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C. Bigogno · SciRah

Researcher profile · Semantic Scholar

C. Bigogno

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C. Bigogno — researcher profile on SciRah

h-index: 20
Works: 49
Citations: 1,578

Most-cited papers

Lipid and fatty acid composition of the green oleaginous alga Parietochloris incisa, the richest plant source of arachidonic acid.
C. Bigogno, I. Khozin-Goldberg, S. Boussiba, A. Vonshak +1 more
2002Phytochemistry384 citations
Semantic Scholar
NITROGEN STARVATION INDUCES THE ACCUMULATION OF ARACHIDONIC ACID IN THE FRESHWATER GREEN ALGA PARIETOCHLORIS INCISA (TREBUXIOPHYCEAE) 1
I. Khozin-Goldberg, C. Bigogno, P. Shrestha, Z. Cohen
2002126 citations
Semantic Scholar
1,3,4-Oxadiazole-containing histone deacetylase inhibitors: anticancer activities in cancer cells.
S. Valente, D. Trisciuoglio, T. De Luca, A. Nebbioso +9 more
2014Journal of Medicinal Chemistry113 citations Open access
Semantic Scholar
Accumulation of arachidonic acid-rich triacylglycerols in the microalga Parietochloris incisa (Trebuxiophyceae, Chlorophyta).
C. Bigogno, I. Khozin-Goldberg, Z. Cohen
2002Phytochemistry101 citations
Semantic Scholar
Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion.
I. Peretto, S. Radaelli, C. Parini, M. Zandi +20 more
2005Journal of Medicinal Chemistry94 citations Open access
Semantic Scholar
Evaluation of in vitro brain penetration: optimized PAMPA and MDCKII-MDR1 assay comparison.
Simone Carrara, Veronica Reali, Paola Misiano, G. Dondio +1 more
2007International journal of pharmaceutics63 citations
Semantic Scholar
Biosynthesis of arachidonic acid in the oleaginous microalga Parietochloris incisa (Chlorophyceae): Radiolabeling studies
C. Bigogno, I. Khozin-Goldberg, D. Adlerstein, Z. Cohen
2002Lipids61 citations
Semantic Scholar
New perspectives in bio-analytical techniques for preclinical characterization of a drug candidate: UPLC-MS/MS in in vitro metabolism and pharmacokinetic studies.
Samuele Pedraglio, M. Rozio, Paola Misiano, Veronica Reali +2 more
2007Journal of Pharmaceutical and Biomedical Analysis52 citations
Semantic Scholar
Discovery, synthesis, and pharmacological evaluation of spiropiperidine hydroxamic acid based derivatives as structurally novel histone deacetylase (HDAC) inhibitors.
M. Varasi, F. Thaler, Agnese Abate, C. Bigogno +10 more
2011Journal of Medicinal Chemistry50 citations Open access
Semantic Scholar
New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer
G. La Regina, Ruo-Li Bai, Antonio Coluccia, Valeria Famiglini +29 more
2015Journal of Medicinal Chemistry47 citations Open access
Semantic Scholar
Recommendations on the interpretation of the new European Medicines Agency Guideline on Bioanalytical Method Validation by Global CRO Council for Bioanalysis (GCC).
Mark Boterman, Mira Doig, M. Breda, S. Lowes +64 more
2012Bioanalysis46 citations Open access
Semantic Scholar
Elucidation of the Biosynthesis of Eicosapentaenoic Acid (EPA) in the Microalga Porphyridium Cruentum
I. Khozin, D. Adlerstein, C. Bigogno, Z. Cohen
199739 citations
Semantic Scholar
Synthesis and biological evaluation of N-hydroxyphenylacrylamides and N-hydroxypyridin-2-ylacrylamides as novel histone deacetylase inhibitors.
F. Thaler, Andrea Colombo, A. Mai, R. Amici +19 more
2010Journal of Medicinal Chemistry34 citations Open access
