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P. Puttfarcken · SciRah

Researcher profile · Semantic Scholar

P. Puttfarcken

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P. Puttfarcken — researcher profile on SciRah

h-index: 34
Works: 55
Citations: 6,659

Most-cited papers

Oxidative stress, glutamate, and neurodegenerative disorders.
J. Coyle, P. Puttfarcken
1993Science3,962 citations
Semantic Scholar
Broad-spectrum, non-opioid analgesic activity by selective modulation of neuronal nicotinic acetylcholine receptors.
A. Bannon, M. W. Decker, M. Holladay, P. Curzon +8 more
1998Science351 citations Open access
Semantic Scholar
Effects of chronic morphine exposure on opioid inhibition of adenylyl cyclase in 7315c cell membranes: a useful model for the study of tolerance at mu opioid receptors.
P. Puttfarcken, L. L. Werling, B. Cox
1988Molecular Pharmacology120 citations
Semantic Scholar
Acute and chronic nicotine exposures modulate the immune system through different pathways.
S. Singh, Roma Kalra, P. Puttfarcken, A. Kozak +2 more
2000Toxicology and Applied Pharmacology97 citations
Semantic Scholar
ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I. In vitro characterization.
D. Donnelly-Roberts, P. Puttfarcken, Theresa A. Kuntzweiler, C. Briggs +8 more
1998Journal of Pharmacology and Experimental Therapeutics97 citations
Semantic Scholar
Kainic acid-induced lipid peroxidation: protection with butylated hydroxytoluene and U78517F in primary cultures of cerebellar granule cells.
P. Puttfarcken, R. Getz, J. Coyle
1993Brain Research96 citations
Semantic Scholar
Preclinical Characterization of A‐582941: A Novel α7 Neuronal Nicotinic Receptor Agonist with Broad Spectrum Cognition‐Enhancing Properties
Karin R. Tietje, David J. Anderson, R. Bitner, E. Blomme +35 more
2008CNS Neuroscience & Therapeutics88 citations Open access
Semantic Scholar
Developmental time course and ionic dependence of kainate-mediated toxicity in rat cerebellar granule cell cultures.
K. Kato, P. Puttfarcken, W. Lyons, Joseph T. Coyle
1990Journal of Pharmacology and Experimental Therapeutics86 citations
Semantic Scholar
Effect of Apolipoprotein E on Neurite Outgrowth and β‐Amyloid‐Induced Toxicity in Developing Rat Primary Hippocampal Cultures
P. Puttfarcken, A. Manelli, M. Falduto, G. Getz +1 more
1997Journal of Neurochemistry83 citations
Semantic Scholar
Reduced nicotinic receptor-mediated antinociception following in vivo antisense knock-down in rat.
R. Bitner, A. Nikkel, P. Curzon, D. Donnelly-Roberts +5 more
2000Brain Research81 citations
Semantic Scholar
N-acetyl-aspartylglutamate modulation of N-methyl-D-aspartate-stimulated [3H]norepinephrine release from rat hippocampal slices.
P. Puttfarcken, J. Handen, D. Montgomery, Joseph T. Coyle +1 more
1993Journal of Pharmacology and Experimental Therapeutics78 citations
Semantic Scholar
Pharmacology of Modality-Specific Transient Receptor Potential Vanilloid-1 Antagonists That Do Not Alter Body Temperature
R. M. Reilly, H. McDonald, P. Puttfarcken, S. Joshi +17 more
2012Journal of Pharmacology and Experimental Therapeutics77 citations
Semantic Scholar
Multiple agonist-affinity states of opioid receptors: regulation of binding by guanyl nucleotides in guinea pig cortical, NG108-15, and 7315c cell membranes.
L. L. Werling, P. Puttfarcken, B. M. Cox
1988Molecular Pharmacology73 citations
Semantic Scholar
Selective alpha7 nicotinic acetylcholine receptor activation regulates glycogen synthase kinase3beta and decreases tau phosphorylation in vivo.
R. Bitner, A. Nikkel, S. Markosyan, S. Otte +2 more
2009Brain Research72 citations
Semantic Scholar
A‐995662 [(R)‐8‐(4‐methyl‐5‐(4‐(trifluoromethyl)phenyl)oxazol‐2‐ylamino)‐1,2,3,4‐tetrahydronaphthalen‐2‐ol], a novel, selective TRPV1 receptor antagonist, reduces spinal release of glutamate and CGRP in a rat knee joint pain model
P. Puttfarcken, P. Han, S. Joshi, T. Neelands +12 more
2010Pain69 citations
Semantic Scholar
TRPV1b overexpression negatively regulates TRPV1 responsiveness to capsaicin, heat and low pH in HEK293 cells
