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W. Senapedis · SciRah

Researcher profile · Semantic Scholar

W. Senapedis

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W. Senapedis — researcher profile on SciRah

h-index: 33
Works: 143
Citations: 3,359

Most-cited papers

Targeting super-enhancer-associated oncogenes in oesophageal squamous cell carcinoma
Yan-Yi Jiang, D. Lin, A. Mayakonda, M. Hazawa +14 more
2016Gut187 citations Open access
Semantic Scholar
XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer
Jimi Kim, Elizabeth A. McMillan, Hyun Seok Kim, Niranjan Venkateswaran +19 more
2016Nature187 citations Open access
Semantic Scholar
PAK4 inhibition improves PD-1 blockade immunotherapy
Gabriel Abril-Rodríguez, D. Torrejon, Wei Liu, J. Zaretsky +17 more
2019Nature Cancer149 citations Open access
Semantic Scholar
Dual and specific inhibition of NAMPT and PAK4 by KPT-9274 decreases kidney cancer growth
Omran Abu Aboud, Ching-Hsien Chen, W. Senapedis, E. Baloglu +2 more
2016Molecular Cancer Therapeutics138 citations Open access
Semantic Scholar
Selinexor, a Selective Inhibitor of Nuclear Export (SINE) compound, acts through NF-κB deactivation and combines with proteasome inhibitors to synergistically induce tumor cell death
T. Kashyap, C. Argueta, A. Aboukameel, T. Unger +10 more
2016OncoTarget136 citations Open access
Semantic Scholar
KPT-8602, a second-generation inhibitor of XPO1-mediated nuclear export, is well tolerated and highly active against AML blasts and leukemia-initiating cells
Julia Etchin, A. Berezovskaya, A. Conway, I. Galinsky +8 more
2016Leukemia116 citations Open access
Semantic Scholar
Clinical Implications of Targeting XPO1‐mediated Nuclear Export in Multiple Myeloma
Ujjawal H. Gandhi, W. Senapedis, E. Baloglu, T. Unger +3 more
2018Clinical Lymphoma, Myeloma & Leukemia113 citations Open access
Semantic Scholar
Target identification of small molecules using large-scale CRISPR-Cas mutagenesis scanning of essential genes
J. E. Neggers, B. Kwanten, T. Dierckx, H. Noguchi +11 more
2018Nature Communications93 citations Open access
Semantic Scholar
Novel p21-activated kinase 4 (PAK4) allosteric modulators overcome drug resistance and stemness in pancreatic ductal adenocarcinoma
A. Aboukameel, I. Muqbil, W. Senapedis, E. Baloglu +6 more
2016Molecular Cancer Therapeutics75 citations Open access
Semantic Scholar
A novel orally bioavailable compound KPT-9274 inhibits PAK4, and blocks triple negative breast cancer tumor growth
Chetan K Rane, W. Senapedis, E. Baloglu, Y. Landesman +3 more
2017Scientific Reports63 citations Open access
Semantic Scholar
Venetoclax response is enhanced by selective inhibitor of nuclear export compounds in hematologic malignancies.
Melissa A. Fischer, S. Friedlander, M. Arrate, Hua Chang +14 more
2020Blood Advances61 citations Open access
Semantic Scholar
Selective targeting of NAMPT by KPT-9274 in acute myeloid leukemia.
Shaneice R. Mitchell, Karilyn T. M. Larkin, N. Grieselhuber, Tzung-Huei Lai +22 more
2019Blood Advances61 citations Open access
Semantic Scholar
The Second-Generation Exportin-1 Inhibitor KPT-8602 Demonstrates Potent Activity against Acute Lymphoblastic Leukemia
T. Vercruysse, J. de Bie, J. E. Neggers, M. Jacquemyn +10 more
2016Clinical Cancer Research56 citations Open access
Semantic Scholar
Selinexor reduces the expression of DNA damage repair proteins and sensitizes cancer cells to DNA damaging agents
T. Kashyap, C. Argueta, T. Unger, B. Klebanov +7 more
2018OncoTarget55 citations Open access
Semantic Scholar
XPO1 Inhibition Enhances Radiation Response in Preclinical Models of Rectal Cancer
I. Ferreiro-Neira, Nancy E Torres, Lukas F. Liesenfeld, C. Chan +6 more
2015Clinical Cancer Research48 citations Open access
Semantic Scholar
Selinexor synergizes with dexamethasone to repress mTORC1 signaling and induce multiple myeloma cell death
C. Argueta, T. Kashyap, B. Klebanov, T. Unger +7 more
2018OncoTarget44 citations Open access
Semantic Scholar
Functional role and therapeutic targeting of p21-activated kinase 4 in multiple myeloma.
