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D. Rotili · SciRah

Researcher profile · Semantic Scholar

D. Rotili

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D. Rotili — researcher profile on SciRah

h-index: 51
Works: 238
Citations: 8,284

Most-cited papers

SIRT6 Protects Against Lipopolysaccharide-Induced Inflammation in Human Pulmonary Lung Microvascular Endothelial Cells
Jin-Ping Wang, Jin-Que Luo, D. Rotili, A. Mai +3 more
2023Inflammation155 citations
Semantic Scholar
Metabolic Rewiring by Loss of Sirt5 Promotes Kras-induced Pancreatic Cancer Progression
Tuo Hu, S. Shukla, E. Vernucci, Chun-Bo He +27 more
2021Gastroenterology122 citations Open access
Semantic Scholar
Epigenetic Polypharmacology: A New Frontier for Epi-Drug Discovery
Daniela Tomaselli, Alessia Lucidi, D. Rotili, A. Mai
2019Medicinal research reviews (Print)95 citations Open access
Semantic Scholar
METTL3 from Target Validation to the First Small-Molecule Inhibitors: A Medicinal Chemistry Journey
Francesco Fiorentino, Martina Menna, D. Rotili, S. Valente +1 more
2023Journal of Medicinal Chemistry87 citations Open access
Semantic Scholar
GreenMedChem- the challenge in the next decade toward eco-friendly compounds and processes in drug design
Carola Castiello, Pierre Junghanns, Annika Mergel, Claus Jacob +6 more
2023Green Chemistry80 citations Open access
Semantic Scholar
Emerging Therapeutic Potential of SIRT6 Modulators
F. Fiorentino, A. Mai, D. Rotili
2021Journal of Medicinal Chemistry73 citations Open access
Semantic Scholar
Sirt4: A Multifaceted Enzyme at the Crossroads of Mitochondrial Metabolism and Cancer
Daniela Tomaselli, C. Steegborn, A. Mai, D. Rotili
2020Frontiers in Oncology72 citations Open access
Semantic Scholar
The Two-Faced Role of SIRT6 in Cancer
F. Fiorentino, V. Carafa, G. Favale, L. Altucci +2 more
2021Cancers69 citations Open access
Semantic Scholar
Histone deacetylase inhibitors exert anti-tumor effects on human adherent and stem-like glioma cells
H. Waś, S. Król, D. Rotili, A. Mai +3 more
2019Clinical Epigenetics68 citations Open access
Semantic Scholar
Emerging Roles of SIRT5 in Metabolism, Cancer, and SARS-CoV-2 Infection
Emanuele Fabbrizi, Francesco Fiorentino, V. Carafa, L. Altucci +2 more
2023Cells64 citations Open access
Semantic Scholar
Therapeutic Potential and Activity Modulation of the Protein Lysine Deacylase Sirtuin 5
Francesco Fiorentino, Carola Castiello, A. Mai, D. Rotili
2022Journal of Medicinal Chemistry58 citations Open access
Semantic Scholar
Gold Nanoparticles and Nanorods in Nuclear Medicine: A Mini Review
D. Maccora, Valentina Dini, C. Battocchio, I. Fratoddi +8 more
2019Applied Sciences57 citations Open access
Semantic Scholar
Identification of novel quinazoline derivatives as potent antiplasmodial agents.
Anne Bouchut, D. Rotili, C. Pierrot, S. Valente +13 more
2019European journal of medicinal chemistry55 citations Open access
Semantic Scholar
Sirtuin modulators: where are we now? A review of patents from 2015 to 2019
Nicola Mautone, Clemens Zwergel, A. Mai, D. Rotili
2020Expert Opinion on Therapeutic Patents49 citations
Semantic Scholar
Sirtuin modulators: past, present, and future perspectives.
Francesco Fiorentino, Nicola Mautone, Martina Menna, Francesca D’Acunzo +2 more
2022Future Medicinal Chemistry46 citations Open access
Semantic Scholar
Targeting histone acetylation/deacetylation in parasites: an update (2017-2020).
R. Fioravanti, Nicola Mautone, Annarita Rovere, D. Rotili +1 more
2020Current Opinion in Chemical Biology46 citations
Semantic Scholar
Neuroprotective Effects of PARP Inhibitors in Drosophila Models of Alzheimer’s Disease
A. Maggiore, A. M. Casale, Walter Toscanelli, U. Cappucci +6 more
2022Cells40 citations Open access
Semantic Scholar
Inhibition of Histone Demethylases LSD1 and UTX Regulates ERα Signaling in Breast Cancer
R. Benedetti, C. Dell'Aversana, Tommaso de Marchi, D. Rotili +18 more
2019Cancers35 citations Open access
Semantic Scholar
SIRT5 Inhibition Induces Brown Fat-Like Phenotype in 3T3-L1 Preadipocytes