Melissa Vos, T. Neelands, H. McDonald, W. Choi +5 more
2006Journal of Neurochemistry69 citations
Semantic Scholar
Different nicotinic acetylcholine receptor subtypes mediating striatal and prefrontal cortical [3H]dopamine release.
Ying-Jun Cao, C. Surowy, P. Puttfarcken
2005Neuropharmacology68 citations
Semantic Scholar
beta-Amyloid-induced toxicity in rat hippocampal cells: in vitro evidence for the involvement of free radicals.
A. Manelli, P. Puttfarcken
1995Brain Research Bulletin68 citations
Semantic Scholar
Galanthamine, an acetylcholinesterase inhibitor: a time course of the effects on performance and neurochemical parameters in mice.
Joanne E. Sweeney, P. Puttfarcken, J. Coyle
1989Pharmacology, Biochemistry and Behavior68 citations Open access
Semantic Scholar
Morphine-induced desensitization and down-regulation at mu-receptors in 7315C pituitary tumor cells.
P. Puttfarcken, Brian M. Cox
1989Life Science68 citations
Semantic Scholar
High content screen microscopy analysis of A beta 1-42-induced neurite outgrowth reduction in rat primary cortical neurons: neuroprotective effects of alpha 7 neuronal nicotinic acetylcholine receptor ligands.
Min Hu, M. Schurdak, P. Puttfarcken, Rachid El Kouhen +2 more
2007Brain Research67 citations
Semantic Scholar
In Vitro Pharmacological Characterization of a Novel Selective α7 Neuronal Nicotinic Acetylcholine Receptor Agonist ABT-107
J. Malysz, David J. Anderson, J. H. Grønlien, Jian-Guo Ji +18 more
2010Journal of Pharmacology and Experimental Therapeutics61 citations
Semantic Scholar
Evidence for Nicotinic Receptors Potentially Modulating Nociceptive Transmission at the Level of the Primary Sensory Neuron: Studies with F11 Cells
P. Puttfarcken, A. Manelli, Stephen P. Arneric, D. Donnelly-Roberts
1997Journal of Neurochemistry54 citations
Semantic Scholar
Sodium regulation of agonist binding at opioid receptors. I. Effects of sodium replacement on binding at mu- and delta-type receptors in 7315c and NG108-15 cells and cell membranes.
P. Puttfarcken, L. L. Werling, S. R. Brown, T. Cote +1 more
1986Molecular Pharmacology54 citations
Semantic Scholar
Structure-activity studies and analgesic efficacy of N-(3-pyridinyl)-bridged bicyclic diamines, exceptionally potent agonists at nicotinic acetylcholine receptors.
William H. Bunnelle, Jerome F. Daanen, Keith B. Ryther, M. Schrimpf +15 more
2007Journal of Medicinal Chemistry52 citations Open access
Semantic Scholar
Sodium regulation of agonist binding at opioid receptors. II. Effects of sodium replacement on opioid binding in guinea pig cortical membranes.
L. L. Werling, S. R. Brown, P. Puttfarcken, B. M. Cox
1986Molecular Pharmacology49 citations
Semantic Scholar
Assessment of nicotinic acetylcholine receptor-mediated release of [(3)H]-norepinephrine from rat brain slices using a new 96-well format assay.
David J. Anderson, P. Puttfarcken, I. Jacobs, C. Faltynek
2000Neuropharmacology46 citations
Semantic Scholar
Dissociation of nitric oxide generation and kainate-mediated neuronal degeneration in primary cultures of rat cerebellar granule cells.
P. Puttfarcken, W. Lyons, Joseph T. Coyle
1992Neuropharmacology45 citations
Semantic Scholar
Characterization of nicotinic acetylcholine receptor-mediated [(3)H]-dopamine release from rat cortex and striatum.
P. Puttfarcken, I. Jacobs, C. Faltynek
2000Neuropharmacology43 citations
Semantic Scholar
Discovery of (R)-1-(7-chloro-2,2-bis(fluoromethyl)chroman-4-yl)-3-(3-methylisoquinolin-5-yl)urea (A-1165442): a temperature-neutral transient receptor potential vanilloid-1 (TRPV1) antagonist with analgesic efficacy.
E. Voight, A. Gomtsyan, J. Daanen, R. Perner +24 more
2014Journal of Medicinal Chemistry40 citations Open access
Semantic Scholar
The role of neuronal nicotinic acetylcholine receptors in antinociception: effects of ABT-594.
M. W. Decker, P. Curzon, M. Holladay, A. Nikkel +8 more
1998Journal of Physiology - Paris39 citations
Semantic Scholar
Inhibition of Age-Induced β-Amyloid Neurotoxicity in Rat Hippocampal Cells
P. Puttfarcken, A. Manelli, J. Neilly, D. Frail