Semantic Scholar
Toward the identification of neuroprotective agents: g-scale synthesis, pharmacokinetic evaluation and CNS distribution of (R)-RC-33, a promising SIGMA1 receptor agonist.
Annamaria Marra, D. Rossi, L. Pignataro, C. Bigogno +9 more
2016Future Medicinal Chemistry32 citations
Semantic Scholar
Recommendations on bioanalytical method stability implications of co-administered and co-formulated drugs by Global CRO Council for Bioanalysis (GCC).
S. Lowes, Mark Boterman, Mira Doig, M. Breda +87 more
2012Bioanalysis32 citations
Semantic Scholar
THE EFFECT OF GROWTH TEMPERATURE AND CULTURE DENSITY ON THE MOLECULAR SPECIES COMPOSITION OF THE GALACTOLIPIDS IN THE RED MICROALGA PORPHYHDIUM CRUENTUM (RHODOPHYTA) 1
D. Adlerstein, C. Bigogno, I. Khozin, Z. Cohen
199732 citations
Semantic Scholar
Neuroprotective effects of lignan 7-hydroxymatairesinol (HMR/lignan) in a rodent model of Parkinson's disease.
C. Giuliano, F. Siani, L. Mus, C. Ghezzi +4 more
2019Nutrition (Burbank, Los Angeles County, Calif.)25 citations
Semantic Scholar
Mutual Effects of Single and Combined CFTR Modulators and Bacterial Infection in Cystic Fibrosis
C. Cigana, Ruggero Giannella, A. Colavolpe, B. Alcalá-Franco +6 more
2023Microbiology spectrum24 citations Open access
Semantic Scholar
Recommendations on ISR in multi analyte assays, QA/bioanalytical consultants and GCP by Global CRO Council for Bioanalysis (GCC).
Timothy Sangster, J. Maltas, P. Struwe, J. Hillier +26 more
2012Bioanalysis24 citations
Semantic Scholar
Discovery of diaryl imidazolidin-2-one derivatives, a novel class of muscarinic M3 selective antagonists (Part 1).
I. Peretto, R. Forlani, C. Fossati, G. Giardina +24 more
2007Journal of Medicinal Chemistry23 citations Open access
Semantic Scholar
Givinostat-Liposomes: Anti-Tumor Effect on 2D and 3D Glioblastoma Models and Pharmacokinetics
Lorenzo Taiarol, C. Bigogno, S. Sesana, M. Kravicz +13 more
2022Cancers19 citations Open access
Semantic Scholar
Anti-tumor Efficacy Assessment of the Sigma Receptor Pan Modulator RC-106. A Promising Therapeutic Tool for Pancreatic Cancer
A. Tesei, M. Cortesi, S. Pignatta, C. Arienti +12 more
2019Frontiers in Pharmacology18 citations Open access
Semantic Scholar
Induction of Ferroptosis in Glioblastoma and Ovarian Cancers by a New Pyrrole Tubulin Assembly Inhibitor
Michela Puxeddu, Jianchao Wu, Ruo-Li Bai, M. D'Ambrosio +16 more
2022Journal of Medicinal Chemistry17 citations Open access
Semantic Scholar
In Vivo and In Vitro Activities and ADME-Tox Profile of a Quinolizidine-Modified 4-Aminoquinoline: A Potent Anti-P. falciparum and Anti-P. vivax Blood-Stage Antimalarial
N. Basilico, S. Parapini, A. Sparatore, S. Romeo +14 more
2017Molecules14 citations Open access
Semantic Scholar
Novel analgesic/anti-inflammatory agents: 1,5-Diarylpyrrole nitrooxyethyl sulfides and related compounds as Cyclooxygenase-2 inhibitors containing a nitric oxide donor moiety endowed with vasorelaxant properties.
M. Saletti, S. Maramai, A. Reale, M. Paolino +15 more
2022European journal of medicinal chemistry12 citations Open access
Semantic Scholar
Synthesis and biological characterization of spiro[2H-(1,3)-benzoxazine-2,4'-piperidine] based histone deacetylase inhibitors.
F. Thaler, M. Varasi, Agnese Abate, Giacomo Carenzi +12 more
