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A. Lew · SciRah

Researcher profile · Semantic Scholar

A. Lew

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A. Lew — researcher profile on SciRah

h-index: 62
Works: 241
Citations: 13K

Most-cited papers

Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8+ T Cells.
A. Bachem, Christina Makhlouf, K. Binger, D. D. de Souza +21 more
2019Immunity610 citations Open access
Semantic Scholar
Mucosal Profiling of Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and Therapeutic Pathways.
Bing Huang, Zhang-Hua Chen, L. Geng, Jun Wang +38 more
2019Cell277 citations Open access
Semantic Scholar
This information is current as Phenotype Responses Biased toward a Follicular Helper via Clec 9 A Induces Potent CD 4 T Cell Targeting Antigen to Mouse Dendritic Cells and
Fatma Ahmet, S. Kitsoulis, Soo S. Wan, D. Vremec +11 more
2011212 citations
Semantic Scholar
Potential therapeutic effects of dipyridamole in the severely ill patients with COVID-19
Xiao-Yan Liu, Zhe Li, Shuai Liu, Jing Sun +21 more
2020Acta Pharmaceutica Sinica B210 citations Open access
Semantic Scholar
Adoptive cellular therapy with T cells expressing the dendritic cell growth factor Flt3L drives epitope spreading and antitumor immunity
Junyun Lai, Sherly Mardiana, Imran G. House, K. Sek +16 more
2020Nature Immunology196 citations
Semantic Scholar
Antigen affinity, costimulation, and cytokine inputs sum linearly to amplify T cell expansion
Julia M. Marchingo, A. Kan, R. Sutherland, K. Duffy +6 more
2014Science193 citations
Semantic Scholar
Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to maintain survival of immune cell populations both in vitro and in vivo
Emma M. Carrington, Y. Zhan, J. Brady, Jian-Guo Zhang +14 more
2017Cell Death and Differentiation149 citations Open access
Semantic Scholar
A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production
U. Nachbur, Che Stafford, Aleksandra Bankovacki, Y. Zhan +24 more
2015Nature Communications139 citations Open access
Semantic Scholar
Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β
Man Lyang Kim, J. Chae, Y. Park, D. De Nardo +13 more
2015Journal of Experimental Medicine139 citations Open access
Semantic Scholar
Liver Immune Profiling Reveals Pathogenesis and Therapeutics for Biliary Atresia.
Jun Wang, Yanhui Xu, Zhang-Hua Chen, Jiankun Liang +32 more
2020Cell133 citations
Semantic Scholar
GM-CSF–Responsive Monocyte-Derived Dendritic Cells Are Pivotal in Th17 Pathogenesis
Hyun-Ja Ko, J. Brady, Victoria Ryg-Cornejo, D. S. Hansen +4 more
2014Journal of Immunology114 citations Open access
Semantic Scholar
The polycomb repressive complex 2 governs life and death of peripheral T cells.
Yuxia Zhang, S. Kinkel, J. Maksimovic, E. Bandala-Sanchez +9 more
2014Blood111 citations
Semantic Scholar
GM‐CSF increases cross‐presentation and CD103 expression by mouse CD8+ spleen dendritic cells
Y. Zhan, Emma M. Carrington, A. V. van Nieuwenhuijze, S. Bedoui +7 more
2011European Journal of Immunology109 citations Open access
Semantic Scholar
BH3 mimetics antagonizing restricted prosurvival Bcl-2 proteins represent another class of selective immune modulatory drugs
Emma M. Carrington, I. Vikstrom, A. Light, R. Sutherland +5 more
2010Proceedings of the National Academy of Sciences of the United States of America104 citations Open access
Semantic Scholar
Contribution of Thy1+ NK cells to protective IFN-γ production during Salmonella Typhimurium infections
Andreas Kupz, T. Scott, G. Belz, D. Andrews +7 more
2013Proceedings of the National Academy of Sciences of the United States of America102 citations Open access
Semantic Scholar
MicroRNA-independent roles of the RNase III enzymes Drosha and Dicer
Timothy M. Johanson, A. Lew, M. M. Chong
2013Open Biology100 citations Open access
