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P. Carpinelli · SciRah

Researcher profile · Semantic Scholar

P. Carpinelli

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P. Carpinelli — researcher profile on SciRah

h-index: 17
Works: 36
Citations: 1,455

Most-cited papers

PHA-739358, a potent inhibitor of Aurora kinases with a selective target inhibition profile relevant to cancer
P. Carpinelli, R. Ceruti, M. Giorgini, P. Cappella +18 more
2007Molecular Cancer Therapeutics245 citations Open access
Semantic Scholar
1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: identification of a potent Aurora kinase inhibitor with a favorable antitumor kinase inhibition profile.
D. Fancelli, J. Moll, M. Varasi, R. Bravo +21 more
2006Journal of Medicinal Chemistry183 citations Open access
Semantic Scholar
PHA-680632, a Novel Aurora Kinase Inhibitor with Potent Antitumoral Activity
C. Soncini, P. Carpinelli, L. Gianellini, D. Fancelli +14 more
2006Clinical Cancer Research170 citations Open access
Semantic Scholar
Potent and selective Aurora inhibitors identified by the expansion of a novel scaffold for protein kinase inhibition.
D. Fancelli, D. Berta, S. Bindi, A. Cameron +19 more
2005Journal of Medicinal Chemistry136 citations Open access
Semantic Scholar
Crystal structure of the T315I Abl mutant in complex with the aurora kinases inhibitor PHA-739358.
M. Modugno, E. Casale, C. Soncini, P. Rosettani +8 more
2007Cancer Research121 citations Open access
Semantic Scholar
Phase I pharmacokinetic and pharmacodynamic study of the aurora kinase inhibitor danusertib in patients with advanced or metastatic solid tumors.
N. Steeghs, F. Eskens, H. Gelderblom, J. Verweij +8 more
2009Journal of Clinical Oncology107 citations
Semantic Scholar
A phase I study of danusertib (PHA-739358) in adult patients with accelerated or blastic phase chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia resistant or intolerant to imatinib and/or other second generation c-ABL therapy
G. Borthakur, H. Dombret, P. Schafhausen, T. Brummendorf +8 more
2015Haematologica56 citations Open access
Semantic Scholar
Aurora kinase inhibitors: identification and preclinical validation of their biomarkers
P. Carpinelli, J. Moll
2008Expert opinion on therapeutic targets55 citations
Semantic Scholar
Analysis of the molecular species generated by mdm2 gene amplification in liposarcomas
E. Tamborini, G. della Torre, C. Lavarino, A. Azzarelli +3 more
2001International Journal of Cancer55 citations Open access
Semantic Scholar
Cloning and overexpression in Escherichia coli of the genes encoding NAD-dependent alcohol dehydrogenase from two Sulfolobus species
Raffaele Cannio, Gabriella Fiorentino, P. Carpinelli, M. Rossi +1 more
1996Journal of Bacteriology51 citations Open access
Semantic Scholar
Phase I dose escalation study of NMS-1286937, an orally available Polo-Like Kinase 1 inhibitor, in patients with advanced or metastatic solid tumors
G. Weiss, G. Jameson, D. V. Von Hoff, B. Valsasina +9 more
2018Investigational new drugs42 citations
Semantic Scholar
Aurora kinases and their inhibitors: more than one target and one drug.
P. Carpinelli, J. Moll
2008Advances in Experimental Medicine and Biology40 citations
Semantic Scholar
Structural insight into maternal embryonic leucine zipper kinase (MELK) conformation and inhibition toward structure-based drug design.
G. Canevari, Stefania Re Depaolini, U. Cucchi, J. Bertrand +5 more
2013Biochemistry29 citations
Semantic Scholar
Identification of Myb-binding Protein 1A (MYBBP1A) as a Novel Substrate for Aurora B Kinase
C. Perrera, R. Colombo, B. Valsasina, P. Carpinelli +7 more
2010Journal of Biological Chemistry29 citations Open access
Semantic Scholar
Thieno[3,2-c]pyrazoles: a novel class of Aurora inhibitors with favorable antitumor activity.
S. Bindi, D. Fancelli, C. Alli, D. Berta +22 more
2010Bioorganic & Medicinal Chemistry26 citations Open access
Semantic Scholar
Characterization of the BUD31 gene of Saccharomyces cerevisiae.
Barbara Masciadri, L. Areces, P. Carpinelli, M. Foiani +2 more
2004Biochemical and Biophysical Research Communications - BBRC24 citations
