Skip to content

Home Search Authors Pakistan News Saved

SciRah

SciRah does not host or store research papers. Results come live from free, official scholarly APIs, and every paper links back to its original source.

Data sources

OpenAlex
Semantic Scholar
Crossref
CORE
arXiv
PubMed

Privacy policy Terms of service

C. Faltynek · SciRah

Researcher profile · Semantic Scholar

C. Faltynek

Share profile

C. Faltynek — researcher profile on SciRah

h-index: 46
Works: 140
Citations: 8,080

Most-cited papers

A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat
M. Jarvis, P. Honore, C. Shieh, Mark L. Chapman +33 more
2007Proceedings of the National Academy of Sciences of the United States of America510 citations Open access
Semantic Scholar
A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat
M. Jarvis, E. Burgard, S. McGaraughty, P. Honore +21 more
2002Proceedings of the National Academy of Sciences of the United States of America488 citations Open access
Semantic Scholar
A-740003 [N-(1-{[(Cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a Novel and Selective P2X7 Receptor Antagonist, Dose-Dependently Reduces Neuropathic Pain in the Rat
P. Honore, D. Donnelly-Roberts, M. Namovic, G. Hsieh +13 more
2006Journal of Pharmacology and Experimental Therapeutics425 citations
Semantic Scholar
TRPV1 Receptors in the CNS Play a Key Role in Broad-Spectrum Analgesia of TRPV1 Antagonists
M. Cui, P. Honore, Chengmin Zhong, D. Gauvin +16 more
2006Journal of Neuroscience306 citations Open access
Semantic Scholar
Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation
Jun Chen, S. Joshi, S. Didomenico, R. Perner +18 more
2011Pain278 citations Open access
Semantic Scholar
A-425619 [1-Isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a Novel Transient Receptor Potential Type V1 Receptor Antagonist, Relieves Pathophysiological Pain Associated with Inflammation and Tissue Injury in Rats
P. Honore, Carol T. Wismer, J. Mikusa, Chang Z. Zhu +9 more
2005Journal of Pharmacology and Experimental Therapeutics246 citations
Semantic Scholar
Structure−Activity Relationship Studies on a Series of Novel, Substituted 1-Benzyl-5-phenyltetrazole P2X7 Antagonists
D. Nelson, R. Gregg, M. Kort, A. Pérez-Medrano +10 more
2006245 citations Open access
Semantic Scholar
Analgesic profile of intrathecal P2X3 antisense oligonucleotide treatment in chronic inflammatory and neuropathic pain states in rats
P. Honore, K. Kage, J. Mikusa, A. Watt +5 more
2002Pain237 citations
Semantic Scholar
P2X7-related modulation of pathological nociception in rats.
S. McGaraughty, Katharine L. Chu, M. Namovic, D. Donnelly-Roberts +15 more
2007Neuroscience228 citations
Semantic Scholar
Effects of A‐317491, a novel and selective P2X3/P2X2/3 receptor antagonist, on neuropathic, inflammatory and chemogenic nociception following intrathecal and intraplantar administration
S. McGaraughty, Carol T. Wismer, Chang Z. Zhu, J. Mikusa +5 more
2003British Journal of Pharmacology184 citations Open access
Semantic Scholar
Involvement of the TTX‐resistant sodium channel Nav 1.8 in inflammatory and neuropathic, but not post‐operative, pain states
S. Joshi, J. Mikusa, G. Hernandez, Scott J. Baker +11 more
2006Pain172 citations
Semantic Scholar
Novel transient receptor potential vanilloid 1 receptor antagonists for the treatment of pain: structure-activity relationships for ureas with quinoline, isoquinoline, quinazoline, phthalazine, quinoxaline, and cinnoline moieties.
A. Gomtsyan, E. Bayburt, Robert G. Schmidt, G. Zheng +19 more