Semantic Scholar
Transcription Factor PU.1 Promotes Conventional Dendritic Cell Identity and Function via Induction of Transcriptional Regulator DC‐SCRIPT
Michael Chopin, Aaron T. L. Lun, Y. Zhan, J. Schreuder +14 more
2019Immunity95 citations Open access
Semantic Scholar
IL-17 production by tissue-resident MAIT cells is locally induced in children with pneumonia
Bingtai Lu, Ming Liu, Jun Wang, Huifeng Fan +16 more
2020Mucosal Immunology93 citations Open access
Semantic Scholar
Life and Death of Activated T Cells: How Are They Different from Naïve T Cells?
Y. Zhan, Emma M. Carrington, Yu-Xia Zhang, S. Heinzel +1 more
2017Frontiers in Immunology93 citations Open access
Semantic Scholar
Macrophages, rather than DCs, are responsible for inflammasome activity in the GM-CSF BMDC model
Ziv Erlich, Inbar Shlomovitz, L. Edry-Botzer, H. Cohen +7 more
2019Nature Immunology91 citations
Semantic Scholar
The Pleiotropic Effects of the GM-CSF Rheostat on Myeloid Cell Differentiation and Function: More Than a Numbers Game
Y. Zhan, A. Lew, Michael Chopin
2019Frontiers in Immunology85 citations Open access
Semantic Scholar
The regulation of the development and function of dendritic cell subsets by GM-CSF: more than a hematopoietic growth factor.
Y. Zhan, Yuekang Xu, A. Lew
2012Molecular Immunology84 citations
Semantic Scholar
Repurposed JAK1/JAK2 Inhibitor Reverses Established Autoimmune Insulitis in NOD Mice
P. Trivedi, K. Graham, N. Scott, M. Jenkins +10 more
2017Diabetes83 citations
Semantic Scholar
Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment
Robyn L. Schenk, Selma Tuzlak, Emma M. Carrington, Y. Zhan +8 more
2017Cell Death and Differentiation72 citations Open access
Semantic Scholar
Mutually exclusive regulation of T cell survival by IL-7R and antigen receptor-induced signals
Paul Koenen, S. Heinzel, Emma M. Carrington, L. Happo +7 more
2013Nature Communications69 citations Open access
Semantic Scholar
Pathogenic mechanisms in type 1 diabetes: the islet is both target and driver of disease.
K. Graham, R. Sutherland, Stuart I. Mannering, Yu-Xing Zhao +5 more
2012The review of diabetic studies : RDS69 citations Open access
Semantic Scholar
Regulation of asymmetric cell division and polarity by Scribble is not required for humoral immunity
E. Hawkins, J. Oliaro, A. Kallies, G. Belz +12 more
2013Nature Communications66 citations Open access
Semantic Scholar
Monocyte-Derived Dendritic Cells Promote Th Polarization, whereas Conventional Dendritic Cells Promote Th Proliferation
K. Chow, A. Lew, R. Sutherland, Y. Zhan
2016Journal of Immunology63 citations Open access
Semantic Scholar
Therapeutic effects of dipyridamole on COVID-19 patients with coagulation dysfunction
Xiao-Yan Liu, Zhe Li, Shuai Liu, Zhang-Hua Chen +20 more
2020medRxiv62 citations Open access
Semantic Scholar
Effector-Memory T Cells Develop in Islets and Report Islet Pathology in Type 1 Diabetes
Jonathan Chee, Hyun-Ja Ko, A. Skowera, G. Jhala +8 more
2014Journal of Immunology60 citations Open access
Semantic Scholar
Excessive deubiquitination of NLRP3-R779C variant contributes to very-early-onset inflammatory bowel disease development.
Lingli Zhou, Tao Liu, Bing Huang, Man Luo +24 more
2020Journal of Allergy and Clinical Immunology57 citations Open access
Semantic Scholar
MCL-1 is required throughout B-cell development and its loss sensitizes specific B-cell subsets to inhibition of BCL-2 or BCL-XL
I. Vikström, A. Slomp, Emma M. Carrington, Laura M. Moesbergen +10 more
2016Cell Death and Disease54 citations Open access
Semantic Scholar
Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells
Emma M. Carrington, Jian-Guo Zhang, R. Sutherland, I. Vikstrom +16 more
2015Proceedings of the National Academy of Sciences of the United States of America54 citations Open access
