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T. Pirtskhalava · SciRah

Researcher profile · Semantic Scholar

T. Pirtskhalava

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T. Pirtskhalava — researcher profile on SciRah

h-index: 39
Works: 68
Citations: 18K

Most-cited papers

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
Yi Zhu, T. Tchkonia, T. Pirtskhalava, A. Gower +29 more
2015Aging Cell2,276 citations Open access
Semantic Scholar
Senolytics Improve Physical Function and Increase Lifespan in Old Age
Ming Xu, T. Pirtskhalava, J. Farr, B. M. Weigand +29 more
2018Nature Medicine2,070 citations Open access
Semantic Scholar
Cellular senescence mediates fibrotic pulmonary disease
M. Schafer, T. White, K. Iijima, A. Haak +19 more
2017Nature Communications1,486 citations Open access
Semantic Scholar
Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease
L. Hickson, Larissa P. G. Langhi Prata, Shane A. Bobart, Tamara K. Evans +29 more
2019EBioMedicine1,249 citations Open access
Semantic Scholar
Targeting cellular senescence prevents age-related bone loss in mice
J. Farr, Ming Xu, Megan M. Weivoda, D. Monroe +14 more
2017Nature Medicine1,072 citations Open access
Semantic Scholar
Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors
Yi Zhu, T. Tchkonia, Heike Fuhrmann-Stroissnigg, H. Dai +10 more
2016Aging Cell1,046 citations Open access
Semantic Scholar
Fisetin is a senotherapeutic that extends health and lifespan
Matthew J. Yousefzadeh, Yi Zhu, S. J. McGowan, Luise A. Angelini +18 more
2018EBioMedicine955 citations Open access
Semantic Scholar
JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age
Ming Xu, T. Tchkonia, H. Ding, M. Ogrodnik +10 more
2015Proceedings of the National Academy of Sciences of the United States of America840 citations Open access
Semantic Scholar
Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice
Carolyn M. Roos, Bin Zhang, A. Palmer, M. Ogrodnik +11 more
2016Aging Cell702 citations Open access
Semantic Scholar
Physiological frailty index (PFI): quantitative in-life estimate of individual biological age in mice
Yi Zhu, E. Doornebal, T. Pirtskhalava, N. Giorgadze +6 more
2017Aging667 citations Open access
Semantic Scholar
Targeting senescent cells alleviates obesity‐induced metabolic dysfunction
A. Palmer, Ming Xu, Yi Zhu, T. Pirtskhalava +29 more
2019Aging Cell575 citations Open access
Semantic Scholar
Targeting senescent cells enhances adipogenesis and metabolic function in old age
Ming Xu, A. Palmer, H. Ding, Megan M. Weivoda +10 more
2015eLife533 citations Open access
Semantic Scholar
Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis
M. Ogrodnik, Yi Zhu, Larissa G. P. Langhi, T. Tchkonia +20 more
2019Cell Metabolism458 citations Open access
Semantic Scholar
Transplanted Senescent Cells Induce an Osteoarthritis-Like Condition in Mice
Ming Xu, Elizabeth W. Bradley, Megan M. Weivoda, S. Hwang +10 more
2016The journals of gerontology. Series A, Biological sciences and medical sciences361 citations Open access
Semantic Scholar
Identification of depot-specific human fat cell progenitors through distinct expression profiles and developmental gene patterns.
T. Tchkonia, M. Lenburg, Thomas Thomou, N. Giorgadze +12 more
2007American Journal of Physiology. Endocrinology and Metabolism360 citations
Semantic Scholar
Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice
M. Ogrodnik, Shane A. Evans, E. Fielder, S. Victorelli +19 more
2021Aging Cell347 citations Open access
Semantic Scholar
Adipogenesis and aging: does aging make fat go MAD?
J. Kirkland, T. Tchkonia, T. Pirtskhalava, Jian-Rong Han +1 more
2002Experimental Gerontology337 citations
Semantic Scholar
Senolytics reduce coronavirus-related mortality in old mice
Christina D. Camell, Matthew J. Yousefzadeh, Yi Zhu, Larissa P. G. Langhi Prata +30 more
2021Science297 citations Open access
Semantic Scholar
