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J. Vijg · SciRah

Researcher profile · Semantic Scholar

J. Vijg

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J. Vijg — researcher profile on SciRah

h-index: 77
Works: 372
Citations: 22K

Most-cited papers

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA.
M. Demaria, Naoko Ohtani, S. Youssef, F. Rodier +10 more
2026Developmental Cell1,402 citations
Semantic Scholar
The central role of DNA damage in the ageing process
B. Schumacher, J. Pothof, J. Vijg, J. Hoeijmakers
2021Nature778 citations Open access
Semantic Scholar
Evidence for a limit to human lifespan
Xiao Dong, B. Milholland, J. Vijg
2016Nature387 citations
Semantic Scholar
Differences between germline and somatic mutation rates in humans and mice
B. Milholland, Xiao Dong, Lei Zhang, X. Hao +2 more
2017Nature Communications365 citations Open access
Semantic Scholar
Deep biomarkers of human aging: Application of deep neural networks to biomarker development
E. Putin, Polina Mamoshina, Alexander Aliper, Mikhail Korzinkin +6 more
2016Aging355 citations Open access
Semantic Scholar
SIRT6 is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species
Xiao Tian, D. Firsanov, Zhi-Hui Zhang, Yang Cheng +24 more
2019Cell307 citations Open access
Semantic Scholar
Mechanisms of cancer resistance in long-lived mammals
A. Seluanov, V. Gladyshev, J. Vijg, V. Gorbunova
2018Nature Reviews. Cancer276 citations Open access
Semantic Scholar
Nuclear Genomic Instability and Aging.
L. Niedernhofer, Aditi U. Gurkar, Yin-Sheng Wang, J. Vijg +2 more
2018Annual Review of Biochemistry233 citations Open access
Semantic Scholar
Diet restriction delays accelerated aging and genomic stress in DNA repair deficient mice
W. Vermeij, M. Dollé, E. Reiling, D. Jaarsma +20 more
2016Nature225 citations Open access
Semantic Scholar
Analysis of individual cells identifies cell‐to‐cell variability following induction of cellular senescence
Christopher D. Wiley, J. M. Flynn, Christapher S. Morrissey, R. Lebofsky +6 more
2017Aging Cell222 citations Open access
Semantic Scholar
Accurate identification of single nucleotide variants in whole genome amplified single cells
Xiao Dong, Lei Zhang, B. Milholland, Moonsook Lee +3 more
2017Nature Methods213 citations Open access
Semantic Scholar
Pathogenic mechanisms of somatic mutation and genome mosaicism in aging
J. Vijg, Xiao Dong
2020Cell209 citations Open access
Semantic Scholar
Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan
Lei Zhang, Xiao Dong, Moonsook Lee, A. Maslov +2 more
2019Proceedings of the National Academy of Sciences of the United States of America209 citations Open access
Semantic Scholar
Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking
Zhen-Qiu Huang, Shi-Xiang Sun, Moonsook Lee, A. Maslov +11 more
2022Nature Genetics109 citations Open access
Semantic Scholar
Single-cell genome-wide bisulfite sequencing uncovers extensive heterogeneity in the mouse liver methylome
Silvia Gravina, Xiao Dong, Bo Yu, J. Vijg
2016Genome Biology108 citations Open access
Semantic Scholar
From DNA damage to mutations: all roads lead to aging
J. Vijg
2021Ageing Research Reviews105 citations Open access
Semantic Scholar
Somatic Mutagenesis in Mammals and Its Implications for Human Disease and Aging
Lei Zhang, J. Vijg
2018Annual Review of Genetics101 citations Open access
Semantic Scholar
Single-cell analysis reveals different age-related somatic mutation profiles between stem and differentiated cells in human liver
K. Brazhnik, Shi-Xiang Sun, O. Alani, M. Kinkhabwala +4 more
2019Science Advances95 citations Open access
