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T. Kashyap · SciRah

Researcher profile · Semantic Scholar

T. Kashyap

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T. Kashyap — researcher profile on SciRah

h-index: 19
Works: 113
Citations: 1,596

Most-cited papers

CRM1 inhibition induces tumor cell cytotoxicity and impairs osteoclastogenesis in multiple myeloma: molecular mechanisms and therapeutic implications
Yu-Tzu Tai, Y. Landesman, C. Acharya, Y. Calle +20 more
2013Leukemia304 citations Open access
Semantic Scholar
A phase 1 clinical trial of single-agent selinexor in acute myeloid leukemia.
R. Garzon, M. Savona, R. Baz, M. Andreeff +15 more
2017Blood140 citations Open access
Semantic Scholar
Selinexor, a Selective Inhibitor of Nuclear Export (SINE) compound, acts through NF-κB deactivation and combines with proteasome inhibitors to synergistically induce tumor cell death
T. Kashyap, C. Argueta, A. Aboukameel, T. Unger +10 more
2016OncoTarget136 citations Open access
Semantic Scholar
XPO1 inhibitor combination therapy with bortezomib or carfilzomib induces nuclear localization of IκBα and overcomes acquired proteasome inhibitor resistance in human multiple myeloma
J. Turner, T. Kashyap, J. Dawson, Juan A. Gomez +7 more
2016OncoTarget89 citations Open access
Semantic Scholar
XPO1 Inhibition Using Selinexor Synergizes With Chemotherapy in Acute Myeloid Leukemia (AML) by Targeting DNA Repair and Restoring Topoisomerase IIα to the Nucleus
Parvathi Ranganathan, T. Kashyap, Xue-Yan Yu, Xiao-yan Meng +10 more
2016Clinical Cancer Research88 citations Open access
Semantic Scholar
Selinexor-induced thrombocytopenia results from inhibition of thrombopoietin signaling in early megakaryopoiesis.
K. Machlus, Stephen K. Wu, Prakrith Vijey, T. Soussou +9 more
2017Blood73 citations Open access
Semantic Scholar
Venetoclax response is enhanced by selective inhibitor of nuclear export compounds in hematologic malignancies.
Melissa A. Fischer, S. Friedlander, M. Arrate, Hua Chang +14 more
2020Blood Advances61 citations Open access
Semantic Scholar
Selinexor, a novel selective inhibitor of nuclear export, reduces SARS-CoV-2 infection and protects the respiratory system in vivo
T. Kashyap, J. Murray, C. Walker, Hua Chang +6 more
2021Antiviral Research58 citations Open access
Semantic Scholar
Selinexor reduces the expression of DNA damage repair proteins and sensitizes cancer cells to DNA damaging agents
T. Kashyap, C. Argueta, T. Unger, B. Klebanov +7 more
2018OncoTarget55 citations Open access
Semantic Scholar
Selective nuclear export inhibitor KPT-330 enhances the antitumor activity of gemcitabine in human pancreatic cancer
S. Kazim, M. Malafa, D. Coppola, K. Husain +7 more
2015Molecular Cancer Therapeutics55 citations Open access
Semantic Scholar
Novel Small Molecule XPO1/CRM1 Inhibitors Induce Nuclear Accumulation of TP53, Phosphorylated MAPK and Apoptosis in Human Melanoma Cells
Jennifer Yang, Matthew A. Bill, Gregory S. Young, K. L. La Perle +8 more
2014PLoS ONE51 citations Open access
Semantic Scholar
Selinexor synergizes with dexamethasone to repress mTORC1 signaling and induce multiple myeloma cell death
C. Argueta, T. Kashyap, B. Klebanov, T. Unger +7 more
2018OncoTarget44 citations Open access
Semantic Scholar
Targeting the XPO1-dependent nuclear export of E2F7 reverses anthracycline resistance in head and neck squamous cell carcinomas
Natalia Sáenz-Ponce, Rachael Pillay, Lilia M. de Long, T. Kashyap +9 more
2018Science Translational Medicine41 citations Open access
Semantic Scholar
Clinical dosing regimen of selinexor maintains normal immune homeostasis and T cell effector function in mice: implications for combination with immunotherapy
Paul M. Tyler, Mariah M. Servos, Romy C. de Vries, B. Klebanov +5 more
2016Molecular Cancer Therapeutics36 citations Open access
Semantic Scholar
Biologic activity of the novel orally bioavailable selective inhibitor of nuclear export (SINE) KPT-335 against canine melanoma cell lines
M. Breit, W. Kisseberth, Misty D. Bear, Y. Landesman +5 more
2014BMC Veterinary Research30 citations Open access
Semantic Scholar
The exportin-1 inhibitor selinexor exerts superior anti-tumor activity when combined with T cell checkpoint inhibitors
M. Farren, Rebecca C. Hennessey, Reena Shakya, O. Elnaggar +9 more
2017Molecular Cancer Therapeutics29 citations Open access
Semantic Scholar
