D. Ferraris

Most-cited papers

1. Structure of the human receptor tyrosine kinase met in complex with the Listeria invasion protein InlB.

   H. Niemann, V. Jäger, P. Butler, J. van den Heuvel +4 more

   2007Cell168 citations Open access

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2. AI is a viable alternative to high throughput screening: a 318-target study

   Izhar Wallach, Denzil Bernard, Kong Nguyen, Gregory Ho +496 more

   2024Scientific Reports112 citations Open access

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3. Extracellular NAD+ enhances PARP-dependent DNA repair capacity independently of CD73 activity

   A. Wilk, Faisal Hayat, Richard Cunningham, Jianfeng Li +11 more

   2020Scientific Reports82 citations Open access

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4. Mycobacterium tuberculosis Pathogenesis, Infection Prevention and Treatment

   R. Miggiano, M. Rizzi, D. Ferraris

   2020Pathogens80 citations Open access

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5. Single-molecule photobleaching reveals increased MET receptor dimerization upon ligand binding in intact cells

   M. Dietz, Daniel Haße, D. Ferraris, Antonia Göhler +2 more

   2013BMC Biophysics54 citations Open access

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6. Imidazo[1,2-a]pyridine Derivatives as Aldehyde Dehydrogenase Inhibitors: Novel Chemotypes to Target Glioblastoma Stem Cells.

   Luca Quattrini, E. Gelardi, Vito Coviello, S. Sartini +5 more

   2020Journal of Medicinal Chemistry53 citations Open access

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7. The Synthesis of Kynurenic Acid in Mammals: An Updated Kynurenine Aminotransferase Structural KATalogue

   F. Rossi, R. Miggiano, D. Ferraris, M. Rizzi

   2019Frontiers in Molecular Biosciences46 citations Open access

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8. Ligand-mediated dimerization of the Met receptor tyrosine kinase by the bacterial invasion protein InlB.

   D. Ferraris, E. Gherardi, Ying Di, D. Heinz +1 more

   2010Journal of Molecular Biology46 citations Open access

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9. Development of Potent Inhibitors of the Mycobacterium tuberculosis Virulence Factor Zmp1 and Evaluation of Their Effect on Mycobacterial Survival inside Macrophages

   M. Paolino, M. Brindisi, Alessandra Vallone, S. Butini +18 more

   2018ChemMedChem44 citations Open access

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10. A Selective Competitive Inhibitor of Aldehyde Dehydrogenase 1A3 Hinders Cancer Cell Growth, Invasiveness and Stemness In Vitro

    E. Gelardi, G. Colombo, Francesca Picarazzi, D. Ferraris +7 more

    2021Cancers43 citations Open access

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11. Mycobacterium tuberculosis Molecular Determinants of Infection, Survival Strategies, and Vulnerable Targets

    D. Ferraris, R. Miggiano, F. Rossi, M. Rizzi

    2018Pathogens42 citations Open access

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12. Expanding benzoxazole based inosine 5’-monophosphate dehydrogenase (IMPDH) inhibitor structure-activity as potential anti-tuberculosis agents

    Shibin Chacko, H. Boshoff, Vinayak Singh, D. Ferraris +9 more

    2018Journal of Medicinal Chemistry34 citations Open access

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13. Crystal Structure of Mycobacterium tuberculosis Zinc-dependent Metalloprotease-1 (Zmp1), a Metalloprotease Involved in Pathogenicity*

    D. Ferraris, D. Sbardella, Agnese Petrera, S. Marini +4 more

    2011Journal of Biological Chemistry33 citations Open access

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14. Synthesis and Structure–Activity relationship of 1-(5-isoquinolinesulfonyl)piperazine analogues as inhibitors of Mycobacterium tuberculosis IMPDH

    Vinayak Singh, A. Pacitto, S. Donini, D. Ferraris +8 more

    2019European journal of medicinal chemistry30 citations Open access

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15. Structures of citrate synthase and malate dehydrogenase of Mycobacterium tuberculosis

    D. Ferraris, R. Spallek, W. Oehlmann, Mahavir Singh +1 more

    2015Proteins: Structure, Function, and Bioinformatics29 citations

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16. Discovery of the first potent and selective Mycobacterium tuberculosis Zmp1 inhibitor.

    M. Mori, Francesca Moraca, D. Deodato, D. Ferraris +4 more

    2014Bioorganic & Medicinal Chemistry Letters28 citations Open access

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17. Hit discovery of Mycobacterium tuberculosis inosine 5'-monophosphate dehydrogenase, GuaB2, inhibitors.

