydroxamic acid based derivatives as structurally novel histone deacetylase (HDAC) inhibitors.
M. Varasi, F. Thaler, Agnese Abate, C. Bigogno +10 more
2011Journal of Medicinal Chemistry50 citations Open access
Semantic Scholar
Fragment‐based Identification of Hsp90 Inhibitors
J. Barker, Oliver Barker, R. Boggio, V. Chauhan +22 more
2009ChemMedChem50 citations
Semantic Scholar
3-Amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: a new class of CDK2 inhibitors.
P. Pevarello, D. Fancelli, A. Vulpetti, R. Amici +10 more
2006Bioorganic & Medicinal Chemistry Letters48 citations Open access
Semantic Scholar
Ergoline derivatives: receptor affinity and selectivity.
S. Mantegani, E. Brambilla, M. Varasi
1999Il Farmaco48 citations
Semantic Scholar
New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer
G. La Regina, Ruo-Li Bai, Antonio Coluccia, Valeria Famiglini +29 more
2015Journal of Medicinal Chemistry47 citations Open access
Semantic Scholar
A new glycociamidine ring precursor: syntheses of (Z)-hymenialdisine, (Z)-2-debromohymenialdisine, and (+/-)-endo-2-debromohymenialdisine.
G. Papeo, Helena Posteri, D. Borghi, M. Varasi
2005Organic Letters40 citations
Semantic Scholar
LSD1-directed therapy affects glioblastoma tumorigenicity by deregulating the protective ATF4-dependent integrated stress response
S. Faletti, D. Osti, E. Ceccacci, C. Richichi +18 more
2021Science Translational Medicine39 citations Open access
Semantic Scholar
GTF2I dosage regulates neuronal differentiation and social behavior in 7q11.23 neurodevelopmental disorders
Alejandro López-Tóbon, R. Shyti, C. E. Villa, C. Cheroni +14 more
2022bioRxiv35 citations Open access
Semantic Scholar
Synthesis and biological evaluation of N-hydroxyphenylacrylamides and N-hydroxypyridin-2-ylacrylamides as novel histone deacetylase inhibitors.
F. Thaler, Andrea Colombo, A. Mai, R. Amici +19 more
2010Journal of Medicinal Chemistry34 citations Open access
Semantic Scholar
New 6- and 7-heterocyclyl-1H-indole derivatives as potent tubulin assembly and cancer cell growth inhibitors.
G. La Regina, Ruo-Li Bai, Antonio Coluccia, Valentina Naccarato +16 more
2018European journal of medicinal chemistry33 citations Open access
Semantic Scholar
Tuning mTORC1 activity dictates the response of acute myeloid leukemia to LSD1 inhibition
Amal Kamal Abdel-Aziz, I. Pallavicini, E. Ceccacci, G. Meroni +3 more
2019Haematologica31 citations Open access
Semantic Scholar
Modulation of the kynurine pathway of tryptophan metabolism in search for neuroprotective agents. Focus on kynurenine-3-hydroxylase.
R. Pellicciari, Laura Amori, G. Costantino, A. Giordani +5 more
2003Advances in Experimental Medicine and Biology31 citations
Semantic Scholar
Pure enantiomers of benzoylamino-tranylcypromine: LSD1 inhibition, gene modulation in human leukemia cells and effects on clonogenic potential of murine promyelocytic blasts.
S. Valente, V. Rodriguez, C. Mercurio, P. Vianello +14 more
2015European journal of medicinal chemistry30 citations Open access
Semantic Scholar
Synthesis, biological characterization and molecular modeling insights of spirochromanes as potent HDAC inhibitors.
F. Thaler, L. Moretti, R. Amici, Agnese Abate +10 more
2016European journal of medicinal chemistry29 citations Open access
Semantic Scholar
Tranylcypromine-based LSD1 Inhibitors: Structure-Activity Relationship, Antiproliferative Effect in Leukemias and Gene Target Modulation
R. Fioravanti, Annalisa Romanelli, Nicola Mautone, Elisabetta Di Bello +16 more
2020ChemMedChem26 citations Open access
Semantic Scholar
Thieno[3,2-c]pyrazoles: a novel class of Aurora inhibitors with favorable antitumor activity.
S. Bindi, D. Fancelli, C. Alli, D. Berta +22 more
2010Bioorganic & Medicinal Chemistry26 citations Open access
Semantic Scholar
Total synthesis of (±)-cyclooroidin
G. Papeo, Maria Antonia Gomez-Zurita Frau, D. Borghi, M. Varasi
200526 citations
Semantic Scholar
Further insights into the SAR of α-substituted cyclopropylamine derivatives as inhibitors of histone demethylase KDM1A.
M. Pieroni, Giannamaria Annunziato, Elisa Azzali, P. Dessanti +8 more
2015European journal of medicinal chemistry25 citations Open access
Semantic Scholar
6‐Substituted Pyrrolo[3,4‐c]pyrazoles: An Improved Class of CDK2 Inhibitors
Maria Gabriella Brasca, C. Albanese, R. Amici, D. Ballinari +17 more
2007ChemMedChem25 citations
Semantic Scholar
High-throughput screening identifies histone deacetylase inhibitors that modulate GTF2I expression in 7q11.23 microduplication autism spectrum disorder patient-derived cortical neurons
F. Cavallo, Flavia Troglio, G. Fagà, D. Fancelli +15 more
2020Molecular Autism23 citations Open access
Semantic Scholar
Pyrrole- and indole-containing tranylcypromine derivatives as novel lysine-specific demethylase 1 inhibitors active on cancer cells
V. Rodriguez, S. Valente, S. Rovida, D. Rotili +11 more
201523 citations
Semantic Scholar
Anticonvulsant Activity of PNU‐151774E 1 in the Amygdala Kindled Model of Complex Partial Seizures
R. Maj, R. Fariello, P. Pevarello, M. Varasi +2 more
1999Epilepsia22 citations Open access
Semantic Scholar
Pure Diastereomers of a Tranylcypromine-Based LSD1 Inhibitor: Enzyme Selectivity and In-Cell Studies.
S. Valente, V. Rodriguez, C. Mercurio, P. Vianello +12 more
2015ACS Medicinal Chemistry Letters19 citations Open access
Semantic Scholar
Nicotinoyl azide (NCA)-mediated Mitsunobu reaction: An expedient one-pot transformation of alcohols into azides
G. Papeo, Helena Posteri, P. Vianello, M. Varasi
200418 citations
Semantic Scholar
Discovery of Reversible Inhibitors of KDM1A Efficacious in Acute Myeloid Leukemia Models.
Alessia Romussi, Anna Cappa, P. Vianello, S. Brambillasca +16 more
2020ACS Medicinal Chemistry Letters17 citations Open access
Semantic Scholar
Caloric restriction leads to druggable LSD1-dependent cancer stem cells expansion
Rani Pallavi, Elena Gatti, Tiphanie Durfort, Massimo Stendardo +20 more
2024Nature Communications15 citations Open access
Semantic Scholar
Novel pyridine-containing histone deacetylase inhibitors strongly arrest proliferation, induce apoptosis and modulate miRNAs in cancer cells.
Elisabetta Di Bello, Veronica Sian, Giulio Bontempi, Clemens Zwergel +15 more
2022European journal of medicinal chemistry15 citations Open access
Semantic Scholar

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