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N. Giorgadze · SciRah

Researcher profile · Semantic Scholar

N. Giorgadze

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N. Giorgadze — researcher profile on SciRah

h-index: 25
Works: 62
Citations: 12K

Most-cited papers

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
Yi Zhu, T. Tchkonia, T. Pirtskhalava, A. Gower +29 more
2015Aging Cell2,276 citations Open access
Semantic Scholar
Senolytics Improve Physical Function and Increase Lifespan in Old Age
Ming Xu, T. Pirtskhalava, J. Farr, B. M. Weigand +29 more
2018Nature Medicine2,071 citations Open access
Semantic Scholar
Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease
L. Hickson, Larissa P. G. Langhi Prata, Shane A. Bobart, Tamara K. Evans +29 more
2019EBioMedicine1,249 citations Open access
Semantic Scholar
Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors
Yi Zhu, T. Tchkonia, Heike Fuhrmann-Stroissnigg, H. Dai +10 more
2016Aging Cell1,046 citations Open access
Semantic Scholar
JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age
Ming Xu, T. Tchkonia, H. Ding, M. Ogrodnik +10 more
2015Proceedings of the National Academy of Sciences of the United States of America840 citations Open access
Semantic Scholar
Physiological frailty index (PFI): quantitative in-life estimate of individual biological age in mice
Yi Zhu, E. Doornebal, T. Pirtskhalava, N. Giorgadze +6 more
2017Aging667 citations Open access
Semantic Scholar
Targeting senescent cells enhances adipogenesis and metabolic function in old age
Ming Xu, A. Palmer, H. Ding, Megan M. Weivoda +10 more
2015eLife533 citations Open access
Semantic Scholar
Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat
T. Schulz, Tian-Lian Huang, Thien T. Tran, Hongbin Zhang +11 more
2010Proceedings of the National Academy of Sciences of the United States of America492 citations Open access
Semantic Scholar
Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis
M. Ogrodnik, Yi Zhu, Larissa G. P. Langhi, T. Tchkonia +20 more
2019Cell Metabolism458 citations Open access
Semantic Scholar
Regional differences in cellular mechanisms of adipose tissue gain with overfeeding
Y. Tchoukalova, S. Votruba, T. Tchkonia, N. Giorgadze +2 more
2010Proceedings of the National Academy of Sciences of the United States of America371 citations Open access
Semantic Scholar
Identification of depot-specific human fat cell progenitors through distinct expression profiles and developmental gene patterns.
T. Tchkonia, M. Lenburg, Thomas Thomou, N. Giorgadze +12 more
2007American Journal of Physiology. Endocrinology and Metabolism360 citations
Semantic Scholar
Senolytics reduce coronavirus-related mortality in old mice
Christina D. Camell, Matthew J. Yousefzadeh, Yi Zhu, Larissa P. G. Langhi Prata +30 more
2021Science297 citations Open access
Semantic Scholar
Fat depot origin affects adipogenesis in primary cultured and cloned human preadipocytes.
T. Tchkonia, N. Giorgadze, T. Pirtskhalava, Y. Tchoukalova +10 more
2002American Journal of Physiology. Regulatory Integrative and Comparative Physiology261 citations
Semantic Scholar
Abundance of two human preadipocyte subtypes with distinct capacities for replication, adipogenesis, and apoptosis varies among fat depots.
T. Tchkonia, Y. Tchoukalova, N. Giorgadze, T. Pirtskhalava +8 more
2005American Journal of Physiology. Endocrinology and Metabolism258 citations
Semantic Scholar
Fat Depot–Specific Characteristics Are Retained in Strains Derived From Single Human Preadipocytes
T. Tchkonia, N. Giorgadze, T. Pirtskhalava, Thomas Thomou +7 more
2006Diabetes228 citations Open access
Semantic Scholar
Pathogenesis of Pancreatic Cancer Exosome-Induced Lipolysis in Adipose Tissue
G. Sagar, R. Sah, N. Javeed, S. Dutta +7 more
2015Gut226 citations Open access
Semantic Scholar
Sex- and depot-dependent differences in adipogenesis in normal weight humans