F. Molinari, A. Feraco, Simone Mirabilii, Serena Saladini +12 more
2021Cells33 citations Open access
Semantic Scholar
M6A reduction relieves FUS-associated ALS granules
G. Di Timoteo, A. Giuliani, A. Setti, Martina C. Biagi +12 more
2023bioRxiv31 citations Open access
Semantic Scholar
CDK9 as a Valuable Target in Cancer: From Natural Compounds Inhibitors to Current Treatment in Pediatric Soft Tissue Sarcomas
M. Cassandri, R. Fioravanti, S. Pomella, S. Valente +5 more
2020Frontiers in Pharmacology31 citations Open access
Semantic Scholar
Targeting of H19/cell adhesion molecules circuitry by GSK-J4 epidrug inhibits metastatic progression in prostate cancer
V. Pecci, Fabiola Troisi, A. Aiello, S. De Martino +16 more
2024Cancer Cell International27 citations Open access
Semantic Scholar
Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models.
Martina Menna, Francesco Fiorentino, B. Marrocco, Alessia Lucidi +18 more
2022European journal of medicinal chemistry27 citations Open access
Semantic Scholar
Activation and inhibition of sirtuins: From bench to bedside
Francesco Fiorentino, Emanuele Fabbrizi, A. Mai, D. Rotili
2024Medicinal research reviews (Print)26 citations Open access
Semantic Scholar
Tranylcypromine-based LSD1 Inhibitors: Structure-Activity Relationship, Antiproliferative Effect in Leukemias and Gene Target Modulation
R. Fioravanti, Annalisa Romanelli, Nicola Mautone, Elisabetta Di Bello +16 more
2020ChemMedChem26 citations Open access
Semantic Scholar
Lysine Acetyltransferase Inhibitors From Natural Sources
F. Fiorentino, A. Mai, D. Rotili
2020Frontiers in Pharmacology26 citations Open access
Semantic Scholar
H19-Dependent Transcriptional Regulation of β3 and β4 Integrins Upon Estrogen and Hypoxia Favors Metastatic Potential in Prostate Cancer
Lorenza Bacci, A. Aiello, C. Ripoli, Rossella Loria +12 more
2019International Journal of Molecular Sciences26 citations Open access
Semantic Scholar
Native mass spectrometry-directed drug discovery: recent advances in investigating protein function and modulation.
Francesco Fiorentino, D. Rotili, A. Mai
2023Drug Discovery Today24 citations Open access
Semantic Scholar
Structure-based mechanism of riboregulation of the metabolic enzyme SHMT1.
S. Spizzichino, Federica Di Fonzo, Chiara Marabelli, A. Tramonti +23 more
2024Molecules and Cells21 citations Open access
Semantic Scholar
The α-tubulin acetyltransferase ATAT1: structure, cellular functions, and its emerging role in human diseases
Angela Iuzzolino, F. Pellegrini, D. Rotili, Francesca Degrassi +1 more
2024Cellular and Molecular Life Sciences21 citations Open access
Semantic Scholar
Enhancing sensitivity of triple‐negative breast cancer to DNA‐damaging therapy through chemical inhibition of the m6A methyltransferase METTL3
Bianca Cesaro, Alessia Iaiza, Fabio Piscopo, Marco Tarullo +14 more
2023Cancer Communications21 citations Open access
Semantic Scholar
Effects of Structurally Different HDAC Inhibitors against Trypanosoma cruzi, Leishmania, and Schistosoma mansoni
Elisabetta Di Bello, Beatrice Noce, R. Fioravanti, Clemens Zwergel +12 more
2022ACS Infectious Diseases21 citations Open access
Semantic Scholar
A potent HDAC inhibitor blocks Toxoplasma gondii tachyzoite growth and profoundly disrupts parasite gene expression.
Thomas Mouveaux, D. Rotili, Tom Boissavy, E. Roger +3 more
2022International Journal of Antimicrobial Agents21 citations Open access
Semantic Scholar
Novel 1,4-Dihydropyridines as Specific Binders and Activators of SIRT3 Impair Cell Viability and Clonogenicity and Downregulate Hypoxia-Induced Targets in Cancer Cells
Clemens Zwergel, Michele Aventaggiato, Sabrina Garbo, Elisabetta Di Bello +17 more
2023Journal of Medicinal Chemistry20 citations Open access
Semantic Scholar
Biochemical Functions and Clinical Characterizations of the Sirtuins in Diabetes-Induced Retinal Pathologies
S. Taurone, C. De Ponte, D. Rotili, Elena De Santis +5 more
2022International Journal of Molecular Sciences20 citations Open access
Semantic Scholar
Hydrophilic Gold Nanoparticles as Anti‐PD‐L1 Antibody Carriers: Synthesis and Interface Properties