Semantic Scholar
Genome-wide, Single-Cell DNA Methylomics Reveals Increased Non-CpG Methylation during Human Oocyte Maturation
Bo Yu, Xiao Dong, Silvia Gravina, Önder Kartal +6 more
2017Stem Cell Reports81 citations Open access
Semantic Scholar
Genetics of extreme human longevity to guide drug discovery for healthy ageing
Zheng-Dong D. Zhang, S. Milman, Jhih-Rong Lin, Shayne D. Wierbowski +8 more
2020Nature Metabolism59 citations Open access
Semantic Scholar
A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A
Matthew Simon, Jiping Yang, Jonathan Gigas, E. Earley +27 more
2021bioRxiv54 citations Open access
Semantic Scholar
Mechanisms and consequences of aneuploidy and chromosome instability in the aging brain
G. Andriani, J. Vijg, C. Montagna
2016Mechanisms of Ageing and Development50 citations Open access
Semantic Scholar
Age-related somatic mutation burden in human tissues
Peijun Ren, Xiao Dong, J. Vijg
2022Frontiers in Aging48 citations Open access
Semantic Scholar
ARDD 2020: from aging mechanisms to interventions
G. Mkrtchyan, K. Abdelmohsen, P. Andreux, I. Bagdonaite +62 more
2020Aging48 citations Open access
Semantic Scholar
Single-molecule, quantitative detection of low-abundance somatic mutations by high-throughput sequencing
A. Maslov, S. Makhortov, Shi-Xiang Sun, J. Heid +3 more
2022Science Advances46 citations Open access
Semantic Scholar
Rare genetic coding variants associated with human longevity and protection against age-related diseases
Jhih-Rong Lin, P. Sin‐Chan, V. Napolioni, G. G. Torres +23 more
2021Nature Aging46 citations
Semantic Scholar
The dark side of circulating nucleic acids
Silvia Gravina, J. Sedivy, J. Vijg
2016Aging Cell45 citations Open access
Semantic Scholar
SomaMutDB: a database of somatic mutations in normal human tissues
Shi-Xiang Sun, Yujue Wang, A. Maslov, Xiao Dong +1 more
2021Nucleic Acids Res.43 citations Open access
Semantic Scholar
Maintenance of genome sequence integrity in long- and short-lived rodent species
Lei Zhang, Xiao Dong, Xiao Tian, Moonsook Lee +8 more
2021Science Advances43 citations Open access
Semantic Scholar
Aging and the Inevitable Limit to Human Life Span
J. Vijg, É. Le Bourg
2017Gerontology43 citations
Semantic Scholar
Genome instability: a conserved mechanism of ageing?
J. Vijg, Xiao Dong, B. Milholland, Lei Zhang
2017Essays in Biochemistry40 citations Open access
Semantic Scholar
Mutation and catastrophe in the aging genome
B. Milholland, Y. Suh, J. Vijg
2017Experimental Gerontology39 citations Open access
Semantic Scholar
Genome instability and aging: Cause or effect?
J. Vijg, C. Montagna
201738 citations Open access
Semantic Scholar
Systems-level analysis of human aging genes shed new light on mechanisms of aging.
Quan-Wei Zhang, Rubén Nogales-Cadenas, Jhih-Rong Lin, Wen Zhang +3 more
2016Human Molecular Genetics36 citations Open access
Semantic Scholar
Development and validation of a targeted next generation DNA sequencing panel outperforming whole exome sequencing for the identification of clinically relevant genetic variants
E. Miller, Nicole E. Patterson, Jenna Marcus Zechmeister, Michal Bejerano‐Sagie +12 more
2017OncoTarget31 citations Open access
Semantic Scholar
Clonal Hematopoiesis Analyses in Clinical, Epidemiologic, and Genetic Aging Studies to Unravel Underlying Mechanisms of Age-Related Dysfunction in Humans
K. Walsh, N. Raghavachari, C. Kerr, A. Bick +12 more
2022Frontiers in Aging26 citations Open access
Semantic Scholar
FOXO3a acts to suppress DNA double‐strand break‐induced mutations
Ryan R. White, A. Maslov, Moonsook Lee, Samantha E. Wilner +2 more
