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A. Gomtsyan · SciRah

Researcher profile · Semantic Scholar

A. Gomtsyan

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A. Gomtsyan — researcher profile on SciRah

h-index: 29
Works: 63
Citations: 2,896

Most-cited papers

Heterocycles in drugs and drug discovery
A. Gomtsyan
2012Chemistry of Heterocyclic Compounds513 citations
Semantic Scholar
TRPV1 Receptors in the CNS Play a Key Role in Broad-Spectrum Analgesia of TRPV1 Antagonists
M. Cui, P. Honore, Chengmin Zhong, D. Gauvin +16 more
2006Journal of Neuroscience306 citations Open access
Semantic Scholar
A-425619 [1-Isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a Novel Transient Receptor Potential Type V1 Receptor Antagonist, Relieves Pathophysiological Pain Associated with Inflammation and Tissue Injury in Rats
P. Honore, Carol T. Wismer, J. Mikusa, Chang Z. Zhu +9 more
2005Journal of Pharmacology and Experimental Therapeutics246 citations
Semantic Scholar
Novel transient receptor potential vanilloid 1 receptor antagonists for the treatment of pain: structure-activity relationships for ureas with quinoline, isoquinoline, quinazoline, phthalazine, quinoxaline, and cinnoline moieties.
A. Gomtsyan, E. Bayburt, Robert G. Schmidt, G. Zheng +19 more
2005Journal of Medicinal Chemistry150 citations Open access
Semantic Scholar
Repeated dosing of ABT‐102, a potent and selective TRPV1 antagonist, enhances TRPV1‐mediated analgesic activity in rodents, but attenuates antagonist‐induced hyperthermia
P. Honore, P. Chandran, G. Hernandez, D. Gauvin +22 more
2009Pain135 citations
Semantic Scholar
A-425619 [1-Isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a Novel and Selective Transient Receptor Potential Type V1 Receptor Antagonist, Blocks Channel Activation by Vanilloids, Heat, and Acid
Rachid El Kouhen, C. Surowy, B. Bianchi, T. Neelands +8 more
2005Journal of Pharmacology and Experimental Therapeutics110 citations
Semantic Scholar
ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin- 3-yl)pyrido[2,3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties. II. In vivo characterization in the rat.
E. Kowaluk, J. Mikusa, Carol T. Wismer, Chang Z. Zhu +12 more
2000Journal of Pharmacology and Experimental Therapeutics103 citations
Semantic Scholar
TRPV1 antagonists that cause hypothermia, instead of hyperthermia, in rodents: Compounds’ pharmacological profiles, in vivo targets, thermoeffectors recruited and implications for drug development
A. Garami, E. Pakai, H. McDonald, R. M. Reilly +8 more
2018Acta Physiologica83 citations Open access
Semantic Scholar
MOLECULAR RECOGNITION AND SELF-ASSEMBLY BY WEAK HYDROGEN BONDING : UNPRECEDENTED SUPRAMOLECULAR HELICATE STRUCTURES FROM DIAMINE/DIOL MOTIFS
S. Hanessian, A. Gomtsyan, M. Simard, S. Roelens
199480 citations
Semantic Scholar
Pharmacology of Modality-Specific Transient Receptor Potential Vanilloid-1 Antagonists That Do Not Alter Body Temperature
R. M. Reilly, H. McDonald, P. Puttfarcken, S. Joshi +17 more
2012Journal of Pharmacology and Experimental Therapeutics77 citations
Semantic Scholar
Identification of (R)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)urea (ABT-102) as a potent TRPV1 antagonist for pain management.
A. Gomtsyan, E. Bayburt, Robert G. Schmidt, C. Surowy +9 more
2008Journal of Medicinal Chemistry70 citations Open access
Semantic Scholar
Design of adenosine kinase inhibitors from the NMR-based screening of fragments.
P. Hajduk, A. Gomtsyan, S. Didomenico, M. Cowart +11 more
2000Journal of Medicinal Chemistry62 citations Open access
Semantic Scholar
Asymmetric Synthesis of Enantiomerically Pure and Diversely Functionalized Cyclopropanes.
S. Hanessian, D. Andreotti, A. Gomtsyan
199562 citations
Semantic Scholar
Additive antinociceptive effects of the selective Nav1.8 blocker A-803467 and selective TRPV1 antagonists in rat inflammatory and neuropathic pain models.
S. K. Joshi, P. Honore, G. Hernandez, Robert G. Schmidt +4 more
2009Journal of Pain50 citations Open access
Semantic Scholar
Design, Synthesis, and Structure−Activity Relationship of 6-Alkynylpyrimidines as Potent Adenosine Kinase Inhibitors
A. Gomtsyan, S. Didomenico, Chih-Hung Lee, Mark A. Matulenko +8 more
200250 citations Open access
Semantic Scholar