Y. Tchoukalova, C. Koutsari, S. Votruba, T. Tchkonia +4 more
2010Obesity150 citations Open access
Semantic Scholar
Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis
M. Ogrodnik, Yi Zhu, Larissa G. P. Langhi, T. Tchkonia +20 more
2019Cell Metabolism90 citations Open access
Semantic Scholar
Induction of colitis causes inflammatory responses in fat depots: evidence for substance P pathways in human mesenteric preadipocytes.
Iordanes Karagiannides, E. Kokkotou, Morris F. Tansky, T. Tchkonia +5 more
2006Proceedings of the National Academy of Sciences of the United States of America87 citations
Semantic Scholar
SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3
Utkarsh Tripathi, Rayhane Nchioua, Larissa P. G. Langhi Prata, Yi Zhu +15 more
2021Aging79 citations Open access
Semantic Scholar
Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans
Yi Zhu, Larissa P. G. Langhi Prata, Erin O. Wissler-Gerdes, J. Netto +19 more
2022EBioMedicine78 citations Open access
Semantic Scholar
Corrigendum to ‘Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease’ EBioMedicine 47 (2019) 446–456
L. Hickson, Larissa P. G. Langhi Prata, Shane A. Bobart, Tamara K. Evans +34 more
2020EBioMedicine54 citations Open access
Semantic Scholar
Inflammation and the Depot-Specific Secretome of Human Preadipocytes
Yi Zhu, T. Tchkonia, Michael B. Stout, N. Giorgadze +7 more
2015Obesity46 citations Open access
Semantic Scholar
Substance P promotes expansion of human mesenteric preadipocytes through proliferative and antiapoptotic pathways.
Kara J. Gross, Iordanes Karagiannides, Thomas Thomou, Wai-Ko-On Hon +7 more
2009American Journal of Physiology - Gastrointestinal and Liver Physiology46 citations Open access
Semantic Scholar
Role of substance P in the regulation of glucose metabolism via insulin signaling-associated pathways.
Iordanes Karagiannides, Kyriaki Bakirtzi, E. Kokkotou, D. Stavrakis +5 more
2011Endocrinology33 citations Open access
Semantic Scholar
FBF1 deficiency promotes beiging and healthy expansion of white adipose tissue
Yingying Zhang, Jie-Lu Hao, M. Tarragó, G. Warner +12 more
2021Cell Reports25 citations Open access
Semantic Scholar
Endothelial senescent-cell-specific clearance alleviates metabolic dysfunction in obese mice
Masayoshi Suda, Selim Chaib, Larissa P. G. Langhi Prata, Yi Zhu +22 more
2025Cell Metabolism19 citations Open access
Semantic Scholar
Senescence markers in subcutaneous preadipocytes differ in childhood‐ versus adult‐onset obesity before and after weight loss
Jessica Murphy, Bjorn T. Tam, J. Kirkland, T. Tchkonia +5 more
2023Obesity10 citations Open access
Semantic Scholar
Senolytic‐Resistant Senescent Cells Have a Distinct SASP Profile and Functional Impact: The Path to Developing Senosensitizers
Utkarsh Tripathi, Masayoshi Suda, Vagisha Kulshreshtha, Bryan T. Piatkowski +18 more
2025Aging Cell8 citations Open access
Semantic Scholar
Author response: Targeting senescent cells enhances adipogenesis and metabolic function in old age
Ming Xu, A. Palmer, H. Ding, Megan M. Weivoda +10 more
20157 citations Open access
Semantic Scholar
Senolytic-Resistant Senescent Cells Have a Distinct SASP Profile and Functional Impact: The Path to Developing Senosensitizers
Utkarsh Tripathi, Masayoshi Suda, Vagisha Kulshreshtha, Bryan T. Piatkowski +18 more
2025bioRxiv5 citations
Semantic Scholar
Adsorption of Lead Ions on Carbonaceous Sorbents of Nutshell Obtained from Secondary Raw Material
T. Marsagishvili, G. Tatishvili, N. Ananiashvili, N. Giorgadze +4 more
2019IFMBE Proceedings5 citations
Semantic Scholar
Profiling microRNA expression during senescence and aging: mining for a diagnostic tool of senescent-cell burden
M. Weigl, Teresa L Krammer, M. Pultar, M. Wieser +19 more
2024bioRxiv3 citations Open access
Semantic Scholar
Effect of Combined Dasatinib and Fisetin Treatment on Senescent Cell Clearance in Monkeys