Fat depot origin affects adipogenesis in primary cultured and cloned human preadipocytes.
T. Tchkonia, N. Giorgadze, T. Pirtskhalava, Y. Tchoukalova +10 more
2002American Journal of Physiology. Regulatory Integrative and Comparative Physiology261 citations
Semantic Scholar
Abundance of two human preadipocyte subtypes with distinct capacities for replication, adipogenesis, and apoptosis varies among fat depots.
T. Tchkonia, Y. Tchoukalova, N. Giorgadze, T. Pirtskhalava +8 more
2005American Journal of Physiology. Endocrinology and Metabolism258 citations
Semantic Scholar
Fat Depot–Specific Characteristics Are Retained in Strains Derived From Single Human Preadipocytes
T. Tchkonia, N. Giorgadze, T. Pirtskhalava, Thomas Thomou +7 more
2006Diabetes228 citations Open access
Semantic Scholar
Liver-specific GH receptor gene-disrupted (LiGHRKO) mice have decreased endocrine IGF-I, increased local IGF-I, and altered body size, body composition, and adipokine profiles.
E. List, D. Berryman, K. Funk, A. Jara +16 more
2014Endocrinology142 citations Open access
Semantic Scholar
Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice
Michael B. Stout, T. Tchkonia, T. Pirtskhalava, A. Palmer +12 more
2014Aging123 citations Open access
Semantic Scholar
17α-Estradiol Alleviates Age-related Metabolic and Inflammatory Dysfunction in Male Mice Without Inducing Feminization
Michael B. Stout, F. Steyn, M. Jurczak, J. Camporez +20 more
2016The journals of gerontology. Series A, Biological sciences and medical sciences112 citations Open access
Semantic Scholar
Aging, Depot Origin, and Preadipocyte Gene Expression
M. Cartwright, K. Schlauch, M. Lenburg, T. Tchkonia +4 more
2010The journals of gerontology. Series A, Biological sciences and medical sciences92 citations Open access
Semantic Scholar
Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis
M. Ogrodnik, Yi Zhu, Larissa G. P. Langhi, T. Tchkonia +20 more
2019Cell Metabolism90 citations Open access
Semantic Scholar
A pilot study of senolytics to improve cognition and mobility in older adults at risk for Alzheimer’s disease
Courtney L. Millar, Ike Iloputaife, K. Baldyga, Amani M. Norling +8 more
2025EBioMedicine85 citations Open access
Semantic Scholar
TRAIL RECEPTOR DELETION IN MICE SUPPRESSES THE INFLAMMATION OF NUTRIENT EXCESS
L. Idrissova, H. Malhi, N. Werneburg, N. LeBrasseur +14 more
2014Journal of Hepatology82 citations Open access
Semantic Scholar
Increased TNFalpha and CCAAT/enhancer-binding protein homologous protein with aging predispose preadipocytes to resist adipogenesis.
T. Tchkonia, T. Pirtskhalava, Thomas Thomou, M. Cartwright +6 more
2007American Journal of Physiology. Endocrinology and Metabolism82 citations
Semantic Scholar
SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3
Utkarsh Tripathi, Rayhane Nchioua, Larissa P. G. Langhi Prata, Yi Zhu +15 more
2021Aging79 citations Open access
Semantic Scholar
Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans
Yi Zhu, Larissa P. G. Langhi Prata, Erin O. Wissler-Gerdes, J. Netto +19 more
2022EBioMedicine78 citations Open access
Semantic Scholar
Aging results in paradoxical susceptibility of fat cell progenitors to lipotoxicity.
Wen Guo, T. Pirtskhalava, T. Tchkonia, Weisheng Xie +8 more
2007American Journal of Physiology. Endocrinology and Metabolism76 citations
Semantic Scholar
Partial inhibition of mitochondrial complex I ameliorates Alzheimer’s disease pathology and cognition in APP/PS1 female mice
Andrea Stojakovic, S. Trushin, A. Sheu, Layla Khalili +32 more
2021Communications Biology68 citations Open access
Semantic Scholar
Increased CUG Triplet Repeat-binding Protein-1 Predisposes to Impaired Adipogenesis with Aging*
Iordanes Karagiannides, Thomas Thomou, T. Tchkonia, T. Pirtskhalava +7 more
2006Journal of Biological Chemistry68 citations Open access
Semantic Scholar
Octanoate attenuates adipogenesis in 3T3-L1 preadipocytes.