2005Journal of Medicinal Chemistry150 citations Open access
Semantic Scholar
Repeated dosing of ABT‐102, a potent and selective TRPV1 antagonist, enhances TRPV1‐mediated analgesic activity in rodents, but attenuates antagonist‐induced hyperthermia
P. Honore, P. Chandran, G. Hernandez, D. Gauvin +22 more
2009Pain135 citations
Semantic Scholar
Pore dilation occurs in TRPA1 but not in TRPM8 channels
Jun Chen, Donghee Kim, B. Bianchi, Eric J. Cavanaugh +3 more
2009Molecular Pain132 citations Open access
Semantic Scholar
Oral and cutaneous thermosensory profile of selective TRPV1 inhibition by ABT‐102 in a randomized healthy volunteer trial
M. Rowbotham, W. Nothaft, Rachel W. Duan, Yi Wang +4 more
2011Pain125 citations
Semantic Scholar
Capsaicin infused into the PAG affects rat tail flick responses to noxious heat and alters neuronal firing in the RVM.
S. McGaraughty, Katharine L. Chu, R. Bitner, Brenda R Martino +6 more
2003Journal of Neurophysiology123 citations
Semantic Scholar
Mitogen-Activated Protein Kinase and Caspase Signaling Pathways Are Required for P2X7 Receptor (P2X7R)-Induced Pore Formation in Human THP-1 Cells
D. Donnelly-Roberts, M. Namovic, C. Faltynek, M. Jarvis
2004Journal of Pharmacology and Experimental Therapeutics119 citations
Semantic Scholar
Molecular Determinants of Species-Specific Activation or Blockade of TRPA1 Channels
Jun Chen, Xu-Feng Zhang, M. Kort, J. R. Huth +11 more
2008Journal of Neuroscience117 citations Open access
Semantic Scholar
Interleukin-1αβ gene-deficient mice show reduced nociceptive sensitivity in models of inflammatory and neuropathic pain but not post-operative pain
P. Honore, C. Wade, Chengmin Zhong, R. Harris +7 more
2006114 citations
Semantic Scholar
Transient receptor potential A1 mediates an osmotically activated ion channel
Xu-Feng Zhang, Jun Chen, C. Faltynek, R. Moreland +1 more
2008European Journal of Neuroscience111 citations
Semantic Scholar
A-425619 [1-Isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a Novel and Selective Transient Receptor Potential Type V1 Receptor Antagonist, Blocks Channel Activation by Vanilloids, Heat, and Acid
Rachid El Kouhen, C. Surowy, B. Bianchi, T. Neelands +8 more
2005Journal of Pharmacology and Experimental Therapeutics110 citations
Semantic Scholar
TNP‐ATP, a potent P2X3 receptor antagonist, blocks acetic acid‐induced abdominal constriction in mice: comparison with reference analgesics
P. Honore, J. Mikusa, B. Bianchi, H. McDonald +3 more
2002Pain110 citations
Semantic Scholar
Discovery and biological evaluation of 5-aryl-2-furfuramides, potent and selective blockers of the Nav1.8 sodium channel with efficacy in models of neuropathic and inflammatory pain.
M. Kort, I. Drizin, R. Gregg, M. Scanio +26 more
2008Journal of Medicinal Chemistry82 citations Open access
Semantic Scholar
A Selective Nav1.8 Sodium Channel Blocker, A-803467 [5-(4-Chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], Attenuates Spinal Neuronal Activity in Neuropathic Rats
S. McGaraughty, Katharine L. Chu, M. Scanio, M. Kort +2 more
2008Journal of Pharmacology and Experimental Therapeutics80 citations
Semantic Scholar
Functional expression of P2X7 receptors in non-neuronal cells of rat dorsal root ganglia.
Xu-Feng Zhang, P. Han, C. Faltynek, M. Jarvis +1 more
2005Brain Research80 citations
Semantic Scholar
Pharmacology of Modality-Specific Transient Receptor Potential Vanilloid-1 Antagonists That Do Not Alter Body Temperature
R. M. Reilly, H. McDonald, P. Puttfarcken, S. Joshi +17 more
2012Journal of Pharmacology and Experimental Therapeutics77 citations