R. Colman, T. Tchkonia, T. Pirtskhalava, N. Giorgadze +3 more
2020Innovation in aging2 citations Open access
Semantic Scholar
Space radiation induces distinct senescent phenotypes: Implications for space travel
Louise E. Pitcher, Bipasha Mukherjee, Ashley M. Saathoff, Zachary A. Eduvas +11 more
2025npj Aging1 citations Open access
Semantic Scholar
USE OF NANOCARBON OBTAINED FROM SECONDARY RAW MATERIAL FOR MODIFICATION OF COMPOSITION COATINGS
T. Marsagishvili, G. Tatishvili, N. Ananiashvili, J. Metreveli +5 more
20191 citations
Semantic Scholar
Aging, inflammation and skeletal muscle
Thomas A. White, Yi Zhu, N. Giorgadze, T. Tchkonia +2 more
20121 citations
Semantic Scholar
"Happy Sufferers" in Otar Chiladze's Essays
N. Giorgadze
2026enadakultura0 citations
Semantic Scholar
Blocking PD-L2 prevents senescent cell accumulation and age-related dysfunction.
Selim Chaib, Larissa P. G. Langhi Prata, Masayoshi Suda, Andres Sola +43 more
2026Cell Metabolism0 citations Open access
Semantic Scholar
Left Common Carotid Artery Pseudoaneurysm After Unwitnessed Lithium Button Battery Ingestion in a Toddler: Successful Endovascular Hemostasis Following Life-Threatening Bleeding
Gia Bibilashvili, E. Ekvtimishvili, Z. Goginashvili, S. Ingorokva +11 more
2026GEORGIAN BIOMEDICAL NEWS0 citations Open access
Semantic Scholar
The Philosophical Perception of Death in the Life and Work of Guram Rcheulishvili
N. Giorgadze
2026TRANSACTIONS OF TELAVI STATE UNIVERSITY0 citations
Semantic Scholar
Mikheil Javakhishvili’s Theatrical Writings
N. Giorgadze
2025,,INTERCULTURAL DIALOGUES" TRANSACTIONS0 citations
Semantic Scholar
The poet of the own voice
N. Giorgadze
2024TRANSACTIONS OF TELAVI STATE UNIVERSITY0 citations Open access
Semantic Scholar
Identity of Christianity and Homeland Defense in Hagiography
N. Giorgadze
2023TRANSACTIONS OF TELAVI STATE UNIVERSITY0 citations Open access
Semantic Scholar
A Typological Analysis of “Beowulf’ and “Knight in the Panther’s Skin”
Koba Tsurtsumia, N. Giorgadze
2023GEORGIAN SCIENTISTS0 citations Open access
Semantic Scholar
From Epic Stories to Epos of the King Erekle II
N. Giorgadze
2023TRANSACTIONS OF TELAVI STATE UNIVERSITY0 citations Open access
Semantic Scholar
EXAMINATION OF THE CHEMICAL COMPOSITION OF SPRING WATERS IN AKETI VILLAGE OF LANCHKHUTI MUNICIPALITY
M. Chikovani, Nino Kakhidze, Lali Balavadze, N. Giorgadze +1 more
2023World Science0 citations Open access
Semantic Scholar
GREENHOUSE EFFECT AND GLOBAL WARMING.
N. Chkhartishvili, Ani Kantaria, N. Giorgadze
2022Theoretical & Applied Science0 citations Open access
Semantic Scholar
ORALLY ACTIVE, CLINICALLY TRANSLATABLE SENOLYTICS RESTORE Α-KLOTHO IN MICE AND HUMANS
Yi Zhu, L. Prata, E. Gerdes, J. Netto +4 more
2022Innovation in aging0 citations Open access
Semantic Scholar
Mikheil- Gobron Sabinin
N. Giorgadze
2022TRANSACTIONS OF TELAVI STATE UNIVERSITY0 citations Open access
Semantic Scholar

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T. Tchkonia×32
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T. Tchkonia — researcher profile on SciRah
T. Pirtskhalava×28
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T. Pirtskhalava — researcher profile on SciRah
J. Kirkland×26
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J. Kirkland — researcher profile on SciRah
Yi Zhu×17
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Yi Zhu — researcher profile on SciRah

Kurt O. Johnson

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Larissa P. G. Langhi Prata×9

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Larissa P. G. Langhi Prata — researcher profile on SciRah

N. LeBrasseur×8

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N. LeBrasseur — researcher profile on SciRah

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Ming Xu — researcher profile on SciRah

L. Niedernhofer×7

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M. Jensen — researcher profile on SciRah