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Santina Bruzzone · SciRah

Researcher profile · Semantic Scholar

Santina Bruzzone

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Santina Bruzzone — researcher profile on SciRah

h-index: 53
Works: 181
Citations: 8,042

Most-cited papers

A CD38/CD203a/CD73 ectoenzymatic pathway independent of CD39 drives a novel adenosinergic loop in human T lymphocytes
A. Horenstein, A. Chillemi, Gianluca Zaccarello, Santina Bruzzone +4 more
2013Oncoimmunology266 citations Open access
Semantic Scholar
Slc12a8 is a nicotinamide mononucleotide transporter
Alessia Grozio, K. Mills, Jun Yoshino, Santina Bruzzone +7 more
2019Nature Metabolism254 citations Open access
Semantic Scholar
Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody
Karina Kaczmarek-Hájek, Jiong Zhang, Robin A. Kopp, A. Grosche +13 more
2018eLife168 citations Open access
Semantic Scholar
CD73 Protein as a Source of Extracellular Precursors for Sustained NAD+ Biosynthesis in FK866-treated Tumor Cells*
Alessia Grozio, Giovanna Sociali, L. Sturla, I. Caffa +6 more
2013Journal of Biological Chemistry147 citations Open access
Semantic Scholar
Mesenchymal Stem Cells Shape Microglia Effector Functions Through the Release of CX3CL1
D. Giunti, B. Parodi, C. Usai, L. Vergani +4 more
2012Stem Cells146 citations
Semantic Scholar
Inhibition of Nicotinamide Phosphoribosyltransferase Reduces Neutrophil-Mediated Injury in Myocardial Infarction
F. Montecucco, Inga Bauer, V. Braunersreuther, Santina Bruzzone +22 more
2013Antioxidants and Redox Signaling112 citations Open access
Semantic Scholar
Discovery of novel and selective SIRT6 inhibitors.
M. Parenti, Alessia Grozio, Inga Bauer, Lauretta Galeno +8 more
2014Journal of Medicinal Chemistry110 citations Open access
Semantic Scholar
Regulation and Function of Extracellular Nicotinamide Phosphoribosyltransferase/Visfatin
F. Carbone, L. Liberale, A. Bonaventura, A. Vecchié +7 more
2017Comprehensive Physiology104 citations
Semantic Scholar
Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair.
Francesco Piacente, I. Caffa, S. Ravera, Giovanna Sociali +13 more
2017Cancer Research94 citations Open access
Semantic Scholar
The high-resolution crystal structure of periplasmic Haemophilus influenzae NAD nucleotidase reveals a novel enzymatic function of human CD73 related to NAD metabolism.
S. Garavaglia, Santina Bruzzone, C. Cassani, L. Canella +6 more
2012Biochemical Journal92 citations
Semantic Scholar
Nicotinamide Phosphoribosyltransferase Promotes Epithelial-to-Mesenchymal Transition as a Soluble Factor Independent of Its Enzymatic Activity*
D. Soncini, I. Caffa, G. Zoppoli, M. Cea +18 more
2014Journal of Biological Chemistry77 citations Open access
Semantic Scholar
Abscisic Acid: A Novel Nutraceutical for Glycemic Control
E. Zocchi, R. Hontecillas, A. Leber, A. Einerhand +7 more
2017Frontiers in Nutrition76 citations Open access
Semantic Scholar
Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics.
Giovanna Sociali, Lauretta Galeno, M. Parenti, Alessia Grozio +17 more
2015European journal of medicinal chemistry73 citations Open access
Semantic Scholar
Antitumor effect of combined NAMPT and CD73 inhibition in an ovarian cancer model
Giovanna Sociali, Lizzia Raffaghello, Mirko Magnone, Federica Zamporlini +8 more
2015OncoTarget69 citations Open access
Semantic Scholar
Pharmacological Sirt6 inhibition improves glucose tolerance in a type 2 diabetes mouse model
Giovanna Sociali, Mirko Magnone, S. Ravera, P. Damonte +13 more
2017The FASEB Journal67 citations Open access
Semantic Scholar
Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors as therapeutics: rationales, controversies, clinical experience.
F. Montecucco, M. Cea, Inga Bauer, D. Soncini +6 more
2013Current Drug Targets67 citations Open access
Semantic Scholar
SIRT6 deacetylase activity regulates NAMPT activity and NAD(P)(H) pools in cancer cells
