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K. Sek · SciRah

Researcher profile · Semantic Scholar

K. Sek

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K. Sek — researcher profile on SciRah

h-index: 13
Works: 31
Citations: 2,344

Most-cited papers

Macrophage-Derived CXCL9 and CXCL10 Are Required for Antitumor Immune Responses Following Immune Checkpoint Blockade
Imran G. House, P. Savas, Junyun Lai, Amanda X. Y. Chen +16 more
2019Clinical Cancer Research619 citations Open access
Semantic Scholar
Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy
P. Beavis, M. Henderson, Lauren Giuffrida, J. K. Mills +14 more
2017Journal of Clinical Investigation300 citations Open access
Semantic Scholar
FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy
Jack D. Chan, C. Scheffler, Isabelle Munoz, K. Sek +34 more
2024Nature218 citations Open access
Semantic Scholar
CRISPR/Cas9 mediated deletion of the adenosine A2A receptor enhances CAR T cell efficacy
Lauren Giuffrida, K. Sek, M. Henderson, Junyun Lai +15 more
2021Nature Communications207 citations Open access
Semantic Scholar
Targeting Adenosine Receptor Signaling in Cancer Immunotherapy
K. Sek, C. Mølck, Gregory D. Stewart, L. Kats +2 more
2018International Journal of Molecular Sciences198 citations Open access
Semantic Scholar
Adoptive cellular therapy with T cells expressing the dendritic cell growth factor Flt3L drives epitope spreading and antitumor immunity
Junyun Lai, Sherly Mardiana, Imran G. House, K. Sek +16 more
2020Nature Immunology196 citations
Semantic Scholar
PTP1B is an intracellular checkpoint that limits T cell and CAR T cell anti-tumor immunity
F. Wiede, K. Lu, Xinjie Du, Mara N Zeissig +11 more
2021bioRxiv109 citations Open access
Semantic Scholar
TSTEM-like CAR-T cells exhibit improved persistence and tumor control compared with conventional CAR-T cells in preclinical models
D. Meyran, J. Zhu, Jeannene Butler, Daniela Tantalo +25 more
2023Science Translational Medicine100 citations
Semantic Scholar
IL-15 Preconditioning Augments CAR T Cell Responses to Checkpoint Blockade for Improved Treatment of Solid Tumors.
Lauren Giuffrida, K. Sek, M. Henderson, Imran G. House +16 more
2020Molecular Therapy99 citations Open access
Semantic Scholar
MAIT cells regulate NK cell-mediated tumor immunity
Emma V. Petley, Hui-Fern Koay, M. Henderson, K. Sek +27 more
2021Nature Communications90 citations Open access
Semantic Scholar
Rewiring endogenous genes in CAR T cells for tumour-restricted payload delivery
Amanda X. Y. Chen, K. M. Yap, Joelle S. Kim, K. Sek +30 more
2025Nature77 citations Open access
Semantic Scholar
Dual PD-1 and CTLA-4 Checkpoint Blockade Promotes Antitumor Immune Responses through CD4+Foxp3− Cell–Mediated Modulation of CD103+ Dendritic Cells
P. Beavis, M. Henderson, Lauren Giuffrida, A. Davenport +13 more
2018Cancer immunology research64 citations Open access
Semantic Scholar
Tumor site-directed A1R expression enhances CAR T cell function and improves efficacy against solid tumors
K. Sek, Amanda X. Y. Chen, Thomas J Cole, Jesse D. Armitage +32 more
2025Nature Communications14 citations Open access
Semantic Scholar
CRISPR-Cas9 screening identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9 expression and antitumor immunity.
Imran G. House, Emily B. Derrick, K. Sek, Amanda X. Y. Chen +25 more
2023Cell Reports13 citations Open access
Semantic Scholar
Flt3L-mediated tumor cDC1 expansion enhances immunotherapy by priming stem-like CD8+ T cells in lymph nodes
Junyun Lai, Cheok Weng Chan, Jesse D. Armitage, Katherine M. Audsley +26 more
2026Nature Immunology9 citations Open access
Semantic Scholar