Jian-Rong Han, S. Farmer, J. Kirkland, B. Corkey +4 more
2002Journal of NutriLife56 citations Open access
Semantic Scholar
Corrigendum to ‘Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease’ EBioMedicine 47 (2019) 446–456
L. Hickson, Larissa P. G. Langhi Prata, Shane A. Bobart, Tamara K. Evans +34 more
2020EBioMedicine54 citations Open access
Semantic Scholar
Continuous intermittent clearance of p21-highly-expressing cells extends lifespan and confers sustained benefits to health and physical function
Bin-Sheng Wang, Lichao Wang, Nathan S. Gasek, Chia-Ling Kuo +22 more
2024Cell Metabolism51 citations Open access
Semantic Scholar
Substance P promotes expansion of human mesenteric preadipocytes through proliferative and antiapoptotic pathways.
Kara J. Gross, Iordanes Karagiannides, Thomas Thomou, Wai-Ko-On Hon +7 more
2009American Journal of Physiology - Gastrointestinal and Liver Physiology46 citations Open access
Semantic Scholar
Substance P (SP)-neurokinin-1 receptor (NK-1R) alters adipose tissue responses to high-fat diet and insulin action.
Iordanes Karagiannides, D. Stavrakis, Kyriaki Bakirtzi, E. Kokkotou +10 more
2011Endocrinology45 citations Open access
Semantic Scholar
Transplanting Old Organs Promotes Senescence in Young Recipients
Jasper Iske, Maximilian J. Roesel, Friederike Martin, A. Schroeter +16 more
2023American Journal of Transplantation34 citations Open access
Semantic Scholar
Deleted in Breast Cancer 1 regulates cellular senescence during obesity
C. Escande, Verónica Nin, T. Pirtskhalava, Claudia C. S. Chini +6 more
2014Aging Cell32 citations Open access
Semantic Scholar
Deleted in Breast Cancer 1 Limits Adipose Tissue Fat Accumulation and Plays a Key Role in the Development of Metabolic Syndrome Phenotype
C. Escande, Verónica Nin, T. Pirtskhalava, Claudia C. S. Chini +3 more
2014Diabetes24 citations Open access
Semantic Scholar
Corrigendum: Targeting cellular senescence prevents age-related bone loss in mice
J. Farr, Ming Xu, Megan M. Weivoda, D. Monroe +14 more
2017Nature Medicine22 citations Open access
Semantic Scholar
Endothelial senescent-cell-specific clearance alleviates metabolic dysfunction in obese mice
Masayoshi Suda, Selim Chaib, Larissa P. G. Langhi Prata, Yi Zhu +22 more
2025Cell Metabolism19 citations Open access
Semantic Scholar
A chronic wound model to investigate skin cellular senescence
Saranya P. Wyles, P. Dashti, T. Pirtskhalava, B. Tekin +8 more
2023Aging13 citations Open access
Semantic Scholar
New Scanning Electron Microscopic Method for Determination of Adipocyte Size in Humans and Mice
Wen Guo, Sherman J. Bigornia, I. Leizerman, Weisheng Xie +8 more
2007Obesity13 citations Open access
Semantic Scholar
Senescence markers in subcutaneous preadipocytes differ in childhood‐ versus adult‐onset obesity before and after weight loss
Jessica Murphy, Bjorn T. Tam, J. Kirkland, T. Tchkonia +5 more
2023Obesity10 citations Open access
Semantic Scholar
Senolytic‐Resistant Senescent Cells Have a Distinct SASP Profile and Functional Impact: The Path to Developing Senosensitizers
Utkarsh Tripathi, Masayoshi Suda, Vagisha Kulshreshtha, Bryan T. Piatkowski +18 more
2025Aging Cell8 citations Open access
Semantic Scholar
Author response: Targeting senescent cells enhances adipogenesis and metabolic function in old age
Ming Xu, A. Palmer, H. Ding, Megan M. Weivoda +10 more
20157 citations Open access
Semantic Scholar
Senolytic-Resistant Senescent Cells Have a Distinct SASP Profile and Functional Impact: The Path to Developing Senosensitizers
Utkarsh Tripathi, Masayoshi Suda, Vagisha Kulshreshtha, Bryan T. Piatkowski +18 more
2025bioRxiv5 citations
Semantic Scholar

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N. Giorgadze×23
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Ming Xu — researcher profile on SciRah

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