M. Fulciniti, J. Martínez-López, W. Senapedis, S. Oliva +20 more
2017Blood43 citations Open access
Semantic Scholar
Targeting Nuclear Exporter Protein XPO1/CRM1 in Gastric Cancer
R. Sexton, Zaid Mahdi, R. Chaudhury, R. Beydoun +9 more
2019International Journal of Molecular Sciences42 citations Open access
Semantic Scholar
Targeting the vulnerability to NAD+ depletion in B-cell acute lymphoblastic leukemia
S. Takao, W. Chien, V. Madan, D. Lin +14 more
2018Leukemia38 citations
Semantic Scholar
Targeting the Nuclear Export Protein XPO1/CRM1 Reverses Epithelial to Mesenchymal Transition
A. Azmi, I. Muqbil, Jack S Wu, A. Aboukameel +9 more
2015Scientific Reports37 citations Open access
Semantic Scholar
Anti-tumor activity of selective inhibitor of nuclear export (SINE) compounds, is enhanced in non-Hodgkin lymphoma through combination with mTOR inhibitor and dexamethasone
I. Muqbil, A. Aboukameel, Sivan Elloul, R. Carlson +8 more
2016Cancer Letters35 citations Open access
Semantic Scholar
Therapeutic Potential of Targeting PAK Signaling.
W. Senapedis, M. Crochiere, E. Baloglu, Y. Landesman
2015Anti-Cancer Agents in Medicinal Chemistry35 citations
Semantic Scholar
Targeting Rho GTPase effector p21 activated kinase 4 (PAK4) suppresses p-Bad-microRNA drug resistance axis leading to inhibition of pancreatic ductal adenocarcinoma proliferation
R. Mohammad, Yi-Wei Li, I. Muqbil, A. Aboukameel +5 more
2019Small GTPases34 citations Open access
Semantic Scholar
Exportin 1 (XPO1) inhibition leads to restoration of tumor suppressor miR-145 and consequent suppression of pancreatic cancer cell proliferation and migration.
A. Azmi, Yi-Wei Li, I. Muqbil, A. Aboukameel +7 more
2017OncoTarget34 citations Open access
Semantic Scholar
Dual PAK4-NAMPT Inhibition Impacts Growth and Survival, and Increases Sensitivity to DNA-Damaging Agents in Waldenstrom Macroglobulinemia.
Na Li, Michael A. Lopez, M. Linares, Subodh Kumar +13 more
2018Clinical Cancer Research32 citations Open access
Semantic Scholar
PAK4-NAMPT Dual Inhibition as a Novel Strategy for Therapy Resistant Pancreatic Neuroendocrine Tumors
G. Mpilla, A. Aboukameel, I. Muqbil, Steve H. Kim +12 more
2019Cancers27 citations Open access
Semantic Scholar
Deciphering mechanisms of drug sensitivity and resistance to Selective Inhibitor of Nuclear Export (SINE) compounds
M. Crochiere, T. Kashyap, O. Kalid, Sharon Shechter +4 more
2015BMC Cancer27 citations Open access
Semantic Scholar
PAK4-NAMPT Dual Inhibition Sensitizes Pancreatic Neuroendocrine Tumors to Everolimus
G. Mpilla, M. H. Uddin, M. Al-Hallak, A. Aboukameel +13 more
2021Molecular Cancer Therapeutics25 citations Open access
Semantic Scholar
374PDA first in human phase 1 study of KPT-9274, a first in class dual inhibitor of PAK4 and NAMPT, in patients with advanced solid malignancies or NHL
A. Naing, S. Leong, M. Pishvaian, A. Razak +9 more
201722 citations Open access
Semantic Scholar
XPO1 Inhibition Preferentially Disrupts the 3D Nuclear Organization of Telomeres in Tumor Cells
Cheryl Taylor-Kashton, Daniel Lichtensztejn, E. Baloglu, W. Senapedis +4 more
2016Journal of Cellular Physiology22 citations Open access
Semantic Scholar
A phase 1 clinical trial of oral eltanexor in patients with relapsed or refractory multiple myeloma
R. Cornell, R. Baz, J. R. Richter, A. Rossi +22 more
2021American journal of hematology/oncology20 citations Open access
Semantic Scholar
Exportin 1 (XPO1) inhibition leads to restoration of tumor suppressor miR-145 and consequent suppression of pancreatic cancer cell proliferation and migration
A. Azmi, Yi-Wei Li, I. Muqbil, A. Aboukameel +7 more
2017OncoTarget17 citations Open access
Semantic Scholar
Eltanexor (KPT-8602), a Second-Generation Selective Inhibitor of Nuclear Export (SINE) Compound, in Patients with Refractory Multiple Myeloma
R. Cornell, A. Rossi, R. Baz, C. Hofmeister +10 more
201716 citations
Semantic Scholar
PAK4 and NAMPT as Novel Therapeutic Targets in Diffuse Large B-Cell Lymphoma, Follicular Lymphoma, and Mantle Cell Lymphoma
H. Khan, M. H. Uddin, S. Balasubramanian, N. Sulaiman +9 more
