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T. Neelands · SciRah

Researcher profile · Semantic Scholar

T. Neelands

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T. Neelands — researcher profile on SciRah

h-index: 29
Works: 52
Citations: 2,894

Most-cited papers

TRPV1 Receptors in the CNS Play a Key Role in Broad-Spectrum Analgesia of TRPV1 Antagonists
M. Cui, P. Honore, Chengmin Zhong, D. Gauvin +16 more
2006Journal of Neuroscience306 citations Open access
Semantic Scholar
Respiration and parturition affected by conditional overexpression of the Ca2+-activated K+ channel subunit, SK3.
C. Bond, R. Sprengel, J. Bissonnette, W. Kaufmann +9 more
2000Science240 citations
Semantic Scholar
Domains Responsible for Constitutive and Ca2+-Dependent Interactions between Calmodulin and Small Conductance Ca2+-Activated Potassium Channels
J. Keen, Radwan Khawaled, D. Farrens, T. Neelands +6 more
1999Journal of Neuroscience235 citations Open access
Semantic Scholar
Involvement of the TTX‐resistant sodium channel Nav 1.8 in inflammatory and neuropathic, but not post‐operative, pain states
S. Joshi, J. Mikusa, G. Hernandez, Scott J. Baker +11 more
2006Pain172 citations
Semantic Scholar
Repeated dosing of ABT‐102, a potent and selective TRPV1 antagonist, enhances TRPV1‐mediated analgesic activity in rodents, but attenuates antagonist‐induced hyperthermia
P. Honore, P. Chandran, G. Hernandez, D. Gauvin +22 more
2009Pain135 citations
Semantic Scholar
Properties of recombinant gamma-aminobutyric acid A receptor isoforms containing the alpha 5 subunit subtype.
E. Burgard, E. Tietz, T. Neelands, R. L. Macdonald
1996Molecular Pharmacology118 citations
Semantic Scholar
Molecular Determinants of Species-Specific Activation or Blockade of TRPA1 Channels
Jun Chen, Xu-Feng Zhang, M. Kort, J. R. Huth +11 more
2008Journal of Neuroscience117 citations Open access
Semantic Scholar
Transient receptor potential A1 mediates an osmotically activated ion channel
Xu-Feng Zhang, Jun Chen, C. Faltynek, R. Moreland +1 more
2008European Journal of Neuroscience111 citations
Semantic Scholar
A-425619 [1-Isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a Novel and Selective Transient Receptor Potential Type V1 Receptor Antagonist, Blocks Channel Activation by Vanilloids, Heat, and Acid
Rachid El Kouhen, C. Surowy, B. Bianchi, T. Neelands +8 more
2005Journal of Pharmacology and Experimental Therapeutics110 citations
Semantic Scholar
Spontaneous and γ-Aminobutyric Acid (GABA)-Activated GABAA Receptor Channels Formed by ε Subunit-Containing Isoforms
T. Neelands, J. L. Fisher, M. T. Bianchi, Robert L. Macdonald
1999Molecular Pharmacology103 citations
Semantic Scholar
Pharmacology of Modality-Specific Transient Receptor Potential Vanilloid-1 Antagonists That Do Not Alter Body Temperature
R. M. Reilly, H. McDonald, P. Puttfarcken, S. Joshi +17 more
2012Journal of Pharmacology and Experimental Therapeutics77 citations
Semantic Scholar
A‐995662 [(R)‐8‐(4‐methyl‐5‐(4‐(trifluoromethyl)phenyl)oxazol‐2‐ylamino)‐1,2,3,4‐tetrahydronaphthalen‐2‐ol], a novel, selective TRPV1 receptor antagonist, reduces spinal release of glutamate and CGRP in a rat knee joint pain model
P. Puttfarcken, P. Han, S. Joshi, T. Neelands +12 more
2010Pain69 citations
Semantic Scholar
Activation of TRPA1 Channels by the Fatty Acid Amide Hydrolase Inhibitor 3′-Carbamoylbiphenyl-3-yl cyclohexylcarbamate (URB597)
Wende Niforatos, Xu-Feng Zhang, M. Lake, K. Walter +6 more
2007Molecular Pharmacology69 citations
Semantic Scholar
TRPV1b overexpression negatively regulates TRPV1 responsiveness to capsaicin, heat and low pH in HEK293 cells
Melissa Vos, T. Neelands, H. McDonald, W. Choi +5 more
2006Journal of Neurochemistry69 citations
Semantic Scholar
Incorporation of the π Subunit into Functional γ-Aminobutyric AcidA Receptors
T. Neelands, R. L. Macdonald
1999Molecular Pharmacology65 citations
Semantic Scholar
BL-1249 [(5,6,7,8-Tetrahydro-naphthalen-1-yl)-[2-(1H-tetrazol-5-yl)-phenyl]-amine]: A Putative Potassium Channel Opener with Bladder-Relaxant Properties
S. Tertyshnikova, Ronald J. Knox, M. Plym, G. Thalody +7 more
2005Journal of Pharmacology and Experimental Therapeutics60 citations
Semantic Scholar