Deciphering mechanisms of drug sensitivity and resistance to Selective Inhibitor of Nuclear Export (SINE) compounds
M. Crochiere, T. Kashyap, O. Kalid, Sharon Shechter +4 more
2015BMC Cancer27 citations Open access
Semantic Scholar
Selective Inhibitors of Nuclear Export (SINE) compounds block proliferation and migration of triple negative breast cancer cells by restoring expression of ARRDC3
Y. Soung, T. Kashyap, Thalia Nguyen, Garima Yadav +3 more
2017OncoTarget25 citations Open access
Semantic Scholar
Exportin 1 inhibition induces nerve growth factor receptor expression to inhibit the NF-κB pathway in preclinical models of pediatric high-grade glioma
J. DeSisto, Patrick C. Flannery, Rakeb Lemma, Amrita Pathak +11 more
2019Molecular Cancer Therapeutics18 citations Open access
Semantic Scholar
Down-regulation of AR splice variants through XPO1 suppression contributes to the inhibition of prostate cancer progression
A. Aboukameel, I. Muqbil, E. Baloglu, W. Senapedis +10 more
2018OncoTarget15 citations Open access
Semantic Scholar
Selinexor Demonstrates Marked Synergy with Dexamethasone (Sel-Dex) in Preclinical Models and in Patients with Heavily Pretreated Refractory Multiple Myeloma (MM)
Christine Chen, M. Gutierrez, D. Siegel, J. Richter +24 more
201413 citations
Semantic Scholar
Nuclear Export Inhibitor KPT-8602 Synergizes with PARP Inhibitors in Escalating Apoptosis in Castration Resistant Cancer Cells
M. H. Uddin, Yi-Wei Li, H. Khan, I. Muqbil +7 more
2021International Journal of Molecular Sciences11 citations Open access
Semantic Scholar
SINE compounds activate exportin-1 degradation via an allosteric mechanism
Casey E. Wing, H. Fung, B. Kwanten, Tolga Cagatay +13 more
2025Nature Chemical Biology9 citations Open access
Semantic Scholar
Modulation of anti-tumour immunity by XPO1 inhibitors
J. G. Fisher, Laura G. Bartlett, T. Kashyap, C. Walker +2 more
2025Exploration of Targeted Anti-tumor Therapy9 citations Open access
Semantic Scholar
Synergistic Anti-Tumor Effect of KPT-8602, a Second Generation Selective Inhibitor of Nuclear Export (SINE) Compound, and Panobinostat, a Pan-Histone Deacetylase (HDAC) Inhibitor in Multiple Myeloma
C. Argueta, Hua Chang, T. Kashyap, Sivan Elloul +6 more
20169 citations
Semantic Scholar
Selinexor, a Selective Inhibitor of Nuclear Export (SINE) Compound, Shows Synergistic Anti-Tumor Activity in Combination with Dexamethasone Characterized By Specific Pattern of Gene Expression in Multiple Myeloma (MM)
T. Kashyap, B. Klebanov, Margaret S. Lee, Y. Landesman
20159 citations
Semantic Scholar
First-in-Human Phase I Study of KPT-9274, a First-in-Class Dual Inhibitor of PAK4 and NAMPT, in Patients with Advanced Solid Malignancies
A. Razak, A. Mahipal, Jennifer R. Diamond, Antoni Ribas +8 more
2026Targeted oncology6 citations Open access
Semantic Scholar
Focusing on Selinexor for Holding and Bridging Prior to CAR-T in Relapsed/Refractory Multiple Myeloma
Jack Khouri, D. Sborov, A. Rossi, Thomas Martin +3 more
2025Journal of Clinical Medicine6 citations
Semantic Scholar
Selinexor inhibits growth of patient derived chordomas in vivo as a single agent and in combination with abemaciclib through diverse mechanisms
C. Walker, Hua Chang, Leah Henegar, T. Kashyap +5 more
2022Frontiers in Oncology6 citations Open access
Semantic Scholar
Abstract 4720: Synergistic antitumor effect of selinexor, a selective inhibitor of nuclear export (SINE) compound and panobinostat in a mouse model of multiple myeloma
Sivan Elloul, Hua Chang, B. Klebanov, T. Kashyap +6 more
20166 citations
Semantic Scholar
Efficacy of Selinexor Is Dependent on IκB-α Expression and NF-Kb Deactivation in Multiple Myeloma Cells
T. Kashyap, B. Klebanov, C. Argueta, Margaret S. Lee +4 more
20165 citations
Semantic Scholar
Combination of Selinexor and the Proteasome Inhibitor, Bortezomib Shows Synergistic Cytotoxicity in Diffuse Large B-Cells Lymphoma Cells In Vitro and In Vivo
T. Kashyap, I. Muqbil, A. Aboukameel, B. Klebanov +6 more
20165 citations
Semantic Scholar
HAPLN1 confers multiple myeloma cell resistance to several classes of therapeutic drugs
M. Huynh, Hae Yeun Chang, D. Lisiero, I. Ong +3 more
2022PLoS ONE4 citations Open access
Semantic Scholar
Comparison of Salvage Autologous Hematopoietic Cell Transplantation with Outcomes Following Selinexor Combinations Among Double/Triple Refractory Myeloma Patients