199637 citations
Semantic Scholar
Modulation of human TRPV1 receptor activity by extracellular protons and host cell expression system.
B. Bianchi, Chih-Hung Lee, M. Jarvis, Rachid El Kouhen +3 more
2006European Journal of Pharmacology36 citations
Semantic Scholar
Differential regulation of nicotinic receptor-mediated neurotransmitter release following chronic (-)-nicotine administration.
I. Jacobs, David J. Anderson, C. Surowy, P. Puttfarcken
2002Neuropharmacology35 citations
Semantic Scholar
Synthesis and Pharmacology of (Pyridin-2-yl)methanol Derivatives as Novel and Selective Transient Receptor Potential Vanilloid 3 Antagonists.
A. Gomtsyan, Robert G. Schmidt, E. Bayburt, G. Gfesser +29 more
2016Journal of Medicinal Chemistry34 citations Open access
Semantic Scholar
Nicotinic Acetylcholine Receptor-Mediated [3H]Dopamine Release from Hippocampus
Ying-Jun Cao, C. Surowy, P. Puttfarcken
2005Journal of Pharmacology and Experimental Therapeutics31 citations
Semantic Scholar
TRPV1 ligands with hyperthermic, hypothermic and no temperature effects in rats
A. Gomtsyan, H. McDonald, Robert G. Schmidt, J. Daanen +7 more
2015Temperature22 citations Open access
Semantic Scholar
Differential effects of temperature on acid-activated currents mediated by TRPV1 and ASIC channels in rat dorsal root ganglion neurons.
T. Neelands, Xu-Feng Zhang, H. McDonald, P. Puttfarcken
2010Brain Research22 citations
Semantic Scholar
Discovery of TRPV1 antagonist ABT-116.
B. Brown, Ryan G. Keddy, R. Perner, S. Didomenico +11 more
2010Bioorganic & Medicinal Chemistry Letters21 citations Open access
Semantic Scholar
Characterization of A-425619 at native TRPV1 receptors: a comparison between dorsal root ganglia and trigeminal ganglia.
H. McDonald, T. Neelands, M. Kort, P. Han +4 more
2008European Journal of Pharmacology20 citations
Semantic Scholar
Inhibition of age-induced beta-amyloid neurotoxicity in rat hippocampal cells.
P. Puttfarcken, A. Manelli, J. Neilly, D. Frail
1996Experimental Neurology19 citations
Semantic Scholar
[3H]A-778317 [1-((R)-5-tert-Butyl-indan-1-yl)-3-isoquinolin-5-yl-urea]: a Novel, Stereoselective, High-Affinity Antagonist Is a Useful Radioligand for the Human Transient Receptor Potential Vanilloid-1 (TRPV1) Receptor
B. Bianchi, Rachid El Kouhen, T. Neelands, Chih-Hung Lee +10 more
2007Journal of Pharmacology and Experimental Therapeutics17 citations Open access
Semantic Scholar
β-Amyloid Peptides Initiate the Complement Cascade without Producing a Comparable Effect on the Terminal Pathwayin Vitro☆
E. D. Cadman, P. Puttfarcken
199712 citations
Semantic Scholar
7. The non-excitatory mechanisms of glutamate induced neurotoxicity
J. Coyle, T. H. Murphy, P. Puttfarcken, E. Lyons +1 more
199110 citations
Semantic Scholar
Beta-amyloid peptides initiate the complement cascade without producing a comparable effect on the terminal pathway in vitro.
E. D. Cadman, P. Puttfarcken
1997Experimental Neurology8 citations
Semantic Scholar
Binding of [(3)H]A-778317 to native transient receptor potential vanilloid-1 (TRPV1) channels in rat dorsal root ganglia and spinal cord.
B. Bianchi, Rachid El Kouhen, Jun Chen, P. Puttfarcken
2010European Journal of Pharmacology5 citations
Semantic Scholar
Editorial Central & Peripheral Nervous Systems: Amyloid β Peptide in Alzheimer's Disease Pathology: Towards a Rational Basis for Drug Discovery?
Michael Williams, K. Shiosaki, P. Puttfarcken
19955 citations
Semantic Scholar
Amyloid p peptide in Alzheimer's disease pathology: Towards a rational basis for drug discovery?
M. Williams, K. Shiosaki, P. Puttfarcken
19953 citations
Semantic Scholar
The presence of the complement cascade does not lead to neuronal cell death in primary hippocampal cultures.
A. Manelli, E. D. Cadman, K. Shiosaki, P. Puttfarcken
1997Brain Research Bulletin2 citations
Semantic Scholar
Chapter 4. Emerging Opportunities in Neuroinflammatory Mechanisms of Neurodegeneration
K. Shiosaki, P. Puttfarcken
19952 citations
Semantic Scholar

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