Semantic Scholar
Identification of (R)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)urea (ABT-102) as a potent TRPV1 antagonist for pain management.
A. Gomtsyan, E. Bayburt, Robert G. Schmidt, C. Surowy +9 more
2008Journal of Medicinal Chemistry70 citations Open access
Semantic Scholar
A‐995662 [(R)‐8‐(4‐methyl‐5‐(4‐(trifluoromethyl)phenyl)oxazol‐2‐ylamino)‐1,2,3,4‐tetrahydronaphthalen‐2‐ol], a novel, selective TRPV1 receptor antagonist, reduces spinal release of glutamate and CGRP in a rat knee joint pain model
P. Puttfarcken, P. Han, S. Joshi, T. Neelands +12 more
2010Pain69 citations
Semantic Scholar
Activation of TRPA1 Channels by the Fatty Acid Amide Hydrolase Inhibitor 3′-Carbamoylbiphenyl-3-yl cyclohexylcarbamate (URB597)
Wende Niforatos, Xu-Feng Zhang, M. Lake, K. Walter +6 more
2007Molecular Pharmacology69 citations
Semantic Scholar
TRPV1b overexpression negatively regulates TRPV1 responsiveness to capsaicin, heat and low pH in HEK293 cells
Melissa Vos, T. Neelands, H. McDonald, W. Choi +5 more
2006Journal of Neurochemistry69 citations
Semantic Scholar
A-887826 is a structurally novel, potent and voltage-dependent Na(v)1.8 sodium channel blocker that attenuates neuropathic tactile allodynia in rats.
Xu-Feng Zhang, C. Shieh, Mark L. Chapman, Mark A. Matulenko +9 more
2010Neuropharmacology57 citations
Semantic Scholar
Contributions of central and peripheral TRPV1 receptors to mechanically evoked and spontaneous firing of spinal neurons in inflamed rats.
S. McGaraughty, Katharine L. Chu, B. Brown, Chang Z. Zhu +5 more
2008Journal of Neurophysiology57 citations
Semantic Scholar
Increased WDR spontaneous activity and receptive field size in rats following a neuropathic or inflammatory injury: implications for mechanical sensitivity.
Katharine L. Chu, C. Faltynek, M. Jarvis, S. McGaraughty
2004Neuroscience Letters54 citations
Semantic Scholar
Differential action potentials and firing patterns in injured and uninjured small dorsal root ganglion neurons after nerve injury.
Xu-Feng Zhang, Chang Z. Zhu, R. Thimmapaya, W. Choi +7 more
2004Brain Research53 citations
Semantic Scholar
Systemic and site-specific effects of A-425619, a selective TRPV1 receptor antagonist, on wide dynamic range neurons in CFA-treated and uninjured rats.
S. McGaraughty, Katharine L. Chu, C. Faltynek, M. Jarvis
2006Journal of Neurophysiology52 citations
Semantic Scholar
(R)-(5-tert-Butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)-urea (ABT-102) Blocks Polymodal Activation of Transient Receptor Potential Vanilloid 1 Receptors in Vitro and Heat-Evoked Firing of Spinal Dorsal Horn Neurons in Vivo
C. Surowy, T. Neelands, B. Bianchi, S. McGaraughty +13 more
2008Journal of Pharmacology and Experimental Therapeutics48 citations
Semantic Scholar
Central pituitary adenylate cyclase 1 receptors modulate nociceptive behaviors in both inflammatory and neuropathic pain states.
Rachel A. Davis-Taber, Scott J. Baker, S. Lehto, Chengmin Zhong +4 more
2008Journal of Pain47 citations Open access
Semantic Scholar
Interleukin-1alphabeta gene-deficient mice show reduced nociceptive sensitivity in models of inflammatory and neuropathic pain but not post-operative pain.
P. Honore, C. Wade, Chengmin Zhong, R. Harris +7 more
2006Behavioural Brain Research47 citations
Semantic Scholar
Acidification of rat TRPV1 alters the kinetics of capsaicin responses
T. Neelands, M. Jarvis, P. Han, C. Faltynek +1 more
2005Molecular Pain47 citations Open access
Semantic Scholar