Semantic Scholar
Is there a future for Aurora kinase inhibitors for anticancer therapy?
P. Carpinelli, J. Moll
2009Current opinion in drug discovery & development19 citations
Semantic Scholar
PHA-680626 Is an Effective Inhibitor of the Interaction between Aurora-A and N-Myc
D. Boi, Fani Souvalidou, D. Capelli, Federica Polverino +15 more
2021International Journal of Molecular Sciences13 citations Open access
Semantic Scholar
In-vivo brain H1-MR-Spectroscopy identification and quantification of 2-hydroxyglutarate in L-2-Hydroxyglutaric aciduria.
E. Anghileri, N. Bertolino, E. Salsano, L. Antelmi +7 more
2016Brain Research12 citations Open access
Semantic Scholar
Effect of cytidine analogs on cell growth and differentiation on a human neuroblastoma line
S. Bartolucci, M. Estenoz, V. de Franciscis, P. Carpinelli +3 more
1989Cell Biophysics11 citations
Semantic Scholar
Combined cisplatin and aurora inhibitor treatment increase neuroblastoma cell death but surviving cells overproduce BDNF
Alessio Polacchini, C. Albani, G. Baj, A. Colliva +2 more
2016Biology Open8 citations Open access
Semantic Scholar
Transcriptional analysis of the Aurora inhibitor Danusertib leading to biomarker identification in TP53 wild type cells.
R. Bosotti, P. Carpinelli, Sandra Healy, G. Locatelli +5 more
2012Gene7 citations
Semantic Scholar
Synthesis and biological activity of five-coordinate platinum(II) complexes including organotin fragments.
P. Carpinelli, S. Bartolucci, F. Ruffo
1995Anti-Cancer Drug Design7 citations
Semantic Scholar
27 ORAL Phase I dose escalation study of the aurora kinase inhibitor PHA-739358 administered as a 6-hour infusion on days 1, 8 and 15 every 4 weeks in patients with advanced/metastatic solid tumors
M. D. de Jonge, N. Steeghs, J. Verweij, J. Nortier +7 more
20065 citations
Semantic Scholar
GDF15 as a Novel Biomarker for Monitoring Danusertib Activity
P. Carpinelli, P. Cappella
20122 citations Open access
Semantic Scholar
Exploring the molecular mechanisms of a small molecule inhibitor of Aurora kinases
P. Carpinelli, L. Gianellini, C. Soncini, M. Giorgini +9 more
20052 citations
Semantic Scholar
Targeted inhibition of the gatekeeper mutant T315I of Bcr-Abl by an Aurora kinase inhibitor
M. Modugno, E. Casale, C. Soncini, P. Rosettani +11 more
20071 citations
Semantic Scholar
A Focused Small-Molecule Screen Identifies PHA-680626 as an Amphosteric Inhibitor Disrupting the Interaction between Aurora-A and N-Myc
Fani Souvalidou, D. Boi, R. Montanari, Federica Polverino +14 more
2021bioRxiv0 citations Open access
Semantic Scholar
Abstract 3795: Novel and selective MELK kinase inhibitors active in breast cancer cell lines
P. Carpinelli, M. Montemartini, N. Amboldi, D. Ballinari +14 more
20160 citations
Semantic Scholar
31 N-Myc amplification sensitizes tumor cells to inhibition by Danusertib, an Aurora kinase inhibitor
P. Carpinelli, R. Ceruti, R. Alzani, C. Re +9 more
20140 citations
Semantic Scholar
517 Identification and characterization of selective MELK kinase inhibitors
P. Carpinelli, N. Amboldi, D. Ballinari, S. R. Depaolini +9 more
20140 citations
Semantic Scholar
Crystal structure of unphosphorylated Maternal Embryonic Leucine zipper Kinase (MELK) in complex with a benzodipyrazole inhibitor
G. Canevari, S. R. Depaolini, U. Cucchi, B. Forte +2 more
20130 citations
Semantic Scholar
Crystal structure of unphosphorylated Maternal Embryonic Leucine zipper Kinase (MELK) in complex with AMP-PNP
G. Canevari, S. Re-Depaolini, U. Cucchi, B. Forte +2 more
20130 citations
Semantic Scholar
Crystal structure of the T315I Abl mutant in complex with the inhibitor PHA-739358
M. Modugno, E. Casale, C. Soncini, P. Rosettani +8 more
20070 citations
Semantic Scholar
In vitro and in vivo biomarker modulation by a small molecule inhibitor of Aurora kinases.
P. Carpinelli, L. Gianellini, C. Soncini, M. Giorgini +8 more
20060 citations
Semantic Scholar
Synthesis and cytostatic activity of five-coordinate platinum(II) complexes
S. Bartolucci, P. Carpinelli, V. De Felice, A. De Renzi +2 more
19900 citations
Semantic Scholar

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