Semantic Scholar
Bcl‐2 Antagonists Kill Plasmacytoid Dendritic Cells From Lupus‐Prone Mice and Dampen Interferon‐α Production
Y. Zhan, Emma M. Carrington, Hyun-Ja Ko, I. Vikstrom +11 more
2015Arthritis & Rheumatology51 citations
Semantic Scholar
The inflammatory cytokine, GM‐CSF, alters the developmental outcome of murine dendritic cells
Y. Zhan, J. Vega-Ramos, Emma M. Carrington, J. Villadangos +2 more
2012European Journal of Immunology49 citations Open access
Semantic Scholar
Plasmacytoid dendritic cells are short-lived: reappraising the influence of migration, genetic factors and activation on estimation of lifespan
Y. Zhan, K. Chow, Priscilla Soo, Zhen Xu +7 more
2016Scientific Reports48 citations Open access
Semantic Scholar
The life and death of immune cell types: the role of BCL‐2 anti‐apoptotic molecules
Emma M. Carrington, D. Tarlinton, D. Gray, N. Huntington +2 more
2017Immunology and Cell Biology43 citations Open access
Semantic Scholar
GM-CSF Quantity Has a Selective Effect on Granulocytic vs. Monocytic Myeloid Development and Function
Li Sun, J. Rautela, Rebecca B Delconte, F. Souza-Fonseca-Guimaraes +7 more
2018Frontiers in Immunology42 citations Open access
Semantic Scholar
Heterogeneity, functional specialization and differentiation of monocyte‐derived dendritic cells
K. Chow, R. Sutherland, Y. Zhan, A. Lew
2017Immunology and Cell Biology41 citations
Semantic Scholar
Defects in the ‘Bcl-2-regulated’ apoptotic pathway leads to preferential increase of CD25lowFoxP3+ anergic CD4+ T cells
Y. Zhan, Yuxia Zhang, D. Gray, Emma M. Carrington +6 more
2011Journal of Immunology38 citations Open access
Semantic Scholar
Xenotransplantation of Genetically Modified Neonatal Pig Islets Cures Diabetes in Baboons
W. Hawthorne, E. Salvaris, Y. Chew, Heather Burns +7 more
2022Frontiers in Immunology37 citations Open access
Semantic Scholar
The role of microRNAs in lymphopoiesis
Timothy M. Johanson, Jarrod P. J. Skinner, Amit Kumar, Y. Zhan +2 more
2014International journal of hematology36 citations Open access
Semantic Scholar
Type 1 conventional dendritic cell fate and function are controlled by DC-SCRIPT
Shengbo Zhang, H. Coughlan, Mitra Ashayeripanah, Simona Seizova +12 more
2021Science immunology35 citations
Semantic Scholar
Targeted insertion of an anti-CD2 monoclonal antibody transgene into the GGTA1 locus in pigs using FokI-dCas9
M. Nottle, E. Salvaris, N. Fisicaro, S. Mcilfatrick +6 more
2017Scientific Reports35 citations Open access
Semantic Scholar
Immune insufficiency during GVHD is due to defective antigen presentation within dendritic cell subsets.
K. Markey, M. Koyama, R. Kuns, K. Lineburg +16 more
2012Blood35 citations
Semantic Scholar
Drosha controls dendritic cell development by cleaving messenger RNAs encoding inhibitors of myelopoiesis
Timothy M. Johanson, Ashleigh A. Keown, M. Cmero, Janet H. C. Yeo +4 more
2015Nature Immunology33 citations
Semantic Scholar
The Closely Related CD103+ Dendritic Cells (DCs) and Lymphoid-Resident CD8+ DCs Differ in Their Inflammatory Functions
Z. Jiao, S. Bedoui, J. Brady, A. Walter +9 more
2014PLoS ONE33 citations Open access
Semantic Scholar
Transplantation of Xenogeneic Islets: Are We There Yet?
P. O'Connell, P. Cowan, W. Hawthorne, S. Yi +1 more
2013Current Diabetes Reports32 citations
Semantic Scholar
Genetic modification of pigs for solid organ xenotransplantation.
H. Gock, M. Nottle, A. Lew, A. d'Apice +1 more
2011Transplantation reviews27 citations
Semantic Scholar
Preclinical screening for acute toxicity of therapeutic monoclonal antibodies in a hu-SCID model
J. Brady, L. Harrison, D. Goodman, P. Cowan +4 more
2014Clinical & Translational Immunology26 citations Open access
Semantic Scholar

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