S. Garavaglia

Most-cited papers

1. The structure of Rigidoporus lignosus Laccase containing a full complement of copper ions, reveals an asymmetrical arrangement for the T3 copper pair.

   S. Garavaglia, M. Cambria, M. Miglio, Santa Ragusa +5 more

   2004Journal of Molecular Biology150 citations

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2. AI is a viable alternative to high throughput screening: a 318-target study

   Izhar Wallach, Denzil Bernard, Kong Nguyen, Gregory Ho +496 more

   2024Scientific Reports112 citations Open access

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3. The high-resolution crystal structure of periplasmic Haemophilus influenzae NAD nucleotidase reveals a novel enzymatic function of human CD73 related to NAD metabolism.

   S. Garavaglia, Santina Bruzzone, C. Cassani, L. Canella +6 more

   2012Biochemical Journal92 citations

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4. Crystal structure of human aldehyde dehydrogenase 1A3 complexed with NAD+ and retinoic acid

   A. Moretti, Jianfeng Li, S. Donini, R. Sobol +2 more

   2016Scientific Reports87 citations Open access

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5. Nicotinamide/nicotinic acid mononucleotide adenylyltransferase, new insights into an ancient enzyme

   R. Zhai, M. Rizzi, S. Garavaglia

   2009Cellular and Molecular Life Sciences84 citations Open access

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6. Extracellular NAD+ enhances PARP-dependent DNA repair capacity independently of CD73 activity

   A. Wilk, Faisal Hayat, Richard Cunningham, Jianfeng Li +11 more

   2020Scientific Reports82 citations Open access

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7. Structure of Human NMN Adenylyltransferase

   S. Garavaglia, I. D'Angelo, M. Emanuelli, F. Carnevali +3 more

   2002Journal of Biological Chemistry63 citations Open access

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8. Perfluoropolyether polymers by UV curing: design, synthesis and characterization

   R. Bongiovanni, A. Medici, Alberto Zompatori, S. Garavaglia +1 more

   201257 citations Open access

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9. Docking Simulation and Competitive Experiments Validate the Interaction Between the 2,5-Xylidine Inhibitor and Rigidoporus lignosus Laccase

   M. Cambria, D. Di Marino, M. Falconi, S. Garavaglia +1 more

   2010Journal of Biomolecular Structure and Dynamics54 citations

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10. Crystal Structure of Human Kynurenine Aminotransferase II, a Drug Target for the Treatment of Schizophrenia*

    F. Rossi, S. Garavaglia, V. Montalbano, M. Walsh +1 more

    2008Journal of Biological Chemistry54 citations Open access

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11. Imidazo[1,2-a]pyridine Derivatives as Aldehyde Dehydrogenase Inhibitors: Novel Chemotypes to Target Glioblastoma Stem Cells.

    Luca Quattrini, E. Gelardi, Vito Coviello, S. Sartini +5 more

    2020Journal of Medicinal Chemistry53 citations Open access

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12. Crystal Structure-Based Selective Targeting of the Pyridoxal 5′-Phosphate Dependent Enzyme Kynurenine Aminotransferase II for Cognitive Enhancement

    F. Rossi, Casazza Valentina, S. Garavaglia, K. V. Sathyasaikumar +6 more

    2010Journal of Medicinal Chemistry51 citations Open access

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13. A Novel Fold Revealed by Mycobacterium tuberculosis NAD Kinase, a Key Allosteric Enzyme in NADP Biosynthesis*

    S. Garavaglia, N. Raffaelli, L. Finaurini, G. Magni +1 more

    2004Journal of Biological Chemistry50 citations Open access

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14. Allosteric Regulation of Bacillus subtilis NAD Kinase by Quinolinic Acid

    S. Garavaglia, A. Galizzi, M. Rizzi

    2003Journal of Bacteriology50 citations Open access

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15. A Selective Competitive Inhibitor of Aldehyde Dehydrogenase 1A3 Hinders Cancer Cell Growth, Invasiveness and Stemness In Vitro

    E. Gelardi, G. Colombo, Francesca Picarazzi, D. Ferraris +7 more

    2021Cancers43 citations Open access

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16. Signalling inhibitors against Mycobacterium tuberculosis--early days of a new therapeutic concept in tuberculosis.