Expression of functional GABAA receptors in transfected L929 cells isolated by immunomagnetic bead separation.
L. Greenfield, S. Fang, T. Neelands, E. Burgard +2 more
1997Neuropharmacology56 citations
Semantic Scholar
Contrasting actions of lanthanum on different recombinant gamma-aminobutyric acid receptor isoforms expressed in L929 fibroblasts.
N. Saxena, T. Neelands, R. L. Macdonald
1997Molecular Pharmacology54 citations
Semantic Scholar
Functional expression of L-, N-, P/Q-, and R-type calcium channels in the human NT2-N cell line.
T. Neelands, A. P. King, R. L. Macdonald
2000Journal of Neurophysiology52 citations
Semantic Scholar
GABAA Receptor Pharmacology and Subtype mRNA Expression in Human Neuronal NT2-N Cells
T. Neelands, L. J. Greenfield, Jie Zhang, R. S. Turner +1 more
1998Journal of Neuroscience52 citations Open access
Semantic Scholar
(R)-(5-tert-Butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)-urea (ABT-102) Blocks Polymodal Activation of Transient Receptor Potential Vanilloid 1 Receptors in Vitro and Heat-Evoked Firing of Spinal Dorsal Horn Neurons in Vivo
C. Surowy, T. Neelands, B. Bianchi, S. McGaraughty +13 more
2008Journal of Pharmacology and Experimental Therapeutics48 citations
Semantic Scholar
Acidification of rat TRPV1 alters the kinetics of capsaicin responses
T. Neelands, M. Jarvis, P. Han, C. Faltynek +1 more
2005Molecular Pain47 citations Open access
Semantic Scholar
Distribution and functional characterization of human Nav1.3 splice variants
R. Thimmapaya, T. Neelands, Wende Niforatos, Rachel A. Davis-Taber +8 more
2005European Journal of Neuroscience45 citations
Semantic Scholar
Discovery of (R)-1-(7-chloro-2,2-bis(fluoromethyl)chroman-4-yl)-3-(3-methylisoquinolin-5-yl)urea (A-1165442): a temperature-neutral transient receptor potential vanilloid-1 (TRPV1) antagonist with analgesic efficacy.
E. Voight, A. Gomtsyan, J. Daanen, R. Perner +24 more
2014Journal of Medicinal Chemistry40 citations Open access
Semantic Scholar
GABAA Receptors Expressed in Undifferentiated Human Teratocarcinoma NT2 Cells Differ from Those Expressed by Differentiated NT2-N Cells
T. Neelands, Jie Zhang, R. Macdonald
1999Journal of Neuroscience40 citations Open access
Semantic Scholar
A-1048400 is a novel, orally active, state-dependent neuronal calcium channel blocker that produces dose-dependent antinociception without altering hemodynamic function in rats.
V. Scott, T. Vortherms, Wende Niforatos, A. Swensen +15 more
2012Biochemical Pharmacology36 citations
Semantic Scholar
Synthesis and Pharmacology of (Pyridin-2-yl)methanol Derivatives as Novel and Selective Transient Receptor Potential Vanilloid 3 Antagonists.
A. Gomtsyan, Robert G. Schmidt, E. Bayburt, G. Gfesser +29 more
2016Journal of Medicinal Chemistry34 citations Open access
Semantic Scholar
Small‐conductance calcium‐activated potassium currents in mouse hyperexcitable denervated skeletal muscle
T. Neelands, P. Herson, David Jacobson, J. P. Adelman +1 more
2001Journal of Physiology33 citations Open access
Semantic Scholar
2′, 3′‐O‐(2,4,6,Trinitrophenyl)‐ATP and A‐317491 are competitive antagonists at a slowly desensitizing chimeric human P2X3 receptor
T. Neelands, E. Burgard, M. Uchic, H. McDonald +4 more
2003British Journal of Pharmacology30 citations Open access
Semantic Scholar
Biological Characterization of F508delCFTR Protein Processing by the CFTR Corrector ABBV-2222/GLPG2222
Ashvani K. Singh, Yihong Fan, C. Balut, S. Al-Ani +15 more
2019Journal of Pharmacology and Experimental Therapeutics27 citations Open access
Semantic Scholar
Coexpression and activation of TRPV1 suppress the activity of the KCNQ2/3 channel
Xu-Feng Zhang, P. Han, T. Neelands, S. McGaraughty +3 more
2011The Journal of General Physiology24 citations Open access
Semantic Scholar
Substituted Indazoles as Nav1.7 Blockers for the Treatment of Pain.
J. Frost, D. Degoey, Lei Shi, R. Gum +12 more
2016Journal of Medicinal Chemistry23 citations Open access
Semantic Scholar
Differential effects of temperature on acid-activated currents mediated by TRPV1 and ASIC channels in rat dorsal root ganglion neurons.
T. Neelands, Xu-Feng Zhang, H. McDonald, P. Puttfarcken
2010Brain Research22 citations