(R)-(5-tert-Butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)-urea (ABT-102) Blocks Polymodal Activation of Transient Receptor Potential Vanilloid 1 Receptors in Vitro and Heat-Evoked Firing of Spinal Dorsal Horn Neurons in Vivo
C. Surowy, T. Neelands, B. Bianchi, S. McGaraughty +13 more
2008Journal of Pharmacology and Experimental Therapeutics48 citations
Semantic Scholar
Asymmetric conjugate additions of chiral allyl- and crotylphosphonamide anions to .alpha.,.beta.-unsaturated carbonyl compounds: highly stereocontrolled access to vicinally substituted carbon centers and chemically asymmetrized chirons
S. Hanessian, A. Gomtsyan, A. Payne, Yolande Hervé +1 more
199348 citations
Semantic Scholar
5-(3-Bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3-d]pyrimidin-4-ylamine: structure-activity relationships of 7-substituted heteroaryl analogs as non-nucleoside adenosine kinase inhibitors.
Mark A. Matulenko, Chih-Hung Lee, Mei-Qun Jiang, Robin R. Frey +20 more
2005Bioorganic & Medicinal Chemistry43 citations
Semantic Scholar
Chroman and tetrahydroquinoline ureas as potent TRPV1 antagonists.
Robert G. Schmidt, E. Bayburt, S. Latshaw, John R. Koenig +10 more
2011Bioorganic & Medicinal Chemistry Letters41 citations Open access
Semantic Scholar
Discovery of (R)-1-(7-chloro-2,2-bis(fluoromethyl)chroman-4-yl)-3-(3-methylisoquinolin-5-yl)urea (A-1165442): a temperature-neutral transient receptor potential vanilloid-1 (TRPV1) antagonist with analgesic efficacy.
E. Voight, A. Gomtsyan, J. Daanen, R. Perner +24 more
2014Journal of Medicinal Chemistry40 citations Open access
Semantic Scholar
Synthesis and structure-activity relationships of 5-heteroatom-substituted pyridopyrimidines as adenosine kinase inhibitors.
G. Gfesser, E. Bayburt, M. Cowart, S. Didomenico +6 more
2003European journal of medicinal chemistry36 citations
Semantic Scholar
The synthesis of enantiomerically pure, symmetrically substituted cyclopropane phosphonic acids — A constrained analog of the GABA antagonist phaclophen
S. Hanessian, L. Cantin, Stéphan Roy, D. Andreotti +1 more
199736 citations
Semantic Scholar
Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design.
Justin D. Dietrich, K. Longenecker, Noel S. Wilson, C. Goess +25 more
2020Journal of Medicinal Chemistry35 citations Open access
Semantic Scholar
Synthesis and Pharmacology of (Pyridin-2-yl)methanol Derivatives as Novel and Selective Transient Receptor Potential Vanilloid 3 Antagonists.
A. Gomtsyan, Robert G. Schmidt, E. Bayburt, G. Gfesser +29 more
2016Journal of Medicinal Chemistry34 citations Open access
Semantic Scholar
Synthesis and biological evaluation of pteridine and pyrazolopyrimidine based adenosine kinase inhibitors.
A. Gomtsyan, S. Didomenico, Chih-Hung Lee, A. Stewart +3 more
2004Bioorganic & Medicinal Chemistry Letters34 citations Open access
Semantic Scholar
Synthesis and biological evaluation of 5-substituted and 4,5-disubstituted-2-arylamino oxazole TRPV1 antagonists.
R. Perner, John R. Koenig, S. Didomenico, A. Gomtsyan +10 more
2010Bioorganic & Medicinal Chemistry33 citations Open access
Semantic Scholar
4-amino-5-aryl-6-arylethynylpyrimidines: structure-activity relationships of non-nucleoside adenosine kinase inhibitors.
Mark A. Matulenko, E. S. Paight, Robin R. Frey, A. Gomtsyan +15 more
2007Bioorganic & Medicinal Chemistry30 citations Open access
Semantic Scholar
Alpha-methylation at benzylic fragment of N-aryl-N'-benzyl ureas provides TRPV1 antagonists with better pharmacokinetic properties and higher efficacy in inflammatory pain model.
A. Gomtsyan, E. Bayburt, Ryan G. Keddy, S. Turner +13 more
2007Bioorganic & Medicinal Chemistry Letters29 citations Open access
Semantic Scholar
Pyridopyrimidine analogues as novel adenosine kinase inhibitors.
G. Zheng, Chih-Hung Lee, J. Pratt, R. Perner +19 more
2001Bioorganic & Medicinal Chemistry Letters29 citations Open access
Semantic Scholar
Vanilloid receptor TRPV1 in drug discovery
A. Gomtsyan, C. Faltynek
201027 citations
Semantic Scholar
Crystal structures of human adenosine kinase inhibitor complexes reveal two distinct binding modes.
S. Muchmore, R. Smith, A. Stewart, M. Cowart +9 more
2006Journal of Medicinal Chemistry26 citations Open access
Semantic Scholar