Giovanna Sociali, Alessia Grozio, I. Caffa, Susanne Schuster +12 more
2018The FASEB Journal62 citations Open access
Semantic Scholar
Depletion of SIRT6 enzymatic activity increases acute myeloid leukemia cells’ vulnerability to DNA-damaging agents
A. Cagnetta, D. Soncini, S. Orecchioni, G. Talarico +19 more
2017Haematologica57 citations Open access
Semantic Scholar
Nampt controls skeletal muscle development by maintaining Ca2+ homeostasis and mitochondrial integrity
A. Basse, Marianne Agerholm, J. Farup, Emilie Dalbram +17 more
2021Molecular Metabolism55 citations Open access
Semantic Scholar
Abscisic Acid: A Conserved Hormone in Plants and Humans and a Promising Aid to Combat Prediabetes and the Metabolic Syndrome
Mirko Magnone, L. Sturla, L. Guida, Sonia Spinelli +4 more
2020Nutrients53 citations Open access
Semantic Scholar
Sirtuin 6 inhibition protects against glucocorticoid-induced skeletal muscle atrophy by regulating IGF/PI3K/AKT signaling
S. Mishra, C. Cosentino, A. Tamta, Danish Khan +20 more
2022Nature Communications52 citations Open access
Semantic Scholar
Nicotinamide phosphoribosyltransferase inhibition reduces intraplaque CXCL1 production and associated neutrophil infiltration in atherosclerotic mice
A. Nencioni, R. D. da Silva, Rodrigo A. Fraga-Silva, S. Steffens +21 more
2013Thrombosis and Haemostasis52 citations Open access
Semantic Scholar
Emerging strategies, applications and challenges of targeting NAD+ in the clinic
Jianying Zhang, He-Ling Wang, Sofie Lautrup, H. Nilsen +24 more
2025Nature Aging50 citations Open access
Semantic Scholar
G-protein coupling and nuclear translocation of the human abscisic acid receptor LANCL2
Chiara Fresia, Tiziana Vigliarolo, L. Guida, V. Booz +7 more
2016Scientific Reports46 citations Open access
Semantic Scholar
SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice
P. Becherini, I. Caffa, Francesco Piacente, P. Damonte +16 more
2021Cancer & Metabolism44 citations Open access
Semantic Scholar
Impaired Increase of Plasma Abscisic Acid in Response to Oral Glucose Load in Type 2 Diabetes and in Gestational Diabetes
Pietro Ameri, Santina Bruzzone, Elena Mannino, Giovanna Sociali +11 more
2015PLoS ONE44 citations Open access
Semantic Scholar
The enzymatic activities of CD38 enhance CLL growth and trafficking: implications for therapeutic targeting
T. Vaisitti, V. Audrito, Sara Serra, R. Buonincontri +12 more
2014Leukemia44 citations Open access
Semantic Scholar
Sirt6 inhibition delays the onset of experimental autoimmune encephalomyelitis by reducing dendritic cell migration
G. Ferrara, A. Benzi, L. Sturla, D. Marubbi +9 more
2020Journal of Neuroinflammation42 citations Open access
Semantic Scholar
SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects.
P. Damonte, Giovanna Sociali, M. Parenti, D. Soncini +15 more
2017Bioorganic & Medicinal Chemistry41 citations Open access
Semantic Scholar
Abscisic acid enhances glucose disposal and induces brown fat activity in adipocytes in vitro and in vivo.
L. Sturla, Elena Mannino, S. Scarfì, Santina Bruzzone +12 more
2017Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids39 citations
Semantic Scholar
Tolerability and efficacy study of P2X7 inhibition in experimental Charcot-Marie-Tooth type 1A (CMT1A) neuropathy.
Giovanna Sociali, Davide Visigalli, T. Prukop, I. Cervellini +5 more
2016Neurobiology of Disease38 citations Open access
Semantic Scholar
APO866 Increases Antitumor Activity of Cyclosporin-A by Inducing Mitochondrial and Endoplasmic Reticulum Stress in Leukemia Cells
A. Cagnetta, I. Caffa, C. Acharya, D. Soncini +18 more
2015Clinical Cancer Research37 citations Open access
Semantic Scholar
A critical role of autophagy in antileukemia/lymphoma effects of APO866, an inhibitor of NAD biosynthesis
V. Ginet, J. Puyal, C. Rummel, Dominique Aubry +9 more
2014Autophagy33 citations Open access
Semantic Scholar
Nicotinamide phosphoribosyltransferase as a target in inflammation- related disorders.
