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D. Daelemans · SciRah

Researcher profile · Semantic Scholar

D. Daelemans

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D. Daelemans — researcher profile on SciRah

h-index: 41
Works: 205
Citations: 9,127

Most-cited papers

Cellular host factors for SARS-CoV-2 infection
Jim Baggen, E. Vanstreels, S. Jansen, D. Daelemans
2021Nature Microbiology207 citations Open access
Semantic Scholar
Genome-wide CRISPR screening identifies TMEM106B as a proviral host factor for SARS-CoV-2
Jim Baggen, L. Persoons, E. Vanstreels, S. Jansen +15 more
2021Nature Genetics201 citations Open access
Semantic Scholar
XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer
Jimi Kim, Elizabeth A. McMillan, Hyun Seok Kim, Niranjan Venkateswaran +19 more
2016Nature187 citations Open access
Semantic Scholar
TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry
Jim Baggen, M. Jacquemyn, L. Persoons, E. Vanstreels +21 more
2023Cell128 citations Open access
Semantic Scholar
Design, Synthesis, and Evaluation of Thiophene[3,2-d]pyrimidine Derivatives as HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Significantly Improved Drug Resistance Profiles.
Dong-Wei Kang, Zengjun Fang, Zhen-Yu Li, Boshi Huang +10 more
2016Journal of Medicinal Chemistry123 citations Open access
Semantic Scholar
The material properties of a bacterial-derived biomolecular condensate tune biological function in natural and synthetic systems
Keren Lasker, S. Boeynaems, Vinson Lam, D. Scholl +9 more
2022Nature Communications116 citations Open access
Semantic Scholar
Target identification of small molecules using large-scale CRISPR-Cas mutagenesis scanning of essential genes
J. E. Neggers, B. Kwanten, T. Dierckx, H. Noguchi +11 more
2018Nature Communications93 citations Open access
Semantic Scholar
Structure-Based Optimization of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Improved Potency against Resistance-Associated Variants.
Dong-Wei Kang, Zengjun Fang, Boshi Huang, Xueyi Lu +14 more
2017Journal of Medicinal Chemistry86 citations Open access
Semantic Scholar
Targeting the entrance channel of NNIBP: Discovery of diarylnicotinamide 1,4-disubstituted 1,2,3-triazoles as novel HIV-1 NNRTIs with high potency against wild-type and E138K mutant virus
Ye Tian, Zhao-Qiang Liu, Jinghan Liu, Boshi Huang +9 more
2018European journal of medicinal chemistry81 citations Open access
Semantic Scholar
Exploiting the Tolerant Region I of the Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Binding Pocket: Discovery of Potent Diarylpyrimidine-Typed HIV-1 NNRTIs against Wild-Type and E138K Mutant Virus with Significantly Improved Water Solubility and Favorable Safety Profiles.
Boshi Huang, Wenmin Chen, Tong Zhao, Zhen-Yu Li +13 more
2019Journal of Medicinal Chemistry71 citations Open access
Semantic Scholar
Near-native, site-specific and purification-free protein labeling for quantitative protein interaction analysis by MicroScale Thermophoresis
Tanja Bartoschik, Stefanie Galinec, Christian Kleusch, K. Walkiewicz +8 more
2018Scientific Reports68 citations Open access
Semantic Scholar
The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A
Inmaculada Segura, Christian Lange, Ellen Knevels, A. Moskalyuk +13 more
2016Cell Reports53 citations Open access
Semantic Scholar
C9orf72-generated poly-GR and poly-PR do not directly interfere with nucleocytoplasmic transport
Joni Vanneste, T. Vercruysse, S. Boeynaems, Adria Sicart +3 more
2019Scientific Reports52 citations Open access
Semantic Scholar
ATXN1 repeat expansions confer risk for amyotrophic lateral sclerosis and contribute to TDP-43 mislocalization
Gijs H. P. Tazelaar, S. Boeynaems, Mathias De Decker, J. V. van Vugt +34 more
2020Brain Communications51 citations Open access
Semantic Scholar
STK38 kinase acts as XPO1 gatekeeper regulating the nuclear export of autophagy proteins and other cargoes
A. Martin, M. Jacquemyn, J. Lipecka, C. Chhuon +12 more
2019EMBO Reports48 citations Open access
Semantic Scholar
Preclinical assessment with clinical validation of Selinexor with gemcitabine and nab-paclitaxel for the treatment of pancreatic ductal adenocarcinoma
A. Azmi, H. Khan, A. Aboukameel, I. Muqbil +11 more
2019Clinical Cancer Research44 citations Open access
Semantic Scholar
Targeting the XPO1-dependent nuclear export of E2F7 reverses anthracycline resistance in head and neck squamous cell carcinomas