Targeting PTPN2 enhances human CAR T cell efficacy and the development of long-term memory in mouse xenograft models.
Xin Du, Pei K. Goh, Chenkai Ma, E. Coughlan +16 more
2025Science Translational Medicine9 citations
Semantic Scholar
A2AR eGFP reporter mouse enables elucidation of A2AR expression dynamics during anti-tumor immune responses
Kirsten L. Todd, Junyun Lai, K. Sek, Yu-Kuan Huang +23 more
2023Nature Communications9 citations Open access
Semantic Scholar
Pharmacological and genetic strategies for targeting adenosine to enhance adoptive T cell therapy of cancer.
K. Sek, L. Kats, P. Darcy, P. Beavis
2020Current opinion in pharmacology (Print)8 citations
Semantic Scholar
Adoptive transfer of tumor-specific Th9 cells eradicates heterogeneous antigen-expressing tumor cells.
K. Sek, Cheok Weng Chan, P. Beavis, P. Darcy
2021Cancer Cell5 citations Open access
Semantic Scholar
CRISPR-Cas9 screening identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9 expression and antitumor immunity.
Imran G. House, Emily B. Derrick, K. Sek, Amanda X. Y. Chen +25 more
2024Cell Reports4 citations Open access
Semantic Scholar
Cytokine armored CAR T cells for cancer immunotherapy
K. Sek, K. M. Yap, Wo-On-Xuan Hong, P. Darcy
2026Immunology and Cell Biology3 citations
Semantic Scholar
126 Early-phenotype Lewis Y CAR-T cells persist better in vivo and induce solid tumor regression in combination with anti-PD1
D. Meyran, J. Zhu, Jeannene Butler, S. Macdonald +8 more
20203 citations Open access
Semantic Scholar
Rewiring immunity with in vivo CAR T cell engineering
C. Slaney, Rachel Xu, Shi-Yi Wu, K. Sek +4 more
2026Nature Cancer2 citations
Semantic Scholar
A Novel Target Antigen for the Treatment of Acute Myeloid Leukemia by CAR T Cells.
P. Beavis, K. Sek, P. Darcy
2017Molecular Therapy2 citations Open access
Semantic Scholar
Abstract 144: In vivo CAR mRNA engineering of both adaptive and myeloid cells enables potent anti-tumor control of solid cancers.
Jun-Ming Tong, Moore Z. Chen, K. Sek, Meghan Harris +7 more
2026Cancer Research1 citations
Semantic Scholar
Immunotherapy: OMNI-CAR, A UNIVERSAL CAR T CELL THERAPY UTILIZING COVALENT SPYTAG/SPYCATCHER BINDING TO TARGET MULTIPLE ANTIGENS IN DIFFERENT TUMORS
K. Sek, J. Li, J. Tong, R. Lim +2 more
2023Cytotherapy1 citations
Semantic Scholar
Refuel and endure: improving metabolic fitness and efficacy in CAR-T therapy
Isabelle Munoz, P. Beavis, Phillip K. Darcy, K. Sek
2026Immuno-Oncology Technology0 citations Open access
Semantic Scholar
Immunotherapy: IMPROVING CAR T CELL EFFICACY IN A PRECLINICAL MODEL OF BREAST CANCER THROUGH MODIFIED MANUFACTURING METHODS AND ADJUVANT THERAPY
J. Li, J. Tong, K. Sek, S. Yatomi-Clarke +3 more
2023Cytotherapy0 citations
Semantic Scholar
EARLY-PHENOTYPE LEWIS Y CAR-T CELLS PERSIST BETTER IN VIVO AND INDUCE SOLID TUMOR REGRESSION IN COMBINATION WITH ANTI-PD1
D. Meyran, J. Zhu, J. Butler, S. Macdonald +8 more
20200 citations
Semantic Scholar
MAIT cells regulate NK cell mediated tumor immunity
Emma V. Petley, Hui-Fern Koay, M. Henderson, K. Sek +25 more
20200 citations Open access
Semantic Scholar
Volume 54 / Issue 4/2009
K. Sek, M. Plons
20190 citations
Semantic Scholar

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P. Darcy×25
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P. Beavis×22
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Imran G. House×14
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Junyun Lai×14
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Amanda X. Y. Chen

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Kirsten L. Todd×13

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Emma V. Petley×12

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