2020Aging Cell26 citations Open access
Semantic Scholar
Development of a Method to Implement Whole-Genome Bisulfite Sequencing of cfDNA from Cancer Patients and a Mouse Tumor Model
Elaine C. Maggi, Silvia Gravina, Hai-Ying Cheng, B. Piperdi +5 more
2018Frontiers in Genetics26 citations Open access
Semantic Scholar
Mitigating age-related somatic mutation burden
J. Vijg, B. Schumacher, Abdulkadir Abakir, M. Antonov +10 more
2023Trends in Molecular Medicine24 citations Open access
Semantic Scholar
Inducible aging in Hydra oligactis implicates sexual reproduction, loss of stem cells, and genome maintenance as major pathways
Shi-Xiang Sun, Ryan R. White, K. Fischer, Zheng-Dong D. Zhang +2 more
2020GeroScience20 citations Open access
Semantic Scholar
SCCNV: A Software Tool for Identifying Copy Number Variation From Single-Cell Whole-Genome Sequencing
Xiao Dong, Lei Zhang, X. Hao, Tao Wang +1 more
2019bioRxiv20 citations Open access
Semantic Scholar
A review of the biomedical innovations for healthy longevity
Alexey Moskalev, V. Anisimov, A. Aliper, Artem V. Artemov +66 more
2017Aging20 citations Open access
Semantic Scholar
A direct comparison of interphase FISH versus low-coverage single cell sequencing to detect aneuploidy reveals respective strengths and weaknesses
G. Andriani, Elaine C. Maggi, Daniel G. Piqué, Samuel E. Zimmerman +7 more
2019Scientific Reports19 citations Open access
Semantic Scholar
Measuring cell-to-cell expression variability in single-cell RNA-sequencing data: a comparative analysis and applications to B cell aging
Hui-Wen Zheng, J. Vijg, A. Fard, J. Mar
2022bioRxiv18 citations Open access
Semantic Scholar
Age‐related telomere attrition causes aberrant gene expression in sub‐telomeric regions
Xiao Dong, Shi-Xiang Sun, Lei Zhang, Seungsoo Kim +7 more
2021Aging Cell17 citations Open access
Semantic Scholar
Cell replacement to reverse brain aging: challenges, pitfalls, and opportunities
J. Hébert, J. Vijg
2018Trends in Neurosciences17 citations Open access
Semantic Scholar
Genomic expansion of Aldh1a1 protects beavers against high metabolic aldehydes from lipid oxidation
Quan-Wei Zhang, Gregory Tombline, J. Ablaeva, Lei Zhang +14 more
2021Cell Reports16 citations Open access
Semantic Scholar
Bleomycin-induced genome structural variations in normal, non-tumor cells
Wilber Quispe-Tintaya, Moonsook Lee, Xiao Dong, D. Weiser +2 more
2018Scientific Reports13 citations Open access
Semantic Scholar
Sensitivity of primary fibroblasts in culture to atmospheric oxygen does not correlate with species lifespan
A. Patrick, Michael Seluanov, Chaewon Hwang, J. Tam +22 more
2016Aging13 citations Open access
Semantic Scholar
Single-cell analysis of somatic mutation burden in mammary epithelial cells of pathogenic BRCA1/2 mutation carriers
Shi-Xiang Sun, K. Brazhnik, Moonsook Lee, A. Maslov +6 more
2022Journal of Clinical Investigation12 citations Open access
Semantic Scholar

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V. Gorbunova×11
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Lei Zhang×10
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Moonsook Lee×9

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V. Gladyshev×8

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Zheng-Dong D. Zhang×7

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Shi-Xiang Sun×7

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C. Montagna — researcher profile on SciRah

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A. Seluanov — researcher profile on SciRah

J. Hoeijmakers×5

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