    B. Hegymegi-Barakonyi, R. Székely, Z. Varga, R. Kiss +20 more

    2008Current Medicinal Chemistry43 citations

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17. A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cells

    Jianfeng Li, S. Garavaglia, Zhaofeng Ye, A. Moretti +16 more

    2021Communications Biology37 citations Open access

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18. Crystal structure of human nicotinic acid phosphoribosyltransferase

    Ada Serena Marletta, A. Massarotti, G. Orsomando, G. Magni +2 more

    2015FEBS Open Bio35 citations Open access

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19. Crystal structure of the Anopheles gambiae 3-hydroxykynurenine transaminase.

    F. Rossi, S. Garavaglia, G. Giovenzana, B. Arcà +2 more

    2006Proceedings of the National Academy of Sciences of the United States of America35 citations Open access

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20. Biochemical and Structural Studies of the Mycobacterium tuberculosis O6-Methylguanine Methyltransferase and Mutated Variants

    R. Miggiano, Valentina Casazza, S. Garavaglia, M. Ciaramella +3 more

    2013Journal of Bacteriology30 citations Open access

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21. In silico study of structural determinants modulating the redox potential of Rigidoporus lignosus and other fungal laccases

    M. Cambria, Danilo Gullotto, S. Garavaglia, A. Cambria

    2012Journal of Biomolecular Structure and Dynamics30 citations

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22. A nicotinamide phosphoribosyltransferase–GAPDH interaction sustains the stress-induced NMN/NAD+ salvage pathway in the nucleus

    A. Grolla, R. Miggiano, D. Di Marino, M. Bianchi +21 more

    2020Journal of Biological Chemistry29 citations Open access

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23. The crystal structure of human α‐amino‐β‐carboxymuconate‐ε‐semialdehyde decarboxylase in complex with 1,3‐dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis

    S. Garavaglia, S. Perozzi, Luca Galeazzi, N. Raffaelli +1 more

    2009The FEBS Journal27 citations Open access

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24. Chikungunya infection in a human immunodeficiency virus‐infected kidney transplant recipient returning to Italy from the Dominican Republic

    D. D. Gasperina, M. Balsamo, S. Garavaglia, F. Rovida +2 more

    2015Transplant Infectious Disease26 citations

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25. Biochemical and structural investigations on phosphoribosylpyrophosphate synthetase from Mycobacterium smegmatis

    S. Donini, S. Garavaglia, D. Ferraris, R. Miggiano +3 more

    2017PLoS ONE25 citations Open access

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26. Progress in the Field of Aldehyde Dehydrogenase Inhibitors: Novel Imidazo[1,2-a]pyridines against the 1A Family.

    Luca Quattrini, E. Gelardi, Giovanni Petrarolo, G. Colombo +5 more

    2020ACS Medicinal Chemistry Letters23 citations Open access

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27. A New Vista of Aldehyde Dehydrogenase 1A3 (ALDH1A3): New Specific Inhibitors and Activity-Based Probes Targeting ALDH1A3 Dependent Pathways in Glioblastoma, Mesothelioma and Other Cancers

    Lorenzo Magrassi, Giulia Pinton, S. Luzzi, Sergio Comincini +7 more

    2024Cancers21 citations Open access

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28. Synthesis and Degradation of Adenosine 5'-Tetraphosphate by Nicotinamide and Nicotinate Phosphoribosyltransferases.

    A. Amici, A. Grolla, E. Del Grosso, R. Bellini +8 more

    2017Cell Chemical Biology21 citations Open access

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29. Crystal structure of Mycobacterium tuberculosis O6-methylguanine-DNA methyltransferase protein clusters assembled on to damaged DNA.

    R. Miggiano, G. Perugino, M. Ciaramella, Mario Serpe +7 more

    2016Biochemical Journal19 citations

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30. Toxic aldehydes in cooking vegetable oils: Generation, toxicity and disposal methods

    Fabio Scianò, Bianca Laura Bernardoni, Ilaria D'Agostino, G. Ferrara +3 more

    2025Food Chemistry: X16 citations Open access

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31. Curcumin-based-fluorescent probes targeting ALDH1A3 as a promising tool for glioblastoma precision surgery and early diagnosis

    E. Gelardi, Diego Caprioglio, G. Colombo, E. Del Grosso +11 more

    2021Communications Biology15 citations Open access

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32. A Selective ALDH1A3 Inhibitor Impairs Mesothelioma 3-D Multicellular Spheroid Growth and Neutrophil Recruitment

    Sara Boumya, S. Fallarini, Sonia Siragusa, Giovanni Petrarolo +6 more

    2023International Journal of Molecular Sciences9 citations Open access

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33. New acrylic‐allylic resins containing perfluoropolyether chains for UV‐cured coatings

    V. Lombardi, R. Bongiovanni, G. Malucelli, A. Priola +2 more

    19999 citations

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34. Targeting NAD-dependent dehydrogenases in drug discovery against infectious diseases and cancer.

