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Clemens Zwergel · SciRah

Researcher profile · Semantic Scholar

Clemens Zwergel

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Clemens Zwergel — researcher profile on SciRah

h-index: 32
Works: 108
Citations: 2,818

Most-cited papers

The emerging role of epigenetics in human autoimmune disorders
R. Mazzone, Clemens Zwergel, M. Artico, S. Taurone +3 more
2019Clinical Epigenetics248 citations Open access
Semantic Scholar
Epi-drugs in combination with immunotherapy: a new avenue to improve anticancer efficacy
R. Mazzone, Clemens Zwergel, A. Mai, S. Valente
2017Clinical Epigenetics141 citations Open access
Semantic Scholar
Six Years (2012–2018) of Researches on Catalytic EZH2 Inhibitors: The Boom of the 2-Pyridone Compounds
R. Fioravanti, G. Stazi, Clemens Zwergel, S. Valente +1 more
2018The chemical record101 citations Open access
Semantic Scholar
The Innovative Potential of Statins in Cancer: New Targets for New Therapies
Elisabetta Di Bello, Clemens Zwergel, A. Mai, S. Valente
2020Frontiers in Chemistry95 citations Open access
Semantic Scholar
m6A RNA methylation and beyond - the epigenetic machinery and potential treatment options.
Sabrina Garbo, Clemens Zwergel, Cecilia Battistelli
2021Drug Discovery Today86 citations Open access
Semantic Scholar
GreenMedChem- the challenge in the next decade toward eco-friendly compounds and processes in drug design
Carola Castiello, Pierre Junghanns, Annika Mergel, Claus Jacob +6 more
2023Green Chemistry80 citations Open access
Semantic Scholar
The innovative potential of selenium-containing agents for fighting cancer and viral infections.
Wesam Ali, R. Benedetti, J. Handzlik, Clemens Zwergel +1 more
2020Drug Discovery Today74 citations Open access
Semantic Scholar
Emerging approaches for histone deacetylase inhibitor drug discovery
Clemens Zwergel, S. Valente, C. Jacob, A. Mai
2015Expert Opinion on Drug Discovery73 citations
Semantic Scholar
1,4-Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells.
S. Valente, Paolo Mellini, Francesco Spallotta, V. Carafa +18 more
2016Journal of Medicinal Chemistry66 citations
Semantic Scholar
Design of First-in-Class Dual EZH2/HDAC Inhibitor: Biochemical Activity and Biological Evaluation in Cancer Cells.
Annalisa Romanelli, G. Stazi, R. Fioravanti, Clemens Zwergel +11 more
2020ACS Medicinal Chemistry Letters65 citations Open access
Semantic Scholar
Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells.
G. Di Pompo, Manuela Salerno, D. Rotili, S. Valente +5 more
2015Journal of Medicinal Chemistry63 citations Open access
Semantic Scholar
DNA Methyltransferases Inhibitors from Natural Sources.
Clemens Zwergel, S. Valente, A. Mai
2015Current Topics in Medicinal Chemistry60 citations
Semantic Scholar
SIRT3 Activation a Promise in Drug Development? New Insights into SIRT3 Biology and Its Implications on the Drug Discovery Process
Chiara Lambona, Clemens Zwergel, S. Valente, A. Mai
2024Journal of Medicinal Chemistry53 citations Open access
Semantic Scholar
Sirtuin modulators: where are we now? A review of patents from 2015 to 2019
Nicola Mautone, Clemens Zwergel, A. Mai, D. Rotili
2020Expert Opinion on Therapeutic Patents49 citations
Semantic Scholar
Selenium-Containing Agents Acting on Cancer—A New Hope?
Sabrina Garbo, S. Di Giacomo, D. Łażewska, Ewelina Honkisz-Orzechowska +4 more
2022Pharmaceutics47 citations Open access
Semantic Scholar
LSD1 inhibitors: a patent review (2010-2015)
G. Stazi, Clemens Zwergel, S. Valente, A. Mai
2016Expert Opinion on Therapeutic Patents46 citations
Semantic Scholar
Histone Deacetylase Inhibitors: Updated Studies in Various Epigenetic-Related Diseases
Clemens Zwergel, G. Stazi, S. Valente, A. Mai
201646 citations
Semantic Scholar
The histone methyltransferase EZH2 as a druggable target in SHH medulloblastoma cancer stem cells
E. Miele, S. Valente, Vincenzo Alfano, M. Silvano +16 more
2017OncoTarget44 citations Open access
Semantic Scholar
EZH2 inhibitors: a patent review (2014-2016)
G. Stazi, Clemens Zwergel, A. Mai, S. Valente
2017Expert Opinion on Therapeutic Patents43 citations
Semantic Scholar
Potent and specific activators for the mitochondrial Sirtuins Sirt3 and Sirt5
Benjamin Suenkel, S. Valente, Clemens Zwergel, S. Weiss +14 more
2022Journal of Medicinal Chemistry42 citations Open access
Semantic Scholar
Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction.
Daohai Du, Dandan Xu, Li-Cheng Zhu, G. Stazi +19 more
2021Journal of Medicinal Chemistry42 citations Open access
Semantic Scholar
Polycomb Repressive Complex 2 Modulation through the Development of EZH2–EED Interaction Inhibitors and EED Binders
Stefano Tomassi, Annalisa Romanelli, Clemens Zwergel, S. Valente +1 more
2021Journal of Medicinal Chemistry42 citations Open access
Semantic Scholar
Selenium-containing compounds: a new hope for innovative treatments in Alzheimer's disease and Parkinson's disease.
Patryk Pyka, Sabrina Garbo, Rossella Fioravanti, Claus Jacob +4 more
2024Drug Discovery Today40 citations Open access
Semantic Scholar
Advancements in Hydrazide-Based HDAC Inhibitors: A Review of Recent Developments and Therapeutic Potential
Alessia Raucci, Clemens Zwergel, S. Valente, A. Mai
2025Journal of Medicinal Chemistry37 citations Open access
Semantic Scholar
Identification of a novel quinoline-based DNA demethylating compound highly potent in cancer cells
Clemens Zwergel, M. Schnekenburger, Federica Sarno, Cecilia Battistelli +17 more
2019Clinical Epigenetics37 citations Open access
Semantic Scholar
Discovery of phenylselenoether-hydantoin hybrids as ABCB1 efflux pump modulating agents with cytotoxic and antiproliferative actions in resistant T-lymphoma.
Wesam Ali, Gabriella Spengler, Annamária Kincses, Márta Nové +11 more
2020European journal of medicinal chemistry35 citations Open access
Semantic Scholar
A Quinoline-Based DNA Methyltransferase Inhibitor as a Possible Adjuvant in Osteosarcoma Therapy
M. Manara, S. Valente, C. Cristalli, G. Nicoletti +12 more
2018Molecular Cancer Therapeutics35 citations Open access
Semantic Scholar
One‐Pot Synthesis of Benzopyran‐4‐ones with Cancer Preventive and Therapeutic Potential
Oualid Talhi, Lidia Brodziak-Jarosz, Jana Panning, Barbora Orlíková +12 more
201633 citations
Semantic Scholar
First-in-Class Selenium-Containing Potent Serotonin Receptor 5-HT6 Agents with a Beneficial Neuroprotective Profile against Alzheimer’s Disease
Patryk Pyka, Wawrzyniec Haberek, M. Więcek, Ewa Szymańska +32 more
2024Journal of Medicinal Chemistry32 citations Open access
Semantic Scholar
HDAC1 inhibition by MS-275 in mesothelial cells limits cellular invasion and promotes MMT reversal
Lúcia Rossi, Cecilia Battistelli, V. de Turris, Valeria Noce +11 more
2018Scientific Reports32 citations Open access
Semantic Scholar
MC1568 inhibits HDAC6/8 activity and influenza A virus replication in lung epithelial cells: role of Hsp90 acetylation.
Simona Panella, M. E. Marcocci, I. Celestino, S. Valente +6 more
2016Future Medicinal Chemistry31 citations
Semantic Scholar
Histone deacetylase inhibitors restore IL-10 expression in lipopolysaccharide-induced cell inflammation and reduce IL-1β and IL-6 production in breast silicone implant in C57BL/6J wild-type murine model
R. Di Liddo, S. Valente, S. Taurone, Clemens Zwergel +8 more
2016Autoimmunity30 citations Open access
Semantic Scholar
Tranylcypromine-based LSD1 Inhibitors: Structure-Activity Relationship, Antiproliferative Effect in Leukemias and Gene Target Modulation
R. Fioravanti, Annalisa Romanelli, Nicola Mautone, Elisabetta Di Bello +16 more
2020ChemMedChem26 citations Open access
Semantic Scholar
Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells.
G. Stazi, Cecilia Battistelli, V. Piano, R. Mazzone +19 more
2019European journal of medicinal chemistry26 citations
Semantic Scholar
Novel coumarin- and quinolinone-based polycycles as cell division cycle 25-A and -C phosphatases inhibitors induce proliferation arrest and apoptosis in cancer cells.
Clemens Zwergel, Brigitte Czepukojc, Emilie Evain-Bana, Zhanjie Xu +12 more
2017European journal of medicinal chemistry25 citations Open access
Semantic Scholar
Editorial: Multi-target directed ligands for the treatment of cancer
M. Brindisi, S. Kessler, Vinod Kumar, Clemens Zwergel
2022Frontiers in Oncology24 citations Open access
Semantic Scholar
Effect of Class II HDAC inhibition on glutamate transporter expression and survival in SOD1-ALS mice.
A. Lapucci, L. Cavone, Daniela Buonvicino, R. Felici +5 more
2017Neuroscience Letters24 citations
Semantic Scholar
Effects of Class II-Selective Histone Deacetylase Inhibitor on Neuromuscular Function and Disease Progression in SOD1-ALS Mice.
