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L. Niedernhofer · SciRah

Researcher profile · Semantic Scholar

L. Niedernhofer

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L. Niedernhofer — researcher profile on SciRah

h-index: 75
Works: 207
Citations: 26K

Most-cited papers

Senolytics Improve Physical Function and Increase Lifespan in Old Age
Ming Xu, T. Pirtskhalava, J. Farr, B. M. Weigand +29 more
2018Nature Medicine2,071 citations Open access
Semantic Scholar
Fisetin is a senotherapeutic that extends health and lifespan
Matthew J. Yousefzadeh, Yi Zhu, S. J. McGowan, Luise A. Angelini +18 more
2018EBioMedicine955 citations Open access
Semantic Scholar
A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues
D. Saul, R. Kosinsky, Elizabeth J. Atkinson, Madison L. Doolittle +15 more
2021Nature Communications902 citations Open access
Semantic Scholar
An aged immune system drives senescence and ageing of solid organs
Matthew J. Yousefzadeh, Rafael R. Flores, Yi Zhu, Zoe C. Schmiechen +29 more
2021Nature878 citations Open access
Semantic Scholar
Physiological frailty index (PFI): quantitative in-life estimate of individual biological age in mice
Yi Zhu, E. Doornebal, T. Pirtskhalava, N. Giorgadze +6 more
2017Aging667 citations Open access
Semantic Scholar
Identification of HSP90 inhibitors as a novel class of senolytics
Heike Fuhrmann-Stroissnigg, Yuan Ling, Jing Zhao, S. J. McGowan +16 more
2017Nature Communications638 citations Open access
Semantic Scholar
Targeting cellular senescence with senotherapeutics: senolytics and senomorphics
Lei Zhang, Louise E. Pitcher, Vaishali Prahalad, L. Niedernhofer +1 more
2022The FEBS Journal584 citations
Semantic Scholar
Cellular senescence: a key therapeutic target in aging and diseases
Lei Zhang, Louise E. Pitcher, Matthew J. Yousefzadeh, L. Niedernhofer +2 more
2022Journal of Clinical Investigation521 citations Open access
Semantic Scholar
Guidelines for Minimal Information on Cellular Senescence Experimentation in vivo
M. Ogrodnik, Juan Carlos Acosta, Peter D. Adams, Fabrizio d'Adda di Fagagna +28 more
2024Cell333 citations Open access
Semantic Scholar
Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span
P. Robbins, D. Jurk, S. Khosla, J. Kirkland +6 more
2020Annual Review of Pharmacology and Toxicology316 citations Open access
Semantic Scholar
DNA damage—how and why we age?
Matthew J. Yousefzadeh, Chathurika Henpita, Rajesh Vyas, Carolina Soto-Palma +2 more
2021eLife312 citations Open access
Semantic Scholar
Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice
Matthew J. Yousefzadeh, Jing Zhao, Christina Bukata, Erin A. Wade +10 more
2020Aging Cell300 citations Open access
Semantic Scholar
Senolytics reduce coronavirus-related mortality in old mice
Christina D. Camell, Matthew J. Yousefzadeh, Yi Zhu, Larissa P. G. Langhi Prata +30 more
2021Science297 citations Open access
Semantic Scholar
Nuclear Genomic Instability and Aging.
L. Niedernhofer, Aditi U. Gurkar, Yin-Sheng Wang, J. Vijg +2 more
2018Annual Review of Biochemistry233 citations Open access
Semantic Scholar
Senolytic combination of Dasatinib and Quercetin alleviates intestinal senescence and inflammation and modulates the gut microbiome in aged mice.
T. Saccon, R. Nagpal, H. Yadav, M. Cavalcante +10 more
2021The journals of gerontology. Series A, Biological sciences and medical sciences222 citations Open access
Semantic Scholar
Systems biology guided by XCMS Online metabolomics
Tao Huan, E. Forsberg, Duane Rinehart, Caroline H. Johnson +19 more
2017Nature Methods179 citations Open access
Semantic Scholar
Senotherapeutics for healthy ageing
L. Niedernhofer, P. Robbins
2018Nature reviews. Drug discovery177 citations
Semantic Scholar
Molecular Damage in Aging
V. Gladyshev, S. Kritchevsky, Steven G. Clarke, A. Cuervo +12 more
2021Nature Aging168 citations Open access
