J. Bruning

Most-cited papers

1. AI is a viable alternative to high throughput screening: a 318-target study

   Izhar Wallach, Denzil Bernard, Kong Nguyen, Gregory Ho +496 more

   2024Scientific Reports112 citations Open access

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2. The therapeutic potential of inhibiting PPARγ phosphorylation to treat type 2 diabetes

   R. Frkic, K. Richter, J. Bruning

   2021Journal of Biological Chemistry64 citations Open access

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3. Shooting three inflammatory targets with a single bullet: Novel multi-targeting anti-inflammatory glitazones.

   Perihan A. Elzahhar, Rana A. Alaaeddine, Tamer M. Ibrahim, Rasha A. Nassra +10 more

   2019European journal of medicinal chemistry44 citations Open access

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4. JAK2 Alterations in Acute Lymphoblastic Leukemia: Molecular Insights for Superior Precision Medicine Strategies

   Charlotte E. J. Downes, B. McClure, D. McDougal, S. Heatley +4 more

   2022Frontiers in Cell and Developmental Biology33 citations Open access

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5. Structure, Mechanism, and Inhibition of Aspergillus fumigatus Thioredoxin Reductase

   A. Marshall, S. Kidd, Stephanie J. Lamont-Friedrich, G. Arentz +3 more

   2019Antimicrobial Agents and Chemotherapy29 citations Open access

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6. Biophysical techniques to distinguish ligand binding modes in cytochrome P450 monooxygenases.

   M. N. Podgorski, Joshua S. Harbort, T. Coleman, J. E. Stok +7 more

   2020Biochemistry22 citations Open access

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7. Investigating the Active Oxidants Involved in Cytochrome P450 Catalyzed Sulfoxidation Reactions

   M. N. Podgorski, T. Coleman, L. Churchman, J. Bruning +2 more

   2022Chemistry19 citations Open access

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8. Enabling Aromatic Hydroxylation in a Cytochrome P450 Monooxygenase Enzyme through Protein Engineering

   T. Coleman, Joel H. Z. Lee, A. M. Kirk, Daniel Z. Doherty +6 more

   2022Chemistry16 citations Open access

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9. Targeting Unconventional Pathways in Pursuit of Novel Antifungals

   Stephanie Nguyen, J. Truong, J. Bruning

   2021Frontiers in Molecular Biosciences16 citations Open access

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10. Constitutive JAK/STAT signaling is the primary mechanism of resistance to JAKi in TYK2-rearranged acute lymphoblastic leukemia.

    Paniz Tavakoli Shirazi, L. Eadie, Elyse C. Page, S. Heatley +2 more

    2021Cancer Letters15 citations

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11. A comparison of steroid and lipid binding cytochrome P450s from Mycobacterium marinum and Mycobacterium tuberculosis.

    S. A. Child, Amna Ghith, J. Bruning, S. Bell

    2020Journal of Inorganic Biochemistry14 citations

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12. Cytochrome P450-catalyzed oxidation of halogen-containing substrates.

    T. Coleman, M. N. Podgorski, Maya L. Doyle, J. M. Scaffidi-Muta +4 more

    2023Journal of Inorganic Biochemistry13 citations Open access

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13. Exploring the Factors which Result in Cytochrome P450 Catalyzed Desaturation Versus Hydroxylation

    T. Coleman, Daniel Z. Doherty, Ting Zhang, M. N. Podgorski +6 more

    2022Chemistry - An Asian Journal11 citations Open access

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14. The Oxidation of Oxygen and Sulfur-Containing Heterocycles by Cytochrome P450 Enzymes.

    M. N. Podgorski, Angus Keto, T. Coleman, J. Bruning +3 more

    2023Chemistry10 citations Open access

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15. Immunogenicity study of engineered ferritins with C- and N-terminus insertion of Epstein-Barr nuclear antigen 1 epitope.

    Yiran Qu, Bing-Yang Zhang, Yingli Wang, Shuang Yin +5 more

    2021Vaccine10 citations

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16. Characterisation of the heme aqua-ligand coordination environment in an engineered peroxygenase cytochrome P450 variant.