2013European journal of medicinal chemistry12 citations Open access
Semantic Scholar
Spiro[chromane‐2,4′‐piperidine]‐Based Histone Deacetylase Inhibitors with Improved in vivo Activity
F. Thaler, M. Varasi, Giacomo Carenzi, Andrea Colombo +12 more
2012ChemMedChem12 citations
Semantic Scholar
A Convenient Approach to the N-Substituted Amino Dienes, N-Benzyl-5-ethenyl-3,4-dihydropyridin-2-one and N-Cbz-5-Ethenyl-1,2,3,4-tetrahydropyridine
D. Passarella, C. Bigogno, B. Danieli, G. Lesma
199512 citations Open access
Semantic Scholar
Novel N-(Heterocyclylphenyl)benzensulfonamide Sharing an Unreported Binding Site with T-Cell Factor 4 at the β-Catenin Armadillo Repeats Domain as an Anticancer Agent
M. Nalli, L. Di Magno, Yi-Mei Wen, Xin Liu +25 more
2023ACS Pharmacology & Translational Science9 citations Open access
Semantic Scholar
Aryltriflates as a Neglected Moiety in Medicinal Chemistry: A Case Study from a Lead Optimization of CXCL8 Inhibitors.
A. Moriconi, C. Bigogno, Gianluca Bianchini, A. Caligiuri +4 more
2011ACS Medicinal Chemistry Letters8 citations Open access
Semantic Scholar
Development of an inhalable antiviral powder formulation against respiratory syncytial virus.
R. Heida, R. Akkerman, Paulo H. Jacob Silva, Anke J. Lakerveld +8 more
2023Journal of Controlled Release7 citations Open access
Semantic Scholar
Synthesis and biological evaluation of new N-alkyl 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides as cannabinoid receptor ligands.
R. Silvestri, A. Ligresti, G. La Regina, F. Piscitelli +15 more
2010European journal of medicinal chemistry7 citations Open access
Semantic Scholar
Ferroptosis Induction by a New Pyrrole Derivative in Triple Negative Breast Cancer and Colorectal Cancer.
Domiziana Masci, Lele Ling, Lian Yang, Michela Puxeddu +16 more
2025Journal of Medicinal Chemistry6 citations
Semantic Scholar
Chiral Resolution and Pharmacological Characterization of the Enantiomers of the Hsp90 Inhibitor 2‐Amino‐7‐[4‐fluoro‐2‐(3‐pyridyl)phenyl]‐4‐methyl‐7,8‐dihydro‐6H‐quinazolin‐5‐one Oxime
R. Amici, C. Bigogno, R. Boggio, Andrea Colombo +12 more
2014ChemMedChem5 citations
Semantic Scholar
Targeting the Grb2 cSH3 domain: Design, synthesis and biological evaluation of the first series of modulators.
Marianna Bufano, Michela Puxeddu, M. Nalli, G. La Regina +10 more
2023Bioorganic chemistry (Print)4 citations Open access
Semantic Scholar
Salicylhydroxamic acid inhibits Δ6 desaturation in the microalga Porphyridium cruentum11Part III in the series ‘Elucidation of the biosynthesis of eicosapentaenoic acid (EPA)’.
I. Khozin-Goldberg, C. Bigogno, Z. Cohen
19994 citations
Semantic Scholar
Effect on Environmental Conditions on the Molecular Species Composition of Galactolipids in the Alga Porphyridium Cruentum
D. Adlerstein, I. Khozin, C. Bigogno, Z. Cohen
19974 citations
Semantic Scholar
Development of N-(4-(1H-Imidazol-1-yl)phenyl)-4-chlorobenzenesulfonamide, a Novel Potent Inhibitor of β-Catenin with Enhanced Antitumor Activity and Metabolic Stability.
Michela Puxeddu, Lele Ling, Silvia Ripa, Michele D'Ambrosio +19 more
2024Journal of Medicinal Chemistry3 citations
Semantic Scholar
4-(3-Phenylsulfonylindol-2-yl)-1-(pyridin-2-yl)piperazinyl-methanones as Potent Inhibitors of both SARS-CoV-2 and HCoV-OC43 Viruses.
Michela Puxeddu, M. Donalisio, J. Bugert, A. Corona +21 more