Structure-activity studies of a novel series of 5,6-fused heteroaromatic ureas as TRPV1 antagonists.
I. Drizin, A. Gomtsyan, E. Bayburt, Robert G. Schmidt +18 more
2006Bioorganic & Medicinal Chemistry25 citations Open access
Semantic Scholar
TRPV1 ligands with hyperthermic, hypothermic and no temperature effects in rats
A. Gomtsyan, H. McDonald, Robert G. Schmidt, J. Daanen +7 more
2015Temperature22 citations Open access
Semantic Scholar
In vitro structure-activity relationship and in vivo characterization of 1-(aryl)-3-(4-(amino)benzyl)urea transient receptor potential vanilloid 1 antagonists.
R. Perner, S. Didomenico, John R. Koenig, A. Gomtsyan +18 more
2007Journal of Medicinal Chemistry22 citations Open access
Semantic Scholar
Novel Sequential Process from N-Methoxyamides and Vinyl Grignard Reagents: New Synthesis of β-Aminoketones
A. Gomtsyan, R. J. Koenig, Chih-Hung Lee
200122 citations Open access
Semantic Scholar
Highly stereocontrolled sequential asymmetric Michael addition reactions with cinnamate esters - generation of three and four contiguous stereogenic centers on seven-carbon acyclic motifs
S. Hanessian, A. Gomtsyan
199422 citations
Semantic Scholar
[3H]A-778317 [1-((R)-5-tert-Butyl-indan-1-yl)-3-isoquinolin-5-yl-urea]: a Novel, Stereoselective, High-Affinity Antagonist Is a Useful Radioligand for the Human Transient Receptor Potential Vanilloid-1 (TRPV1) Receptor
B. Bianchi, Rachid El Kouhen, T. Neelands, Chih-Hung Lee +10 more
2007Journal of Pharmacology and Experimental Therapeutics17 citations Open access
Semantic Scholar
Nonnucleoside inhibitors of adenosine kinase.
A. Gomtsyan, Chih-Hung Lee
2004Current pharmaceutical design15 citations
Semantic Scholar
TRPV3 modulates nociceptive signaling through peripheral and supraspinal sites in rats.
S. McGaraughty, Katharine L. Chu, Jun Xu, L. Leys +6 more
2017Journal of Neurophysiology14 citations Open access
Semantic Scholar
Novel Approaches to Cross-linking High Molecular Weight Polysaccharides: Application to Guar-based Hydraulic Fracturing Fluids
P. Coveney, H. De Silva, A. Gomtsyan, Andrew Whiting +1 more
200014 citations
Semantic Scholar
a Novel Transient Receptor Potential Type V 1 Receptor Antagonist , Relieves Pathophysiological Pain Associated with Inflammation and Tissue Injury in Rats
P. Honore, Carol T. Wismer, J. Mikusa, Chang Z. Zhu +9 more
200513 citations
Semantic Scholar
Stereoselective Synthesis of a Dipyridyl Transient Receptor Potential Vanilloid-3 (TRPV3) Antagonist.
E. Voight, J. Daanen, Robert G. Schmidt, A. Gomtsyan +2 more
2016Journal of Organic Chemistry9 citations
Semantic Scholar
Clinical and Preclinical Experience with TRPV1 Antagonists as Potential Analgesic Agents
A. Gomtsyan, J. Brederson
20159 citations
Semantic Scholar
α‐Methylation at Benzylic Fragment of N‐Aryl‐N′‐benzyl Ureas Provides TRPV1 Antagonists with Better Pharmacokinetic Properties and Higher Efficacy in Inflammatory Pain Model.
A. Gomtsyan
20075 citations
Semantic Scholar
Synthesis of a branched pentasaccharide fragment of the O-antigen of Shigella flexneri serotype 5b
A. Gomtsyan, Narguiz É. Byramova, L. V. Backinowsky, N. K. Kochetkov
19854 citations
Semantic Scholar
Synthesis and Structure—Activity Relationships of 5-Heteroatom-Substituted Pyridopyrimidines as Adenosine Kinase Inhibitors.
G. Gfesser, E. Bayburt, M. Cowart, S. Didomenico +6 more
20033 citations
Semantic Scholar
Synthesis of methyl 3-amino-deoxy-d-alluronate
A. Gomtsyan, I. Savelyeva, S. Belyakov, I. Kalvinsh
19923 citations
Semantic Scholar
Discovery of Orally Efficacious Bridged Piperazines as smTNF Modulators.
Zhiguo Bian, Robert G. Schmidt, Noel S Wilson, D. B. Duignan +18 more
2025Journal of Medicinal Chemistry2 citations
Semantic Scholar
Targeting TRP channels: beyond TRPV1
A. Gomtsyan, A. Szallasi
2015Naunyn-Schmiedeberg's Archives of Pharmacology2 citations Open access
Semantic Scholar
Direct Synthesis of β-Aminoketones from Amides via Novel Sequential Nucleophilic Substitution/Michael Reaction.
A. Gomtsyan
20102 citations
Semantic Scholar

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Chih-Hung Lee×22
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M. Jarvis×19
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C. Faltynek×17
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