Semantic Scholar
Characterization of A-425619 at native TRPV1 receptors: a comparison between dorsal root ganglia and trigeminal ganglia.
H. McDonald, T. Neelands, M. Kort, P. Han +4 more
2008European Journal of Pharmacology20 citations
Semantic Scholar
Inhibition of calcium-dependent motility of cochlear outer hair cells by the protein kinase inhibitor, ML-9.
D. Coling, S. Bartolami, Douglas J. Rhee, T. Neelands
1998Hearing Research20 citations
Semantic Scholar
SK channels are necessary but not sufficient for denervation‐induced hyperexcitability
David Jacobson, P. Herson, T. Neelands, J. Maylie +1 more
2002Muscle and Nerve18 citations
Semantic Scholar
Expression and purification of human TRPV1 in baculovirus-infected insect cells for structural studies.
A. Korepanova, Ana Pereda-Lopez, L. Solomon, K. Walter +8 more
2009Protein Expression and Purification17 citations
Semantic Scholar
[3H]A-778317 [1-((R)-5-tert-Butyl-indan-1-yl)-3-isoquinolin-5-yl-urea]: a Novel, Stereoselective, High-Affinity Antagonist Is a Useful Radioligand for the Human Transient Receptor Potential Vanilloid-1 (TRPV1) Receptor
B. Bianchi, Rachid El Kouhen, T. Neelands, Chih-Hung Lee +10 more
2007Journal of Pharmacology and Experimental Therapeutics17 citations Open access
Semantic Scholar
Mechanistic insights into the analgesic efficacy of A-1264087, a novel neuronal Ca(2+) channel blocker that reduces nociception in rat preclinical pain models.
Chang Z. Zhu, T. Vortherms, Min Zhang, Jun Xu +22 more
2014Journal of Pain13 citations Open access
Semantic Scholar
Elevated temperatures alter TRPV1 agonist-evoked excitability of dorsal root ganglion neurons
T. Neelands, M. Jarvis, C. Faltynek, C. Surowy
2008Inflammation Research10 citations
Semantic Scholar
Activation of TRPA 1 Channels by the Fatty Acid Amide Hydrolase Inhibitor 3-Carbamoylbiphenyl-3-yl cyclohexylcarbamate ( URB 597 )
Wende Niforatos, Xu-Feng Zhang, M. Lake, K. Walter +6 more
200710 citations
Semantic Scholar
Comparative analysis of inactivated-state block of N-type (Cav2.2) calcium channels
T. Vortherms, A. Swensen, Wende Niforatos, J. Limberis +11 more
2011Inflammation Research9 citations
Semantic Scholar
Spontaneous and gamma-aminobutyric acid (GABA)-activated GABA(A) receptor channels formed by epsilon subunit-containing isoforms.
T. Neelands, J. L. Fisher, M. Bianchi, R. L. Macdonald
1999Molecular Pharmacology9 citations
Semantic Scholar
CryoEM structures of the human CLC-2 voltage gated chloride channel reveal a ball and chain gating mechanism
Meng-Yuan Xu, T. Neelands, A. Powers, Yan Liu +6 more
2023bioRxiv8 citations Open access
Semantic Scholar
534 Defining a mechanistic link between TRPV3 activity and psoriasis through IL-1α and EGFR signaling pathways
V. Scott, H. Patel, J. Wetter, R. Edlmayer +9 more
20168 citations Open access
Semantic Scholar
CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism
Meng-Yuan Xu, T. Neelands, A. Powers, Yan Liu +6 more
2024eLife6 citations Open access
Semantic Scholar
Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Nav1.7/ Nav1.8 blockers for the treatment of pain.
Meena V. Patel, H. Peltier, Mark A. Matulenko, John R. Koenig +20 more
2022Bioorganic & Medicinal Chemistry6 citations Open access
Semantic Scholar
Development and Validation of a Medium-Throughput Electrophysiological Assay for KCNQ2/3 Channel Openers Using QPatch HT
Xu-Feng Zhang, Di Zhang, C. Surowy, B. Yao +3 more
2013Assay and drug development technologies3 citations
Semantic Scholar
A Novel, Stereoselective, High-Affinity Antagonist is a Useful Radioligand For The Human TRPV1 Receptor
B. Bianchi, Rachid El Kouhen, T. Neelands, Chih-Hung Lee +12 more
20072 citations
Semantic Scholar
Short Communication Elevated temperatures alter TRPV1 agonist-evoked excitability of dorsal root ganglion neurons
T. Neelands, M. Jarvis, C. Faltynek, Carol S. Surowy
20080 citations
Semantic Scholar

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C. Faltynek — researcher profile on SciRah
H. McDonald×13
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M. Jarvis×12
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Wende Niforatos×11
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