Semantic Scholar
Systemic clearance of p16INK4a‐positive senescent cells mitigates age‐associated intervertebral disc degeneration
Prashanti R. Patil, Qing D. Dong, Dong Wang, Jian-Hui Chang +10 more
2019Aging Cell148 citations Open access
Semantic Scholar
Mesenchymal stem cell‐derived extracellular vesicles reduce senescence and extend health span in mouse models of aging
A. Dorronsoro, F. E. Santiago, D. Grassi, Tian-Peng Zhang +19 more
2021Aging Cell143 citations Open access
Semantic Scholar
Aging and chronic inflammation: highlights from a multidisciplinary workshop
D. Saavedra, A. L. Añé-Kourí, N. Barzilai, C. Caruso +14 more
2023Immunity & Ageing136 citations Open access
Semantic Scholar
COVID-19 and cellular senescence
C. Schmitt, T. Tchkonia, L. Niedernhofer, Paul D. Robbins +2 more
2022Nature reviews. Immunology135 citations Open access
Semantic Scholar
Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging
A. Robinson, Matthew J. Yousefzadeh, Tania A. Rozgaja, Jin Wang +38 more
2018Redox Biology129 citations Open access
Semantic Scholar
NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health
Patty J. Lee, C. Benz, P. Blood, K. Börner +237 more
2022Nature Aging124 citations Open access
Semantic Scholar
Spatial mapping of cellular senescence: emerging challenges and opportunities
Aditi U. Gurkar, A. Gerencser, A. Mora, Andrew C. Nelson +41 more
2023Nature Aging120 citations Open access
Semantic Scholar
Targeted clearance of p21‐ but not p16‐positive senescent cells prevents radiation‐induced osteoporosis and increased marrow adiposity
Abhishek Chandra, A. Lagnado, J. Farr, Madison L. Doolittle +10 more
2022Aging Cell111 citations Open access
Semantic Scholar
Epigenetics, DNA damage, and aging
Carolina Soto-Palma, L. Niedernhofer, Christopher D. Faulk, Xiao Dong
2022Journal of Clinical Investigation111 citations Open access
Semantic Scholar
ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging
Jing Zhao, Lei Zhang, A. Lu, Yingchao Han +20 more
2020Aging110 citations Open access
Semantic Scholar
Role of Cellular Senescence in Type II Diabetes.
Akilavalli Narasimhan, Rafael R. Flores, Paul D. Robbins, L. Niedernhofer
2021Endocrinology109 citations Open access
Semantic Scholar
Expansion of myeloid‐derived suppressor cells with aging in the bone marrow of mice through a NF‐κB‐dependent mechanism
Rafael R. Flores, Cheryl L. Clauson, Joonseok Cho, Byeong‐Chel Lee +4 more
2017Aging Cell102 citations Open access
Semantic Scholar
Urinary Extracellular Vesicles Carrying Klotho Improve the Recovery of Renal Function in an Acute Tubular Injury Model
C. Grange, E. Papadimitriou, Veronica Dimuccio, Cecilia Pastorino +6 more
2019Molecular Therapy96 citations Open access
Semantic Scholar
Strategies to Prevent or Remediate Cancer and Treatment-Related Aging.
Jennifer L. Guida, T. Agurs-Collins, T. Ahles, J. Campisi +23 more
2020Journal of the National Cancer Institute91 citations Open access
Semantic Scholar
Cytoskeleton stiffness regulates cellular senescence and innate immune response in Hutchinson–Gilford Progeria Syndrome
Xiaodong Mu, Chieh Tseng, W. S. Hambright, Polina R Matre +11 more
2020Aging Cell91 citations Open access
Semantic Scholar
Hsp90 inhibitors as senolytic drugs to extend healthy aging
Heike Fuhrmann-Stroissnigg, L. Niedernhofer, P. Robbins
2018Cell Cycle88 citations Open access
Semantic Scholar
Recent advances in the discovery of senolytics
Lei Zhang, Louise E. Pitcher, Vaishali Prahalad, L. Niedernhofer +1 more
2021Mechanisms of Ageing and Development82 citations Open access
Semantic Scholar
SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3
Utkarsh Tripathi, Rayhane Nchioua, Larissa P. G. Langhi Prata, Yi Zhu +15 more
2021Aging79 citations Open access
Semantic Scholar
Novel small molecule inhibition of IKK/NF‐κB activation reduces markers of senescence and improves healthspan in mouse models of aging