Assessment of nicotinic acetylcholine receptor-mediated release of [(3)H]-norepinephrine from rat brain slices using a new 96-well format assay.
David J. Anderson, P. Puttfarcken, I. Jacobs, C. Faltynek
2000Neuropharmacology46 citations
Semantic Scholar
Discovery and biological evaluation of novel cyanoguanidine P2X(7) antagonists with analgesic activity in a rat model of neuropathic pain.
A. Pérez-Medrano, D. Donnelly-Roberts, P. Honore, G. Hsieh +7 more
2009Journal of Medicinal Chemistry45 citations Open access
Semantic Scholar
Tetrahydropyridine-4-carboxamides as novel, potent transient receptor potential vanilloid 1 (TRPV1) antagonists.
B. Brown, Ryan G. Keddy, G. Zheng, Robert G. Schmidt +10 more
2008Bioorganic & Medicinal Chemistry45 citations Open access
Semantic Scholar
Capsaicin causes protein synthesis inhibition and microtubule disassembly through TRPV1 activities both on the plasma membrane and intracellular membranes.
P. Han, H. McDonald, B. Bianchi, Rachid El Kouhen +4 more
2007Biochemical Pharmacology45 citations
Semantic Scholar
Distribution and functional characterization of human Nav1.3 splice variants
R. Thimmapaya, T. Neelands, Wende Niforatos, Rachel A. Davis-Taber +8 more
2005European Journal of Neuroscience45 citations
Semantic Scholar
Endogenous opioid mechanisms partially mediate P2X3/P2X2/3‐related antinociception in rat models of inflammatory and chemogenic pain but not neuropathic pain
S. McGaraughty, P. Honore, Carol T. Wismer, J. Mikusa +5 more
2005British Journal of Pharmacology44 citations Open access
Semantic Scholar
Synthesis and Structure−Activity Relationship Studies of 3,6-Diazabicyclo[3.2.0]heptanes as Novel α4β2 Nicotinic Acetylcholine Receptor Selective Agonists
Jian-Guo Ji, M. Schrimpf, K. Sippy, W. Bunnelle +7 more
200743 citations Open access
Semantic Scholar
Characterization of nicotinic acetylcholine receptor-mediated [(3)H]-dopamine release from rat cortex and striatum.
P. Puttfarcken, I. Jacobs, C. Faltynek
2000Neuropharmacology43 citations
Semantic Scholar
Effects of methotrexate on nucleotide pools in normal human T cells and the CEM T cell line.
G. Budzik, Lynn Colletti, C. Faltynek
2000Life Science43 citations
Semantic Scholar
A-366833: a novel nicotinonitrile-substituted 3,6-diazabicyclo[3.2.0]-heptane alpha4beta2 nicotinic acetylcholine receptor selective agonist: Synthesis, analgesic efficacy and tolerability profile in animal models.
Jian-Guo Ji, W. Bunnelle, David J. Anderson, C. Faltynek +8 more
2007Biochemical Pharmacology42 citations
Semantic Scholar
Chroman and tetrahydroquinoline ureas as potent TRPV1 antagonists.
Robert G. Schmidt, E. Bayburt, S. Latshaw, John R. Koenig +10 more
2011Bioorganic & Medicinal Chemistry Letters41 citations Open access
Semantic Scholar

Frequent co-authors

Invite them to SciRah by sharing their profile.

M. Jarvis×30
Invite
M. Jarvis — researcher profile on SciRah
P. Honore×28
Invite
P. Honore — researcher profile on SciRah
S. McGaraughty×13
Invite
S. McGaraughty — researcher profile on SciRah
J. Mikusa×13
Invite
J. Mikusa — researcher profile on SciRah

×13

Invite

H. McDonald — researcher profile on SciRah

T. Neelands×13

Invite

T. Neelands — researcher profile on SciRah

Katharine L. Chu×12

Invite

Katharine L. Chu — researcher profile on SciRah

Chengmin Zhong×12

Invite

Chengmin Zhong — researcher profile on SciRah

J. Sullivan×12

Invite

J. Sullivan — researcher profile on SciRah

Invite

B. Bianchi — researcher profile on SciRah

Xu-Feng Zhang×11

Invite

Xu-Feng Zhang — researcher profile on SciRah

Invite

M. Kort — researcher profile on SciRah