2021Cancers15 citations Open access
Semantic Scholar
Down-regulation of AR splice variants through XPO1 suppression contributes to the inhibition of prostate cancer progression
A. Aboukameel, I. Muqbil, E. Baloglu, W. Senapedis +10 more
2018OncoTarget15 citations Open access
Semantic Scholar
Anti-cystogenic activity of a small molecule PAK4 inhibitor may be a novel treatment for Autosomal Dominant Polycystic Kidney Disease
Vicki J. Hwang, Xia Zhou, Xiao-Nan Chen, J. Trott +9 more
2017Kidney International11 citations Open access
Semantic Scholar
Synergistic Anti-Tumor Effect of KPT-8602, a Second Generation Selective Inhibitor of Nuclear Export (SINE) Compound, and Panobinostat, a Pan-Histone Deacetylase (HDAC) Inhibitor in Multiple Myeloma
C. Argueta, Hua Chang, T. Kashyap, Sivan Elloul +6 more
20169 citations
Semantic Scholar
A Phase 1/2 Study of the Second Generation Selective Inhibitor of Nuclear Export (SINE) Compound, KPT-8602, in Patients with Relapsed Refractory Multiple Myeloma
R. Cornell, A. Rossi, R. Baz, C. Hofmeister +14 more
20169 citations
Semantic Scholar
Anti-Cancer Activity of PAK4/NAMPT Inhibitor and Programmed Cell Death Protein-1 Antibody in Kidney Cancer
J. Trott, Omran Abu Aboud, B. McLaughlin, K. L. Anderson +9 more
2020Kidney3608 citations Open access
Semantic Scholar
Decrypting the PAK4 transcriptome profile in mammary tumor forming cells using Next Generation Sequencing.
Chetan K Rane, Misaal Patel, L. Cai, W. Senapedis +2 more
2017Genomics8 citations Open access
Semantic Scholar
Recurrent Mutations of the Exportin 1 Gene (XPO1) in Primary Mediastinal B-Cell Lymphoma: A Lysa Study
F. Jardin, A. Pujals, L. Pelletier, E. Bohers +33 more
20156 citations
Semantic Scholar
Anticancer Efficacy of KRASG12C Inhibitors Is Potentiated by PAK4 Inhibitor KPT9274 in Preclinical Models of KRASG12C-Mutant Pancreatic and Lung Cancers
H. Khan, M. Nagasaka, A. Aboukameel, O. Alkhalili +16 more
2023Molecular Cancer Therapeutics5 citations Open access
Semantic Scholar
Anticancer efficacy of KRASG12C inhibitors is potentiated by PAK4 inhibitor KPT9274 in preclinical models of KRASG12C mutant pancreatic and lung cancers
H. Khan, M. Nagasaka, A. Aboukameel, O. Alkhalili +16 more
2023bioRxiv5 citations Open access
Semantic Scholar
Eltanexor (KPT-8602), a Second-Generation Selective Inhibitor of Nuclear Export (SINE) Compound, in Patients with Higher-Risk Myelodysplastic Syndrome
Sangmin Lee, Bhavana Bhatnagar, Sanjay R. Mohan, W. Senapedis +5 more
2019Blood5 citations
Semantic Scholar
Efficacy of Selinexor Is Dependent on IκB-α Expression and NF-Kb Deactivation in Multiple Myeloma Cells
T. Kashyap, B. Klebanov, C. Argueta, Margaret S. Lee +4 more
20165 citations
Semantic Scholar
Combination of Selinexor and the Proteasome Inhibitor, Bortezomib Shows Synergistic Cytotoxicity in Diffuse Large B-Cells Lymphoma Cells In Vitro and In Vivo
T. Kashyap, I. Muqbil, A. Aboukameel, B. Klebanov +6 more
20165 citations
Semantic Scholar
Next Generation XPO1 Inhibitor KPT-8602 for the Treatment of Drug-Resistant Multiple Myeloma
J. Turner, J. Dawson, C. Cubitt, Erkan Baluglo +7 more
20155 citations
Semantic Scholar
Abstract LB-308: KPT-9274 inhibits cellular NAD and synergizes with doxorubicin to treat dogs with lymphoma
C. London, Megan E. Brown, E. Warry, Elizabeth M. Schuh +7 more
20174 citations
Semantic Scholar
Combination of Selective Inhibitor of Nuclear Export (SINE) Compounds, Selinexor and KPT-8602, with Venetoclax (ABT-199) Displays Enhanced Activity in Leukemia and Large Cell Lymphoma
Melissa A. Fischer, S. Friedlander, L. Hogdal, Pia M. Arrate +9 more
20164 citations
Semantic Scholar
Eltanexor (KPT-8602), a second-generation selective inhibitor of nuclear export (SINE) compound, in patients with metastatic colorectal cancer (mCRC).
J. Hays, J. Zhang, J. Berlin, M. O'Hara +7 more
2018Annals of Oncology3 citations Open access
Semantic Scholar

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I. Muqbil — researcher profile on SciRah

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