    M. N. Podgorski, Joel H. Z. Lee, Joshua S. Harbort, G. Nguyen +5 more

    2023Journal of Inorganic Biochemistry7 citations Open access

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17. A comparison of the bacterial CYP51 cytochrome P450 enzymes from Mycobacterium marinum and Mycobacterium tuberculosis.

    Hebatallah E. Mohamed, S. A. Child, J. Bruning, S. Bell

    2022Journal of Steroid Biochemistry and Molecular Biology7 citations

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18. Discovery of an ʟ-amino acid ligase implicated in Staphylococcal sulfur amino acid metabolism

    J. L. Pederick, Aimee J. Horsfall, B. Jovcevski, J. Klose +3 more

    2022Journal of Biological Chemistry7 citations Open access

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19. The oxidation of cholesterol derivatives by the CYP124 and CYP142 enzymes from Mycobacterium marinum.

    Amna Ghith, J. Bruning, S. Bell

    2023Journal of Steroid Biochemistry and Molecular Biology6 citations

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20. Identification and characterisation of MdUGT78T2 as a galactosyltransferase with dual activity on flavonol and anthocyanidin substrates in red-skinned apple fruit (Malus domestica L.).

    Daniel Clayton-Cuch, D. McDougal, Julian G. Schwerdt, Long Yu +5 more

    2023Food Chemistry6 citations

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21. TSC-insensitive Rheb mutations induce oncogenic transformation through a combination of constitutively active mTORC1 signalling and proteome remodelling

    Jianling Xie, Stuart P. De Poi, Sean J. Humphrey, L. Hein +5 more

    2021Cellular and Molecular Life Sciences6 citations Open access

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22. Structural determination and characterisation of the CYP105Q4 cytochrome P450 enzyme from Mycobacterium marinum.

    Hebatallah A. Mohamed, S. A. Child, Daniel Z. Doherty, J. Bruning +1 more

    2024Archives of Biochemistry and Biophysics5 citations Open access

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23. The stereoselective oxidation of para-substituted benzenes by a cytochrome P450 biocatalyst.

    Rebecca R. Chao, I. Lau, T. Coleman, L. Churchman +5 more

    2021Chemistry5 citations

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24. Structure-guided design and synthesis of ATP-competitive N-acyl-substituted sulfamide d-alanine-d-alanine ligase inhibitors.

    Rouven Becker, J. L. Pederick, Edward G. Dawes, J. Bruning +1 more

    2023Bioorganic & Medicinal Chemistry4 citations Open access

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25. The catalytic activity and structure of the lipid metabolizing CYP124 cytochrome P450 enzyme from Mycobacterium marinum.

    Amna Ghith, J. Bruning, S. Bell

    2023Archives of Biochemistry and Biophysics4 citations

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26. Biochemical and in silico characterization of glycosyltransferases from red sweet cherry (Prunus avium L.) reveals their broad specificity toward phenolic substrates

    Daniel Clayton-Cuch, Long Yu, D. McDougal, C. Burbidge +4 more

    2023Food Chemistry: Molecular Sciences4 citations Open access

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27. Characterization of functionally deficient SIM2 variants found in patients with neurological phenotypes

    E. Button, Joseph J. Rossi, D. McDougal, J. Bruning +4 more

    2022Biochemical Journal4 citations Open access

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28. Evolutionary insights into the selectivity of sterol oxidising cytochrome P450 enzymes based on ancestral sequence reconstruction

    Daniel Z. Doherty, J. D. De Voss, J. Bruning, Stephen G. Bell

    2025Chemical Science3 citations Open access

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29. Proteoliposomes reconstituted with human aquaporin-1 reveal novel single-ion-channel properties

    S. Henderson, Y. Nakayama, M. Whitelaw, J. Bruning +5 more

    2023Biophysics Reports3 citations Open access

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30. A cell permeable bimane-constrained PCNA-interacting peptide

    Aimee J. Horsfall, B. Vandborg, Zoya Kikhtyak, D. Scanlon +4 more

    2021RSC Chemical Biology3 citations Open access

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31. Acquired Mutations within the JAK2 Kinase Domain Confer Resistance to JAK Inhibitors in an in Vitro model of a High-Risk Acute Lymphoblastic Leukemia

    C. Downes, B. McClure, J. Rehn, James Breen +3 more

    20203 citations

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32. Author Correction: AI is a viable alternative to high throughput screening: a 318-target study

    Izhar Denzil Kong Gregory Adrian Adrian Andreana Ann Mar Wallach Bernard Nguyen Ho Morrison Stecula Rosnik , Izhar Wallach, Denzil Bernard, Kong Nguyen +496 more

    2024Scientific Reports2 citations Open access

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33. An In Crystallo Reaction with an Engineered Cytochrome P450 Peroxygenase.