I. Venditti, A. Cartoni, S. Cerra, Raoul Fioravanti +20 more
2022Particle & particle systems characterization20 citations
Semantic Scholar
First-in-Class Selective Inhibitors of the Lysine Acetyltransferase KAT8
Francesco Fiorentino, Sara Sementilli, Martina Menna, Federica Turrisi +15 more
2023Journal of Medicinal Chemistry19 citations Open access
Semantic Scholar
α,γ-Diketocarboxylic Acids and Their Esters Act as Carbonic Anhydrase IX and XII Selective Inhibitors.
A. Nocentini, Alessia Lucidi, F. Perut, A. Massa +6 more
2019ACS Medicinal Chemistry Letters19 citations Open access
Semantic Scholar
Pharmacological targeting of CBP/p300 drives a redox/autophagy axis leading to senescence-induced growth arrest in non-small cell lung cancer cells
Mohammad Salik Zeya Ansari, V. Stagni, Angela Iuzzolino, D. Rotili +5 more
2022Cancer Gene Therapy18 citations Open access
Semantic Scholar
Off-Target Inhibition of Human Dihydroorotate Dehydrogenase (hDHODH) Highlights Challenges in the Development of Fat Mass and Obesity-Associated Protein (FTO) Inhibitors
Marco Tarullo, Guillermo Fernández-Rodríguez, Alessia Iaiza, S. Venezia +17 more
2024ACS Pharmacology & Translational Science16 citations Open access
Semantic Scholar
Regulatory Interplay between miR-181a-5p and Estrogen Receptor Signaling Cascade in Breast Cancer
R. Benedetti, Chiara Papulino, G. Sgueglia, U. Chianese +7 more
2021Cancers16 citations Open access
Semantic Scholar
Recent advances in epigenetic proteolysis targeting chimeras (Epi-PROTACs).
Daniela Tomaselli, Nicola Mautone, A. Mai, D. Rotili
2020European journal of medicinal chemistry16 citations Open access
Semantic Scholar
Molecular insights into RmcA-mediated c-di-GMP consumption: Linking redox potential to biofilm morphogenesis in Pseudomonas aeruginosa.
Chiara Scribani Rossi, Kelly N. Eckartt, Elisabetta Scarchilli, Simone Angeli +15 more
2023Microbiology Research15 citations Open access
Semantic Scholar
The Pan-Sirtuin Inhibitor MC2494 Regulates Mitochondrial Function in a Leukemia Cell Line
V. Carafa, R. Russo, Laura Della Torre, Francesca Cuomo +10 more
2020Frontiers in Oncology15 citations Open access
Semantic Scholar
Enzymatic and Biological Characterization of Novel Sirtuin Modulators against Cancer
V. Carafa, Angelita Poziello, Laura Della Torre, P. Giovannelli +10 more
2019International Journal of Molecular Sciences15 citations Open access
Semantic Scholar
Structure-Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from Schistosoma Mansoni (SmSirt2).
Daria Monaldi, D. Rotili, Julien Lancelot, M. Marek +8 more
2019Journal of Medicinal Chemistry15 citations Open access
Semantic Scholar
The role of structural biology in the design of sirtuin activators.
Francesco Fiorentino, A. Mai, D. Rotili
2023Current Opinion in Structural Biology14 citations Open access
Semantic Scholar
Quinoline-based compounds can inhibit diverse enzymes that act on DNA
Ju-Jun Zhou, Qin Chen, Ren Ren, Jie Yang +15 more
2024Cell Chemical Biology13 citations Open access
Semantic Scholar
Simultaneous administration of EZH2 and BET inhibitors inhibits proliferation and clonogenic ability of metastatic prostate cancer cells
Aide Negri, Marina Marozzi, D. Trisciuoglio, D. Rotili +2 more
2023Journal of Enzyme Inhibition and Medicinal Chemistry13 citations Open access
Semantic Scholar
Specific Inhibitors of Mitochondrial Deacylase Sirtuin 4 Endowed with Cellular Activity.
M. Pannek, Zayan Alhalabi, Daniela Tomaselli, Martina Menna +13 more
2024Journal of Medicinal Chemistry12 citations Open access
Semantic Scholar

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A. Mai — researcher profile on SciRah
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S. Valente×9
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Alessia Lucidi — researcher profile on SciRah

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Martina Menna — researcher profile on SciRah

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Nicola Mautone — researcher profile on SciRah