2024ACS Infectious Diseases2 citations Open access
Semantic Scholar
4‐(5‐Chloro‐3‐(3,4,5‐trimethoxybenzoyl)‐1H‐indol‐1‐yl)benzenesulfonamide: A Novel Polypharmacology Agent to Target Carbonic Anhydrase IX and XII With Improved Selectivity, Wnt/β‐Catenin Signaling Pathway, and P‐Glycoprotein
Michela Puxeddu, Rosa Bordone, C. Colla, Gabriele Rotili +18 more
2026ChemMedChem1 citations Open access
Semantic Scholar
SAR Analysis of Novel Coxsackie virus A9 Capsid Binders.
Chiara Tammaro, Zlatka Plavec, Laura Myllymäki, C. Mitchell +15 more
2024Journal of Medicinal Chemistry1 citations Open access
Semantic Scholar
(S,S)‑5-Chloro-3-((3,5-dimethylphenyl)sulfonyl)‑N‑(1-oxo-1-((1-(pyridin-4-yl)ethyl)amino)propan-2-yl)‑1H‑indole-2-carboxamide, a New Dishevelled 1 and P‑Glycoprotein Dual Inhibitor as a Anticancer Agent
Michela Puxeddu, Ze-Yu Cui, C. Colla, M. Nalli +18 more
2026Journal of Medicinal Chemistry0 citations Open access
Semantic Scholar
Correction to "Ferroptosis Induction by a New Pyrrole Derivative in Triple Negative Breast Cancer and Colorectal Cancer".
Domiziana Masci, Lele Ling, Lian Yang, Michela Puxeddu +17 more
2026Journal of Medicinal Chemistry0 citations Open access
Semantic Scholar
Correction to “Novel N‑(Heterocyclylphenyl)benzensulfonamide Sharing an Unreported Binding Site with T‑Cell Factor 4 at the β‑Catenin Armadillo Repeats Domain as Anticancer Agent”
M. Nalli, L. Di Magno, Yichao Wen, Xin Liu +25 more
2025ACS Pharmacology & Translational Science0 citations Open access
Semantic Scholar
Linking CFTR modulators to opportunistic bacterial infections in cystic fibrosis
C. Cigana, Ruggero Giannella, A. Colavolpe, B. Alcalá-Franco +6 more
2022bioRxiv0 citations Open access
Semantic Scholar
528 Linking CFTR modulators to opportunistic bacterial infections in cystic fibrosis
C. Cigana, R. Giannella, A. Colavolpe, B. Alcalá-Franco +6 more
2022Journal of Cystic Fibrosis0 citations Open access
Semantic Scholar
In vivo pharmacokinetic study and CNS distribution of the sigma1 receptor agonist (R)-RC-33, a promising neuroprotective agent
Annamaria Marra, D. Rossi, G. Dondio, C. Bigogno +5 more
20150 citations
Semantic Scholar
Towards the identification of neuroprotective agents. Pharmacokinetic evaluation and CNS distribution of (R)-RC-33, a promising sigma1 receptor agonist
Annamaria Marra, D. Rossi, G. Dondio, C. Bigogno +5 more
20150 citations
Semantic Scholar
A Convenient Approach to the N‐Substituted Amino Dienes, N‐Benzyl‐5‐ ethenyl‐3,4‐dihydropyridin‐2‐one and N‐Cbz‐5‐ethenyl‐1,2,3,4‐ tetrahydropyridine.
C. Bigogno, B. Danieli, G. Lesma, D. Passarella
19950 citations
Semantic Scholar

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G. Dondio×30
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G. La Regina×12
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Antonio Coluccia×11
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Michela Puxeddu×10
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M. Nalli — researcher profile on SciRah

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R. Silvestri×8

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Domiziana Masci×7

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M. Varasi — researcher profile on SciRah

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I. Khozin-Goldberg — researcher profile on SciRah