Daniela Buonvicino, R. Felici, G. Ranieri, R. Caramelli +9 more
2018Neuroscience23 citations
Semantic Scholar
Restoration of WT1/miR-769-5p axis by HDAC1 inhibition promotes MMT reversal in mesenchymal-like mesothelial cells
Giulio Bontempi, Michela Terri, Sabrina Garbo, Claudia Montaldo +11 more
2022Cell Death and Disease22 citations Open access
Semantic Scholar
Acute and chronic neurobehavioral effects of the designer drug and bath salt constituent 3,4-methylenedioxypyrovalerone in the rat
Luisa Alessandra Atehortua-Martinez, Cyriaque Masniere, P. Campolongo, Stéphanie Chasseigneaux +8 more
2019Journal of Psychopharmacology22 citations
Semantic Scholar
Pyrazole-based inhibitors of enhancer of zeste homologue 2 induce apoptosis and autophagy in cancer cells
Paolo Mellini, B. Marrocco, D. Borovika, Lucia Polletta +9 more
2018Philosophical Transactions of the Royal Society B: Biological Sciences22 citations Open access
Semantic Scholar
Metabolite profiling of ascidian Styela plicata using LC–MS with multivariate statistical analysis and their antitumor activity
Satheesh Kumar Palanisamy, D. Trisciuoglio, Clemens Zwergel, D. Del Bufalo +1 more
2017Journal of Enzyme Inhibition and Medicinal Chemistry22 citations Open access
Semantic Scholar
PD-L1 small-molecule modulators: a new hope in epigenetic-based multidrug cancer therapy?
Clemens Zwergel, R. Fioravanti, A. Mai
2022Drug Discovery Today21 citations Open access
Semantic Scholar
Effects of Structurally Different HDAC Inhibitors against Trypanosoma cruzi, Leishmania, and Schistosoma mansoni
Elisabetta Di Bello, Beatrice Noce, R. Fioravanti, Clemens Zwergel +12 more
2022ACS Infectious Diseases21 citations Open access
Semantic Scholar
HDAC1/2 control mesothelium/ovarian cancer adhesive interactions impacting on Talin-1-α5β1-integrin-mediated actin cytoskeleton and extracellular matrix protein remodeling
Michela Terri, P. Sandoval, Giulio Bontempi, Claudia Montaldo +16 more
2024Journal of experimental & clinical cancer research : CR20 citations Open access
Semantic Scholar
Novel 1,4-Dihydropyridines as Specific Binders and Activators of SIRT3 Impair Cell Viability and Clonogenicity and Downregulate Hypoxia-Induced Targets in Cancer Cells
Clemens Zwergel, Michele Aventaggiato, Sabrina Garbo, Elisabetta Di Bello +17 more
2023Journal of Medicinal Chemistry20 citations Open access
Semantic Scholar
Sirtuins
Clemens Zwergel, Daniela Tomaselli, A. Mai
2021Encyclopedia of Molecular Pharmacology17 citations
Semantic Scholar
Seleno-vs. thioether triazine derivatives in search for new anticancer agents overcoming multidrug resistance in lymphoma.
Wesam Ali, Sabrina Garbo, Annamária Kincses, Márta Nové +16 more
2022European journal of medicinal chemistry16 citations Open access
Semantic Scholar
Novel pyridine-containing histone deacetylase inhibitors strongly arrest proliferation, induce apoptosis and modulate miRNAs in cancer cells.
Elisabetta Di Bello, Veronica Sian, Giulio Bontempi, Clemens Zwergel +15 more
2022European journal of medicinal chemistry15 citations Open access
Semantic Scholar
Heterocycles–Containing HDAC Inhibitors Active in Cancer: An Overview of the Last Fifteen Years
Alessia Raucci, Carola Castiello, A. Mai, Clemens Zwergel +1 more
2024ChemMedChem14 citations Open access
Semantic Scholar

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A. Mai×38
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A. Mai — researcher profile on SciRah
S. Valente×35
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S. Valente — researcher profile on SciRah
Cecilia Battistelli×14
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Cecilia Battistelli — researcher profile on SciRah
R. Fioravanti×13
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G. Stazi — researcher profile on SciRah

Elisabetta Di Bello×8

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Elisabetta Di Bello — researcher profile on SciRah

Sabrina Garbo×7

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R. Strippoli×7

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M. Tripodi — researcher profile on SciRah

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D. Rotili — researcher profile on SciRah

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R. Mazzone — researcher profile on SciRah

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J. Handzlik — researcher profile on SciRah