    Joel H. Z. Lee, J. Bruning, Stephen G. Bell

    2023Chemistry2 citations Open access

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34. Biochemical and structural characterization of meningococcal methylenetetrahydrofolate reductase

    Wanita Pantong, J. L. Pederick, S. Maenpuen, R. Tinikul +5 more

    2023Protein Science2 citations

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35. The role of N-terminal heterocycles in hydrogen bonding to α-chymotrypsin.

    Nicholas C. Schumann, J. Bruning, A. Marshall, A. Abell

    2019Bioorganic & Medicinal Chemistry Letters2 citations Open access

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36. Structural insights into a plant-conserved DHFR-TS reveal a selective herbicide target.

    J. Haywood, Karen J. Breese, D. McDougal, C. Verdonk +9 more

    2025Molecular Plant1 citations Open access

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37. A structural model of the human plasminogen and Aspergillus fumigatus enolase complex: insights for antifungal drug discovery

    S. Nguyen, B. Jovcevski, J. Truong, T. Pukala +1 more

    2023Acta Crystallographica Section A: Foundations and Advances1 citations Open access

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38. Derivatization of Protein Crystals with I3C using Random Microseed Matrix Screening.

    J. Truong, Stephanie Nguyen, J. Bruning, K. Shearwin

    2021Journal of Visualized Experiments1 citations Open access

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39. Biophysical techniques for distinguishing ligand binding modes in cytochrome P450 monooxygenases

    N. Podgorski, Joshua S. Harbort, T. Coleman, J. E. Stok +7 more

    20211 citations

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40. Structural and Catalytic Architecture of the Cysteine Synthase Cys1a

    Isis Pinner, Isabel Schultz, J. L. Pederick, B. Jovcevski +3 more

    2026bioRxiv0 citations Open access

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41. Structural basis for substrate-dependent allostery in oxygen activation by a cytochrome P450 enzyme revealed by analysis at different temperatures

    M. N. Podgorski, D. McDougal, E. Campbell, J. Bruning +1 more

    2026Chemical Science0 citations Open access

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42. Identification of cysteine metabolism regulator (CymR)-derived pentapeptides as nanomolar inhibitors of Staphylococcus aureus O-acetyl-ʟ-serine sulfhydrylase (CysK)

    J. L. Pederick, Bethiney C Vandborg, Amir George, Hannah Bovermann +3 more

    2024bioRxiv0 citations Open access

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43. Mycobacterium tuberculosis dethiobiotin synthetase in complex with fragment analogue 9

    J. P. Pederick, J. Bruning

    20210 citations

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44. Crystal structure of a lambda-186 hybrid repressor

    J. Truong, J. Bruning, K. Shearwin

    20210 citations

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45. Zoogloea ramigera biosynthetic thiolase Q183Y/Y218E mutant, RbCl soak

    A. Marshall, J. Bruning

    20210 citations

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46. The crystal structure of 4-vinylbenzoate-bound wild-type CYP199A4

    T. Coleman, J. Bruning, Stephen J. Bell

    20210 citations

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47. PPARα and δ Ligand Design: Honing the Traditional Empirical Method with a More Holistic Overview

    B. S. Chua, J. Bruning

    2021Nuclear Receptors0 citations

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48. Zoogloea ramigera biosynthetic thiolase Q183Y/Y218E mutant

    A. Marshall, J. Bruning

    20210 citations

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49. Heavy chain ferritin with C-terminal EBNA1 epitope

    J. L. Pederick, J. Bruning

    20210 citations

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50. Mycobacterium tuberculosis dethiobiotin synthetase in complex with Tetrazole 2

    J. P. Pederick, J. Bean, J. Bruning

    20210 citations

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