Lei Zhang, Jing Zhao, Xiaodong Mu, S. J. McGowan +11 more
2021Aging Cell77 citations Open access
Semantic Scholar
Development of Clinical Trials to Extend Healthy Lifespan
J. Justice, L. Niedernhofer, P. Robbins, V. Aroda +4 more
2018Cardiovascular endocrinology & metabolism73 citations Open access
Semantic Scholar
Heterochronic parabiosis regulates the extent of cellular senescence in multiple tissues
Matthew J. Yousefzadeh, J. Wilkinson, Brian Hughes, Namrata Gadela +5 more
2020GeroScience68 citations Open access
Semantic Scholar
Local senolysis in aged mice only partially replicates the benefits of systemic senolysis
J. Farr, D. Saul, Madison L. Doolittle, J. Kaur +17 more
2023Journal of Clinical Investigation67 citations Open access
Semantic Scholar
Genetics of extreme human longevity to guide drug discovery for healthy ageing
Zheng-Dong D. Zhang, S. Milman, Jhih-Rong Lin, Shayne D. Wierbowski +8 more
2020Nature Metabolism59 citations Open access
Semantic Scholar
ARDD 2020: from aging mechanisms to interventions
G. Mkrtchyan, K. Abdelmohsen, P. Andreux, I. Bagdonaite +62 more
2020Aging48 citations Open access
Semantic Scholar
Rare genetic coding variants associated with human longevity and protection against age-related diseases
Jhih-Rong Lin, P. Sin‐Chan, V. Napolioni, G. G. Torres +23 more
2021Nature Aging46 citations
Semantic Scholar
Rapamycin Rescues Age-Related Changes in Muscle-Derived Stem/Progenitor Cells from Progeroid Mice
Y. Kawakami, W. S. Hambright, K. Takayama, Xiaodong Mu +10 more
2019Molecular Therapy: Methods & Clinical Development46 citations Open access
Semantic Scholar
Fisetin for COVID-19 in Skilled Nursing Facilities (COVID-FIS): Senolytic Trials in the COVID Era
B. Verdoorn, Tamara K. Evans, G. J. Hanson, Yi Zhu +23 more
2021Journal of The American Geriatrics Society44 citations Open access
Semantic Scholar
Oxidative stress-induced senescence markedly increases disc cell bioenergetics.
Prashanti R. Patil, M. Falabella, A. Saeed, Dayeon Lee +9 more
2019Mechanisms of Ageing and Development43 citations
Semantic Scholar
Molecular Mechanisms and Cardiovascular Implications of Cancer Therapy-induced Senescence
I. Abdelgawad, K. Sadak, Diana W Lone, Mohamed S. Dabour +2 more
2020Pharmacology and Therapeutics42 citations Open access
Semantic Scholar
Dysregulation of DAF-16/FOXO3A-mediated stress responses accelerates oxidative DNA damage induced aging
Aditi U. Gurkar, A. Robinson, Yuxiang Cui, Xuesen Li +11 more
2018Redox Biology42 citations Open access
Semantic Scholar
Mouse models of accelerated cellular senescence
Matthew J. Yousefzadeh, Kendra I. Melos, Luise A. Angelini, C. Burd +2 more
2018Methods in molecular biology40 citations Open access
Semantic Scholar
Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation
Jing Zhao, Lei Zhang, Xiaodong Mu, Christelle Doebelin +14 more
2018PLoS Biology40 citations Open access
Semantic Scholar

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P. Robbins×28
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J. Kirkland×15
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T. Tchkonia×14
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Paul D. Robbins×14
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Matthew J. Yousefzadeh

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S. J. McGowan×10

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Yi Zhu — researcher profile on SciRah

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Lei Zhang — researcher profile on SciRah

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D. Jurk — researcher profile on SciRah

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S. Khosla — researcher profile on SciRah

Luise A. Angelini×7

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Luise A. Angelini — researcher profile on SciRah