F. Montecucco, M. Cea, A. Cagnetta, P. Damonte +5 more
2013Current Topics in Medicinal Chemistry29 citations Open access
Semantic Scholar
Abscisic Acid Stimulates Glucagon-Like Peptide-1 Secretion from L-Cells and Its Oral Administration Increases Plasma Glucagon-Like Peptide-1 Levels in Rats
Santina Bruzzone, Mirko Magnone, Elena Mannino, Giovanna Sociali +6 more
2015PLoS ONE27 citations Open access
Semantic Scholar
Amino acid depletion triggered by ʟ-asparaginase sensitizes MM cells to carfilzomib by inducing mitochondria ROS-mediated cell death.
D. Soncini, P. Minetto, C. Martinuzzi, P. Becherini +18 more
2020Blood Advances26 citations Open access
Semantic Scholar
Selectivity hot-spots of sirtuin catalytic cores.
M. Parenti, Santina Bruzzone, A. Nencioni, Alberto Del Rio
2015Molecular Biosystems26 citations
Semantic Scholar
P2X7 Receptor Antagonist Reduces Fibrosis and Inflammation in a Mouse Model of Alpha-Sarcoglycan Muscular Dystrophy
Lizzia Raffaghello, E. Principi, S. Baratto, C. Panicucci +9 more
2022Pharmaceuticals24 citations Open access
Semantic Scholar
CD38 downregulation modulates NAD+ and NADP(H) levels in thermogenic adipose tissues.
A. Benzi, L. Sturla, M. Heine, Alexander W. Fischer +13 more
2020Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids23 citations
Semantic Scholar
Mitochondrial rewiring drives metabolic adaptation to NAD(H) shortage in triple negative breast cancer cells
A. Carreira, S. Ravera, C. Zucal, Natthakan Thongon +10 more
2023Neoplasia22 citations Open access
Semantic Scholar
eATP/P2X7R Axis: An Orchestrated Pathway Triggering Inflammasome Activation in Muscle Diseases
C. Panicucci, Lizzia Raffaghello, Santina Bruzzone, S. Baratto +4 more
2020International Journal of Molecular Sciences22 citations Open access
Semantic Scholar
Identification of NAPRT Inhibitors with Anti-Cancer Properties by In Silico Drug Discovery
Moustafa S. Ghanem, I. Caffa, Alberto Del Rio, Jorge Franco +11 more
2022Pharmaceuticals21 citations Open access
Semantic Scholar
Neuroprotective Potential of Dendritic Cells and Sirtuins in Multiple Sclerosis
Francesco Piacente, M. Bottero, A. Benzi, T. Vigo +3 more
2022International Journal of Molecular Sciences19 citations Open access
Semantic Scholar
CD38-Induced Metabolic Dysfunction Primes Multiple Myeloma Cells for NAD+-Lowering Agents
P. Becherini, D. Soncini, S. Ravera, Elisa Gelli +19 more
2023Antioxidants16 citations Open access
Semantic Scholar
SIRT6 pharmacological inhibition delays skin cancer progression in the squamous cell carcinoma.
Elena Abbotto, C. Miro, Francesco Piacente, A. Salis +11 more
2023Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie15 citations Open access
Semantic Scholar
Novel Thiazole-Based SIRT2 Inhibitors Discovered via Molecular Modelling Studies and Enzymatic Assays
Elena Abbotto, Beatrice Casini, Francesco Piacente, Naomi Scarano +7 more
2023Pharmaceuticals15 citations Open access
Semantic Scholar
Virtual Screening in the Identification of Sirtuins’ Activity Modulators
Elena Abbotto, Naomi Scarano, Francesco Piacente, E. Millo +2 more
2022Molecules15 citations Open access
Semantic Scholar
Structure-Based Identification and Biological Characterization of New NAPRT Inhibitors
Jorge Franco, Francesco Piacente, M. Walter, Simone Fratta +11 more
2022Pharmaceuticals14 citations Open access
Semantic Scholar
The Danger Signal Extracellular ATP Is Involved in the Immunomediated Damage of α-Sarcoglycan-Deficient Muscular Dystrophy.
E. Gazzerro, S. Baratto, S. Assereto, S. Baldassari +14 more
2019American Journal of Pathology14 citations Open access
Semantic Scholar
Recent Advances in the Discovery of SIRT1/2 Inhibitors via Computational Methods: A Perspective
Naomi Scarano, C. Brullo, Francesca Musumeci, E. Millo +3 more
2024Pharmaceuticals13 citations Open access
Semantic Scholar

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