    Niteshkumar U. Sahu, Vinayak Singh, D. Ferraris, M. Rizzi +1 more

    2018Bioorganic & Medicinal Chemistry Letters26 citations

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18. Structural investigations on orotate phosphoribosyltransferase from Mycobacterium tuberculosis, a key enzyme of the de novo pyrimidine biosynthesis

    S. Donini, D. Ferraris, R. Miggiano, A. Massarotti +1 more

    2017Scientific Reports26 citations Open access

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19. Biochemical and structural investigations on phosphoribosylpyrophosphate synthetase from Mycobacterium smegmatis

    S. Donini, S. Garavaglia, D. Ferraris, R. Miggiano +3 more

    2017PLoS ONE25 citations Open access

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20. Functional characterization of the Mycobacterium tuberculosis zinc metallopeptidase Zmp1 and identification of potential substrates

    Agnese Petrera, Beat Amstutz, Magda Gioia, J. Hähnlein +8 more

    2012Biological chemistry24 citations Open access

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21. Progress in the Field of Aldehyde Dehydrogenase Inhibitors: Novel Imidazo[1,2-a]pyridines against the 1A Family.

    Luca Quattrini, E. Gelardi, Giovanni Petrarolo, G. Colombo +5 more

    2020ACS Medicinal Chemistry Letters23 citations Open access

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22. Single-molecule imaging and molecular dynamics simulations reveal early activation of the MET receptor in cells

    Yunqing Li, Serena M Arghittu, M. Dietz, Gabriel J Hella +9 more

    2024Nature Communications20 citations Open access

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23. Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold: SAR of the Aryloxyaryl Moiety

    S. Sainas, M. Giorgis, P. Circosta, G. Poli +21 more

    2022Journal of Medicinal Chemistry19 citations Open access

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24. Crystal structure of the Mycobacterium tuberculosis phosphate binding protein PstS3

    D. Ferraris, R. Spallek, W. Oehlmann, Mahavir Singh +1 more

    2014Proteins: Structure, Function, and Bioinformatics19 citations Open access

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25. Design, synthesis, SAR and biological investigation of 3-(carboxymethyl)rhodanine and aminothiazole inhibitors of Mycobacterium tuberculosis Zmp1.

    M. Mori, D. Deodato, Mohan Kasula, D. Ferraris +4 more

    2018Bioorganic & Medicinal Chemistry Letters16 citations Open access

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26. Curcumin-based-fluorescent probes targeting ALDH1A3 as a promising tool for glioblastoma precision surgery and early diagnosis

    E. Gelardi, Diego Caprioglio, G. Colombo, E. Del Grosso +11 more

    2021Communications Biology15 citations Open access

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27. The integration of AlphaFold-predicted and crystal structures of human trans-3-hydroxy-l-proline dehydratase reveals a regulatory catalytic mechanism

    E. Ferrario, R. Miggiano, M. Rizzi, D. Ferraris

    2022Computational and Structural Biotechnology Journal9 citations Open access

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28. Crystal structure of a thermophilic O6-alkylguanine-DNA alkyltransferase-derived self-labeling protein-tag in covalent complex with a fluorescent probe.

    F. Rossi, Castrese Morrone, A. Massarotti, D. Ferraris +3 more

    2018Biochemical and Biophysical Research Communications - BBRC9 citations

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29. Targeting NAD-dependent dehydrogenases in drug discovery against infectious diseases and cancer.

    D. Ferraris, E. Gelardi, S. Garavaglia, R. Miggiano +1 more

    2020Biochemical Society Transactions8 citations

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30. Engineering, Characterization, and Biological Evaluation of an Antibody Targeting the HGF Receptor

    C. Desole, Simona Gallo, Annapia Vitacolonna, E. Vigna +9 more

    2021Frontiers in Immunology7 citations Open access

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31. Biochemical characterization of Mycobacterium tuberculosis dihydroorotate dehydrogenase and identification of a selective inhibitor

    Marta Alberti, S. Sainas, E. Ronchi, M. Lolli +4 more

    2023FEBS Letters6 citations Open access

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32. Expanding Benzoxazole-Based Inosine 5'-Monophosphate Dehydrogenase (IMPDH) Inhibitor Structure-Activity As Potential Antituberculosis Agents.

    Shibin Chacko, H. Boshoff, Vinayak Singh, D. Ferraris +9 more

    2021Journal of Medicinal Chemistry6 citations

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33. Structure of Thermococcus litoralis trans-3-hydroxy-l-proline dehydratase in the free and substrate-complexed form.