    D. Ferraris, E. Gelardi, S. Garavaglia, R. Miggiano +1 more

    2020Biochemical Society Transactions8 citations

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35. Author Correction: AI is a viable alternative to high throughput screening: a 318-target study

    Izhar Denzil Kong Gregory Adrian Adrian Andreana Ann Mar Wallach Bernard Nguyen Ho Morrison Stecula Rosnik , Izhar Wallach, Denzil Bernard, Kong Nguyen +496 more

    2024Scientific Reports2 citations Open access

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36. Discovery of a new selective Endoplasmic Reticulum Aminopeptidase 1 inhibitor for Hedgehog-dependent cancers treatment.

    Francesca Bufalieri, Antonino Cucinotta, Silvia Cammarone, F. Agnoli +26 more

    2025Molecular Therapy1 citations Open access

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37. A scaffold repositioning approach: dihydroBenzoImidazoTriazineDione (BITD) derivatives as selective ALDH1A1 inhibitors

    Bianca Laura Bernardoni, Ilaria D'Agostino, Sonia Siragusa, Mattia Mori +2 more

    2025Molecular diversity0 citations

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38. Crystal structure of human Aldehyde dehydrogenase 1A3 in complex with a selective inhibitor

    S. Garavaglia, M. Rizzi

    20210 citations

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39. Crystal structure of human aldehyde dehydrogenase 1A3 in complex with selective NR6 inhibitor compound

    E. L. M. Gelardi, S. Garavaglia

    20210 citations Open access

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40. Crystal structure of human Aldehyde dehydrogenase 1A3 in complex with MF13 inhibitor compound

    E. L. M. Gelardi, S. Garavaglia

    20210 citations

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41. 2,6-Diphenyl-imidazopyridine derivatives as novel prototypes of anticancer agents targeting aldehyde dehydrogenases

    Giovanni Petrarolo, E. Gelardi, G. Colombo, Francesca Picarazzi +5 more

    20200 citations Open access

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42. Crystal Structure of human ALDH1A3 in complex with 2,6-diphenylimidazo[1,2-a]pyridine (compound GA11) and NAD+

    E. L. M. Gelardi, L. Quattrini, C. LaMotta, D. Ferraris +1 more

    20200 citations

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43. Crystal structure of phosphoribosylpyrophosphate synthetase from Mycobacterium smegmatis

    S. Donini, S. Garavaglia, D. Ferraris, R. Miggiano +3 more

    20170 citations

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44. Human aldehyde dehydrogenase 1A3 complexed with NAD(+) and retinoic acid

    A. Moretti, M. Rizzi, S. Garavaglia

    20160 citations

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45. Crystal structure of Mycobacterium tuberculosis OGT in complex with DNA

    R. Miggiano, F. Rossi, S. Garavaglia, M. Rizzi

    20150 citations

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46. Crystal structure of Mycobacterium tuberculosis OGT-Y139F

    R. Miggiano, F. Rossi, S. Garavaglia, M. Rizzi

    20150 citations

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47. Crystal structure of Mycobacterium tuberculosis O6-METHYLGUANINE METHYLTRANSFERASE

    R. Miggiano, Valentina Casazza, S. Garavaglia, M. Ciaramella +3 more

    20130 citations

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48. CRYSTAL STRUCTURE OF THE M. TUBERCULOSIS O6-METHYLGUANINE METHYLTRANSFERASE R37L VARIANT

    R. Miggiano, Valentina Casazza, S. Garavaglia, M. Ciaramella +3 more

    20130 citations

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49. Structure of Haemophilus influenzae NAD nucleotidase (NadN)

    S. Garavaglia, Santina Bruzzone, C. Cassani, L. Canella +6 more

    20110 citations

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50. Crystal structure of human KAT II-inhibitor complex

    F. Rossi, Valentina Casazza, S. Garavaglia, K. V. Sathyasaikumar +6 more

    20100 citations

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