Guldane Cengiz, B. Karakaya, H. Yilmaz, D. Koyun +10 more
2021Blood4 citations Open access
Semantic Scholar
Abstract LB-308: KPT-9274 inhibits cellular NAD and synergizes with doxorubicin to treat dogs with lymphoma
C. London, Megan E. Brown, E. Warry, Elizabeth M. Schuh +7 more
20174 citations
Semantic Scholar
Combination of Selective Inhibitor of Nuclear Export (SINE) Compounds, Selinexor and KPT-8602, with Venetoclax (ABT-199) Displays Enhanced Activity in Leukemia and Large Cell Lymphoma
Melissa A. Fischer, S. Friedlander, L. Hogdal, Pia M. Arrate +9 more
20164 citations
Semantic Scholar
Abstract 3810: Selinexor (KPT-330), a novel selective inhibitor of nuclear export (SINE), shows single agent efficacy against alveolar soft part sarcoma (ASPS) in vivo
M. Crochiere, T. Kashyap, B. Klebanov, W. Senapedis +14 more
20144 citations
Semantic Scholar
Selinexor, mezigdomide, and dexamethasone in patients with Relapsed/Refractory multiple myeloma who relapsed or are ineligible for T-cell–redirecting therapy: Stomp Phase 1 results
Clifton C. Mo, Cristina Gasparetto, Cristiana Costa, A. Cowan +6 more
2025Blood3 citations
Semantic Scholar
MPN-527 Selinexor and Ruxolitinib Impact on Symptom Burden in Patients With Myelofibrosis Is Potentially Driven by Inhibition of NF-κB and Activation of P53 Pathways
S. Tantravahi, A. Kishtagari, Keri Maher, S. Mohan +6 more
2024Clinical Lymphoma, Myeloma & Leukemia3 citations
Semantic Scholar
Small molecule inhibitors of nuclear export ameliorate lupus by modulating plasma cell generation and survival
J. Rangel-Moreno, Maria de la Luz Garcia-Hernandez, Teresa Owen, J. Barnard +9 more
2022Arthritis & Rheumatology3 citations Open access
Semantic Scholar
Abstract 329: Selinexor or KPT-8602 mediated XPO1 inhibition synergizes with dexamethasone to repress convergent pathways in the mTORC1 signaling network and drive cell death in multiple myeloma
C. Argueta, T. Kashyap, B. Klebanov, Hua Chang +7 more
20173 citations
Semantic Scholar
SINE compounds activate exportin-1 degradation via an allosteric mechanism
Casey E. Wing, H. Fung, B. Kwanten, T. Cagatay +13 more
2024bioRxiv2 citations Open access
Semantic Scholar
Abstract 5519: Selinexor synergizes with anti-PD-1 antibody and inhibits tumor growth and metastasis in syngeneic mouse models of KRAS mutant colorectal cancer
Hua Chang, Leah Henegar, C. Walker, T. Kashyap +7 more
2022Cancer Research2 citations
Semantic Scholar
Abstract 2219: Selinexor, a selective inhibitor of nuclear export (SINE) compound, shows synergistic anti-tumor activity when combined with PD-1 blockade in a mouse model of colon cancer
Sivan Elloul, Hua Chang, B. Klebanov, T. Kashyap +6 more
20162 citations
Semantic Scholar
Abstract 1299: Selinexor, a selective inhibitor of nuclear export (SINE) compound shows enhanced anti-tumor activity when combined with either venetoclax or bendamustine in diffuse large B cell lymphoma (DLBCL) mouse models
Sivan Elloul, Hua Chang, B. Klebanov, T. Kashyap +6 more
20162 citations
Semantic Scholar
Combination Therapy with Bortezomib or Carfilzomib and Selinexor Induces Nuclear Localization of Ikbα and Overcomes Acquired Proteasome Inhibitor Resistance in Human Multiple Myeloma
J. Turner, T. Kashyap, J. Dawson, Juan A. Gomez +7 more
20162 citations
Semantic Scholar
Combination Therapy of Selinexor with Bortezomib or Carfilzomib Overcomes Drug Resistance to Proteasome Inhibitors (PI) in Human Multiple Myeloma
D. Sullivan, T. Kashyap, J. Dawson, Y. Landesman +6 more
20152 citations
Semantic Scholar
247 Selective inhibitors of nuclear export (SINE) block the expression of DNA damage repair proteins and sensitize cancer cells to DNA damage therapeutic agents
T. Kashyap, M. Crochiere, S. Friedlander, B. Klebanov +10 more
20142 citations
Semantic Scholar
In vitro characterization of polymeric nanoparticles encapsulating plasmid DNA for gene therapy
T. Kashyap, Tomer Bonshtein, Asiel Mena, Shira Orr
2025International Journal of Polymeric Materials and Polymeric Biomaterials1 citations Open access
Semantic Scholar
Selinexor and Ruxolitinib Impact on Symptom Burden in Patients With Myelofibrosis Is Potentially Driven by Inhibition of NF-κB and Activation of P53 Pathways
S. Tantravahi, A. Kishtagari, Keri Maher, S. Mohan +6 more
2024Clinical Lymphoma, Myeloma & Leukemia1 citations
Semantic Scholar

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