    D. Ferraris, R. Miggiano, Seiya Watanabe, M. Rizzi

    2019Biochemical and Biophysical Research Communications - BBRC4 citations

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34. An alternative conformation of the N-terminal loop of human dihydroorotate dehydrogenase drives binding to a potent antiproliferative agent.

    Marta Alberti, G. Poli, L. Broggini, S. Sainas +8 more

    2024Acta Crystallographica Section D: Structural Biology3 citations

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35. Structure of Thermococcus litoralis Δ1-pyrroline-2-carboxylate reductase in complex with NADH and L-proline.

    E. Ferrario, R. Miggiano, M. Rizzi, D. Ferraris

    2020Acta Crystallographica Section D: Structural Biology3 citations

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36. Zinc‐Dependent Metalloprotease‐1 (Zmp1)

    D. Ferraris, M. Rizzi

    20133 citations

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37. Author Correction: AI is a viable alternative to high throughput screening: a 318-target study

    Izhar Denzil Kong Gregory Adrian Adrian Andreana Ann Mar Wallach Bernard Nguyen Ho Morrison Stecula Rosnik , Izhar Wallach, Denzil Bernard, Kong Nguyen +496 more

    2024Scientific Reports2 citations Open access

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38. Single-molecule imaging and molecular dynamics simulations reveal early activation of the MET receptor in situ

    Yunqing Li, Serena M Arghittu, M. Dietz, Gabriel J Hella +7 more

    2024bioRxiv1 citations Open access

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39. Structure of Malate Dehydrogenase from Mycobacterium tuberculosis

    D. Ferraris, M. Rizzi

    20151 citations

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40. Synthesis and StructureeActivity relationship of 1-(5-isoquinolinesulfonyl)piperazine analogues as inhibitors of Mycobacterium tuberculosis IMPDH

    Vinayak Singh, A. Pacitto, S. Donini, D. Ferraris +6 more

    1 citations

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41. Development of N -Hydroxyindole-2-Carboxamides as New Host-Targeted Broad-Spectrum Antiviral Agents Against Human Respiratory Viruses

    G. Bononi, G. Sibille, Erika Plicanti, Fabio Testori +19 more

    2026Journal of Medicinal Chemistry0 citations Open access

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42. A Unified 3D Generative Model for Synthesizable Structure-Based Drug Design

    Ilia Igashov, Arne Schneuing, Adrian W. Dobbelstein, Irina Morozova +24 more

    2026bioRxiv0 citations Open access

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43. FragmentScope - exploring the fragment space with learned surface representations

    Evgenia A. Elizarova, Irina Morozova, Ilia Igashov, Olivia Gampp +8 more

    2025bioRxiv0 citations Open access

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44. Crystal Structure of human ALDH1A3 in complex with 2,6-diphenylimidazo[1,2-a]pyridine (compound GA11) and NAD+

    E. L. M. Gelardi, L. Quattrini, C. LaMotta, D. Ferraris +1 more

    20200 citations

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45. Structure of Thermococcus litoralis Delta(1)-pyrroline-2-carboxylate reductase in complex with NADH and L-proline

    D. Ferraris, R. Miggiano, E. Ferrario, M. Rizzi

    20200 citations

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46. Crystal structure of trans-3-Hydroxy-L-proline dehydratase in complex with substrate - closed conformation

    D. Ferraris, R. Miggiano, M. Rizzi

    20190 citations

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47. Crystal structure of trans-3-Hydroxy-L-proline dehydratase from Thermococcus litoralis - open conformation

    D. Ferraris, R. Miggiano, M. Rizzi

    20190 citations

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48. Absolute structure and structure-function relationships of 4R,2′R and 4S,2′S Pidotimod®

    Simone Sarno, A. M. Manzo, D. Ferraris, R. Miggiano +4 more

    20170 citations

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49. Crystal structure of Mycobacterium tuberculosis H37Rv orotate phosphoribosyltransferase in complex with 5-phospho-alpha-D-ribosyl 1-diphosphate (PRPP)

    S. Donini, D. Ferraris, G. Bolognesi, M. Rizzi

    20170 citations

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50. Crystal structure of Mycobacterium tuberculosis H37Rv orotate phosphoribosyltransferase in complex with Fe(III) dicitrate

    S. Donini, D. Ferraris, G. Bolognesi, M. Rizzi

    20170 citations

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