Natalia Sáenz-Ponce, Rachael Pillay, Lilia M. de Long, T. Kashyap +9 more
2018Science Translational Medicine41 citations Open access
Semantic Scholar
Discovery of Novel Diarylpyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the "NNRTI Adjacent" Binding Site.
Zhi-Peng Huo, Heng Zhang, Dong-Wei Kang, Zhong-Xia Zhou +11 more
2018ACS Medicinal Chemistry Letters35 citations Open access
Semantic Scholar
E3 ubiquitin ligase ASB8 promotes selinexor-induced proteasomal degradation of XPO1.
B. Kwanten, Tine Deconick, C. Walker, Feng Wang +2 more
2023Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie32 citations Open access
Semantic Scholar
Discovery of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the Tolerant Region I of NNIBP.
Dong-Wei Kang, Xiao Ding, Gao-Chan Wu, Zhi-Peng Huo +10 more
2017ACS Medicinal Chemistry Letters31 citations Open access
Semantic Scholar
Design, synthesis and biological evaluation of novel acetamide-substituted doravirine and its prodrugs as potent HIV-1 NNRTIs.
Zhao Wang, Zhao Yu, Dong-Wei Kang, Jian Zhang +6 more
2019Bioorganic & Medicinal Chemistry30 citations Open access
Semantic Scholar
Design, synthesis and anti-HIV evaluation of novel diarylpyridine derivatives targeting the entrance channel of NNRTI binding pocket.
Jiapei Yang, Wenmin Chen, Dong-Wei Kang, Xueyi Lu +8 more
2016European journal of medicinal chemistry30 citations Open access
Semantic Scholar
5-Hydroxypyrido[2,3-b]pyrazin-6(5H)-one derivatives as novel dual inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H and integrase.
Lin Sun, Ping Gao, Guanyu Dong, Xujie Zhang +9 more
2018European journal of medicinal chemistry29 citations Open access
Semantic Scholar
Design, synthesis, and biological evaluation of piperidinyl‐substituted [1,2,4]triazolo[1,5‐a]pyrimidine derivatives as potential anti‐HIV‐1 agents with reduced cytotoxicity
Boshi Huang, Dong-Wei Kang, Ye Tian, D. Daelemans +4 more
2020Chemical Biology and Drug Design28 citations Open access
Semantic Scholar
Further Exploring Solvent-Exposed Tolerant Regions of Allosteric Binding Pocket for Novel HIV-1 NNRTIs Discovery.
Dong-Wei Kang, Zhao Wang, Heng Zhang, Gao-Chan Wu +16 more
2018ACS Medicinal Chemistry Letters28 citations Open access
Semantic Scholar
CRISPR/Cas9 screen in human iPSC-derived cortical neurons identifies NEK6 as a novel disease modifier of C9orf72 poly(PR) toxicity
Wenting Guo, Haibo Wang, Arun Kumar Tharkeshwar, Julien Couthouis +26 more
2022Alzheimer's & Dementia27 citations Open access
Semantic Scholar
Design, synthesis, and antiviral evaluation of novel hydrazone‐substituted thiophene[3,2‐d]pyrimidine derivatives as potent human immunodeficiency virus‐1 inhibitors
Zhao Wang, Dong-Wei Kang, Meng Chen, Gao-Chan Wu +11 more
2018Chemical Biology and Drug Design26 citations
Semantic Scholar
Discovery of novel DAPY-IAS hybrid derivatives as potential HIV-1 inhibitors using molecular hybridization based on crystallographic overlays.
Boshi Huang, Xue-Shun Wang, Xin-Hao Liu, Zi-Tong Chen +8 more
2017Bioorganic & Medicinal Chemistry25 citations Open access
Semantic Scholar
Loss of tRNA-modifying enzyme Elp3 activates a p53-dependent antitumor checkpoint in hematopoiesis
Adeline Rosu, Najla El Hachem, F. Rapino, K. Rouault-Pierre +13 more
2021Journal of Experimental Medicine24 citations Open access
Semantic Scholar
Discovery of novel diarylpyrimidines as potent HIV-1 NNRTIs by investigating the chemical space of a less explored "hydrophobic channel".
Zhong-Xia Zhou, Tao Liu, Dong-Wei Kang, Zhi-Peng Huo +6 more
2018Organic and biomolecular chemistry24 citations Open access
Semantic Scholar
Novel Biologically Active N-Substituted Benzimidazole Derived Schiff Bases: Design, Synthesis, and Biological Evaluation
Anja Beč, M. Cindrić, L. Persoons, M. Banjanac +3 more
2023Molecules21 citations Open access
Semantic Scholar
Imidazo[4,5-b]pyridine derived tubulin polymerization inhibitors: Design, synthesis, biological activity in vitro and computational analysis.
Ida Boček, L. Hok, L. Persoons, D. Daelemans +2 more
2022Bioorganic chemistry (Print)20 citations
Semantic Scholar
Discovery of ( ±)-3-(1 H -pyrazol-1-yl)-6,7-dihydro-5 H -[1,2,4]triazolo[3,4- b ][1,3,4] thiadiazine derivatives with promising in vitro anticoronavirus and antitumoral activity
Parameshwara Chary Jilloju, L. Persoons, S. Kurapati, D. Schols +3 more
2021Molecular diversity20 citations Open access
Semantic Scholar
Inhibition of XPO-1 Mediated Nuclear Export through the Michael-Acceptor Character of Chalcones
Marta Gargantilla, José López-Fernández, M. Camarasa, L. Persoons +3 more
2021Pharmaceuticals20 citations Open access
Semantic Scholar
The stem cell growth factor receptor KIT is not expressed on interstitial cells in bladder
T. Gevaert, D. De Ridder, E. Vanstreels, D. Daelemans +7 more
2016Journal of Cellular and Molecular Medicine20 citations Open access
Semantic Scholar
A modular platform for engineering function of natural and synthetic biomolecular condensates
Keren Lasker, S. Boeynaems, Vinson Lam, Emma Stainton +6 more
2021bioRxiv19 citations Open access
Semantic Scholar
Discovery of novel piperidine-substituted indolylarylsulfones as potent HIV NNRTIs via structure-guided scaffold morphing and fragment rearrangement.
Xiao Li, Ping Gao, Boshi Huang, Zhong-Xia Zhou +8 more
2017European journal of medicinal chemistry19 citations Open access
Semantic Scholar
Antibacterial and antitumoral properties of 1,2,3-triazolo fused triterpenes and their mechanism of inhibiting the proliferation of HL-60 cells.
Rui Wang, Yang Li, Hai-Bo Hu, L. Persoons +5 more
2021European journal of medicinal chemistry18 citations
Semantic Scholar
Synthesis and Biological Evaluation of Pyrrolo[2,1‐f][1,2,4]triazine C‐Nucleosides with a Ribose, 2′‐Deoxyribose, and 2′,3′‐Dideoxyribose Sugar Moiety
Qing-Feng Li, Eveline Lescrinier, Elisabetta Groaz, L. Persoons +3 more
2018ChemMedChem18 citations Open access
Semantic Scholar
Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyrimidine-based protein kinase D inhibitors.
Philippe Gilles, R. Kashyap, M. J. Freitas, Sam Ceusters +9 more
2020European journal of medicinal chemistry17 citations Open access
Semantic Scholar
Drug repurposing: phosphate prodrugs of anticancer and antiviral FDA-approved nucleosides as novel antimicrobials.
Fabrizio Pertusati, Elisa Pileggi, J. Richards, M. Wootton +8 more
2020Journal of Antimicrobial Chemotherapy17 citations Open access
Semantic Scholar
Systemic cytokines and GlycA discriminate disease status and predict corticosteroid response in HTLV-1-associated neuroinflammation
Tatiane Assone, S. Menezes, Fernanda de Toledo Gonçalves, V. Folgosi +17 more
2022Journal of Neuroinflammation16 citations Open access
Semantic Scholar
Benzofuranyl-2-imidazoles as imidazoline I2 receptor ligands for Alzheimer's disease.
Sergio Rodríguez-Arévalo, A. Bagán, C. Griñán-Ferré, Foteini Vasilopoulou +17 more
2021European journal of medicinal chemistry16 citations Open access
Semantic Scholar
Bicyclic -iminophosphonates as highly affinity imidazoline I2 receptor ligands for Alzheimer's Disease.
C. Escolano, Sònia Abás, Sergio Rodríguez-Arévalo, A. Bagán +21 more
2020Journal of Medicinal Chemistry16 citations Open access
Semantic Scholar
CRISPR-Cas9 recognition of enzymatically synthesized base-modified nucleic acids
Hui Yang, E. Eremeeva, M. Abramov, M. Jacquemyn +3 more
2023Nucleic Acids Research15 citations Open access
Semantic Scholar
Hybridization Approach to Identify Salicylanilides as Inhibitors of Tubulin Polymerization and Signal Transducers and Activators of Transcription 3 (STAT3)
Marta Gargantilla, L. Persoons, Tereza Kauerová, Natalia Del Río +4 more
2022Pharmaceuticals15 citations Open access
Semantic Scholar
Structure-Based Design and Discovery of Pyridyl-Bearing Fused Bicyclic HIV-1 Inhibitors: Synthesis, Biological Characterization, and Molecular Modeling Studies.
Boshi Huang, Tiziana Ginex, F. Luque, Xiang-Yi Jiang +8 more
2021Journal of Medicinal Chemistry15 citations Open access
Semantic Scholar
Discovery of potent HIV‐1 non‐nucleoside reverse transcriptase inhibitors by exploring the structure–activity relationship of solvent‐exposed regions I
Dong-Wei Kang, Zhao Wang, Meng Chen, Da Feng +10 more
2019Chemical Biology and Drug Design15 citations
Semantic Scholar
Down-regulation of AR splice variants through XPO1 suppression contributes to the inhibition of prostate cancer progression
A. Aboukameel, I. Muqbil, E. Baloglu, W. Senapedis +10 more
2018OncoTarget15 citations Open access
Semantic Scholar
To disinfect or not to disinfect in postharvest research on the fungal decay of apple?
M. Naets, M. van Dael, E. Vanstreels, D. Daelemans +4 more
2018Journal of food microbiology15 citations
Semantic Scholar

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